Xiang Chen, PhD
Xiang Chen, PhD

Xiang Chen, PhD

Assistant Member, St. Jude Faculty

Departments

Education

BS – Fu Dan University, Shanghai, China
MS – National University of Singapore, Singapore, Rep. of Singapore
MS – Carnegie Mellon University, Pittsburgh, Pennsylvania
PhD – Carnegie Mellon University, Pittsburgh, Pennsylvania
Postdoctoral Training – Yale University, New Haven, Connecticut

Research Interests

  • Algorithm development for assessing the interplays between genetic alterations and epigenetic deregulations
  • Functional consequences of complex genetic alterations in pediatric solid tumors
  • Novel biological discovery from high throughput screening

Selected Publications

Kwizera A, O'Connor R, Vinduska V, Wiliams M, Butch ER, Snyder SE, Chen X, Huang X. Molecular detection and analysis of exosomes using surface enhanced Raman scattering gold nanorods and a miniaturized device. Theranostics Apr 9;8(10):2722-38, 2018. doi: 10.7150/thno.21358.

Wang L, Hiler D, Xu B, AlDiri I, Chen X, Zhou X, Griffiths L, Valentine M, Shirinifard A, Sablauer A, Thiagarajan S, Barabas ME, Zhang J, Johnson D, Frase S, Dyer MA. Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures. Cell Rep Mar 6;22(10):2601-14, 2018. doi: 10.1016/j.celrep.2018.01.075. PMID: 29514090. PMCID: PMC5872828

Ma X, Liu Y, Liu Y, Alexandrov LB, Edmonson MN, Gawad C, Zhou X, Li Y, Rusch MC, Easton J, Huether R, Gonzalez-Pena V, Wilkinson MR, Hermida LC, Davis S, Sioson E, Pounds S, Cao X, Ries RE, Wang Z, Chen X, Dong L, Diskin SJ, Smith MA, Guidry Auvil JM, Meltzer PS, Lau CC, Perlman EJ, Maris JM, Meshinchi S, Hunger SP, Gerhard DS, Zhang J. Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. Nature Mar 15;555(7696):371-6, 2018. doi: 10.1038/nature25795. PubMed PMID: 29489755. PMCID: PMC5854542

Stewart E, Federico SM, Chen X*, Shelat AA, Bradley C, Gordon B, Karlstrom A, Twarog NR, Clay MR, Bahrami A, Freeman BB 3rd, Xu B, Zhou X, Wu J, Honnell V, Ocarz M, Blankenship K, Dapper J, Mardis ER, Wilson RK, Downing J, Zhang J, Easton J, Pappo A, Dyer MA. Orthotopic patient-derived xenografts of paediatric solid tumours. Nature Sep 7;549(7670):96-100, 2017. doi: 10.1038/nature23647. PubMed PMID: 28854174. PMCID: PMC5659286

Chang TC, Carter RA, Li Y, Li Y, Wang H, Edmonson MN, Chen X, Arnold P, Geiger TL, Wu G, Peng J, Dyer M, Downing JR, Green DR, Thomas PG, Zhang J. The Neoepitope Landscape in Pediatric Cancers. Genome Med Aug 31;9(1):78, 2017. doi: 10.1186/s13073-017-0468-3. PubMed PMID: 28854978. PMCID: PMC5577668

Aldiri I, Xu B, Wang L, Chen X, Hiler D, Griffiths L, Valentine M, Shirinifard A, Thiagarajan S, Sablauer A, Barabas ME, Zhang J, Johnson D, Frase S, Zhou X, Easton J, Zhang J, Mardis ER, Wilson RK, Downing JR, Dyer MA. The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis. Neuron May 3;94(3):550-568.e10, 2017. doi: 10.1016/j.neuron.2017.04.022. PubMed PMID: 28472656

Faber ZJ, Chen X*, Gedman AL, Boggs K, Cheng J, Radtke I, Chao JR, Ma J, Walsh MP, Song G, Andersson AK, Dang J, Dong L, Liu Y, Huether R, Cai Z, Mulder H, Wu G, Edmonson M, Rusch M, Qu C, Li Y, Vadodaria B, Wang J, Hedlund E, Cao X, Yergeau D, Nakitandwe J, Pounds SB, Shurtleff S, Fulton RS, Fulton LL, Easton J, Parganas E, Pui CH, Rubnitz JE, Ding L, Mardis ER, Wilson RK, Gruber TA, Mullighan CG, Schlenk RF, Paschka P, Döhner K, Döhner H, Bullinger L, Zhang J, Klco JM, Downing JR. The Genomic Landscape of Core-Binding Factor Acute Myeloid Leukemias. Nat Genet Dec;48(12):1551-1556, 2016. doi: 10.1038/ng.3709. PubMed PMID: 27798625

Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Shao Y, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi S, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui CH, Jeha S, Harvey RC, Chen IL, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrózek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG. Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nat Genet Dec;48(12):1481-1489, 2016. doi: 10.1038/ng.3691. PubMed PMID: 27776115

Zhang J, Walsh MF, Wu G, Edmonson MN, Gruber TA, Easton J, Hedges D, Ma X, Zhou X, Yergeau DA, Wilkinson MR, Vadodaria B, Chen X, McGee RB, Hines-Dowell S, Nuccio R, Quinn E, Shurtleff SA, Rusch M, Patel A, Becksfort JB, Wang S, Weaver MS, Ding L, Mardis ER, Wilson RK, Gajjar A, Ellison DW, Pappo AS, Pui CH, Nichols KE, Downing JR. Germline Mutations in Predisposition Genes in Pediatric Cancer. N Engl J Med Dec 10;373(24):2336-46, 2015. doi: 10.1056/NEJMoa1508054. PubMed PMID: 26580448

Aldiri I, Ajioka I, Xu B, Zhang J, Chen X, Benavente, Finkelstein D, Johnson D, Akiyama J, Pennacchio L, Dyer M. Brg1 Coordinates Multiple Processes During Retinogenesis and is a Tumor Suppressor in Retinoblastoma. Development Dec 1;142(23):4092-106, 2015. doi: 10.1242/dev.124800. PMID: 26628093

Stewart E, Shelat A, Bradley C, Chen X, Federico S, Thiagarajan S, Shirinifard A, Bahrami A, Pappo A, Qu C, Finkelstein D, Sablauer A, Dyer D. Development and characterization of a human orthotopic neuroblastoma xenograft. Developmental Biology Nov 15;407(2):344-55, 2015. doi: 10.1016/j.ydbio.2015.02.002. PMID: 25863122

Ma C, Chen Y, Wilkins D, Chen X, Zhang J. An unsupervised learning approach to find ovarian cancer genes through integration of biological data. BMC Genomics Aug 17;16(Suppl 9):S3, 2015. Doi: 10.1186/1471-2164-16-S9-S3. PMID: 26328548

Hiler D, Chen X, Hazen J, Kupriyanov S, Carroll PA, Qu C, Xu B, Johnson D, Griffiths L, Frase S, Rodriguez AR, Martin G, Zhang J, Jeon J, Fan Y, Finkelstein D, Eisenman RN, Baldwin K, Dyer MA. Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell Jul 2;17(1):101-15, 2015. doi: 10.1016/j.stem.2015.05.015. PMID: 26140606

Chen X, Gupta P, Wang J, Nakitandwe J, Roberts K, Dalton JD, Parker M, Patel S, Holmfeldt L, Payne D, Easton J, Ma J, Rusch M, Wu G, Patel A, Baker SJ, Dyer MA, Shurtleff S, Espy S, Pounds S, Downing JR, Ellison DW, Mullighan CG, Zhang J. CONSERTING: integrating copy-number analysis with structural-variation detection. Nat Methods Jun;12(6):527-30, 2015. doi: 10.1038/nmeth.3394. Epub 2015 May 4. PMID: 25938371

Pinto EM, Chen X*, Easton J, Finkelstein D, Liu Z, Pounds S, Rodriguez-Galindo C, Lund TC, Mardis ER, Wilson RK, Boggs K, Yergeau D, Cheng J, Mulder HL, Manne J, Jenkins J, Mastellaro MJ, Figueiredo BC, Dyer MA, Pappo A, Zhang J, Downing JR, Ribeiro RC, Zambetti GP. Genomic landscape of paediatric adrenocortical tumours. Nat Commun Mar 6;6:6302, 2015. doi: 10.1038/ncomms7302. PMID: 25743702. PMCID: PMC4352712

Andersson AK, Ma J, Wang J, Chen X, Gedman AL, Dang J, Nakitandwe J, Holmfeldt L, Parker M, Easton J, Huether R, Kriwacki R, Rusch M, Wu G, Li Y, Mulder H, Raimondi S, Pounds S, Kang G, Shi L, Becksfort J, Gupta P, Payne-Turner D, Vadodaria B, Boggs K, Yergeau D, Manne J, Song G, Edmonson M, Nagahawatte P, Wei L, Cheng C, Pei D, Sutton R, Venn NC, Chetcuti A, Rush A, Catchpoole D, Heldrup J, Fioretos T, Lu C, Ding L, Pui CH, Shurtleff S, Mullighan CG, Mardis ER, Wilson RK, Gruber TA, Zhang J, Downing JR; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. Nat Genet Apr;47(4):330-7, 2015. doi: 10.1038/ng.3230. Epub 2015 Mar 2. PMID: 25730765

Chen X, Pappo A, Dyer MA. Pediatric solid tumor genomics and developmental pliancy. Oncogene Feb 2, 2015. doi: 10.1038/onc.2014.474. PMID: 25639868

Tirode F, Surdez D, Ma X, Parker M, Le Deley MC, Bahrami A, Zhang Z, Lapouble E, Grossetête-Lalami S, Rusch M, Reynaud S, Rio-Frio T, Hedlund E, Wu G, Chen X, Pierron G, Oberlin O, Zaidi S, Lemmon G, Gupta P, Vadodaria B, Easton J, Gut M, Ding L, Mardis ER, Wilson RK, Shurtleff S, Laurence V, Michon J, Marec-Bérard P, Gut I, Downing J, Dyer M, Zhang J, Delattre O. Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations. Cancer Discov 4(11):1342 – 1353, 2014. doi: 10.1158/2159-8290.CD-14-0622. Epub 2014 Sep 15. PMID: 25223734. PMCID: PMC4264969

Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med Sep 11;371(11):1005-15, 2014. doi: 10.1056/NEJMoa1403088. PMID: 25207766. PMCID: PMC4191900

Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, Zhu X, Qu C, Chen X, Zhang J, Easton J, Edmonson M, Ma X, Lu C, Nagahawatte P, Hedlund E, Rusch M, Pounds S, Lin T, Onar-Thomas A, Huether R, Kriwacki R, Parker M, Gupta P, Becksfort J, Wei L, Mulder HL, Boggs K, Vadodaria B, Yergeau D, Russell JC, Ochoa K, Fulton RS, Fulton LL, Jones C, Boop FA, Broniscer A, Wetmore C, Gajjar A, Ding L, Mardis ER, Wilson RK, Taylor MR, Downing JR, Ellison DW, Zhang J, Baker SJ. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet May;46(5):444-50, 2014. doi: 10.1038/ng.2938. Epub 2014 Apr 6. PMID: 24705251. PMCID: PMC4056452

Chen X*, Bahrami A, Pappo A, Easton J, Dalton J, Hedlund E, Ellison D, Shurtleff S, Wu G, Wei L, Parker M, Rusch M, Nagahawatte P, Wu J, Mao S, Boggs K, Mulder H, Yergeau D, Lu C, Ding L, Edmonson M, Qu C, Wang J, Li Y, Navid F, Daw NC, Mardis ER, Wilson RK, Downing JR, Zhang J, Dyer MA. Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep Apr 10;7(1):104-12, 2014. doi: 10.1016/j.celrep.2014.03.003. Epub 2014 Apr 3. PMID: 24703847. PMCID: PMC4096827

Huether R, Dong L, Chen X, Wu G, Parker M, Wei L, Ma J, Edmonson MN, Hedlund EK, Rusch MC, Shurtleff SA, Mulder HL, Boggs K, Vadordaria B, Cheng J, Yergeau D, Song G, Becksfort J, Lemmon G, Weber C, Cai Z, Dang J, Walsh M, Gedman AL, Faber Z, Easton J, Gruber T, Kriwacki RW, Partridge JF, Ding L, Wilson RK, Mardis ER, Mullighan CG, Gilbertson RJ, Baker SJ, Zambetti G, Ellison DW, Zhang J, Downing JR. The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes. Nat Commun Apr 8;5:3630, 2014. doi: 10.1038/ncomms4630. PMID: 24710217. PMCID: PMC4119022

Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li Y, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksford J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL, Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. Nature Feb 27;506(7489):451-5, 2014. doi: 10.1038/nature13109. Epub 2014 Feb 19. PMID: 24553141. PMCID: PMC4050669

McEvoy J, Nagahawatte P, Finkelstein D, Richards-Yutz J, Valentine M, Ma J, Mullighan C, Song G, Chen X, Wilson M, Brennan R, Pounds S, Becksfort J, Huether R, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Easton J, Zhang J, Downing JR, Ganguly A, Dyer MA. RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget Jan 30;5(2):438-50, 2014. PMID: 24509483. PMCID: PMC3964219

Chen X*, Stewart E, Shelat A, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt S, Valentine M, Valentine V, Krafcik F, Lang W, Wierdl M, Tsurkan L, Tolleman V, Federico S, Morton C, Lu C, Ding L, Easton J, Rusch M, Nagahawatte P, Wang J, Parker M, Wei L, Hedlund E, Finkelstein D, Edmonson M, Shurtleff S, Boggs K, Mulder H, Yergeau D, Skapek S, Hawkins D, Ramirez N, Potter PM, Sandoval J, Davidoff AM, Mardis ER, Wilson RK, Zhang J, Downing JR, Dyer MA. Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell Dec 9;24(6):710-24, 2013. doi: 10.1016/j.ccr.2013.11.002. PMID: 24332040. PMCID: PMC3904731

Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B, Orisme W, Punchihewa C, Parker M, Qaddoumi I, Boop FA, Lu C, Kandoth C, Ding L, Lee R, Huether R, Chen X, Hedlund E, Nagahawatte P, Rusch M, Boggs K, Cheng J, Becksfort J, Ma J, Song G, Li Y, Wei L, Wang J, Shurtleff S, Easton J, Zhao D, Fulton RS, Fulton LL, Dooling DJ, Vadodaria B, Mulder HL, Tang C, Ochoa K, Mullighan CG, Gajjar A, Kriwacki R, Sheer D, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Baker SJ, Ellison DW. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet Jun;45(6):602-12, 2013. doi: 10.1038/ng.2611. Epub 2013 Apr 14. PMID: 23583981 PMCID: PMC3727232

Holmfeldt L, Wei L, Diaz-Flores E, Walsh M, Zhang J, Ding L, Payne-Turner D, Churchman M, Andersson A, Chen SC, McCastlain K, Becksfort J, Ma J, Wu G, Patel SN, Heatley SL, Phillips LA, Song G, Easton J, Parker M, Chen X, Rusch M, Boggs K, Vadodaria B, Hedlund E, Drenberg C, Baker S, Pei D, Cheng C, Huether R, Lu C, Fulton RS, Fulton LL, Tabib Y, Dooling DJ, Ochoa K, Minden M, Lewis ID, To LB, Marlton P, Roberts AW, Raca G, Stock W, Neale G, Drexler HG, Dickins RA, Ellison DW, Shurtleff SA, Pui CH, Ribeiro RC, Devidas M, Carroll AJ, Heerema NA, Wood B, Borowitz MJ, Gastier-Foster JM, Raimondi SC, Mardis ER, Wilson RK, Downing JR, Hunger SP, Loh ML, Mullighan CG. The genetic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet Mar;45(3):242-52, 2013. doi: 10.1038/ng.2532. Epub 2013 Jan 20. PMID: 23334668. PMCID: PMC3919793

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Parker M, Chen X, Bahrami A, Dalton J, Rusch M, Wu G, Easton J, Cheung NK, Dyer M, Mardis ER, Wilson RK, Mullighan C, Gilbertson R, Baker SJ, Zambetti G, Ellison DW, Downing JR, Zhang J. Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing. Genome Biol Dec 11;13(12):R113, 2012. doi: 10.1186/gb-2012-13-12-r113. PMID: 23232254. PMCID: PMC3580411

Roberts KG, Morin R, Zhang J, Hirst M, Zhao Y, Su X, Chen S, Payne-Turner D, Churchman M, Chen X, Harvey R, Kasap C, Yan C, Becksfort J, Finney R, Teachey D, Maude S, Tse K, Moore R, Jones S, Mungall K, Birol I, Edmonson M, Hu Y, Buetow K, Chen IM, Carol W, Wei L, Ma J, Kleppe M, Levine R, Garcia-Manero G; Larsen E, Shah N, Devidas M, Reaman G, Smith M, Paugh S, Evans W, Grupp S, Jeha S, Pui CH, Gerhard D, Downing J, Willman C, Loh M, Hunger S, Marra M, Mullighan CG. Genetic alterations activating kinase and cytokine receptor signaling in high risk acute lymphoblastic leukemia.  Cancer Cell Aug 14;22(2):153-66, 2012. doi: 10.1016/j.ccr.2012.06.005. PMID: 22897847. PMCID: PMC3422513

Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Beckford J, Gupta P, Ma J, Easton J, Vadodaria B, Pounds S, Zhao D, Gajjar A, Kawauchi D, Roussel MF, Finkelstein D, Elliso DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature Aug 2;488(7409):43-8, 2012. doi: 10.1038/nature11213. PMID: 22722829. PMCID: PMC3412905

Cheung NV, Zhang J, Lu C, Parker M, Bahrami A, Tickoo SK, Heguy A, Pappo AS, Federico S, Dalton J, Cheung IY, Ding L, Fulton B, Wang J, Chen X, Becksfort J, Wu J, Billups CA, Ellison D, Mardis ER, Wilson RK, Downing JR, Dyer MA. Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma.  JAMA Mar 14;307(10):1062-71, 2012. doi: 10.1001/jama.2012.228. PMID: 22416102 [PubMed - indexed for MEDLINE] PMCID: PMC3527076

Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature Jan 11;481(7381):329-34, 2012. doi: 10.1038/nature10733. PMID: 22237022. PMCID: PMC3289956

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature Jan 11;481(7380):157-63, 2012. doi: 10.1038/nature10725. PMID: 22237106.  PMCID: PMC3267575

Chen X, Wang M, Zhang H. The use of classification trees for bioinformatics. Wiley Interdiscip Rev Data Min Knowl Discov Jan;1(1):55-63, 2011. Epub 2011 Jan 6. PMID: 22523608. PMCID: PMC3329156

Chen X*, Cho K, Singer BH, Zhang H. The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.  PLoS One Jan 27;6(1):e16002, 2011. doi: 10.1371/journal.pone.0016002. PMID: 21298047. PMCID: PMC3029286

Zhang J, Mullighan CG, Harvey RC, Wu G, Chen X, Edmonson M, Buetow KH, Carroll WL, Chen IM, Devidas M, Devidas M, Gerhard DS, Loh ML, Reaman GH, Relling MV, Camitta BM, Bowman WP, Smith MA, Willman CL, Downing JR, Hunger SP. Key pathways are frequently mutated in high risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood Sep 15;118(11):3080-7, 2011. doi: 10.1182/blood-2011-03-341412. Epub 2011 Jun 16. PMID: 21680795. PMCID: PMC3175785

Last update: April 2018