Meenakshi Devidas, PhD
Meenakshi Devidas, PhD

Meenakshi Devidas, PhD

Member, St. Jude Faculty

  • Director, Global Analytics Unit

Departments

Education

BS - Bangalore University, Bangalore, India
MBA - Bangalore University, Bangalore, India
MS - University of Memphis, Memphis, TN
PhD - University of Memphis, Memphis, TN

Research Interests

  • Pediatric Hematology and Oncology
  • Clinical trial design, analysis, and monitoring
  • Innovative trial designs for rare cancers and other diseases

Selected Publications

Raetz EA, Loh ML, Devidas M, Maloney K, Mattano Jr LA, Larsen E, Carroll A, Heerema NA, Gastier-Foster J, Wood B, Borowitz MJ, Winick N, Hunger SP, Carroll WL.  Impact of Corticosteroid Pretreatment in Pediatric Patients with Newly Diagnosed B-Lymphoblastic Leukemia:  A Report from the Children’s Oncology Group.  Haematologica Apr 19, 2019. pii: haematol.2018.215616. doi: 10.3324/haematol.2018.215616. [Epub ahead of print]

Burke* MJ, Salzer* WL, Devidas M, Gore L, Hilden JM, Larsen E, Rabin KR, Zweidler-McKay PA, Borowitz MJ, Wood B, Heerema NA, Carroll AJ, Winick N, Carroll WL, Raetz** EA,  Loh** ML, Hunger** SP.  Replacement of cyclophosphamide/cytarabine/mercaptopurine with cyclophosphamide /etoposide during Consolidation/Delayed Intensification does not improve outcome for pediatric B-ALL: a report from the COG. Haematologica Dec 13, 2018. [Epub ahead of print].  PMID:  30545921.

Horton TM, Whitlock JA, Lu X, O’Brien MM, Borowitz MJ, Devidas M, Raetz EA, Brown PA, Carroll WL, Hunger SP.  Bortezomib Reinduction Chemotherapy in High-Risk ALL in First Relapse: A Report from the Children’s Oncology Group. Br J Haematol Apr 7, 2019. doi: 10.1111/bjh.15919. [Epub ahead of print]

Qian M, Zhao X, Devidas M, Yang W, Smith C, Gastier-Foster JM, Li Y, Xu H, Zhang S, Jeha5 S, Sanda T, Winter SS, Dunsmore KP, Raetz EA, Carroll WL, Winick NJ, Rabin KR, Zweidler-Mckay PA, Wood B, Pui C-H, Evans WE, Hunger SP, Mullighan CG, Relling MV, Loh ML, Yang J.  Genome-wide association study of susceptibility loci for T-cell acute lymphoblastic leukemia in children. Journal of the National Cancer Institute Apr 2, 2019. [Epub ahead of print].  PMID:  30938820.

McNeer JL, Devidas M, Dai Y, Carroll AJ, Heerema NA, Gastier-Foster JM, Borowitz MJ, Wood B, Larsen E, Maloney KW, Mattano L, Winick NJ, Schultz KR, Hunger SP, Carroll WL, Loh ML, Raetz EA.  Hematopoietic Stem Cell Transplantation Does not Improve the Poor Outcome of Children and Young Adults with Hypodiploid ALL: A Report from the Children’s Oncology Group.  Journal of Clinical Oncology April 1;37:780-789, 2019. DOI: 10.1200/JCO.18.00884, Epub 2019 Feb 11]. PMID: 30742559.

Steinherz PG, Seibel NL, Sather H, Ji L, Xu X, Devidas M, Gaynon PS. Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children's Oncology Group. Leukemia Feb 28, 2019. doi: 10.1038/s41375-019-0422-z. [Epub ahead of print] PubMed PMID: 30816331.

Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Hagiwara K, Shi L, Pounds S, Cheng C, Pei D, Qu C, Dai Y, Devidas M, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans W, Jeha S, Pui C-H, Yang J, Paietta E, Downing J, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven Subtypes of B-progenitor Acute Lymphoblastic Leukemia.  Nature Genetics Feb;51:296-307, 2019. [Epub 2019 Jan 14].  PMID: 30643249.

Schore RJ, Devidas M, Bleyer A, Reaman GH, Winick N, Loh ML, Raetz EA, Carroll WL, Hunger SP, Angiolillo AL. Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children's Oncology Group AALL07P4. Leuk Lymphoma Jan 10:1-9, 2019. doi: 10.1080/10428194.2018.1542146. [Epub ahead of print] PubMed PMID: 30626253.

Qian M*, Xu H*, Zhang H, Yang W, Zhang S, Roberts KG, Perez-Andreu V, Smith C, Devidas M, Gastier-Foster JM, Raetz E, Larsen E, Burchard EG, Torgerson DG, Winick N, Bowman WP, Martin PL, Borowitz M, Wood B, Pui C-H, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ.  Novel Susceptibility Variants at the ERG Locus for Childhood Acute Lymphoblastic Leukemia in Hispanics.  Blood 133:724-729, 2019. [Epub 2018 Dec 3] pii: blood-2018-07-862946. doi: 10.1182/blood-2018-07-862946. [Epub ahead of print] PMID:  30510082.

Urtishak KA, Wang L-S, Culjkovic-Kraljacic B, Davenport JW, Porazzi P, Vincent TL, Teachey DT, Tasian SK, Moore JS, Seif AE, Jin S, Barrett JS, Robinson BW, Chen I-M, Harvey RC, Carroll MP, Carroll AJ, Heerema NA, Devidas M, Dreyer ZE, Hilden JM, Hunger SP, Willman CL, Borden KLB, Felix CA.  Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene 38:2241-2262, 2019. [Epub 2018 Nov 26].  PMID:  30478448.

Ariës I, Bodarr K, Karim SA, Ni Chonghaile T, Hinze L, Burns M, Pfirrman M, Degar J, Landrigan J, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin KR, Winter SS, Dunsmore KP, Wood B, Silverman LB, Sallan SE, Van Vlierberghe P, Orkin SH, Birgit K, Letai AG, Gutierrez A. (2017), PRC2 Loss Induces Chemoresistance by Repressing Apoptosis in T-Cell Acute Lymphoblastic Leukemia. J Exp Med Nov 7, 2018. pii: jem.20180570. doi: 10.1084/jem.20180570. [Epub ahead of print] PubMed PMID: 30404791.

Galimberti S, Devidas M, Lucenti A, Cazzaniga G, Möricke A, Bartram CR, Mann G, Carroll W, Larsen E, Winick N, Borowitz M, Wood B, Basso G, Conter V, Zimmerman M, Suciu S, Biondi A, Schrappe M, Hunger S, and Valsecchi MG. Validation of minimal residual disease as surrogate endpoint for event free survival in childhood acute lymphoblastic leukemia. JNCI Cancer Spectrum Oct;2(4): pky069, 2018. pky069, https://doi.org/10.1093/jncics/pky069

Burns MA, Liao ZW, Yamagata N, Pouliot GP, Stevenson KE, Neuberg DS, Thorner AR, Ducar M, Silverman EA, Hunger SP, Loh ML, Winter SS, Dunsmore KP, Wood B, Devidas M, Harris MH, Silverman LB, Sallan SE, Gutierrez A. Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. Leukemia Oct;32(10):2126-2137, 2018. doi: 10.1038/s41375-018-0097-x. Epub 2018 Mar 20. PubMed PMID: 29654263; PubMed Central PMCID: PMC6148437.

Alexander TB*, Gu Z*, Iacobucci I*, Dickerson K, Choi JK, Xu B, Payne-Turner D, Yoshihara H, Loh ML, Horan J, Buldini B, Basso G, Elitzur S, de Haas V, Zwaan CM, Yeoh A, Reinhardt D, Tomizawa D, Kiyokawa N, Lammens T, De Moerloose B, Zhou L, Hori H, Moorman A, Moore AS, Hrusak O, Meshinchi S, Orgel E, Devidas M, Borowitz M, Wood B, Heerema NA, Carroll A, Yang Y-L, Smith MA, Davidsen TM, Hermida LC, Gesuwan P, Marra MA, Ma Y, Mungall AJ, Moore RA, Jones SJM, Valentine M, Janke L, Rubnitz JE, Pui C-H, Ding L, Liu Y, Zhang J, Nichols KE, Downing JR, Cao X, Shi L, Pounds S, Newman S, Pei D, Guidry Auvil JM, Gerhard DS, Hunger SP, Inaba H, Mullighan CG. The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature Sep 12, 2018. doi: 10.1038/s41586-018-0436-0. [Epub ahead of print] PubMed PMID: 30209392.

Winter SS*, Dunsmore KP*, Devidas M, Wood BL, Esiashvili N, Chen Z, Eisenberg N, Briegel N, Hayashi RJ, Gastier-Foster JM, Carroll AJ, Heerema NA, Asselin B, Gaynon P, Borowitz M, Loh ML, Rabin KR, Raetz EA, Zweidler-Mckay PA, Winick NJ**, Carroll WL**, Hunger SP**.  Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization. J Clin Oncol Aug 23:JCO2018777250, 2018. doi: 10.1200/JCO.2018.77.7250. [Epub ahead of print] PubMed PMID: 30138085.

Roberts* KG, Reshmi* SC, Harvey* RC, Chen I-M, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Liu Y, Li Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Mattano L, Maloney KW, Carroll WL, Loh** ML, Mullighan** CG, Willman** CL, Gastier-Foster** JM, Hunger** SP.  Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood Aug 23;132(8):815-824, 2018. doi: 10.1182/blood-2018-04-841676. Epub 2018 Jul 11. PMID: 29997224; PubMed Central PMCID: PMC6107876.

Kang H, Sharma ND, Nickl CK, Devidas M, Loh ML, Hunger SP, Dunsmore KP, Winter SS, Matlawska-Wasowska K. Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL. Biomarker Research Aug 23;6:27, 2018. doi: 10.1186/s40364-018-0141-z. eCollection 2018. PubMed PMID: 30159143; PubMed Central PMCID: PMC6107954.

Slayton WB, Schultz KR, Kairalla JA, Devidas M, Mi X, Pulsipher MA, Chang BH, Mullighan C, Iacobucci I, Silverman LB, Borowitz MJ, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Mizrahy SL, Merchant T, Brown VI, Sieger L, Siegel MJ, Raetz EA, Winick NJ, Loh ML, Carroll WL, Hunger SP. Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622. Journal of Clinical Oncology Aug 1;36(22):2306-2314, 2018. doi: 10.1200/JCO.2017.76.7228. Epub 2018 May 29. PubMed PMID: 29812996; PubMed Central PMCID: PMC6067800.

Burke MJ, Devidas M, Maloney K, Angiolillo A, Schore R, Dunsmore K, Larsen E, Mattano LA Jr, Salzer W, Winter SS, Carroll W, Winick NJ, Loh ML, Raetz E, Hunger SP, Bleyer A. Severe pegaspargase hypersensitivity reaction rates (grade ≥3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children's oncology group (COG) clinical trials. Leukemia Lymphoma Jul;59(7):1624-1633, 2018. doi: 10.1080/10428194.2017.1397658. Epub 2017 Nov 8. PMID: 29115886; PubMed Central PMCID: PMC5940583.

Gupta* S, Devidas* M, Loh ML, Raetz EA, Chen S, Wang C, Brown P, Carroll AJ, Heerema NA, Gastier-Foster JM, Dunsmore KP, Larsen EC, Maloney KW, Mattano Jr. LA, Winter SS, Winick NJ, Carroll WL, Hunger SP, Borowitz** MJ, Wood** BL.  Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group (COG). Leukemia Jun;32(6):1370-1379, 2018. doi: 10.1038/s41375-018-0039-7. Epub 2018 Feb 23. PubMed PMID: 29472723; PubMed Central PMCID: PMC5992047.

See full list of publications 

Last update: May 2019