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Shane Cross, PharmD, BCPS

Shane Cross, PharmD, BCPS

  • Infectious Diseases Pharmacy Residency Coordinator
  • Clinical Pharmacy Specialist-Antimicrobial Stewardship
  • Assistant Professor, The University of Tennessee Health Sciences Center, Department of Clinical Pharmacy and Translational Science

Board Certification  

  • BCPS


  • PharmD – University of Missouri, Kansas City (UMKC) School of Pharmacy, Kansas City, Missouri

Post-Graduate Training  

  • Pediatric Pharmacotherapy ResidencySt. Jude Children’s Research Hospital, Memphis, Tennessee
  • Clinical Pharmacokinetics Fellowship –  St. Jude Children’s Research Hospital, Memphis, Tennessee

Focused Area of Practice

  • Antimicrobial Stewardship / Infectious Diseases
  • Leukemia/Lymphoma
  • Hematopoietic Stem Cell Transplantation


  • 2020  Clinical Care Improvement Award for Clinical Pharmacy Services, St. Jude Children’s Research Hospital 
  • 2018  St. Jude Compliance Champion Award
  • 2014  St. Jude Family-Centered Care Champion
  • 2011  St. Jude 5100 Club (Employee of the Quarter) – Clinical Division

Research Interests

  • Clinical Pharmacokinetics
  • Investigational Pharmacokinetics

St. Jude Committee Service

  • Antimicrobial Utilization and Improvement Committee, Co-chair
  • Institutional Review Board (IRB)
  • Residency Advisory Committee
  • Pharmacogenetics Oversight Committee

Pharmacy Organizations/Committee Service

  • American College of Clinical Pharmacy (ACCP)
  • Pediatric Infectious Diseases Society (PIDS)
  • Hematology Oncology Pharmacy Association (HOPA)
  • Tennessee Pharmacists Association (TPA)

Selected Publications

Hijano DR, Ferrolino JA, Swift EG, Michaels C, Max A, Hayden RT, Wolf J, Dallas RH, Greene WL, Richardson JL, Hakim H, Morton TH, Cross SJ.  SARS-CoV-2 Infection in High-risk Children Following Tixagevimab-Cilgavimab (Evusheld) Pre-exposure Prophylaxis: A Single Center Observational Study.  Front Oncol. 2023 [Accepted for publication]

Shapiro K, Cross SJ, Morton TH, Inaba H, Holland A, Fasipe FR, Adderson EE.  Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum.  Emerg Infect Dis. 2023 Aug;29(8):[early release]

Swanson HD, Hakim H, Hijano DR, Morton T, Cross S, Inaba H, Jeha S, Pui CH, Karol SE.  Vaccines against SARS-CoV-2 are safe to administer in patients with antibodies to pegaspargase.  Cancer Med.  2022 Jul 15;[online ahead of print]

Bami S, Hidinger J, Madni A, Hargest V, Schultz-Cherry S, Cortez V, Cross SJ, Ward DA, Hayden RT, Rubnitz J, Pui CH, Khan RB, Hijano DR.  Human Astrovirus VA1 Encephalitis in Pediatric Patients with Cancer: Report of 2 Cases and Review of the Literature.  J Pediatric Infect Dis Soc. 2022 Jul 18;[online ahead of print]

Cross SJ, Patel JR, Wolf J.  Diagnosis and Management of Typhlitis and Neutropenic Enterocolitis in Children with Cancer.  Pediatr Infect Dis J. 2022 Aug 1;41(8):e326-8. Epub 2022 Jul 13

Cross SJ, Morton TH, Wolf J.  Epidemiology, Diagnosis, and Treatment of Clostridioides difficile Infection in Immunocompromised Children.  J Pediatric Infect Dis Soc. 2021 [in press]

Dallas RH, Rains JK, Wilder K, Humphrey W, Cross SJ, Ghafoor S, Brazelton de Cardenas JN, Hayden RT, Hijano DR.  The Aerogen® Solo Is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin.  Pharmaceutics. 2020 Nov 29;12(12):1163.

Bhoopalan SV, Cross SJ, Panetta JC, Triplett BM.  Pharmacokinetics of alemtuzumab in pediatric patients undergoing ex vivo T-cell-depleted haploidentical hematopoietic cell transplantation.  Cancer Chemother Pharmacol. 2020 Dec;86(6):711-717. Epub 2020 Oct 10.

Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Oliveira CR, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich ML, Goldman DL, Groves HE, Rajapakse NS, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM.  Multicenter Interim Guidance on Use of Antivirals for Children With COVID-19/SARS-CoV-2.  J Pediatric Infect Dis Soc. 2021 Feb 13;10(1):34-48. Epub 2020 Sep 12.

Karol SE, Sun Y, Tang L, Pui CH, Ferrolino J, Allison KJ, Cross SJ, Evans WE, Crews KR, Jeha S, Wolf J.  Fluoroquinolone prophylaxis does not increase risk of neuropathy in children with acute lymphoblastic leukemia.  Cancer Med.  2020 Sep;9(18):6550-6555. Epub 2020 Jul 25.

Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich M, Goldman DL, Groves HE, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM.  Multicenter Initial Guidance on Use of Antivirals for Children With COVID-19/SARS-CoV-2.  J Pediatric Infect Dis Soc. 2020 Dec 31;9(6):701-715. Epub 2020 Apr 22.

Mamcarz E, Zhou S, Lockey T, Abdelsamed H, Cross SJ, Kang G, Ma Z, Condori J, Dowdy J, Triplett B, Li C, Maron G, Aldave Becerra JC, Church JA, Dokmeci E, Love JT, da Matta Ain AC, van der Watt H, Tang X, Janssen W, Ryu BY, De Ravin SS, Weiss MJ, Youngblood B, Long-Boyle JR, Gottschalk S, Meagher MM, Malech HL, Puck JM, Cowan MJ, Sorrentino BP.  Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1. N Engl J Med. 2019 Apr 18;380(16):1525-34.

Dove AP, Manole BA, Wakefield DV, Cross SJ, Doubrovin M, Shulkin BL, Merchant TE, Davidoff AM, Furman WL, Krasin MJ, Santana VM, Lucas JT Jr.  Managing local-regional failure in children with high-risk neuroblastoma: A single institution experience.  Pediatr Blood Cancer. 2018 Dec;65(12):e27408. Epub 2018 Sep 30.

Sharma A, Kang G, Sunkara A, Inaba H, Jeha S, Cross SJ, Geiger T, Triplett B.  Haploidentical Donor Transplantation Using a Novel Clofarabine-containing Conditioning Regimen for Very High-risk Hematologic Malignant Neoplasms.  J Pediatr Hematol Oncol 2018 Nov;40(8):e479-e485. Epub 2018 May.

Triplett BM, Muller B, Kang G, Li Y, Cross SJ, Moen J, Cunningham L, Janssen W, Mamcarz E, Shook DR, Srinivasan A, Choi J, Hayden RT, Leung W.  Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared with CD3-targeted T-cell depletion.  Transpl Infect Dis. 2018 Feb;20(1):e12823. Epub 2018 Jan 16.

Flerlage T, Hayden R, Cross SJ, Dallas R, Srinivasan A, Tang L, Sun Y, Maron G.  Rotavirus Infection in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients: Clinical Course and Experience Using Nitazoxanide and Enterally Administered Immunoglobulins.  Pediatr Infect Dis J. 2018 Feb;37(2):176-81. Epub 2017 Aug 3

Millisor VE, Roberts JK, Sun Y, Tang L, Daryani VM, Gregornik D, Cross SJ, Ward D, Pauley JL, Molinelli A, Brennan RC, Stewart CF.  Derivation of new equations to estimate glomerular filtration rate in pediatric oncology patients.  Pediatr Nephrol.  2017 Sep;32(9):1575-84. Epub 2017 Jun 2

Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agúndez JA, Wingard JR, McLeod HL, Klein TE, Cross SJ, Caudle KE, Walsh TJ.  Clinical Pharmacogenetics Implementation Consortium (CPIC®) Guideline for CYP2C19 and Voriconazole Therapy.  Clin Pharmacol Ther. 2017 Jul;102(1):45-51. Epub 2016 Dec 16

Duggin K, Tickle K, Norman G, Yang J, Wang C, Cross SJ, Gajjar A, Mandrell B.  Aprepitant reduces chemotherapy-induced vomiting in children and young adults with brain tumors. J Pediatr Oncol Nurs Sept-Oct;31(5):277-83, 2014. Epub 2014 Jun 27.

Srinivasan A, Panetta JC, Cross SJ, Pillai A, Triplett BM, Shook DR, Dallas MH, Hartford C, Sunkara A, Kang G, Jacobsen J, Choi J, Leung W. Phase I study of the safety and pharmacokinetics of plerixafor in children undergoing a second allogeneic hematopoietic stem cell transplantation for relapsed or refractory leukemia. Biol Blood Marrow Transplant Aug;20(8):1224-8, 2014. Epub 2014 Apr 23.

Bell GC, Crews KR, Wilkinson MR, Haidar CE, Hicks JK, Baker DK, Kornegay NM, Yang W, Cross SJ, Howard SC, Freimuth RR, Evans WE, Broeckel U, Relling MV, Hoffman JM. Development and use of active clinical decision support for preemptive pharmacogenomics. J Am Med Inform Assoc Feb;21:e93-e99, 2014. Epub 2013 Aug 26.

Bernardo VA, Cross SJ, Crews KR, Flynn PM, Hoffman JM, Knapp KM, Pauley JL, Molinelli AR, Greene WL. Posaconazole therapeutic drug monitoring in pediatric patients and young adults with cancer. Ann Pharmacother Jul-Aug;47(7-8):976-83, 2013.  Epub 2013 Jun 4.

Hicks JK, Crews KR, Hoffman JM, Kornegay NM, Wilkinson MR, Lorier R, Stoddard A, Yang W, Smith C, Fernandez CA,  Cross SJ, Haidar C, Baker BK, Howard SC, Evans WE, Broeckel U, Relling MV. A Clinician-Driven Automated System for Integration of Pharmacogenetic Interpretations Into an Electronic Medical Record. Clin Pharmacol Ther Nov;92(5):563-6, 2012. Epub 2012 Sept 19.

Srinivasan A, Kasow KA, Cross S, Parrish M, Wang C, Srivastava DK, Cai X, Panetta JC, Leung W. Phase I study of the tolerability and pharmacokinetics of palifermin in children undergoing allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant Aug;18(8):1309-14, 2012. Epub 2012 Apr 25.

Crews KR, Cross SJ, McCormick JN, Baker DK, Molinelli AR, Mullins R, Relling MV, Hoffman JM. Development and implementation of a pharmacist-managed clinical pharmacogenetics service. Am J Health Syst Pharm Jan 15;68(2):143-50, 2011.

Cross SJ, Rodman JH, Lindsey JC, Robbins BL, Rose CH, Yuen GJ, D'angelo LJ. Abacavir and Metabolite Pharmacokinetics in HIV-1-infected Children and Adolescents. J Acquir Immune Defic Syndr May 1;51(1):54-9, 2009.

Sleasman JW, Robbins BL, Cross SJ, Lindsey JC, Kraimer JM, Heckman BE, Sprenger HL, Tustin NB, Rose CH, Poston PA, Neal EF, Pakes GE, Nikanjam M, Capparelli EV. Abacavir Pharmacokinetics During Chronic Therapy in HIV-1-Infected Adolescents and Young Adults. Clin Pharmacol Ther Apr;85(4):394-401, 2009. Epub 2008 Dec 31.

Last update: September 2023