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Stacey L. Schultz-Cherry, PhD
Stacey L. Schultz-Cherry, PhD

Stacey L. Schultz-Cherry, PhD

Member, St. Jude Faculty

  • Deputy Director, World Health Organization Collaborating Centre for Studies on the Ecology of Influenza in Animals and Birds
  • Senior Associate Dean, Academic Affairs, Graduate School for Biomedical Sciences



BS – University of Wisconsin, Platteville, Wisconsin
PhD – University of Alabama, Birmingham, Alabama

Research Interests

  • Influenza Virus Pathogenesis
  • Astrovirus Pathogenesis
  • Novel Vaccines and Therapeutics
  • Microbial Co-Infections

Selected Publications

Cortez, V., Margolis, E., Schultz-Cherry S. Astrovirus and the microbiome. Current Opin Virol. 37:10-15. 2019. PMID: 31163291

Honce, R.R. Schultz-Cherry S. Impact of obesity on influenza A virus pathogenesis, immune response and evolution. Front Immunol. 10:1071. 2019. PMID: 31134099

Cortez, V., Sharp, B., Yao, J., Livingston, B., Vogel, P., Schultz-Cherry S. Characterizing a murine model for astrovirus using viral isolates from persistently infected immunocompromised mice. J Virol. Jun 14;93(13) 2019. PMID: 30971471

Rowe, H.M., Meliopoulos, V., Iverson, A., Bomme, P., Schultz-Cherry, S., Rosch, J.W. Direct interactions with influenza promote bacterial adherence during respiratory infections. Nat Microbiol. 2019. PMID: 31110359

Rowe, H.M., Karlsson, E.A., Echlin, H., Chang, T-C., Wei, L., van Opijnen, T., Pounds, S., Schultz-Cherry, S., Rosch, J.W. Bacterial Factors Required for Transmission of Streptococcus pneumoniae in Mammalian Hosts. Cell Host Microbe. 25:884-891. 2019. PMID: 31126758

Ingle, H., Lee. S., Ai, T., Orvedahl, A., Rodgers, R., Zhao, G., Sullender, M., Peterson, S., Locke, M., Liu, T-C., Yokoyama, C., Sharp, B., Schultz-Cherry, S., Miner, J.J., Baldridge, M. Viral complementation of immunodeficiency confers protection against enteric pathogens via IFN-λ. Nature Microbiol. 2019. PMID: 30936486

Meliopoulos V, Livingston B, Van de Velde LA, Honce R, Schultz-Cherry S. 2018. Absence of β6 integrin reduces influenza disease severity in highly susceptible obese mice. J Virol. Oct 31. pii: JVI.01646-18. 2018 PMID: 30381485. Chosen as article of significant interest and cover image

Estrada, L.D. Schultz-Cherry S. Development of a Universal Influenza Vaccine. J Immunol 202:392-398. 2019. PMID: 30617121

Meliopoulos, VA. Schultz-Cherry, S. Although it’s painful, the importance of stringent antibody validation. PLoS Pathog 14(1):e1006701. 2018. PMID: 29300781

Karlsson, E.A., Meliopoulos, V., van de Velde, N.C., van de Velde, L-A., Rosch, J., Tuomanen, E., McCullers, J., Vogel, P., Schultz-Cherry, S. A perfect storm: increased colonization and failure of vaccination leads to severe secondary bacterial infection in influenza infected obese mice. MBio. Sep 19;8(5). pii: e00889-17. 2017. PMID: 28928207

Ghedin, E. Schultz-Cherry, S. Host response: Pregnancy impairs flu defenses. Nat Micro. 2:17077. 2017.PMID: 28452981

Karlsson, E.A., Oguin, T.H., Meliopoulos, V., Broadnax, A., Yoon, S-W., Pestina, T., Thomas, P., Webby, R.J., Schultz-Cherry, S., Rosch, J.W. Vascular permeability drives susceptibility to influenza infection in a murine model of sickle cell disease. Sci Rep. 3;7:43308. 2017. PMID: 28256526

Cortez, V., Freiden, P., Gu, Z, Adderson, E., Hayden, R., Schultz-Cherry, S. Persistent Infections with Diverse Co-Circulating Astroviruses in Pediatric Oncology Patients, Memphis, Tennessee, USA. Emerg Infec Dis 23(2): 288-290. 2017.  PMID: 28098537

Marvin, S.A., Russier, M., Huerta, C.T., Russell, C.J., Schultz-Cherry, S. Influenza virus overcomes cellular blocks to productively replicate, impacting macrophage function. J Virol  91(2). pii: e01417-16. 2017.  PMID: 27807237

Karlsson, E.A., Hertz, T., Johnson, C., Krammer, F., Schultz-Cherry, S. Obesity outweighs protection conferred by adjuvanted influenza vaccination. MBio. 7(4). pii: e01144-16. 2016. PMID: 27486196

 Meliopoulos, V.A., Marvin, S.A., Freiden, P., Moser, L.A., Nighot, P., Ali, R., Blikslager, A., Reddivari, M., Heath, R.J., Koci, M.D., Schultz-Cherry, S. Oral administration of astrovirus capsid protein is sufficient to induce acute diarrhea in vivo. MBio  Nov 1;7(6). pii: e01494-16. doi: 10.1128/mBio.01494-16. 2016. PMID: 27803180

Meliopoulos, V.A., Van de Velde, L-A., Van de Velde, N.C., Karlsson, E.A., Neale, G., Vogel, P., Guy, C., Sharma, S., Duan, S., Surman, S.L., Jones, B.G., Johnson, M.D.L., Bosio, C., Jolly, L., Jenkins, R.G., Hurwitz, J.L., Rosch, J.W., Sheppard, D., Thomas, P.G., Murray, P.J., Schultz-Cherry, S. An epithelial integrin regulates the amplitude of protective lung interferon responses against multiple respiratory pathogens. PLoS Pathogens 12(8):e1005804. 2016. PMID: 27505057

Marvin, S., Huerta, C.T., Sharp, B., Freiden, P., Cline, T.D., Schultz-Cherry, S. Type I interferon response limits astrovirus replication and protects against increased barrier permeability in vitro and in vivo.  J Virol. 90: 1988-1996. 2015. PMID: 26656701

Schultz-Cherry, S. Is it possible? A different approach to creating a universal influenza vaccine. MBio Oct 6;6(5). pii: e01580-15. 2015. PMID: 26443464

Karlsson, E.A., Small, C.T., Freiden, P., Feeroz, M.M., Matsen IV, F.A., San, S., Hasan, M.K., Wang, D., Jones-Engel, L., and Schultz-Cherry, S. Non-human primates harbor diverse mammalian and avian astroviruses including those associated with human infections.  PLoS Pathogens Nov 16;11(11):e1005225. 2015. PMID: 26571270

Jones, M.K., Grau, K.R., Costantini, V., Kolawole, A.O., de Graaf, M., Freiden, P., Grave, C.L., Koopmans, M., Wallet, S.M., Tibbetts, S.A., Schultz-Cherry, S., Vinje, J., Wobus, C.E., Karst, S.M. Methods for culturing a human norovirus in B cells. Nature Protocols Dec;10(12):1939-47. 2015. PMID: 26513671

Gu, Z., Zhu, H., Rodriguez, A., Mhaissen, M., Schultz-Cherry, S., Adderson, E., Hayden, R.T. Comparative evaluation of broad-panel PCR assays for the detection of gastrointestinal pathogens in pediatric oncology patients. J Mol Diagn Aug 29. pii: S1525-1578(15)00146-4. 2015. PMID: 26321042

Zaraket, H., Baranovich, T., Kaplan, B., Carter, R., Song, M-S., Paulson, J., Rehg, F., Bahl, J., Crumpton, J., Seiler, P., Edmonson, M., Wu, G., Karlsson, E., Fabrizio II, T., Zhu, H., Guan, Y., Husain, M., Schultz-Cherry, S., Krauss, S., McBride, R., Webster, R.G., Govorkova, E., Zhang, J., Russell, C., Webby, R.J. Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck. Nat Commun 6:6553. 2015. PMID:25850788

Karlsson, E.A., Meliopoulos, V.A., Savage, C., Livingston, B., Mehle, A., Schultz-Cherry S. Visualizing Real-time influenza virus infection, transmission and protection in ferrets. Nat Commun 6:6378. 2015. PMID:25744559

Jolly, L., Stavrou, A., Meliopoulos, V., Habgood, A., Porte, J., Knox, A., Weinreb, P., Violette, S., Hussell, T., Schultz-Cherry S., Jenkins, G. Influenza H1N1 promotes pulmonary fibrosis via epithelial apoptosis induced avb6 integrin mediated TGFb activation. J Biol Chem 289:35246-25263. 2014. PMID: 25339175

Meliopoulos, V.A., Karlsson, E.A., Kercher, L., Cline, T., Freiden, P., Duan, S., Vogel, P., Webby, R.J., Guan, Y., Peiris, M., Thomas, P.G., Schultz-Cherry S. Human H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism. J Virol 88:12982-12991. 2014. PMID: 25210188

Duan, S., Meliopoulos, V.A., McClaren, J.L., Sanders, C.J., Smallwood, H., Webby, R.J., Schultz-Cherry, S., Doherty, P.C., Thomas, P.G. Diverse heterologous primary infections radically alter immunodominance hierarchies and clinical outcomes following H7N9 influenza challenge in mice. PLoS Pathogens 11(2):e1004642. 2015. PMID: 25668410

Karlsson, E.A., Ip, H.S., Hall, J., Yoon, S-W., Johnson, J., Beck, M.A., Webby, R.J., Schultz-Cherry, S. Respiratory transmission of an avian H3N8 influenza virus isolated from a harbor seal. Nat Commun 5:4791. 2014. PMID: 25183346

Holtz, L.R., Bauer, I.K., Jiang, H., Belshe, R., Freiden, P., Schultz-Cherry S., Wang, D. Seroepidemiology of Astrovirus MLB1. Clinical and Vacc Immun 21:908-911. 2014. PMID: 24789796

Christian LM, Porter K, Karlsson E, Schultz-Cherry S, Iams JD. Serum proinflammatory cytokine responses to influenza virus vaccine among women during pregnancy versus non-pregnancy. Am J Reprod Immunol. 70(1):45-53. doi: 10.1111/aji.12117. 2013. PMID:23551710

Milner J.J., Sheridan, P.A., Karlsson, E.A., Schultz-Cherry, S., Shi, Q., Beck, M.A. Diet-induced obese mice exhibit heightened lung inflammatory and cross-reactive CD8+ T-cell responses, not enhanced mortality, during a secondary 2009 pandemic H1N1 infection. J Immunol. 191(5):2474-85. doi: 10.4049/jimmunol.1202429. 2013. PMID:23904168

DuBois, R., Freiden, P., Marvin, S., Reddivari, M., Heath, R., White, S.W., and Schultz-Cherry, S. Crystal structure of the avian astrovirus capsid spike. J Virol. 87(14):7853-63. doi: 10.1128/JVI.03139-12. 2013. PMID:23658448

Ngunjiri, J.M., Mohni, K.N., Sekellick, M.J., Schultz-Cherry, S., Webster, R.G., Marcus, P.I. Lethal H5N1 influenza viruses are not resistant to interferon action in human, simian, porcine, or avian host cells. Nature Medicine. 18(10):1456 – 1457. 2012. PMID:23042343

Paich, H.A., Sheridan, P.A., Handy, J., Karlsson, E.A., Schultz-Cherry, S., Hudgens, M.G., Noah, T.L., Weir, S., Beck, M.A. Overweight and obese humans have a defective immune response to pandemic H1N1 influenza A virus. Obesity. Mar 20. doi: 10.1002/oby.20383. 2013. PMID:23512822

Show More

Cline TD, Karlsson EA, Seufzer BJ, Schultz-Cherry S. The hemagglutinin protein of highly pathogenic H5N1 influenza viruses overcomes an early block in the replication cycle to promote productive replication in macrophages. J Virol November 14, 2012.

Ngunjiri JM, Mohni KN, Sekellick MJ, Schultz-Cherry S, Webster RG, Marcus PI. Lethal H5N1 influenza viruses are not resistant to interferon action in human, simian, porcine or chicken cells. Nat Med 18(10):1456-1457, 2012.

Karlsson EA, Marcelin G, Webby RJ, Schultz-Cherry S. Review on the impact of pregnancy and obesity on influenza virus infection. Influenza Other Respi Viruses 6(6):449-460, 2012.

Fouchier RAM, Garcia-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz J, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Metten-Leiter TC, Osterhaus ADME, Palese P, Peiris JSM, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG. Pause on avian flu transmission research. Science 335(6067):400-401, 2012.

Schultz-Cherry S, Olsen CW, Easterday BC. History of swine influenza. Curr Top Microbiol Immunol January 21, 2012.

O'Brien KB, Vogel P, Duan S, Govorkova EA, Webby RJ, McCullers JA, Schultz-Cherry S. Impaired wound healing predisposes obese mice to severe influenza virus infection. J Infect Dis 205(2):252-261, 2011.

De Benedictis P, Schultz-Cherry S, Burnham A, Cattoli G. Astrovirus infections in humans and animals - molecular biology, genetic diversity, and interspecies transmissions. Infect Genet Evol 85(23):12262-70, 2011.

Cline TD, Karlsson EA, Freiden P, Seufzer BJ, Rehg JE, Webby RJ, Schultz-Cherry S. Increased pathogenicity of a reassortant 2009 pandemic H1N1 influenza virus containing an H5N1 hemagglutinin. J Virol 85(23):12262-122701529-44, 2011.

Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. Virus aggregating peptide enhances the cell-mediated response to influenza virus vaccine. Vaccine August 9, 2011.

O'Brien K, Schultz-Cherry S, Knoll LJ. Parasite-mediated upregulation of NK cell-derived IFN? protects against severe HPAI H5N1 influenza virus infection. J Virol July 6, 2011.

Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ. A distal enhancer in IL12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J Biol Chem 286(26):23581-90, 2011.

O'Brien KB, Morrison TE, Dundore DY, Heise MT, Schultz-Cherry S. A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection. PLoS One 6(3):e17377, 2011.

Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. Identification of the minimal active sequence of an anti-influenza peptide. Antimicrob Agents Chemother January 10, 2011.

Carlson CM, Turpin EA, Moser LA, O'Brien KB, Cline TD, Jones JC, Tumpey TM, Katz JM, Kelley LA, Gauldie J, Schultz-Cherry S. Transforming growth factor-?: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis. PLoS Pathog 6(10):e1001136, 2010.

Schultz-Cherry S, Jones JC. Influenza vaccines: the good, the bad, and the eggs. Adv Virus Res 77:63-84, 2010.

McCullers JA;, Van De Velde LA, Schultz RD, Mitchell CG, Halford CR, Boyd KL, Schultz-Cherry S. Seroprevalence of seasonal and pandemic influenza A viruses in domestic cats. Arch Virol September 28, 2010.

Aguilar-Yanes JM, Portillo-Lara R, Mendoza-Ochoa GI, Garcia-Echauri SA, Lopes-Pacheco F, Bulnes-Abundis D, Salgado-Gallegos J, Lara-Mayorga IM, Webb-Vargas Y, Leon-Angel FO, Rivero-Aranda RE, Oropeza-Almazan Y, Ruiz-Palacios GM, Zertuche-Guerra MI, DuBois RM, White SW, Schultz-Cherry S, Russell CJ, Alvarez MM. An influenza A/H1N1/2009 hemagglutinin vaccine produced in escherichia coli. PLoS One 5(7): e11694, 2010.

Alvarez MM, Lopez-Pacheco F, Aguilar-Yanez JM, Portillo-Lara R, Mendoza-Ochoa GI, Garcia-Echauri S. Freiden P, Schultz-Cherry S, Zertuche-Guerra MI, Bulnes-Abundis D, Salgado-Gallegos J, Elizondo-Montemayor L, Hernandez-Torre M. Specific recognition of influenza A/H1N1/2009 antibodies in human serum: a simple virus-free ELISA method. PLoS One 5(4): e10176, 2010.

Jones JC, Schultz-Cherry S. Developing a Vaccine for Pandemic Influenza: Is it Possible? Controversies in Science and Technology 2009 (in press).

Moser LA, Schultz-Cherry S. Suppression of Astrovirus Replication by an ERK1/2 Inhibitor. J Virol 82:7475-7482, 2008.

Strain E, Kelley L, Schultz-Cherry S, Muse S, Koci M. Genomic Analysis of Closely Related Astroviruses. J Virol 82:5099-5103, 2008.

Moser LA, Carter M, Schultz-Cherry S. Astrovirus Increases Epithelial Barrier Permeability Independently of Viral Replication. J Virol 81:11937-11945, 2007.

Jones JA, Brandt C, Schultz-Cherry S. Influenza Combat: Expanding Our Arsenal with Peptide Antivirals. Future Virology 2:231-233, 2007.

Jones J, Turpin EA, Bultmann H, Brandt C, Schultz-Cherry S. Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells. J Virol 80:11960-11967, 2006.

Schultz-Cherry S, McCullers JA. A step closer to meeting the threat of avian influenza. PLos Medicine 3:e375, 2006.

Tumpey TM, Garcia-Sastre A, Taubenberger JK, Palese P, Swayne DE, Pantin-Jackwood MJ, Schultz-Cherry S, van Rooijen N, Katz JM, Basler CF. Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: a functional role of alveolar macrophages and neutrophils in limiting virus replication and disease severity in mice. J Virol 79:14933-14944, 2005.

Schultz-Cherry S. Guest Editorial: update on enteric viruses. Viral Immunol 18:1-3, 2005.

Turpin E, Luke K, Jones J, Tumpey T, Konan K, Schultz-Cherry S. Influenza virus infection increases p53 activity: role in cell death and viral replication. J Virol 79:8802-8811, 2005.

Last update: September 2019