Andrew M. Davidoff, MD
Andrew M. Davidoff, MD

Andrew M. Davidoff, MD

Member, St. Jude Faculty

  • Chair, Surgery Department
  • Chief, General Pediatric Surgery Division
  • Director, Surgical Research
  • St. Jude Endowed Chair in Surgical Research

Departments

Education

MD – University of Pennsylvania, Philadelphia, Pennsylvania

Research Interests

I am a board certified pediatric surgeon, having completed my residency training in general surgery at Duke University Medical Center and general and thoracic pediatric surgery at the Children's Hospital of Philadelphia. My academic interests at St Jude are focused on clinical and translational investigation and treatment of pediatric solid tumors, neuroblastoma, in particular. My research is focused on the development of new strategies for the treatment of neuroblastoma (and other tumor types). These include angiogenesis inhibition and gene therapy for cancer treatment. In addition, I have a significant effort in the area of gene therapy for monogenetic disorders, hemophilia, in particular.

Angiogenesis appears to be required for the neoplastic growth of tumor cells, making it a potential target for anti-cancer strategies. Long-term expression of an angiogenesis inhibitor is likely to be required for the successful treatment of cancer. Therefore, gene therapy-mediated delivery of these agents is an alternative way to provide long-term expression of these therapeutic proteins. Vectors expressing a number of different angiogenesis inhibitors are currently being designed and tested in vitro and in vivo in murine models of pediatric tumors.

Gene transfer for monogenetic disorders is an attractive approach in which long-term correction of the disease phenotype may be achieved after a single intervention or vector administration. Extensive pre-clinical and clinical studies are ongoing evaluating the safety and efficacy of adeno-associated virus (AAV) vectors.

Selected Publications

von Allmen D, Davidoff AM, London W, Van Ryn, Haas-Kogan D, Kreissman S, Khanna G, Rosen N, Park J, LaQuaglia M. Impact of extent of resection on local control and survival in high risk neuroblastoma patients: A Report from the COG A3973 Study. J Clin Oncol 2016 (in press).

Talleur AC, Navid F, Spunt SL, McCarville MB, Wu J, Mao S, Davidoff AM, Neel MD, Krasin MJ. Limited margin radiation therapy for children and young adults with Ewing sarcoma achieves high rates of local tumor control. International Journal of Radiation Oncology Sep 1;96(1):119-26, 2016. PMID:27319287

Fernandez-Pineda I, Hudson MM, Pappo AS, Bishop MW, Klosky JL, Brinkman TM, Srivastava DK, Neel MD, Rao BN, Davidoff AM, Krull KR, Mulrooney DA, Robison LL, Ness KK. Long-term functional outcomes and quality of life in adult survivors of childhood extremity sarcomas: a report from the St. Jude Lifetime Cohort Study. J Cancer Surviv Jun 4, 2016 (in press). PMID:27262580

Interiano RB, Malkan AD, Loh AH, Hinkle N, Wahid FN, Bahrami A, Mao S, Wu J, Bishop MW, Neel MD, Gold RE, Rao BN, Davidoff AM, Fernandez-Pineda I. Initial diagnostic management of pediatric bone tumors. J Pediatr Surg Mar 2, 2016 (in press). PMID:26995522

Piras BA, Drury JE, Morton CL, Spence Y, Lockey TD, Nathwani AC, Davidoff AM, Meagher MM. Distribution of AAV8 particles in cell lysates and culture media changes with time and is dependent on the recombinant vector. Mol Ther Methods Clin Dev 2016 (in press). PMID:27069949 PMCID:PMC4813606

Nienhuis AW, Nathwani AC, Davidoff AM. Gene Therapy for Hemophilia. Hum Gene Ther Apr;27(4):305-8, 2016. PMID:27021603

Navid F, Herzog CE, Sandoval J, Daryani VM, Stewart CF, Gattuso J, Mandrell B, Phipps S, Chemaitilly W, Sykes A, Davidoff AM, Shulkin BL, Bahrami A, Furman WL, Mao S, Wu J, Schiff D, Rao B, Pappo A. Feasibility of Pegylated Interferon in Children and Young Adults With Resected High-Risk Melanoma. Pediatr Blood Cancer Jul;63(7):1207-13, 2016. PMID:27038395 PMCID:PMC4877209

McCarville MB, Coleman JL, Guo J, Li Y, Li X, Honnoll PJ, Davidoff AM, Navid F. Use of Quantitative Dynamic Contrast-Enhanced Ultrasound to Assess Response to Antiangiogenic Therapy in Children and Adolescents With Solid Malignancies: A Pilot Study. AJR Am J Roentgenol May;206(5):933-9, 2016. PMID:26999488

Fernandez-Pineda I, Ortega-Laureano L, Wu H, Wu J, Sandoval JA, Rao BN, Shochat SJ, Davidoff AM. Guidewire Catheter Exchange in Pediatric Oncology: Indications, Postoperative Complications, and Outcomes. Pediatr Blood Cancer Jun;63(6):1081-5, 2016. PMID:26872097

Fernandez-Pineda I, Sandoval JA, Jones RM, Boateng N, Wu J, Rao BN, Davidoff AM, Shochat SJ. Gastrostomy Complications in Pediatric Cancer Patients: A Retrospective Single-Institution Review. Pediatr Blood Cancer Jul;63(7):1250-3, 2016. PMID:26960180

Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Jason SC, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter SD, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Rice HE. Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. J Pediatr Surg Jan;51(1):122-7, 2016. PMID:26613837

Davidoff AM, Nathwani AC. Genetic Targeting of the Albumin Locus to Treat Hemophilia. N Engl J Med Mar 31;374(13):1288-90, 2016. PMID:27028920

Brimble MA, Reiss UM, Nathwani AC, Davidoff AM. New and improved AAVenues: current status of hemophilia B gene therapy. Expert Opin Biol Ther 16(1):79-92, 2016. PMID:26524468

Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM. The role of histone demethylase KDM4B in Myc signaling in neuroblastoma. J Natl Cancer Inst Jun;107(6):djv080, 2015. PMID:25925418 PMCID:PMC4555638

Yang J, AlTahan A, Jones DT, Buffa FM, Bridges E, Interiano RB, Qu C, Vogt N, Li JL, Baban D, Ragoussis J, Nicholson R, Davidoff AM, Harris AL. Estrogen receptor-alpha directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer. Proc Natl Acad Sci U S A Dec 8;112(49):15172-7, 2015. PMID:26598706 PMCID:PMC4679044

Yang CH, Pfeffer SR, Sims M, Yue J, Wang Y, Linga VG, Paulus E, Davidoff AM, Pfeffer LM. The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesis. J Biol Chem Mar 6;290(10):6037-46, 2015. PMID:25589783 PMCID:PMC4358246

Rice HE, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St PS, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML. Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol Mar;90(3):187-92, 2015. PMID:25382665 PMCID:PMC4333061

Malkan AD, Loh A, Bahrami A, Navid F, Coleman J, Green DM, Davidoff AM, Sandoval JA. An approach to renal masses in pediatrics. Pediatrics Jan;135(1):142-58, 2015. PMID:25452658

Loh A, Bishop M, Krasin M, Davidoff AM, Langham MR, Jr. Long-term physiologic and oncologic outcomes of inferior vena cava thrombosis in pediatric malignant abdominal tumors. J Pediatr Surg Apr;50(4):550-5, 2015. PMID:25840061

Lheriteau E, Davidoff AM, Nathwani AC. Haemophilia gene therapy: Progress and challenges. Blood Rev Sep;29(5):321-8, 2015. PMID:26049173

Kieran K, Davidoff AM. Nephron-sparing surgery for bilateral Wilms tumor. Pediatr Surg Int Mar;31(3):229-36, 2015. PMID:25633157 PMCID:PMC4336577

Interiano RB, Davidoff AM. Current Management of Neonatal Neuroblastoma. Curr Pediatr Rev 11(3):179-87, 2015. PMID:26168943

Interiano RB, Loh AH, Hinkle N, Wahid FN, Malkan AD, Bahrami A, Jenkins JJ, Mao S, Wu J, Proctor K, Santana VM, Pappo AS, Gold RE, Davidoff AM. Safety and diagnostic accuracy of tumor biopsies in children with cancer. Cancer Apr 1;121(7):1098-107, 2015. PMID:25524504 PMCID:PMC4368446

Interiano RB, McCarville MB, Wu J, Davidoff AM, Sandoval J, Navid F. Pneumothorax as a complication of combination antiangiogenic therapy in children and young adults with refractory/recurrent solid tumors. J Pediatr Surg Sep;50(9):1484-9, 2015. PMID:25783402 PMCID:PMC4758326

Interiano RB, Delos SN, Huang S, Srivastava DK, Robison LL, Hudson MM, Green DM, Davidoff AM. Renal function in survivors of nonsyndromic Wilms tumor treated with unilateral radical nephrectomy. Cancer Jul 15;121(14):2449-56, 2015. PMID:25832759

Garner JM, Ellison DW, Finkelstein D, Ganguly D, Du Z, Sims M, Yang CH, Interiano RB, Davidoff AM, Pfeffer LM. Correction: Molecular Heterogeneity in a Patient-Derived Glioblastoma Xenoline is Regulated by Different Cancer Stem Cell Populations. PLoS One 10(12):e0145052, 2015. PMID:26660737 PMCID:PMC4686089

Fernandez-Pineda I, Sandoval JA, Davidoff AM. Hepatic metastatic disease in pediatric and adolescent solid tumors. World J Hepatol Jul 18;7(14):1807-17, 2015. PMID:26207162 PMCID:PMC4506938

Della PM, Badar A, Rosales C, Chokshi S, Kia A, Nathwani D, Galante E, Yan R, Arstad E, Davidoff AM, Williams R, Lythgoe MF, Nathwani AC. Preferential targeting of disseminated liver tumors using a recombinant adeno-associated viral vector. Hum Gene Ther Feb;26(2):94-103, 2015. PMID:25569358 PMCID:PMC4326028

Davidoff AM, Interiano RB, Wynn L, Delos SN, Dome JS, Green DM, Brennan RC, McCarville MB, Krasin MJ, Kieran K, Williams MA. Overall Survival and Renal Function of Patients With Synchronous Bilateral Wilms Tumor Undergoing Surgery at a Single Institution. Ann Surg Oct;262(4):570-6, 2015. PMID:26366536

Bhojwani D, McCarville MB, Choi JK, Sawyer J, Metzger ML, Inaba H, Davidoff AM, Gold R, Shulkin BL, Sandlund JT. The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma. Br J Haematol Mar;168(6):845-53, 2015. PMID:25382494 PMCID:PMC4351138

Show More

Yang CH, Yue J, Pfeffer SR, Fan M, Paulus E, Hosni-Ahmed A, Sims M, Qayyum S, Davidoff AM, Handorf CR, Pfeffer LM. MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3). J Biol Chem Sep 5;289(36):25079-87, 2014. PMID:25059666 PMCID:PMC4155674

Wahid FN, Malkan AD, McCarville MB, Davidoff AM. Double small bowel intussusception complicating bilateral partial nephrectomies. J Pediatr Surg Case Rep Jan;2(1):30-2, 2014. PMID:24795858 PMCID:PMC4005927

Patel N, Reiss U, Davidoff AM, Nathwani AC. Progress towards gene therapy for haemophilia B. Int J Hematol Apr;99(4):372-6, 2014. PMID:24500177 PMCID:PMC4081414

Nathwani AC, Nienhuis AW, Davidoff AM. Our journey to successful gene therapy for hemophilia B. Hum Gene Ther Nov;25(11):923-6, 2014. PMID:25397929 PMCID:PMC4236090

Nathwani AC, Reiss UM, Tuddenham EG, Rosales C, Chowdary P, McIntosh J, Della PM, Lheriteau E, Patel N, Raj D, Riddell A, Pie J, Rangarajan S, Bevan D, Recht M, Shen Y, Halka K, Basner-Tschakarjan E, Mingozzi F, High KA, Allay J, Kay MA, Ng C, Zhou J, Cancio M, Morton CL, Gray JT, Srivastava D, Nienhuis AW, Davidoff AM. Long-term safety and efficacy of factor IX gene therapy in hemophilia B. N Engl J Med Nov 20;371(21):1994-2004, 2014.

Kudo K, Imai C, Lorenzini P, Kamiya T, Kono K, Davidoff AM, Chng WJ, Campana D. T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing. Cancer Res Jan 1;74(1):93-103, 2014. PMID:24197131

Kieran K, Williams MA, McGregor LM, Dome JS, Krasin MJ, Davidoff AM. Repeat nephron-sparing surgery for children with bilateral Wilms tumor. J Pediatr Surg Jan;49(1):149-53, 2014. PMID:24439600

Interiano RB, Yang J, Harris AL, Davidoff AM. Seven In Absentia Homolog 2 (SIAH2) downregulation is associated with tamoxifen resistance in MCF-7 breast cancer cells. J Surg Res Jul;190(1):203-9, 2014. PMID:24656476 PMCID:PMC4215404

Denbo JW, Zhu L, Srivastava D, Stokes DC, Srinivasan S, Hudson MM, Ness KK, Robison LL, Neel M, Rao B, Navid F, Davidoff AM, Green DM. Long-term pulmonary function after metastasectomy for childhood osteosarcoma: a report from the St Jude lifetime cohort study. J Am Coll Surg Aug;219(2):265-71, 2014. PMID:24795268 PMCID:PMC4308956

Last update: February 2017