Selected Publications
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH#. Structural insights into the regulation of human serine palmitoyltransferase complexes. Nat Struct Mol Biol 28:240–248, 2021. (#Corresponding author)
Jiang Y, Liu T, Lee CH, Chang Q, Yang J, Zhang Z. The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1. Nature 588(7839):658-663, 2020.
Lee CH, MacKinnon R. Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell 179:1-8, 2019.
Lee CH, MacKinnon R. Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science 360(6388):508-513, 2018.
Song X, Jensen MØ, Jogini V, Stein RA, Lee CH, Mchaourab HS, Shaw DE, Gouaux E. Mechanism of NMDA receptor channel block by MK-801 and memantine. Nature 556(7702):515-519, 2018.
Lee CH, MacKinnon R. Structures of the human HCN1 hyperpolarization-activated channel. Cell 168(1-2):111-120.e11, 2017.
Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E. Mechanism of NMDA receptor inhibition and activation. Cell 165(3):704-14. 2016.
Lee CH*, Lü W*, Michel JC, Goehring A, Du J, Song X, Gouaux E. NMDA receptor structures reveal subunit arrangement and pore architecture. Nature 511(7508):191-7, 2014. (* equal contribution)
Goehring A*, Lee CH*, Wang K, Michel JC, Claxton D, Baconguis I, Althoff T, Fischer S, Garcia KC, Gouaux E. Screening and large-scale expression of membrane proteins in mammalian cells for structural studies. Nat Protoc 9(11):2574-85, 2014.
Last update: March 2021