Skip to main content
Sara M. Federico, MD
Sara M. Federico, MD

Sara M. Federico, MD

Member, St. Jude Faculty

  • Director, Solid Tumor Division




BA – Stanford University, Palo Alto, California
MD – Virginia Commonwealth University Medical College of Virginia, Richmond, VA
Pediatric Internship – Lucille Packard Children’s Hospital Stanford University, Palo Alto, California
Pediatric Residency – Lucille Packard Children’s Hospital Stanford University, Palo Alto, California
Pediatric Hematology/Oncology Fellowship St. Jude Children’s Research Hospital Memphis, TN

Research Interests

  • Clinical investigation of pediatric soft tissue sarcomas
  • Translational research in pediatric solid tumor malignancies
  • Novel drug development for pediatric solid tumor malignancies 

Selected Publications

Talleur AC, Triplett B, Federico S, Mamcarz E, Janssen W, Shook D, Leung W, Furman WL. Consolidation therapy for newly diagnosed pediatric high-risk neuroblastoma patients using busulfan/melphalan, autologous hematopoietic cell transplant anti-GD2 antibody, GM-CSF, IL-2 and haploidentical NK cells. Biol Blood Marrow Transplant Jul 18, 2017. PMID: 28733263

Stewart E, Federico SM*, Chen X, Shelat AA, Bradley C, Gordon B, Karlstrom A, Twarog NR, Clay MR, Bahrami A, Freeman BB 3rd, Xu B, Zhou X, Wu J, Honnell V, Ocarz M, Blankenship K, Dapper J, Mardis ER, Wilson RK, Downing J, Zhang J, Easton J, Pappo A, Dyer MA. Orthotopic patient-derived xenografts of paediatric solid tumours. Nature Sep 7; 549(7670):96-100, 2017. doi: 10.1038/nature23647. Epub 2017 Aug 30. PMID: 28854174

Federico SM, McCarville MB, Shulkin BL, Sondel PM, Hank JA, Hutson P, Meagher M, Shafer A, Ng CY, Leung W, Janssen WE, Wu J, Mao S, Brennan RC, Santana VM, Pappo AS, Furman WL. A pilot trial of humanized anti-GD2 monoclonal antibody (hu14.18K322A) with chemotherapy and natural killer cells in children with recurrent/refractory neuroblastoma. Clin Cancer Res Sep 22, 2017. doi: 10.1158/1078-0432. CCR-17-0379. [Epub ahead of print] PMID: 28939747

McCarville MB, Federico SM, Bishop MW, Pappo AS, Shulkin BL. Assessment of Chemotherapy Response in Ewing Sarcoma. Radiology Nov;281(2):647-649, 2016. PMID: 27755931

Pearson AD, Federico SM, Aerts I, Hargrave DR, DuBois SG, Iannone R, Geschwindt RD, Wang R, Haluska FG, Trippett TM, Geoerger B. A phase I study of oral ridaforolimus in pediatric patients with advanced solid tumors. Oncotarget Oct 4, 2016. doi: 10.18632/oncotarget.12450. PMID: 27713169

Frappaz D, Federico SM, Pearson AD, Gore L, Macy ME, DuBois SG, Aerts I, Iannone R, Geschwindt R, Van Schanke A, Wang R, Geoerger B. Phase 1 Study of Dalotuzumab Monotherapy and Ridaforolimus-Dalotuzumab Combination Therapy in Pediatric Patients With Advanced Solid Tumors. Eur J Cancer Jul;62:9-17, 2016. Doi:10.1016/j.ejca.2016.03.084. PMID: 27185573

Harreld JH, Bratton EM, Federico SM, Li X, Grover W, Li Y, Kerr NC, Wilson MW, Hoehn ME. Orbital metastasis is associated with decreased survival in stage M neuroblastoma. Pediatr Blood Cancer Apr:63(4):627-33, 2016. Doi: 10.1002/pbc.25847. Epub 2015 Nov 24. PMID: 26599346

Weaver MS, Federico S. Visual Diagnosis: New lung nodules in a 3-year-old girl with wilms tumor. Pediatr Rev Feb;37(2):e5-6, 2016. Doi 10.1542/pir.2015-0047. Review. PubMed PMID: 26834231

Stewart E, Federico S, Karlstrom A, Shelat A, Sablauer A, Pappo A, Dyer MA. The childhood solid tumor network: A new resource for the development biology and oncology research communities. Dev Biol Mar 15;411(2):287-93, 2016. doi:10.1016/j.ydbio.2015.03.001. Epub 2015 Jun 9. PubMed PMID: 260683077

Federico SM. Ditch the scale. JAMA Nov 17;314(19):2025-2026, 2015. Doi:10.1001/jama.2015.5916. PubMed PMID: 26575057

Stewart E, Shelat A, Bradley C, Xiang C, Federico S, Thiagarajan S, Bahrami A, Pappo A, Qu C, Finkelstein D, Sablaur A, Dyer MA. Development and characterization of a human orthotopic neuroblastoma xenograft. Dev Biol  Nov 15;407(2):344-55, 2015. doi: 10.1016/j.ydbio.2015.02.002. PubMed PMID: 25863122

Federico SM, Brady SL, Pappo A, Wu J, Mao S, McPherson VJ, Young A, Furman WL, Kaufman R, Kaste S. The role of chest computed tomography (CT) as a surveillance tool in children with high-risk neuroblastoma. Pediatr Blood Cancer Jun;62(6):976-81, 2015. doi: 10.1002/pbc.25400. Epub 2015 Jan 13. PubMed PMID: 25641708

Federico SM, Gilpin D, Samant S, Billups CA, Spunt SL. Clinical features and outcomes of young patients with head and neck non-rhabdomyosarcoma soft tissue sarcomas. Head Neck Jan;37(1):76-83, 2015. doi: 10.1002/hed.23564. Epub 2014 Feb 12. PMID: 24327514

Federico SM, Allewelt HB, Spunt SL, Hudson MM, Wu J, Billups CA, Jenkins J, Santana VM, Furman WL, McGregor LM. Subsequent malignant neoplasms in pediatric patients initially diagnosed with neuroblastoma. J Pediatr Hematol Oncol 2015 Jan;37(1):e6-e12, 2015. doi: 10.1097/MPH.0000000000000148. PubMed Central PMCID: PMC4266626

Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt S, Valentine MB, Valentine V, Krafcik F, Lang WH, Wierdl M, Tsurkan L, Tolleman V, Federico SM, Morton C, Lu C, Ding L, Easton J, Rusch M, Nagahawatte P, Wang J, Parker M, Wei L, Hedlund E, Finkelstein D, Edmonson M, Shurtleff S, Boggs K, Mulder H, Yergeau D, Skapek S, Hawkins DS, Ramirez N, Potter PM, Sandoval JA, Davidoff AM, Mardis ER, Wilson RK, Zhang J, Downing JR, Dyer MA. Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell Dec 9;24(6):710-24, 2013.  doi: 10.1016/j.ccr.2013.11.002. PubMed Central PMCID: PMC3904731

Federico SM, Spunt SL, Krasin MJ, Billups CA, Wu J, Shulkin B, Mandell G, McCarville MB. Comparison of PET-CT and conventional imaging in staging pediatric rhabdomyosarcoma. Pediatr Blood Cancer Jul;60(7):1128-34, 2013, 2013. doi: 10.1002/pbc.24430. Epub 2012 Dec 19. PubMed Central PMCID: PMC4266929

Cheung NK, Zhang J, Lu C, Parker M, Bahrami A, Tickoo SK, Heguy A, Pappo AS, Federico S, Dalton J, Cheung IY, Ding L, Fulton R, Wang J, Chen X, Becksfort J, Wu J, Billups CA, Ellison D, Mardis ER, Wilson RK, Downing JR, Dyer MA; St Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA Mar 14;307(10):1062-71, 2012. doi: 10.1001/jama.2012.228. PubMed Central PMCID: PMC3527076

Brennn RC, Federico S, Bradley C, Zhang J, Flores-Otero J, Wilson M, Stewart C, Zhu F, Guy K, Dyer MA. Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. Cancer Res Jun 15;71(12):4205-13, 2011. doi: 10.1158/0008-5472.CAN-11-0058. Epub 2011 Apr 22. PubMed Central PMCID: PMC3116943

Teitz T, Stanke JJ, Federico S, Bradley CL, Brennan R, Zhang J, Johnson MD, Sedlacik J, Inoue M, Zhang ZM, Frase S, Rehg JE, Hillenbrand CM, Finkelstein D, Calabrese C, Dyer MA, Lahti JM. Preclinical models for neuroblastoma: establishing a baseline for treatment. PLoS One Apr 29;6(4):e19133, 2011. doi: 10.1371/journal.pone.0019133. PubMed Central PMCID: PMC3084749

Federico S, Brennan R, Dyer MA. Childhood cancer and developmental biology a crucial partnership. Curr Top Dev Biol 94:1-13, 2011. doi: 10.1016/B978-0-12-380916-2.00001-2. PubMed Central PMCID: PMC3551576

Brennan R, Federico S, Dyer MA. The war on cancer: have we won the battle but lost the war? Oncotarget Jun;1(2):77-83, 2010. PubMed Central PMCID: PMC2945373.

Nemeth KM*, Federico S*, Carcaboso AM, Shen Y, Schaiquevich P, Zhang J, Egorin M, Stewart C, Dyer MA. Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma. Cancer Jan 15;117(2):421-34, 2011. doi: 10.1002/cncr.25574. Epub 2010 Sep 3. PubMed Central PMCID: PMC3000447

Federico SM, Rodriguez-Galindo C. 50 Years ago in the Journal of Pediatrics: Approaches to the chemical therapy of tumors. J Pediatr Sept;155(3):420, 2009. 

Last update: February 2018