Giedre Krenciute, PhD
Giedre Krenciute, PhD

Giedre Krenciute, PhD

Research Associate, St. Jude Faculty

Departments

Education

PhD - Baylor College of Medicine, Houston, TX
BS - Vilnius University, Vilnius, Lithuania

Research Interests

  • Developing an effective immunotherapy for gliomas using genetically modified T cells
    Current projects goals are: 
    • generating and optimizing CAR T-cells to target glioma associated antigens
    • enhancing CAR T cell effector functions by different genetic manipulations to render them resistant to tumor microenvironment
    • understanding tumor escape mechanism in order to design superior immunotherapy based treatments

Selected Publications

Krenciute G, Prinzing BL, Yi Z, Wu MF, Liu H, Dotti G, Balyasnikova IV, Gottschalk S. Transgenic expression of IL15 improves antiglioma activity of IL13Ralpha2-CAR T cells but results in antigen-loss variants. Cancer Immunol Res Jul;5(7):571-581, 2017. PMID: 28550091.

Krenciute G, Krebs S, Torres D, Wu MF, Liu H, Dotti G, Li XN, Lesniak MS, Balyasnikova IV, Gottschalk S. Characterization and functional analysis of scFv-based CARs to redirect T cells to IL13Rα2-positive glioma. Mol Ther Feb;24(2):354-63, 2016 PMID: 26514825.  doi: 10.1038/mt.2015.199.

Krenciute G, Liu S, Yi S, Yucer N, Ortiz P, Liu Q, Kim BJ, Odejimi OA, Leng M, Qin J, Wang Y. Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death. J Biol Chem Jul 12;288(28):20547-57, 2013. PMID: 23723067

Malovannaya A, Lanz RB, Jung SY, Bulynko Y, Le NT, Chan DW, Ding C, Shi Y, Yucer N, Krenciute G, Kim BJ, Li C, Chen R, Li W, Wang Y, O'Malley BW, Qin J. Analysis of the human endogenous coregulator complexome. Cell May 27;145(5):787-99, 2011. PMID: 21620140

Last update: August 2017