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Mark E. Hatley, MD, PhD
Mark E. Hatley, MD, PhD

Mark E. Hatley, MD, PhD

Associate Member, St. Jude Faculty

  • Director, Division of Molecular Oncology




BS – University of Central Oklahoma, Edmond, Oklahoma
MD, PhD – University of Texas Southwestern Medical Center at Dallas, Medical Scientist Training Program, Dallas, Texas

Research Interests

  • Cellular and molecular origins of embryonal rhabdomyosarcoma
  • MicroRNAs in pediatric sarcomas
  • Mouse models of pediatric sarcomas
  • Development of novel therapies for pediatric sarcomas

Honors and Awards

  • 2020    Elected member, American Society of Clinical Investigation
  • 2019    Mentor of the Year Award, SJCRH
  • 2018    Summer’s Way Foundation Young Investigator Award
  • 2017    Joseph V. Simone, MD Golden Apple Award, SJCRH
  • 2016    V Foundation Scholar Award
  • 2014    American Society of Clinical Investigation Young Physician-Scientist Award
  • 2011-2016  NIH/NCI Clinical Scientist Career Development Award (K08)
  • 2011    Alex’s Lemonade Stand Foundation Young Investigator Award
  • 2008–2012 NIH/NCI Pediatric Research Loan Repayment Program
  • 2007-2010  Pediatric Scientist Development Program, NICHD

Selected Publications

Hanna JA, Langdon CG, Garcia MR, Benton A, Lanman NA, Finkelstein D, Rehg JE, Hatley ME. Genetic context of oncogenic drivers dictates vascular sarcoma development in aP2-Cre mice. J Pathol May;257(1):109-124, 2022. doi: 10.1002/path.5873. Epub 2022 Feb 15. PMID: 35066877

Langdon CG, Gadek KE, Garcia MR, Evans MK, Reed KB, Bush M, Hanna JA, Drummond CJ, Maguire MC, Leavey PJ, Finkelstein D, Jin H, Schreiner PA, Rehg JE, Hatley ME. Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Nat Commun Sep 17;12(1):5520, 2021. doi: 10.1038/s41467-021-25829-4. PMID: 34535684

Hanna JA, Garcia MR, Lardennois A, Leavey PJ, Maglic D, Fagnan A, Go JC, Roach J, Wang YD, Finkelstein D, Hatley ME. PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. Oncogene Jan 25, 2018.

Drummond CJ, Hanna JA, Garcia MR, Devine DJ, Heyrana AJ, Finkelstein D, Rehg JE, Hatley ME. Hedgehog pathway drives fusion-negative rhabdomyosarcoma initiated from non-myogenic endothelial progenitors. Cancer Cell 33(1):108-124.e5, 2018.

Hanna JA, Drummond CJ, Garcia MR, Go JC, Finkelstein D, Rehg JE, Hatley ME. Biallelic Dicer1 loss mediated by aP2-Cre drives angiosarcoma. Cancer Res 77(22):6109-6118, 2017.

Lakhia R, Hajarnis S, Williams D, Aboudehen K, Yheskel M, Xing C, Hatley ME, Torres VE, Wallace DP, Patel V. MicroRNA-21 aggravates cyst growth in a model of polycystic kidney disease. J Am Soc Nephrol 27(8):2319-2330, 2016.

Hanna JA, Garcia MR, Go JC, Finkelstein D, Kodali K, Pagala V, Wang X, Peng J, Hatley ME. PAX7 is a required target for microRNA-206 induced differentiation of fusion-negative rhabdomyosarcoma. Cell Death Dis 7(6):e2256, 2016.

Kashi VP, Hatley ME,* Galindo RL.* Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems. Nat Rev Cancer 15(7):426-439, 2015. *co-corresponding authors. PMCID: PMC4599785

White K, Dempsie Y, Caruso P, Wallace E, McDonald R, Stevens H, Hatley ME, van Rooij E, Morrell N, MacLean M, Baker A. Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension 64(1):185-194, 2014. 

Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt S, Valentine MB, Valentine V, Krafcik F, Lang WH, Wierdl M, Tsurkan L, Tolleman V, Federico SM, Morton C, Lu C, Ding L, Easton J, Rusch M, Nagahawatte P, Wang J, Parker M, Wei L, Hedlund E, Finkelstein D, Edmonson M, Shurtleff S, Boggs K, Mulder H, Yergeau D, Skapek S, Hawkins DS, Ramirez N, Potter PM, Sandoval JA, Davidoff AM, Mardis ER, Wilson RK, Zhang J, Downing JR, Dyer MA. Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell  24(6):710-724, 2013.  PMCID: PMC3904731.

Hatley ME, Tang W, Garcia MR, Finkelstein D, Millay DP, Liu N, Graff J, Galindo RL, Olson EN. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell 22(4):536-46, 2012. PMCID: PMC3479681

Hatley ME, Patrick DM, Garcia MR, Ricardson JA, Bassel-Duby R, van Rooij, Olson EN. Modulation of K-ras-dependent lung tumorigenesis by microRNA-21. Cancer Cell 18:282-93, 2010. PMCID: PMC2971666.

Hatley ME, Lockless SW, Gibson SK, Gilman AG, Ranganathan R. Allosteric determinants of guanine nucleotide binding proteins. Proceedings of the National Academy of Science 100:14445-50, 2003.

Hatley ME, Gilman AG, Sunahara RK. Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods in Enzymology 345:127-40, 2002.

Hatley ME, Benton BK, Xu J, Manfredi JP, Gilman AG, Sunahara RK. Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase. Journal Biological Chemistry 275(49):38626-32, 2000.

Last update: April 2022