Lu Wang, MD, PhD
Lu Wang, MD, PhD

Lu Wang, MD, PhD

Associate Member, St. Jude Faculty

Departments

Education

PhD - Shanghai Institute of Hematology, Shanghai Second Medical University, Shanghai, China
MD - Shandong University School of Medicine, Jinan, Shandong, China

Research Interests

  • Molecular classification of rare pediatric tumors.
  • Functional analysis of genetic alterations in pediatric tumors.

Selected Publications

Casuscelli J, Weinhold N, Gundem G, Wang L, Zabor EC, Drill E, Wang PI, Nanjangud GJ, Redzematovic A, Nargund AM, Manley BJ, Arcila ME, Donin NM, Cheville JC, Thompson RH, Pantuck AJ, Russo P, Cheng EH, Lee W, Tickoo SK, Ostrovnaya I, Creighton CJ, Papaemmanuil E, Seshan VE, Hakimi AA, Hsieh JJ. Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma. JCI Insight Jun 15;2(12), 2017. PMID: 28614790

Ptashkin RN, Pagan C, Yaeger R, Middha S, Shia J, O'Rourke KP, Berger MF, Wang L, Cimera R, Wang J, Klimstra DS, Saltz L, Ladanyi M, Zehir A, Hechtman JF. Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival. Mol Cancer Res Jun;15(6):708-713, 2017. PMID: 28184012

Wang L, Busam KJ, Benayed R, Cimera R, Wang J, Denley R, Rao M, Aryeequaye R, Mullaney K, Cao L, Ladanyi M, Hameed M. Identification of Recurrent NTRK3 Gene Rearrangement in Spitz Tumor Based on a Genome-wide SNP-array Analysis. J Mol Diagn May;19(3):387-396, 2017. PMID:28433076

Salo-Mullen EE, Lynn PB, Wang L, Walsh M, Gopalan A, Shia J, Tran C, Man FY, McBride S, Schattner M, Zhang L, Weiser MR, Stadler ZK. Contiguous gene deletion of chromosome 2p16.3-p21 as a cause of Lynch syndrome. Fam Cancer May 29, 2017. [Epub ahead of print] PMID: 28555354

Spraggon L, Martelotto LG, Hmeljak J, Hitchman TD, Wang J, Wang L, Slotkin EK, Fan PD, Reis-Filho JS, Ladanyi M. Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair. J Pathol May;242(1):102-112, 2017. PMID: 28188619

Xu B, Wang L, Borsu L, Ghossein R, Katabi N, Ganly I, Dogan S. A proportion of primary squamous cell carcinomas of the parotid gland harbour high-risk human papillomavirus. Histopathology Dec;69(6):921-929, 2016. PMID: 27374168

Drilon A, Rekhtman N, Arcila M, Wang L, Ni A, Albano M, Van Voorthuysen M, Somwar R, Smith RS, Montecalvo J, Plodkowski A, Ginsberg MS, Riely GJ, Rudin CM, Ladanyi M, Kris MG. Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial. Lancet Oncol Dec;17(12):1653-1660, 2016. PMID: 27825636

Chen YB, Xu J, Skanderup AJ, Dong Y, Brannon AR, Wang L, Won HH, Wang PI, Nanjangud GJ, Jungbluth AA, Li W, Ojeda V, Hakimi AA, Voss MH, Schultz N, Motzer RJ, Russo P, Cheng EH, Giancotti FG, Lee W, Berger MF, Tickoo SK, Reuter VE, Hsieh JJ. Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Nat Commun Oct 7;7:13131, 2016. PMID: 27713405

Dogan S, Wang L, Ptashkin RN, Dawson RR, Shah JP, Sherman EJ, Tuttle RM, Fagin J, Klimstra DS, Katabi N, Ghossein RA. Mammary-Analog Secretory Carcinoma of the Thyroid Gland: A Primary Thyroid Adenocarcinoma Harboring ETV6-NTRK3 Fusion. Modern Pathology Sep;29(9):985-95, 2016. PMID: 27282352

Javier BM, Yaeger R, Wang L, Sanchez-Vega F, Zehir A, Middha S, Sadowska J, Vakiani E, Shia J, Klimstra D, Ladanyi M, Iacobuzio-Donahue CA, Hechtman JF. Recurrent, truncating Sox9 mutations are associated with sox9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma. Oncotarget Aug 9;7(32):50875-50882, 2016. PMID: 27248473

Wang L, Zehir A, Nafa K, Zhou N, Berger MF, Casanova J, Sadowska J, Lu C, Allis CD, Gounder M, Chandhanayingyong C, Ladanyi M, Boland PJ, Hameed M. Genomic Aberrations Frequently Alter Chromatin Regulatory Genes in Chordoma. Genes, Chromosomes and Cancer Jul;55(7):591-600, 2016. PMID: 27072194

Hechtman JF, Zehir A, Yaeger RD, Wang L, Middha S, Zheng T, Hyman D, Solit D, Arcila ME, Borsu L, Shia J, Vakiani E, Saltz L, Ladanyi M. Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma that are Preferentially Associated with Wild Type RAS/RAF. Mol Cancer Res Mar;14(3):296-301, 2016. PMID: 26660078

Jour G, Wang L, Middha S, Zehir A, Chen W , Sadowska J, Healey J, Agaram NP, Choi L, Nafa K, Hameed M. The molecular landscape of Extraskeletal Osteosarcoma: A Clinicopathological and Molecular Biomarker study. The Journal of Pathology: Clinical Research January;2(1):9-20, 2016. PMID: 27499911

Wiesner T, Lee W, Obenauf AC, Ran L, Murali R, Zhang QF, Wong EWP, Hu W, Scott SN, Shah R, Landa I, Button J, Lailler N, Sboner A, Gao D, Murphy D, Cao Z, Shukla S, Hollmann TJ, Wang L, Borsu L, Merghoub T, Schwartz G, Postow MA, Ariyan CE, Fagin JA, Zheng D, Ladanyi M, Busam KJ, Berger MF, Chen Y, Chi P. Alternative transcriptional initiation leads to expression of a novel ALK isoform in cancer. Nature Oct 15;526(7573):453-7, 2015. PMID: 26444240

Wang L, Zehir A, Sadowska J, Zhou N, Rosenblum M, Busam K, Agaram N, Travis W, Arcila M, Dogan S, Berger MF, Cheng DT, Ladanyi M, Nafa K, Hameed M. Consistent copy number changes and recurrent PRKAR1A mutations distinguish Melanotic Schwannomas from Melanomas: SNP-array and Next Generation Sequencing analysis. Genes, Chromosomes and Cancer Aug;54(8):463-471, 2015. PMID: 26031761

Paik P, Shen R, Won H, Rekhtman N, Wang L, Sima C, Arora A, Seshan V, Ladanyi M, Berger M, Kris M. Next generation sequencing of stage IV squamous cell lung cancers reveals an association of PI3K aberrations and evidence of clonal heterogeneity in patients with brain metastases. Cancer Discov Jun;5(6):610-21, 2015. PMID: 25929848

Drilon A, Wang L, Arcila ME, Balasubramanian S, Greenbowe JR, Ross JS, Stephens PJ, Lipson D, Miller VA, Kris MG, Ladanyi M, Rizvi NA. Broad, hybrid capture-based next-generation sequencing identifies actionable genomic alterations in "driver-negative" lung adenocarcinomas. Clin Cancer Res Aug 15;21(16):3631-9, 2015. PMID: 25567908

Huse JT, Diamond EL, Wang L, Rosenblum MK. Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true "oligoastrocytoma"? Acta Neuropathol Jan;129(1):151-3, 2015.

Xu XL, Singh HP, Wang L, Qi DL, Poulos BK, Abramson DH, Jhanwar SC, Cobrinik D. Rb suppresses human cone-precursor-derived retinoblastoma tumours. Nature Oct 16;514(7522):385-8. 4, 2014. PMID: 2525297

Kohsaka S, Shukla N, Ameur N, Ito T, Ng CK, Wang L, Lim D, Marchetti A, Viale A, Pirun M, Socci ND, Qin LX, Sciot R, Bridge J, Singer S, Meyers P, Wexler LH, Barr FG, Dogan S, Fletcher JA, Reis-Filho JS, Ladanyi M. A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations. Nat Genet Jun;46(6):595-600, 2014.

Wang L, Rao M, Fang Y, Hameed M, Viale A, Busam K, Jhanwar SC. A Genome-Wide High-Resolution Array-CGH Analysis of Cutaneous Melanoma and Comparison of Array-CGH to FISH in Diagnostic Evaluation. J Mol Diagn Sep;15(5):581-91, 2013.

Drilon A, Wang L, Hasanovic A, Suehara Y, Lipson D, Stephens P, Ross J, Miller V, Ginsberg M, Zakowski MF, Kris MG, Ladanyi M, Rizvi N. Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas. Cancer Discov Jun;3(6):630-5, 2013.

Suehara Y, Arcila M, Wang L, Hasanovic A, Ang D, Ito T, Kimura Y, Drilon A, Guha U, Rusch V, Kris MG, Zakowski MF, Rizvi N, Khanin R, Ladanyi M. Identification of KIF5B-RET and GOPC-ROS1 Fusions in Lung Adenocarcinomas through a Comprehensive mRNA-Based Screen for Tyrosine Kinase Fusions. Clin Cancer Res. Dec 15;18(24):6599-608, 2012.

Wang L, Motoi T, Khanin R, Olshen A, Mertens F, Bridge J,  Dal Cin P, Antonescu C, Singer S, Hameed M, Bovee J, Hogendoorn P.C.W., Socci N, Ladanyi M. Identification of a Novel, Recurrent HEY1-NCOA2 Fusion in Mesenchymal Chondrosarcoma based on a Genome-wide Screen of Exon-level Expression Data. Genes Chromosomes & Cancer Feb;51(2):127-39, 2012.

Bott M, Brevet M, Taylor BS, Shimizu S, Ito T, Wang L, Creaney J, Lake RA, Zakowski MF, Reva B, Sander C, Delsite R, Powell S, Zhou Q, Shen R, Olshen A, Rusch V, Ladanyi M. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet. Jun 5;43(7):668-72, 2011.

Ozawa T, Brennan CW, Wang L, Squatrito M, Sasayama T, Nakada M, Huse JT, Pedraza A, Utsuki S, Yasui Y, Tandon A, Fomchenko EI, Oka H, Levine RL, Fujii K, Ladanyi M, Holland EC. PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. Genes Dev Oct 1;24(19):2205-18, 2010.

Wang L, Bhargava R, Zheng T, Wexler L, Collins MH, Roulston D, Ladanyi M. Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions. J Mol Diagn 9:498-509, 2007.

Wang L, Wang YY, Cao Q, Chen B, Chen Z, Chen SJ. Hornerin gene was involved in a case of acute myeloid leukemia transformed from myelodysplastic syndrome with t(1;2)(q21;q37). Leukemia 20:2184-7, 2006.

Last update: August 2017