Hans-Martin Herz, PhD
Hans-Martin Herz, PhD

Hans-Martin Herz, PhD

Assistant Member, St. Jude Faculty

Departments

Education

BA – University of Technology Darmstadt, Germany
MS – Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg, Germany
PhD – Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg, Germany
Postdoctoral Fellowship – Stowers Institute for Medical Research, Kansas City, Missouri

Professional Societies

  • 2008-present Member, Society for Developmental Biology
  • 2005-present Member, Genetic Society of America

Research Interests

  • Regulation of transcription and enhancer activity by chromatin-modifying proteins
  • Non-histone substrates of histone-modifying enzymes
  • Enhancer malfunction in cancer
  • Histone lysine to methionine mutants in development and disease

Selected Publications

Herz HM*, Morgan M*, Gao X, Jackson J, Rickels R, Swanson SK, Florens L, Washburn MP, Eissenberg J, Shilatifard A. Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling. Science 345:1065-1070, 2014. *Equal contribution.

Herz HM, Hu D, Shilatifard A. Enhancer malfunction in cancer. Mol Cell 53:859-866, 2014. PMCID: PMC4049186.

Herz HM, Garruss A, Shilatifard A. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci 38:621-639, 2013. PMCID: PMC3941473

Hu D, Gao X, Morgan MA, Herz HM, Smith ER, Shilatifard A. The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol 33:4745-4754, 2013. PMCID: PMC3838007.

Tarayrah L, Herz HM, Shilatifard A, Chen X. Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche. Development 140:1014-1023, 2013. PMCID: PMC3583039.

Christiansen AE, Ding T, Fan Y, Graves HK, Herz HM, Lindblad JL, Bergmann A. Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila. Cell Death Differ 20:302-311, 2013. PMCID: PMC3554335.

Herz HM, Mohan M, Garruss AS, Liang K, Takahashi Y, Mickey K, Voets O, Verrijzer CP, Shilatifard A. Enhancer-associated H3K4 mono-methylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev 26:2604-2620, 2012. PMCID: PMC3521626.

Mohan M, Herz HM, Shilatifard A. SnapShot: Histone lysine methylase complexes. Cell 149:498-498, 2012. PMCID: PMC3711870.

Herz HM, Mohan M, Garrett AS, Miller C, Casto D, Zhang Y, Seidel C, Haug JS, Florens L, Washburn MP, Yamaguchi M, Shiekhattar R, Shilatifard A. Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol 32:1683-1693, 2012.

Mohan M, Herz HM, Smith ER, Zhang Y, Jackson J, Washburn MP, Florens L, Eissenberg JC, Shilatifard A. The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol 31:4310-4318, 2011. PMCID: PMC3209330.

Herz HM, Shilatifard A. The JARID2-PRC2 duality. Genes Dev 24:857-861, 2010. PMCID: PMC2861184.

Herz HM, Madden LD, Chen Z, Bolduc C, Buff E, Gupta R, Davuluri R, Shilatifard A, Hariharan IK, Bergmann A. The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol 30:2485-2497, 2010. PMCID: PMC2863695.

Mohan M, Herz HM, Takahashi YH, Lin C, Lai KC, Zhang Y, Washburn MP, Florens L, Shilatifard A. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev 24:574-589, 2010. PMCID: PMC2841335.

Herz HM, Nakanishi S, Shilatifard A. The curious case of bivalent marks. Dev Cell 17:301-303, 2009. PMID: 19758552.

Allton K, Jain AK, Herz HM, Tsai W, Jung SJ, Qin J, Bergmann A, Johnson RL, Barton MC. Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci USA 106:11612-11616, 2009. PMCID: PMC2710642

van Impel A, Schumacher S, Draga M, Herz HM, Grosshans J, Müller HA. Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula. Development 136:813-22, 2009. PMCID: PMC2685947

Herz HM, Bergmann A. Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101. Biochem Soc Trans 37:204-207, 2009. PMID: 19143632.

Herz HM, Woodfield SE, Chen Z, Bolduc C, Bergmann A. Common and distinct genetic properties of ESCRT-II components in Drosophila. PLoS ONE 4:e4165, 2009. PMCID: PMC2613530.

Gawliński P, Nikolay R, Goursot C, Lawo S, Chaurasia B, Herz HM, Kussler-Schneider Y, Ruppert T, Mayer M, Grosshans J. The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins. EMBO Rep 8:490-496, 2007.

Herz HM, Chen Z, Scherr H, Bolduc C, Lackey M, Bergmann A. vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development 133:1871-1880, 2006.

Grosshans J, Wenzl C, Herz HM, Bartoszewski S, Schnorrer F, Vogt N, Schwarz H, Muller HA. RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation. Development 132:1009-1020, 2005.

Last update: August 2015