Akshay Sharma, MBBS
Akshay Sharma, MBBS

Akshay Sharma, MBBS

Assistant Member, St. Jude Faculty

Departments

Education

MBBS – Kasturba Medical College, Manipal University, Mangalore, India
Postdoctoral Fellowship – Emory University, Winship Cancer Center, Atlanta, Georgia
Residency – University of Kentucky, Lexington, Kentucky
Clinical Fellowship – St. Jude Children’s Research Hospital, Memphis, Tennessee

Honors & Awards

  • 2019  Young Investigator Award, American Society of Pediatric Hematology/Oncology (ASPHO)
  • 2019  Young Investigator Travel Award, Pediatric Blood & Marrow Transplant Consortium

Research Interests

  • Gene therapy and gene editing.
  • Bone marrow transplantation for patients with non-malignant hematological conditions.
  • Development of novel reduced intensity and non-myeloablative conditioning regimens.

Contact Information

Akshay Sharma, MBBS Bone Marrow Transplantation & Cellular Therapy MS 1130, Room I3304 St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN 38105-3678

St. Jude Faculty List

Related Topics

Clinical Trials

News Releases

Selected Publications

Sharma A, Boelens JJ, Cancio M, Hankins JS, Bhad P, Azizy M, Lewandowski A, Zhao X, Chitnis S, Peddinti R, Zheng Y, Kapoor N, Ciceri F, Maclachlan T, Yang Y, Liu Y, Yuan J, Naumann U, Yu VWC, Stevenson SC, De Vita S, LaBelle JL. CRISPR-Cas9 editing of the HBG1 and HBG2 promoters to treat sickle cell disease. N Engl J Med 389(9):820-832, 2023.

Sharma A, Logan B, Estrada-Merly N, Lehmann LE, Rangarajan HG, Preussler JM, Troy JD, Akard LP, Bhatt NS, Truong TH, Wood WA, Strouse C, Juckett M, Khera N, Rizzo D, Saber W. Impact of public reporting of center-specific survival analysis scores on patient volumes at hematopoietic cell transplant centers. Transplant Cell Ther 29(8):523-528, 2023.

Piel FB, Rees DC, DeBaun MR, Nnodu O, Ranque B, Thompson AA, Ware RE, Abboud MR, Abraham A, Ambrose EE, Andemariam B, Colah R, Colombatti R, Conran N, Costa FF, Cronin RM, de Montalembert M, Elion J, Esrick E, Greenway AL, Idris IM, Issom DZ, Jain D, Jordan LC, Kaplan ZS, King AA, Lloyd-Puryear M, Oppong SA, Sharma A, Sung L, Tshilolo L, Wilkie DJ, Ohene-Frempong K. Defining global strategies to improve outcomes in sickle cell disease: A Lancet Haematology Commission. Lancet Haematol 10(8): e633-e686, 2023.

Morin CE, Sharma A, Selukar S, Beasley G, Merlocco A, Goode C, Rai P, Towbin JA, Hankins JS, Johnson JN. Diffuse myocardial fibrosis occurs in young patients with sickle cell anemia despite early disease-modifying therapy. Blood 141(11):1358-1362, 2023.

Sharma A, Li Y, Huang S, Talleur AC, Suliman A, Qudeimat A, Srinivasan A, Mamcarz E, Madden R, Cheng C, Gottschalk S, Triplett BM. Outcomes of pediatric patients who relapse after first HCT for acute leukemia or MDS. Bone Marrow Transplant 56(8):1866-1875, 2021.

Newby GA, Yen JS, Woodard KJ, Mayuranathan T, Lazzarotto CR, Li Y, Sheppard-Tillman H, Porter SN, Yao Y, Mayberry K, Everette KA, Jang Y, Podracky CJ, Thaman E, Lechauve C, Sharma A, Henderson JM, Richter MF, Zhao KT, Miller SM, Wang T, Koblan LW, McCaffrey AP, Tisdale JF, Kalfa TA, Pruett-Miller SM, Tsai SQ, Weiss MJ, Liu DR. Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature Jun 2, 2021. doi: 10.1038/s41586-021-03609-w. Online ahead of print.

Frangoul H, Altshuler D, Cappellini MD, Chen YS, Domm J, Eustace BK, Foell J, de la Fuente J, Grupp S, Handgretinger R, Ho TW, Kattamis A, Kernytsky A, Lekstrom-Himes J, Li AM, Locatelli F, Mapara MY, de Montalembert M, Rondelli D, Sharma A, Sheth S, Soni S, Steinberg MH, Wall D, Yen A, Corbacioglu S. CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia.  N Engl J Med Jan 21;384(3):252-260, 2021. doi: 10.1056/NEJMoa2031054. Epub 2020 Dec 5.

Sharma A, Bhatt NS, St Martin A, Abid MB, Bloomquist J, Chemaly RF, Dandoy C, Gauthier J, Gowda L, Perales MA, Seropian S, Shaw BE, Tuschl EE, Zeidan AM, Riches ML, Shah GL. Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: An observational cohort study. Lancet Haematol Jan 19;S2352-3026(20)30429-4, 2021. doi: 10.1016/S2352-3026(20)30429-4. Online ahead of print.

Sharma A, Geiger TL, Federico S, Kamens J, Giles F, Cunningham L. Hypocalcemic tetany after transfusion of a small amount of blood product. Journal of Pediatric Hematology and Oncology 39(8):629-632, 2017. PubMed PMID:28902075.

Sharma A, Easow Mathew M, Sriganesh V, Reiss UM. Gene therapy for haemophilia (Revised). Cochrane Database of Systematic Reviews 12:CD010822, 2016. PubMed PMID: 27996087.

Jagannath VA, Fedorowicz Z, Al Hajeri A, Sharma A. Hematopoietic stem cell transplantation for people with ß-thalassaemia major (Revised). Cochrane Database of Systematic Reviews 11:CD008708, 2016. PubMed PMID: 27900772.

Easow Mathew M, Sharma A, Aravindakshan R. Splenectomy for people with thalassaemia major or intermedia. Cochrane Database of Systematic Reviews 6:CD010517, 2016. PubMed PMID: 27296775.

Sharma A, Myers K, Ye Z, D'Orazio J. Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy. Pediatric Blood & Cancer 61(12):2302-4, 2014. PubMed ID: 25067791.

Lu Y, Giver CR, Sharma A, Li JM, Darlak KA, Owens LM, Roback JD, Galipeau J, Waller EK. IFN-γ and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity. Blood 119(4):1075-85, 2012. PubMed ID: 22130799.

Sharma A, Dhanashree B. Screening of currency in circulation for bacterial contamination. Current Science 100(6):822-5, 2011.

Last update: September 2023

Close
Close