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Hiding in plain sight: Improved CAR T-cell therapy for T-cell acute lymphoblastic leukemia
08/05/2022
St. Jude scientists developed a simple method to select for more effective cancer-destroying CAR T cells to treat T-ALL.
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Getting more mileage from a T-cell therapy for AML
07/28/2022
St. Jude scientists have created a proof-of-principle approach to improve engager T-cell therapy for difficult-to-treat acute myeloid leukemia.
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Frank Fazio named president of Children's GMP and vice president of therapeutics production and quality at St. Jude
07/27/2022
The Good Manufacturing Practices (GMP) facility produces highly specialized biopharmaceuticals and other biological products for the hospital’s clinics.
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Genetics weigh heavy on childhood cancer survivors’ risk of developing obesity
07/25/2022
St. Jude scientists created a way to identify childhood cancer patients at diagnosis who are at the highest risk for developing severe obesity as adults.
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Study reveals a new therapeutic target for aggressive type of rhabdomyosarcoma
07/13/2022
Scientists at St. Jude found an Achilles’ heel in rhabdomyosarcoma driven by a gene fusion which revealed a promising treatment approach in the lab.
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St. Jude Children’s Research Hospital announces expansion of its strategic plan to target pediatric catastrophic diseases
07/13/2022
Six-year plan will now commit $12.9 billion to support 2,300 jobs, among other priorities.
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STEMM immersion program to shape the next generation of scientists
07/11/2022
St. Jude High School and College Research Immersion Program introduces science to a diverse group of students
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Primary cilia in medulloblastoma: mechanisms provide treatment opportunity
07/07/2022
St. Jude scientists have shown how the presence or absence of primary cilia contribute to specific types of the most common malignant childhood brain tumor.
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Researchers create a single-cell framework to potentially enhance CAR T–cell therapy
07/06/2022
St. Jude scientists developed a method that could improve CAR T-cell therapies by identifying the early cells that become effective at killing cancer.
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Arkansas State Rep. Dwight Tosh honored at St. Jude for 60-year survival of childhood cancer
06/24/2022
Tosh is the first St. Jude patient to reach this milestone and was recognized at institution’s 60th anniversary celebration
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St. Jude collaborates with multiple organizations to expand STEM opportunities in Memphis
06/23/2022
New collaboration with multiple organizations is part of national effort to provide equity in STEM education.
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Pushing T cells down “memory lane” may improve cancer therapy
06/22/2022
St. Jude immunologists identified proteins that help decide T cell fate and used the finding to improve CAR-T cell therapy in a solid tumor model.
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U.S. News & World Report ranks St. Jude as outstanding pediatric cancer hospital
06/14/2022
St. Jude Children’s Research Hospital recognized among hospitals delivering exceptionally high-quality care
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A high-risk pair – a drug and DNA variant increase heart disease risk in cancer survivors
06/13/2022
St. Jude scientists identified a genetic difference in childhood cancer survivors treated with chemotherapy that predisposes them to heart problems as adults.
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Unfreezing waters in ligand binding sites
06/07/2022
St. Jude scientists are studying how the temperature at which protein structures are captured can create "artifacts," – errors that cause misleading results.
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St. Jude research highlighted at annual meeting of the American Society of Clinical Oncology
05/31/2022
Learn best practices and hear insights from St. Jude oncologists, psychologists and scientists at the annual gathering of clinical oncology experts.
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Killer T vs. memory – DNA isn’t destiny for T cells
05/20/2022
St. Jude scientists uncovered how one type of T cell creates two genetically identical, but functionally different, daughter cells.
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Research reveals surprising inactivation mechanism for a voltage-gated ion channel
05/20/2022
This the first time researchers have identified the mechanism for closed-state inactivation. These approaches could be applied to other ion channels.
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ZBP1 links interferon treatment and dangerous inflammatory cell death during COVID-19
05/19/2022
St. Jude scientists identified ZBP1 as a key contributor to the inflammatory cell death that drives morbidity and mortality in COVID-19 patients.
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Updates on gene therapy for ‘bubble boy’ disease and cellular immunotherapy at ASGCT
05/12/2022
St. Jude scientists will discuss research on cellular therapies for pediatric cancer and more at the annual meeting.
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A tool to unlock the ‘numbers game’ of big data in rare disease research
05/11/2022
Big data can cause big problems in rare disease genetics research. Scientists at St. Jude created a systematic solution to find the inherited genes contributing to rare disease.
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Strategy overcomes EZH2 inhibitor resistance in SMARCB1 mutated cancer
05/09/2022
Findings from St. Jude demonstrate the role of chromatin regulation in cancer’s resistance to EZH2 inhibitors and offer a way to make treatment more effective.
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Lab findings suggest EGFR inhibitors may prevent rhabdomyosarcoma recurrence
04/27/2022
RMS is the most common soft tissue sarcoma in children. When it recurs after therapy, the survival rate is only 30%.
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Single-molecule techniques illuminate mechanisms of GPCR activation
04/27/2022
St. Jude scientists and their Columbia University collaborators reveal how GPCR signaling is regulated with implications for drug development.
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Study finds jumping “junk” DNA is a novel cause of childhood brain cancer
04/22/2022
St. Jude scientists have found the first known example of a promoter ‘donation’ event from a retrotransposon causing a highly malignant childhood brain cancer.
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J. Paul Taylor, M.D., Ph.D., named scientific director and executive vice president of St. Jude
04/18/2022
Dr. Taylor steps into the role during a pivotal time of growth for St. Jude, as its scientific enterprise will significantly expand.
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American Society of Clinical Oncology honors St. Jude clinical brain tumor researcher
04/12/2022
Dr. Amar Gajjar becomes the seventh St. Jude Children’s Research Hospital investigator to receive the Pediatric Oncology Award
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Dr. Martine Roussel recognized for groundbreaking work
04/10/2022
The AACR also honored the St. Jude scientist for her contributions to advancing women in science.
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St. Jude researchers honored for contributions to treatment of pediatric blood disorders
04/06/2022
St. Jude researchers are recognized by the American Society of Pediatric Hematology/Oncology for their expertise and career achievements
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Immune responses support COVID-19 vaccination regardless of when people were infected
04/05/2022
St. Jude scientists have studied how vaccination before and after primary infections affect the immune response.
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St. Jude at the American Association for Cancer Research Annual Meeting
03/30/2022
Scientists from St. Jude Children’s Research Hospital will participate in the annual gathering of a premier professional society for the cancer research community.
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St. Jude Children’s Research Hospital evacuates second group of patients from Ukraine safely to United States
03/29/2022
Four more Ukrainian children with cancer and their 11 family members arrived at St. Jude Children’s Research Hospital in Memphis, Tennessee.
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First Ukrainian pediatric cancer patients evacuated to U.S. arrive safely at St. Jude Children’s Research Hospital
03/22/2022
St. Jude continues to help move hundreds of Ukrainian children with cancer to safety so they can continue treatment.
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James R. Downing, M.D., elected to Fellows of AACR Academy Class of 2022
03/22/2022
Dr. Downing is honored for his outstanding contributions and innovations in cancer research.
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Chronologically young, biologically old – DNA linked to cancer survivors’ premature aging
03/22/2022
St. Jude Children’s Research Hospital findings lay the groundwork for identifying pediatric cancer survivors at higher risk of accelerated aging and chronic diseases.
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Memphis Airport to open unique lounge for St. Jude Children’s Research Hospital
03/07/2022
Private, comfortable space in newly designed airport concourse will be staffed by St. Jude employees.
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With Fundacja Herosi, St. Jude aids Ukrainian children with cancer and blood disorders at Unicorn Marian Wilemski Clinic
03/06/2022
On Saturday, the Foundation’s building in Bocheniec, now officially named the Unicorn Marian Wilemski Clinic, welcomed the first group of Ukrainian children and their families. Read more about this ongoing effort.
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St. Jude creates HPV cancer prevention awareness campaign to emphasize the need for HPV vaccination
03/04/2022
Emphasizing the need for HPV vaccination, the campaign launches March 4, 2022, International HPV Awareness Day.
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Research reveals high-risk subtype of relapsed pediatric AML
02/17/2022
St. Jude scientists have found a previously overlooked mutation in a subtype of pediatric leukemia that has implications for identifying high-risk patients.
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St. Jude leases interim office space in Peabody Place as campus grows
02/16/2022
The hospital relocates 500 administrative employees to the temporary workspace during the construction phase of its six-year strategic plan.
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Research lays a foundation for prevention of the most common childhood cancer
02/07/2022
St. Jude scientists blocked development of acute lymphoblastic leukemia in mice with a genetic mutation that increases the risk of childhood cancer.
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St. Jude Children’s Research Hospital celebrates 60 years of saving children’s lives
02/04/2022
Diamond jubilee events are planned nationwide for supporters to honor St. Jude visionaries, recognize expanding global impact of scientific, medical achievements
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Young vs. old: How host environment affects immune response
02/04/2022
St. Jude scientists have shown that the active immune system in young hosts may actually work against cancer immunotherapies by exhausting T cells.
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Inherited gene variant powers up an oncogene to drive a high-risk leukemia
02/03/2022
Scientists at St. Jude have revealed how an inherited genetic variant turns on an oncogene, increasing the risk of developing childhood leukemia. Published in Nature Genetics.
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CAR T cells target AML, spare bone marrow
01/31/2022
St. Jude scientists created an immunotherapeutic strategy for a type of pediatric leukemia using CAR T cells that target a tumor-specific antigen.
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Genetic ancestry provides important context for understanding global diversity in childhood leukemia
01/27/2022
St. Jude scientists show that addressing racial disparities in acute lymphoblastic leukemia should include considering how genetic ancestry affects biology and prognosis.
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Common cold coronaviruses hinder antibody immune response to SARS-CoV-2 infection
01/12/2022
St. Jude study also suggests that prior immunity to common cold coronaviruses does not protect against SARS-CoV-2 infection.
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Modular super-enhancer controls retinal development
01/11/2022
Scientists at St. Jude identified distinct functions for regions of a super-enhancer that controls gene expression during retina formation, calling it a ‘modular’ super-enhancer.
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Understanding how autoactivation triggers cell death
01/11/2022
Scientists from St. Jude have captured the structure of autoactivated BAK, a key protein for triggering apoptosis in cancer cells.
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Volunteer registration now open for St. Jude Memphis Marathon Weekend
08/05/2022
New this year, volunteers can fundraise to support the largest single-day fundraising event for St. Jude and one of the biggest events in Memphis — Dec. 1-3, 2022.
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Bids, birdies and beats: Online auction opens ahead of St. Jude JAM concert benefiting St. Jude Children’s Research Hospital
08/03/2022
This annual concert tees off week-long events for FedEx St. Jude Championship of golf.
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2022 St. Jude Memphis to Peoria Run
08/03/2022
Cheers rose up from the St. Jude Children’s Research Hospital campus as hundreds of runners hit the pavement for the 41st annual Memphis to Peoria Run.
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St. Jude patient art paints a global picture during FedEx St. Jude Championship
08/01/2022
This highly anticipated PGA TOUR stop in Memphis benefits St. Jude Children’s Research Hospital.
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