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Marta Derecka, PhD
Marta Derecka, PhD

Marta Derecka, PhD

Instructor, St. Jude Faculty

Departments

Education

BS/MS (Biochemistry) - Jagiellonian University, Cracow, Poland
PhD (Biochemistry and Molecular Biology) - Jagiellonian University, Cracow, Poland
Graduate Research Fellow - Virginia Commonwealth University, Richmond, USA
Postdoctoral Research Fellow - Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Research Interests

  • Regulation of hematopoiesis by bone marrow microenvironment.
  • Transcriptional regulation of bone marrow niche  
  • Niche-driven regulation of hematopoietic stem cells chromatin landscape 

Selected Publications

Lefkopoulos S, Polyzou A, Derecka M, Bergo V, Clapes T, Cauchy P, Jerez-Longres C, Onishi- Seebacher M, Yin N, Martagon-Calderon NA, Potts KS, Klaeyle L, Liu F, Bowman TV, Jenuwein T, Mione MC, Trompouki E. Repetitive elements trigger Rig-I-like receptor signaling that regulates the emergence of hematopoietic stem and progenitor cells. Immunity 2020 (in press).

Kozyra E, Pastro V, Lefkopoulos S, Sahoo S, Busch H, Voss R, Erlacher M, Lebrecht D, Szvetnik E, Hirabayashi S, Pasaulienė R, Pedace L, Tartaglia M, Klemann C, Metzger P, Boerries M, Catala A, Hasle H, De Haas V, Kállay K, Masetti R, De Moerloose B, Dworzak M, Schmugge M, Smith O, Starý J, Mejstrikova E, Ussowicz M , Morris E, Singh P, Collin M, Derecka M, Göhring G, Flotho C, Strahm B, Locatelli F, Niemeyer C, Trompouki E, Wlodarski M, European Working Group of MDS in Childhood (EWOG-MDS). Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency. Leukemia Oct;34(10):2673-2687, 2020.

Derecka M*, Herman JS, Ramamoorthy S, Cauchy P, Lupar E, Grün D, Grosschedl R*. EBF1- deficient bone marrow stroma elicits persistent changes in HSC potential. Nature Immunology Mar 21(3):261-273, 2020. (*co-corresponding author).

Raje V, Derecka M, Cantwell M, Meier J, Szczepanek K, Sisler JD, Strobl B, Gamero A, Harris TE, Larner AC. Kinase inactive Tyrosine kinase (Tyk2) supports differentiation of brown fat cells. Endocrinology Jan 1;158(1):148-157, 2017.

Sisler JD, Morgan M, Raje V, Grande RC, Derecka M, Meier J, Cantwell M, Szczepanek K, Korzun WJ, Lesnefsky EJ, Harris TE, Croniger CM, Larner AC. The Signal Transducer and Activator of Transcription 1 (STAT1) inhibits mitochondrial biogenesis in liver and fatty acid oxidation in adipocytes. PLoS One Dec 21;10(12):e0144444, 2015.

Zhang Q, Raje V, Yakovlev VA, Yacoub A, Szczepanek K, Meier J, Derecka M, Chen Q, Hu Y, Sisler J, Hamed H, Lesnefsky EJ, Valerie K, Dent P, Larner AC. Mitochondrial-Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727. J Biol Chem Oct 25;288(43):31280-8, 2013.

Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Larner AC. The JAK kinase Tyk2 and the Signal Transducer and Activator of Transciption 3 (Stat3) are required for Brown Adipose Tissue Differentiation. Cell Metab Dec 5;16(6):814-24, 2012.

Szczepanek K, Chen Q, Derecka M, Zhang Q, Szelag M, Cichy J, Dulak J, Lesnefsky EJ, Larner AC. Mitochondrial-localized Stat3 protects against ischemia-induced changes in the electron transport chain and generation of reactive oxygen species. J Biol Chem Aug 26;286(34):29610-20, 2011.

Zhang Q, Sturgill J, Szczepanek K, Derecka M, Koebel C, Gamero A, Manjili M, Bear H, Conrad D, Larner AC. The Role of Tyk2 in Regulation of Breast Cancer Growth. J Interferon Cytokine Res Sep;31(9):67-7, 2011.

Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, Larner AC. Function of mitochondrial Stat3 in cellular respiration. Science Feb 6;323(5915):793-7, 2009.

Last update: November 2020