Paul Thomas, PhD

Paul G. Thomas, PhD

Assistant Member, St. Jude Faculty

Departments

Immunology

Contact Information

Paul Thomas, PhD
Immunology
MS 351, Room E7060
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: paul.thomas@stjude.org
Phone: (901) 595-6507
FAX: (901) 595-3107

Education

BS – Wake Forest University, Winston-Salem, North Carolina (1999)
PhD – Harvard University, Cambridge, Massachusetts (2003)


Research Interests


Selected Publications

Rutigliano JA, Sharma S, Morris MY, Oguin TH 3rd, McClaren JL, Doherty PC, Thomas PG. Highly pathologic influenza A virus infection is associated with augmented expression of PD-1 by functionally-compromised virus-specific CD8+ T cells. J Virol November 20, 2013.

Sharma S, Thomas PG. The two faces of heterologous immunity: protection or immunopathology. J Leukoc Biol November 8, 2013.

Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, Brown SA, Surman S, Wilson ZS, Bradley P, Hurwitz J, Chi H, Doherty PC, Thomas PG, McGargill MA. The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol October 20, 2013.

Askovich PS, Sanders CJ, Rosenberger CM, Diercks AH, Dash P, Navarro G, Vogel P, Doherty PC, Thomas PG, Aderem A. Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses PLoS One 8(9):e74863, 2013.

La Gruta NL, Thomas PG. Interrogating the relationship between naive and immune antiviral T cell repertoires. Curr Opin Virol 3(4):447-51, 2013.

Tam VC, Quehenberger O, Oshansky CM, Suen R, Armando AM, Treuting PM, Thomas PG, Dennis EA, Aderem A. Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation. Cell 154(1):213-27, 2013.

Ghoneim HE, Thomas PG, McCullers JA. Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections. J Immunol June 26, 2013.

Sanders CJ, Vogel P, McClaren JL, Bajracharya R, Doherty PC, Thomas PG. Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels. Am J Physiol Lung Cell Mol Physiol 304(7):L481-L488, 2013.

O'Reilly MC, Scott SA, Brown KA, Oguin TH, Thomas PG, Daniels JS, Morrison R, Brown HA, Lindsley CW. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem 56(6):2695-9, 2013.

Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol March 24, 2013.

Thomas PG, Handel A, Doherty PC, La Gruta NL. Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations. Proc Natl Acad Sci U S A January 14, 2013.

Sanders CJ, Johnson B, Frevert CW, Thomas PG. Intranasal influenza infection of mice and methods to evaluate progression and outcome. Methods Mol Biol 1031:177-88, 2013.

Thomas PG, Hertz T. Constrained evolution drives limited influenza diversity. BMC Biol 10(43), 2012.

Wang GC, Dash P, McCullers JA, Doherty PC, Thomas PG. T cell receptor alpha beta diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection. Sci Transl Med 4(128):128ra42, 2012.

Van Stry M, Oguin T, Cheloufi S, Vogel P, Watanabe M, Pillai MR, Dash P, Thomas P, Hannon GJ, Bix M. Enhanced susceptibility to influenza A virus of Ago1/3 double null mice. J Virol 86(8):1451-7, 2012.

Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polic B, Al-Harthi L, Sperling AI, Guevara-Patino JA. NKG2D signaling on CD8(+) T cells represses T-bet and rescues CD4-unhelped CD8(+) T cell memory recall but not effector responses. Nat Med 18(3):422-8, 2012.

Doherty PC, Thomas PG. Dangerous for ferrets: lethal for humans? BMC Biol 10:10, 2012.

Oshansky CM, Thomas PG. The human side of influenza. J Leukoc Biol 2012.

Ruckwardt TJ, Malloy AMW, Gostick E, Price DA, Dash P, McClaren JL, Thomas PG, Graham BS. Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected mice. PLoS Pathog 7(12):2377, 2011.

Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BT. T cell immunoglobulin and mucin protein-3 (Tim-3)/galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses. Proc Natl Acad Sci U S A 108(47):19001-6, 2011.

Moon JJ, Dash P, Oguin TH, McClaren JL, Chu HH, Thomas PG, Jenkins MK. Quantitative impact of thymic selection on Foxp3(+) and Foxp3(-) subsets of self-peptide/MHC class II-specific CD4(+) T cells. Proc Natl Acad Sci U S A 108(35):14602-7, 2011.

Surman SL, Rudraraju R, Woodland DL, Dash P, Thomas PG, Hurwitz JL. Clonally related CD8 T cells responsible for rapid population of both diffuse nasal-associated lymphoid tissue and lung after respiratory virus infection. J Immunol June 20, 2011.

Billam P, Bonaparte KL, Liu J, Ruckwardt TJ, Chen M, Ryder AB, Wang R, Dash P, Thomas PG, Graham BS. T cell receptor clonotype influences epitope hierarchy in the CD8 T cell response to respiratory syncytial virus infection. J Biol Chem 286(6):4829-41, 2011.

Dash P, McClaren JL, Oguin TH, Rothwell W, Todd B, Morris MY, Becksfort J, Reynolds C, Brown SA, Doherty PC, Thomas PG. Paired analysis of TCR[alpha] and TCR[beta] chains at the single-cell level in mice. J Clin Invest 121(1):288-295, 2011.

Rawlings JS, Gatzka M, Thomas PG, Ihle JN. Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence. EMBO J December 17, 2010.

Moffat JM, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL. Influenza epitope-specific CD8( ) T cell avidity, but not cytokine polyfunctionality, can be determined by TCR beta clonotype. J Immunol 185(11):6850-6856, 2010.

Ellebedy AH, Fabrizio T, Kayali G, Oguin T, Brown S, Rehg J, Thomas P, Webby RJ. Contemporary seasonal A (H1N1) influenza virus infection primes for a more robust response to split inactivated pandemic A(H1N1) vaccination in ferrets. Clin Vaccine Immunol October 20, 2010.

Sanders CJ, Doherty PC, Thomas PG. Respiratory epithelial cells in innate immunity to influenza virus infection. Cell Tissue Res September 17, 2010.

Valkenburg SA, Gras S, Guillonneau C, La Gruta NL, Thomas PG, Purcell AW, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K. Protective efficacy of cross-reactive CD8( ) T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold. PLoS Pathog 6(8):1039, 2010.

La Gruta NL, Rothwell WT, Cukalac T, Swan NG, Valkenburg SA, Kedzierska K, Thomas PG, Doherty PC, Turner SJ. Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. J Clin Invest 120(6):1885-1894, 2010.

Thomas PG, Brown SA, Morris MY, Yue W, So J, Reynolds C, Webby RJ, Doherty PC. Physiological numbers of CD4( ) T cells generate weak recall responses following influenza virus challenge. J Immunol 184(4):1721-1727, 2010.

Thomas PG, Doherty PC. New approaches in immunotherapy. Science 327(5963):249, 2010.

Rutigliano JA, Morris MY, Yue W, Keating R, Webby RJ, Thomas PG, Doherty PC. Protective memory responses are modulated by priming events prior to challenge. J Virol 84(2):1047-1056, 2010.

Doherty PC, Brown LE, Kelso A, Thomas PG. Immunity to avian influenza A viruses. Rev Sci Tech 28(1):175-185, 2009.

Turner SJ, La Gruta NL, Kedzierska K, Thomas PG, Doherty PC. Functional implications of T cell receptor diversity. Curr Opin Immunol 21(3): 286-290, 2009.

Thomas PG, Dash P, Aldridge JR, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30(4): 566-575, 2009.

Aldridge JR Jr, Moseley CE, Boltz DA, Negovetich NJ, Reynolds C, Franks J, Brown SA, Doherty PC, Webster RG, Thomas PG. TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A. 2009 Mar 11.

Huber VC, Thomas PG, McCullers JA. A multi-valent vaccine approach that elicits broad immunity within an influenza subtype. Vaccine Feb 18;27(8):1192-200, 2009. Epub Jan 7, 2009.

Thomas PG, Doherty PC. Rules to ‘prime’ by. Nat Immunol Jan;10(1):14-6, 2009.

Kedzierska K*, Thomas PG*, Venturi V, Davenport MP, Doherty PC, Turner SJ, La Gruta NL. TdT is required for the establishment of private virus-specific CD8 TCR repertoires and facilitates optimal CTL responses. J Immunol Aug 15; 181(4):2556-2662, 2008. *These authors contributed equally to the work.

Rutigliano JA, Doherty PC, Franks J, Morris MY, Reynolds C, Thomas PG. Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection. J Immunol Methods Jul 20;336(1):71-7, 2008. Epub Apr 28, 2008.

La Gruta NL, Thomas PG, Webb AI, Dunstone MA, Cukalac T, Doherty PC, Purcell AW, Rossjohn J, Turner SJ. Epitope-specific TCRβ repertoire diversity imparts no functional advantage on the CD8 T cell response to cognate viral peptides. Proc Natl Acad Sci U S A Feb 12;105(6):2034-9, 2008. Epub Jan 31, 2008.

Thomas PG, Brown SA, Keating R, Yue W, Morris MY, So J, Webby RJ, Doherty PC. Hidden Epitopes Emerge in Secondary Influenza Virus-Specific CD8 T Cell Reponses. J Immunol Mar 1; 178(5):3091-8, 2007.

Keating R, Yue W, Rutigliano J, Olivas E, Thomas PG, Doherty PC. Virus-specific CD8 T Cells in the liver: Armed and ready to kill. J Immunol Mar 1;178(5):2737-45, 2007.

Doherty PC, Turner SJ, Webby RG, Thomas PG. Influenza and the challenge for immunology. Nat Immunol May;7(5):449-55, 2006. Review.

Wei L, Sandbulte MR, Thomas PG, Webby RJ, Homayouni R, Pfeffer LM. NF-κB Negatively Regulates Interferon-induced Gene Expression and Anti-influenza Activity. J Biol Chem Apr 28;281(17):11678-11684, 2006.

Thomas PG, Brown SA, Yue W, So J, Webby RJ, Doherty PC. An unexpected antibody response to an engineered influenza virus modifies CD8 T cell responses. Proc Natl Acad Sci U S A 103, 2764-2769 2006.

Thomas PG, Keating R, Hulse-Post DJ, Doherty PC. Cell-mediated protection in influenza infection. Emerg Infect Dis 12(1):48-54, 2006. Review.

Thomas PG, Carter MR, Da’Dara AA, Harn, DA. A helminth glycan induces APC maturation via alternative NF-kB activation independent of IkBa degradation. J Immunol 175(4):2082-90, 2005.

Andreansky SS, Stambas J, Thomas PG, Xie W, Webby RJ, Doherty PC. Consequences of Immunodominant Epitope Deletion for Minor Influenza Virus-Specific CD8 T Cell Responses. J Virol 79(7):4329-39, 2005.

Thomas PG, Harn DA. Immune Biasing by helminth glycans. Cell Microbiol 6(1):13-22, 2004. Review.

Thomas PG, Carter MR, Atochina O, Da'Dara AA, Piskorska D, McGuire E, Harn DA. Maturation of dendritic cell 2 phenotype by a helminth glycan uses a toll-like receptor 4-dependent mechanism. J Immunol 171(11):5837-5841, 2003.

Spolski RJ, Thomas PG, See EJ, Mooney KA, Kuhn RE. Larval Taenia crassiceps secretes a protein with characteristics of murine interferon-gamma. Parasitol Res 88(5):431-438, 2002.

Spolski RJ, Corson J, Thomas PG, Kuhn RE. Parasite-secreted products regulate the host response to larval Taenia crassiceps. Parasite Immunol 22(6):297-305, 2000.


Last updated: December 2013