Christopher Tinkle, MD, PhD
Christopher Tinkle, MD, PhD

Christopher Tinkle, MD, PhD

Assistant Member, St. Jude Faculty

Departments

Education

BA – University of Texas at Austin, Austin, Texas
PhD – Rockefeller University, New York, New York
MD – Weill Cornell Medical College, New York, New York
Transitional Internship – University of Texas Southwestern, Austin Programs, Austin, Texas
Residency (Radiation Oncology) – University of California, San Francisco, San Francisco, California

Honors and Awards

  • 2015 Roentgen Resident/Fellow Award Recipient
  • 2013 ASTRO Annual Meeting Scientific Abstract/Travel Award
  • 2013 Mount Zion Health Fund Travel Award, UCSF
  • 2012 UCSF Clinical and Translational Science Institute Resident Research Funding Award
  • 2012-2014 Resident Research Travel Award, UCSF

Research Interests

My overall aim as a pediatric radiation oncologist is to improve the outcomes and reduce the treatment associated morbidity of children and adolescents with cancer. To this end, my research interests are focused on the application of our advancing molecular understanding of cancer initiation, progression and treatment resistance, as well as the susceptibility to therapy related toxicity to better inform clinical trial development, risk stratification and cancer therapy application. Specific research interests include brain tumors and sarcomas.

Selected Publications

Chiang J, Harreld JH, Tinkle CL, Moreira DC, Li X, Acharya S, Qaddoumi I, Ellison DW. A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration. Acta Neuropathol. 2019 Oct 8. doi: 10.1007/s00401-019-02081-1. [Epub ahead of print]. PMID: 31595312.

Blakely EA*, Faddegon B*, Tinkle C*, Bloch C*, Dominello M*, Griffin RJ*, Joiner MC, Burmeister J. Three discipline collaborative radiation therapy (3DCRT) special debate: The United States needs at least one carbon ion facility. Appl Clin Med Phys. 2019 Oct 1. doi: 10.1002/acm2.12727. [Epub ahead of print]. PMID: 31573146. *these authors contributed equally

Zhong B, Campagne O, Tinkle CL, Stewart CF. An LC/ESI-MS/MS method to quantify the PI3K inhibitor GDC-0084 in human plasma and cerebrospinal fluid: validation and clinical application. Biomed Chromatogr. 2019 Sep 8:e4697. doi: 10.1002/bmc.4697. [Epub ahead of print]. PMID: 31495945.

Tinkle CL, Lu J, Han Y, Li Y, McCarville BM, Neel MD, Bishop MW, Krasin MJ. Curative-intent radiotherapy for pediatric osteosarcoma: the St. Jude experience. Pediatr Blood Cancer 2019 April. doi: 10.1002/pbc.27763. PMID: 31012273.

Acharya S, Wu S, Ashford JM, Tinkle CL, Lucas JT, Qaddoumi I, Gajjar A, Krasin MJ, Conklin HM, Merchant TE. Association between hippocampal dose and memory in survivors of childhood or adolescent low-grade glioma: a 10-year neurocognitive longitudinal study. Neuro Oncol. 2019 Apr 12. pii: noz068. doi: 10.1093/neuonc/noz068. [Epub ahead of print]. PMID: 30977510.

Upadhyaya SA, Robinson GW, Onar-Thomas A, Orr BA, Billups CA, Bowers DC, Bendel AE, Hassall T, Crawford JR, Partap S, Fisher PG, Tatevossian RG, Seah T, Qaddoumi IA, Vinitsky A, Armstrong GT, Sabin ND, Tinkle CL, Klimo P, Indelicato DJ, Boop FA, Merchant TE, Ellison DW, Gajjar A. Molecular Grouping and Outcomes of Young Children with Newly Diagnosed Ependymoma Treated on the Multi-Institutional SJYC07 Trial. Neuro Oncol. 2019 Apr 12. pii: noz069. doi: 10.1093/neuonc/noz069. [Epub ahead of print]. PMID: 30976811.

Tinkle CL, Williams NL, Wu H, Wu J, Kaste SC, Shulkin BL, Talleur AC, Flerlage JE, Hudson MM, Metzger ML, Krasin MJ. Treatment patterns and disease outcomes for pediatric patients with refractory or recurrent Hodgkin lymphoma treated with curative-intent salvage radiotherapy. Radiother Oncol. 2019 May. doi.org/10.1016/j.radonc.2019.01.026. PMID: 31005229.

Larson JD, Kasper LH, Paugh BS, Jin H, Wu G, Kwon CH, Fan Y, Shaw TI, Silveira AB, Qu C, Xu R, Zhu X, Zhang J, Russell HR, Peters JL, Finkelstein D, Xu B, Lin T, Tinkle CL, Patay Z, Onar-Thomas. A, Pounds SB, McKinnon PJ, Ellison DW, Zhang J, Baker SJ. Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression. Cancer Cell. 2018 Dec 11. pii: S1535-6108(18)30536-1. doi: 10.1016/j.ccell.2018.11.015. PMID: 30595505.

Smith SMC, Bianski BM, Orr BA, Harknett G, Onar-Thomas A, Gilbertson RJ, Merchant TE, Roussel MF, Tinkle CL. Preclinical Modeling of Image-Guided Craniospinal Irradiation for Very-High-Risk Medulloblastoma. Int J Radiat Oncol Biol Phys. 2018 Oct 23. pii: S0360-3016(18)33898-7. doi: 10.1016/j.ijrobp.2018.10.015. PMID: 30366006.

Madenci AL, Weil BR, Liu Q, Murphy AJ, Gibson TM, Yasui Y, Leisenring WM, Howell R, Tinkle CL, Nekhlyudov L, Diller L, Armstrong GT, Oeffinger KC, Weldon CB. Long-term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study. J Clin Oncol. 2018 Sep 14:JCO2018784595. doi: 10.1200/JCO.2018.78.4595. PMID: 30216123.

Tinkle CL, Duncan EC, Doubrovin M, Han Y, Li Y, Kim H, Broniscer A, Snyder S, Merchant TE, Shulkin B. Evaluation of [11C]methionine PET and anatomic MRI associations in diffuse intrinsic pontine glioma. J Nucl Med 2018 Aug 2. pii: jnumed.118.212514. doi: 10.2967/jnumed.118.212514. PMID: 30072503.

Weil BR, Weil BR, Madenci AL, Liu Q, Howell RM, Gibson TM, Yasui Y, Neglia JP, Leisenring WM, Smith SA, Tonorezos ES, Friedman DN, Constine LS, Tinkle CL, Diller LR, Armstrong GT, Oeffinger KC, Weldon CB. Late Infection-Related Mortality in Asplenic Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. J Clin Oncol. 2018 Jun 1;36(16):1571-1578. doi: 10.1200/JCO.2017.76.1643. Epub 2018 Apr 17. PMID: 29664715.

Hsu CY, Doubrovin M, Hua CH, Mohammed O, Shulkin BL, Kaste S, Federico S, Metzger M, Krasin M, Tinkle C, Merchant TE, Lucas JT Jr. Radiomics Features Differentiate Between Normal and Tumoral High-FDG uptake. Sci Rep. 2018 Mar 2;8(1):3913. doi: 10.1038/s41598-018-22319-4. PMID: 29500442.

Tinkle CL, Fernandez-Pineda I, Sykes A, Lu Z, Hua C, Neel MD, Bahrami A, Shulkin BL, Kaste SC, Pappo A, Spunt SL, and Krasin MJ.  Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) in Pediatric and Young Adult Patients: Results From a Prospective Study Using Limited Margin Radiotherapy.  Cancer. 2017 Jul 31. doi: 10.1002/cncr.30793. [Epub ahead of print].

Lucas Jr JT, Fernandez-Pineda I, Tinkle CL, Kaste SC, Heda J, Bishop MW, Davidoff AJ, and Krasin MJ.  Late Toxicity and Outcomes Following Radiation Therapy for Chest Wall Sarcomas in Pediatric Patients.  Pract Radiat Oncol, 2017 Apr 26, doi: 10.1016/j.prro.2017.04.015. [Epub 2017 Apr 26.] PMID: 28676226.

Tsang DS, Murphy E. Ezell SE, Lucas, Jr JT, Tinkle CL, and Thomas E. Merchant TE.  Craniospinal Irradiation for Treating Metastatic Pediatric Low-Grade Glioma.  J Neurooncol. 2017 Jun 17. doi: 10.1007/s11060-017-2525-6. [Epub 2017 Jun 17.]. PMID: 28623604.

Lucas Jr. JT, Cooper DA, Hwang S, Tinkle CL, Orr BA, Merchant TE, and Broniscer A.  Prognostic Relevance of Treatment Failure Patterns in Pediatric High Grade Glioma; Is there a Role for a Revised Failure Classification System? Int J Radiat Oncol Biol Phys. 2017 Oct 1;99(2):450-458. doi: 10.1016/j.ijrobp.2017.04.039. Epub 2017 May 4. PMID: 28871996.

Uh J, Krasin MJ, Li, Y, Li X, Tinkle CL, Lucas Jr JT, Merchant TE, Hua C. Quantification of pediatric abdominal organ motion with a 4-dimensional magnetic resonance imaging method. Int J Radiat Oncol Biol Phys, 99 (2017), pp. 227-237. PMID: 28816151.

Tinkle CL, Tsuji SY, Weinberg V, Wustrack R, Braunstein SE, Haas-Kogan DA, DuBois SG, Horvai A, Jahan T, O’Donnell RJ, Gottschalk AR. Intraoperative radiotherapy and limb-sparing surgery in the treatment of primary, non-metastatic extremity soft tissue sarcoma. J Radiat Oncol 4(3):299-307, 2015. 

Tinkle CL, Weinberg V, Braunstein SE, Wustrack R, Horvai A, Jahan T, Haas Kogan DA, O’Donnell RJ, Gottschalk AR. Intraoperative radiotherapy in the management of locally recurrent extremity soft tissue sarcoma. Sarcoma 913565, 2015. PMID: 26346118. PMCID: PMC4546758.

Tinkle CL, Weinberg V, Chen LM, Littell R, Cunha JA, Sethi RA, Chan JK, Hsu IC. Inverse planned high-dose-rate brachytherapy for locoregionally advanced cervical cancer: 4-year outcomes. Int J Radiat Oncol Biol Phys 92(5):1093-1100, 2015. PMID: 26194683.

Tinkle CL, Pasolli HA, Stokes N, Fuchs E. New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci U S A 105(40):15405-15410, 2008. MID: 18809908. PMCID: PMC2547466.

Tinkle CL, Lechler T, Pasolli HA, Fuchs E. Conditional targeting of E- cadherin in skin: Insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A 101(2):552-557, 2004. PMID: 14704278. PMCID: PMC327185.

Coussens LM, Tinkle CL, Hanahan D, Werb Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103(3):481-490, 2000. PMID: 11081634. PMCID: PMC2843102.

Last update: October 2019