John J. Bissler, MD

Medical Director of Nephrology

Professor of Pediatrics, University of Tennessee Health Science Center
Chief, Division of Nephrology, Department of Pediatrics, University of Tennessee Health Science Center
Director of the Tuberous Sclerosis Center of Excellence

Departments

Department of Pediatric Medicine

Contact Information

John J. Bissler, MD UT Le Bonheur Pediatric Specialists 51 N. Dunlap Street, 4th Floor, Suite 400 Memphis, TN 38105

Education

BS – Kent State University, Kent, Ohio
MD – Northeastern Ohio Universities, College of Medicine, Rootstown, Ohio
Graduate Studies – University of Cincinnati, College of Medicine, College of Graduate Studies, Cincinnati, Ohio
Internship and Residency – Children’s Hospital Medical Center of Akron, Akron Children’s Hospital, Akron, Ohio
Fellowship – Children's Hospital Medical Center, Cincinnati Clinical Nephrology, Cincinnati, OH
Fellowship – Children's Hospital Medical Center, Cincinnati Basic Science, Cincinnati, OH

Clinical interests

Pediatrics
Pediatric Nephrology

Selected Publications

F. X. McCormack, N. Gupta, G. R. Finlay, L. R. Young, A. M. Taveira-DaSilva, C. G. Glasgow, W. K. Steagall, S. R. Johnson, S. A. Sahn, J. H. Ryu, C. Strange, K. Seyama, E. J. Sullivan, R. M. Kotloff, G. P. Downey, J. T. Chapman, M. K. Han, J.M. D' Armiento, Y. Inoue, E. P. Henske, J.J. Bissler, T. V Colby, B. W. Kinder, K. A. Wikenheiser-Brokamp, K. K. Brown, J. F. Cordier, C. Meyer, V. Cottin, J. L. Brozek, K. Smith, K. C. Wilson, J. Moss, ATS/JRS Committee on Lymphangioleiomyomatosis, Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. Am J Respir Crit Care Med 194, 748-61 (2016).

J.C. Kingswood, J. J. Bissler, K. Budde, J. Hulbert, L. Guay-Woodford, J. R. Sampson, M. Sauter, J. Cox, U. Patel, F. Elmslie, C. Anderson, B. A. Zonnenberg, Review of the Tuberous Sclerosis Renal Guidelines from the 2012 Consensus Conference: Current Data and Future Study. Nephron 134, 51-58 (2016).

A. Tipimeni-Sajja, R. B. Loeffler, N. Oesingmann, J. Bissler, R. Song, B. Mccarville, D. P. Jones, M. Hudson, S. L. Spunt, C. M. Hillenbrand, Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific twocompartment model. Physiol Rep 4 (2016), doi:10.14814/phy2.12755.

J. Bissler, K. Cappell, H. Charles, X. Song, Z. Liu, J. Prestifilippo, C. Gregory, J. Hulbert, Longterm Clinical Morbidity in Patients With Renal Angiomyolipoma Associated With Tuberous Sclerosis Complex. Urology 95, 80-7 (2016).

K. Budde, B. A. Zonnenberg, M. Frost, W. Cheung, S. Urva, T. Brechenmacher, K. Stein, D. Chen, J.C. Kingswood, J. J. Bissler, Pharmacokinetics and pharmacodynamics of everolimus in patients with renal angiomyolipoma and tuberous sclerosis complex or lymphangioleiomyomatosis. Br J Clin Pharmacol 81, 958-70 (2016).

M. Sahin, E. P. Henske, B. D. Manning, K. C. Ess, J. J. Bissler, E. Klann, D. J. Kwiatkowski, S. L. Roberds, A. J. Silva, C. S. Hillaire-Clarke, L. R. Young, M. Zervas, L. A. Mamounas, Tuberous Sclerosis Complex Working Group to Update the Research Plan, Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol 60, 1-12 (2016).

J. J. Bissler, J. C. Kingswood, E. Radzikowska, B. A. Zonnenberg, M. Frost, E. Belousova, M. Sauter, N. Nonomura, S. Brakemeier, P. J. de Vries, N. Berkowitz, S. Miao, S. Segal, S. Peyrard, K. Budde, Everolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: extension of a randomized controlled trial. Nephrol Dial Transplant 31, 111-9 (2016).

Kwiatkowski, D.J. et al., 2015. Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSCl and TSC2. Eur J Hum Genet Available at: http://www.ncbi.nlm.nih.gov/pubmed/25782670.

Bissler, J.J. et al., 2015. Everolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: extension of a randomized controlled trial. Nephrology Dialysis Transplantation p.gfv249. Available at: http://ndt.oxfordjoumals.org/lookup/doi/10.1093/ndt/gfv249.http://doi.org/l 0.1681/ ASN.20 I 0050 526

Bissler, J. et al., 2015. Rates of interventional procedures in patients with tuberous sclerosis complex-related renal angiomyolipoma. Current Medical Research and Opinion 31 (8), pp.1501-1507. AvaiIable at: http://www.ncbi.nlm.nih.gov/pubmed/26073 843 [Accessed October 17, 2015].

Cabrera-Lopez, C. et al., 2015. Insight into response to mTOR inhibition when PK.DI and TSC2 are mutated. BMC Medical Genetics 16(1), p.39. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26077033 [Accessed October 17, 2015].

Bissler, J. J. (2015). Therapies for polycystic kidney disease. Curr Opin Pediatr 27(2), 227-232. http://doi.org/l 0.1097 /MOP.0000000000000202

Kwiatkowski1DJ, Palmer MR, Jozwiak S, Bissler JJ, Franz D, Segal S, Chen D, Sampson JR. Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC I and TSC2. (2015). Response to everolimus is seen in TSCassociated SEGAs and angiomyolipomas independent of mutation type and site in TSC I and TSC2. European Journal of Human Genetics http://doi.org/l 0.1038/ejhg.2015.47

Guay-Woodford, L.M., Bissler, J.J., Braun, M.C., Bockenhauer, D., Cadnapaphomchai, M.A., Dell, K.M., Kerecuk, L., Liebau, M.C., Alonso-Peclet, M.H., Shneider, B., Emre, S., Heller, T., Karnath, B.M., Murray K.F., Moise, K., Eichenwald, E.E., Evans, J., Keller,. R.L., Wilkins-Haug, L., Bergmann, C., Gunay-Aygun, M., Hooper, S.R., Hardy, K.K., Hartung, E.A., Streisand, R., Perrone, R., and Moxey-Mims, M. (2014) Consensus expert recommendations for diagnosis and management of autosomal recessive polycystic kidney disease: report of an international conference. J Pediatr 165, 611-617.

Siroky, B. J, Yin, H., Dixon, B.P., Reichert, R.J., Hellmann, A.R., Ramkumar, T., Tsuchihashi, Z., Bunni, M., Dillon, J., Bell, P.O., Sampson, J.R., and Bissler, J.J. Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy. 2014 Am J Physiol Renal Physiol 307, F560-570.

Kingswood, J.C., Jozwiak, S., Belousova, E.D., Frost, M.D., Kuperman, R.A., Bebin, E.M., Korf, B.R., Flamini, J.R., Korman, M.H., Sparagana, S.P., Wu, J.Y., Brehenmacher, T., Stein, K., Berkowitz, N., Bissler, J.J., and Franz, D.N. The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: subgroup results from randomized, placebo-controlled, Phase 3 trial EXIST-I. (2014) Nephrol Dial Transplant 29, 1203-1210.

Funk, J.A., Janech, M.G., Dillion, J.C., Bissler, J.J., Siroky, B.J., and Bell, P.O. Characterization of renal toxicity in mice administered the marine biotoxin domoic. Acid J Am Soc Nephrol 25, 1187-1197 (2014).

Henske, E. P., Rasooly, R., Siroky, B. & Bissler, J. Tuberous sclerosis complex, mTOR, and the kidney: report of an NIDDK-sponsored workshop. Am J Physiol Renal Physiol 306, F279-83 (2014).

Northrup H, Krueger DA, International Tuberous Sclerosis Complex Consensus Group. Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 international tuberous sclerosis complex consensus conference. Pediatric neurology 2013;49(4):243-254.

Krueger DA, Northrup H, International Tuberous Sclerosis Complex Consensus Group. Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatric neurology 2013;49( 4):255-265.

O'Brien K, Leach J, Jones B, Bissler J, Zuccarello M, Abruzzo T. Calcifications associated with pediatric intracranial arterial aneurysms: incidence and correlation with pathogenetic subtypes. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2013;29(4):643-649.

Nehus EJ, Laskin BL, Kathman TI, Bissler JJ. Performance of cystatin C-based equations in a pediatric cohort at high risk of kidney injury. Pediatr Nephrol 2013;28(3):453-461.

Henske EP, Rasooly R, Siroky BJ, Bissler JJ. Tuberous Sclerosis Complex, mTOR, and the Kidney: Report of an NIDDK-Sponsored Workshop. Am J Physiol Renal Physiol 2013.

Cudzilo CJ, Szczesniak RD, Brody AS, Rattan MS, Krueger DA, Bissler JJ, Franz DN, McCormack FX, Young LR. Lymphangioleiomyomatosis screening in women with tuberous sclerosis. Chest 2013;144(2):578-585.

Bissler JJ, Kingswood JC, Radzikowska E, et al. Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2013;381(9869):817- 824.

Dawoud, D, Lyndon, W, Mrug, S, Bissler, JJ, Mrug, M: Impact of ultrasound-guided kidney biopsy simulation on trainee confidence and biopsy outcomes. Am J Nephrol 2012; 36: 570-574.

Siroky BJ, Yin H, Babcock JT, Lu L. Hellmann AR, Dixon BP, Quilliam LA, Bissler JJ. Human. TSC-associated renar angiomyolipoma cells are hypersensitive to ER stress. Am J Physiol Renal Physiol 2012; 303 :F831-44.

Liu G, Myers S, Chen X, Bissler J, Sinden R, Leffak M. Replication fork stalling and checkpoint activation by PKDl locus mirror repeat homopurine-homopyrimidine (Pu-Py) tract. J Biol Chem 2012;287:33412-23.