Christopher Tinkle, MD, PhD
Christopher Tinkle, MD, PhD

Christopher Tinkle, MD, PhD

Assistant Member, St. Jude Faculty



BA – University of Texas at Austin, Austin, Texas
PhD – Rockefeller University, New York, New York
MD – Weill Cornell Medical College, New York, New York
Transitional Internship – University of Texas Southwestern, Austin Programs, Austin, Texas
Residency (Radiation Oncology) – University of California, San Francisco, San Francisco, California

Honors and Awards

  • 2015 Roentgen Resident/Fellow Award Recipient
  • 2013 ASTRO Annual Meeting Scientific Abstract/Travel Award
  • 2013 Mount Zion Health Fund Travel Award, UCSF
  • 2012 UCSF Clinical and Translational Science Institute Resident Research Funding Award
  • 2012-2014 Resident Research Travel Award, UCSF

Research Interests

My overall aim as a pediatric radiation oncologist is to improve the outcomes and reduce the treatment associated morbidity of children and adolescents with cancer. To this end, my research interests are focused on the application of our advancing molecular understanding of cancer initiation, progression and treatment resistance, as well as the susceptibility to therapy related toxicity to better inform clinical trial development, risk stratification and cancer therapy application. Specific research interests include brain tumors and sarcomas.

Selected Publications

Tinkle CL, Orr BA, Lucas JT Jr, Klimo P, Patay Z, Baker SJ, Broniscer A, Qaddoumi I. Rapid and fulminant leptomeningeal spread following radiotherapy in diffuse intrinsic pontine glioma. Pediatr Blood Cancer 2017 Jan 13. PMID: 28084680. doi: 10.1002/pbc.26416

Tinkle CL, Tsuji SY, Weinberg V, Wustrack R, Braunstein SE, Haas-Kogan DA, DuBois SG, Horvai A, Jahan T, O’Donnell RJ, Gottschalk AR. Intraoperative radiotherapy and limb-sparing surgery in the treatment of primary, non-metastatic extremity soft tissue sarcoma. J Radiat Oncol 4:299-307, 2015. doi: 10.1007/s13566-015-0211-x.

Tinkle CL, Weinberg V, Braunstein SE, Wustrack R, Horvai A, Jahan T, Haas Kogan DA, O’Donnell RJ, Gottschalk AR. Intraoperative radiotherapy in the management of locally recurrent extremity soft tissue sarcoma. Sarcoma 2015. PMID:  26346118. doi: 10.1155/2015/913565.

Tinkle CL, Weinberg V, Chen LM, Littell R, Cunha JA, Sethi RA, Chan JK, Hsu IC. Inverse planned high-dose-rate brachytherapy for locoregionally advanced cervical cancer: 4-year outcomes. Int J Radiat Oncol Biol Phys 92(5):1093-1100, 2015. PMID: 26194683.

Tinkle CL, Haas-Kogan D. Hepatocellular carcinoma: Natural history, current management and emerging tools. Biologics 6:207-219, 2012. PMID: 22904613. doi: 10.2147/BTT.S23907.

Tinkle CL, Pasolli HA, Stokes N, Fuchs E. New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci USA 105(40):15405-15410, 2008. PMID: 18809908. doi: 10.1073/pnas.0807374105.

Tinkle CL, Lechler T, Pasolli HA, Fuchs E. Conditional targeting of E- cadherin in skin: Insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci USA 101(2):552-557, 2004. PMID: 14704278.

Coussens LM, Tinkle CL, Hanahan D, Werb Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103(3):481-490, 2000. PMID: 11081634.

Last update: March 2017