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Chia-Hsueh Lee, PhD
Chia-Hsueh Lee, PhD

Chia-Hsueh Lee, PhD

Assistant Member, St. Jude Faculty



BS – National Taiwan University, Taipei City Taiwan
MS – National Taiwan University, Taipei City Taiwan
PhD – Oregon Health & Science University, Portland Oregon

Research Interests

  • Structural biology of membrane proteins
  • Functions of ion channels and transporters

We seek to elucidate molecular mechanisms of membrane signaling complexes. We employ biochemical, biophysical, and structural techniques, particularly cryo-electron microscopy, to understand functions and structures of membrane proteins important to human health and disease.

Selected Publications

Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH#. Structural insights into the regulation of human serine palmitoyltransferase complexes. Nat Struct Mol Biol 28:240–248, 2021. (#Corresponding author)

Jiang Y, Liu T, Lee CH, Chang Q, Yang J, Zhang Z. The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1. Nature 588(7839):658-663, 2020.

Lee CH, MacKinnon R. Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell 179:1-8, 2019. 

Lee CH, MacKinnon R. Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science 360(6388):508-513, 2018.

Song X, Jensen MØ, Jogini V, Stein RA, Lee CH, Mchaourab HS, Shaw DE, Gouaux E. Mechanism of NMDA receptor channel block by MK-801 and memantine. Nature 556(7702):515-519, 2018. 

Lee CH, MacKinnon R. Structures of the human HCN1 hyperpolarization-activated channel. Cell 168(1-2):111-120.e11, 2017. 

Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E. Mechanism of NMDA receptor inhibition and activation. Cell 165(3):704-14. 2016.

Lee CH*, Lü W*, Michel JC, Goehring A, Du J, Song X, Gouaux E. NMDA receptor structures reveal subunit arrangement and pore architecture. Nature 511(7508):191-7, 2014. (* equal contribution)

Goehring A*, Lee CH*, Wang K, Michel JC, Claxton D, Baconguis I, Althoff T, Fischer S, Garcia KC, Gouaux E. Screening and large-scale expression of membrane proteins in mammalian cells for structural studies. Nat Protoc 9(11):2574-85, 2014. 

Last update: March 2021