Marcin Wlodarski, MD
Marcin Wlodarski, MD

Marcin Wlodarski, MD

Assistant Member, St. Jude Faculty

Departments

Divisions

Education

Internships - Karolinska Institute Stockholm and NHLBI, NIH Bethesda  
MD - Charitè Medical School, Humboldt Universität zu Berlin, Germany
Research Doctorate Degree - Charitè Medical School, Humboldt Universität zu Berlin, Germany
Graduate Research Fellowship – Cleveland Clinic Cancer Center, USA
Residency (Pediatric and Adolescent Medicine) and Fellowship (Pediatric Hematology/Oncology) – University Children’s Hospital Freiburg, Germany

Honors & Awards

  • 2015  EHA-ASH TRTH (Training Award in Hematology)
  • 2015  Tito Bastianello Young Investigator Award, MDS-Foundation
  • 2014  SIOP Young Investigator Award, Toronto
  • 2010  Humboldt Award for best doctoral thesis, Humboldt Universität zu Berlin

Research Interests

  • Inherited bone marrow failure syndromes
  • Childhood myelodysplastic syndromes and aplastic anemia
  • Predisposition to myeloid malignancies

Selected Publications

Kirschner M, Maurer A, Wlodarski MW, (et al) Kurth I, Schemionek M, Bruemmendorf T, Beier T. Recurrent somatic mutations are rare in patients with cryptic dyskeratosis congenita. Leukemia April 2, 2018.

Al Seraihi A, Rio-Machin A, Tawana K (et al) Wlodarski MW, Niemeyer CM, Scott H, Hahn C, Ellison A, Tummala H, Cardoso SR, Vuliamy T, Dokal I, Butler T, Smith M, Cavenagh J, Fitzgibbon J. GATA2 Monoallelic Expression Underlies Reduced Penetrance in Inherited GATA2-2 mutated MDS/AML. Leukemia April 19, 2018.

Teot LA, Schneider M, Thorner AR, Tian J, Chi YY, Ducar M, Lin L, Wlodarski M, (et al) Rodriguez-Galindo C, Hettmer S. Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology Group. Cancer May 1, 2018. PMID: 29461635

Wlodarski MW (corresponding), Da Costa L (et al) Gleizes PE, MacInnes A. Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia. Haematologica Mar 29, 2018. PMID: 29599205

Grace RF, Bianchi P, (et al) Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Kunz J, Sheth S, Rose MJ, Bradeen HA, Neu N, Guo D, Al-Sayegh H, London WB, Gallagher PG, Zanella A, Barcellini W. The clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. Blood Mar 16, 2018. PMID: 29549173

Pastor VB, Sahoo S, (et al), Niemeyer CM, Wlodarski MW. Constitutional SAMD9L Mutations Cause Familial Myelodysplastic Syndrome and Transient Monosomy 7. Haematologica Mar;103(3):427-437, 2018. PMID: 29217778

Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, (et al), Niemeyer C, Flotho C, Plass C. RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia. Nat Commun  Dec 19;8(1):2126, 2017. PMID: 29259247.234wd

Aspesi A, Monteleone V, Betti M, Actis C, Morleo G, Sculco M, Guarrera S, Wlodarski MW, Ramenghi U, Santoro C, Ellis SR, Loreni F, Follenzi A, Dianzani I. Lymphoblastoid cell lines from Diamond Blackfan anaemia patients exhibit a full ribosomal stress phenotype that is rescued by gene therapy. Sci Rep Sep 20;7(1):12010, 2017. PMID: 28931864

Schwartz JR, Wang S, Ma J, Lamprecht T, Walsh M, Song G, Raimondi SC, Wu G, Walsh MF, McGee RB, Kesserwan C, Nichols KE, Cauff BE, Ribeiro RC, Wlodarski M (*equal corresponding), Klco JM (*). Germline SAMD9 mutation in siblings with monosomy 7 and myelodysplastic syndrome. Leukemia Aug;31(8):1827-1830, 2017. PMID: 28487541

Speckmann C, Sahoo SS, Rizzi M, (et al), Boztug K, Wlodarski MW. Clinical and Molecular Heterogeneity of RTEL1 Deficiency. Front Immunol May 1;8:449, 2017. PMID: 28507545

Buonocore F, Kühnen P, Suntharalingham JP (et al),  Wlodarski MW, Chen W, Kokai GK, Anderson G, Morrogh D, Moulding DA, McKee SA, Niemeyer CM, Grüters A, Achermann JC. Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans. J Clin Invest May 1;127(5):1700-1713, 2017. PMID: 28346228

Paolini NA, Attwood M, (et al), Wlodarski MW, Houtkooper RH, von Lindern M, Kuijpers TW, Dinman JD, Baserga SJ, Cockman ME, MacInnes AW. A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism. Am J Hum Genet Mar 2;100(3):506-522, 2017. PMID: 28257692

Pastor V, Hirabayashi S, Karow A, Wehrle J (et al) Niemeyer CM, Wlodarski M. Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants. Leukemia Dec 9, 2016. doi: 10.1038/leu.2016.342. PMID: 27876779

Wlodarski MW (corresponding), Hirabayashi S, Pastor V, Starý J, Hasle H, Masetti R, Dworzak M (et al), Locatelli F, Baumann I, Strahm B, Niemeyer CM. Prevalence, clinical characteristics and prognosis of GATA2-related myelodysplastic syndromes (MDS) in children and adolescents. Blood Mar 17, 2016. PMID: 26702063

Weidner CI, Lin Q, Birkhofer C, Gerstenmaier U, Kaifie A, Kirschner M, Bruns H, Balabanov S, Trummer A, Stockklausner C, Höchsmann B, Schrezenmeier H, Wlodarski M, Panse J, Brümmendorf TH, Beier F, Wagner W. DNA methylation in PRDM8 is indicative for dyskeratosis congenita. Oncotarget Mar 8, 2016. PMID: 26909595

Sjögren SE, Siva K, Soneji S, George AJ, Winkler M, Jaako P, Wlodarski M, Karlsson S, Hannan RD, Flygare J. Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia. Br J Haematol Nov;171(4):517-29, 2015. PMID:26305041

Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, (et al) Lausch E, Hanson IC. PGM3 Mutations Cause a Congenital Disorder of Glycosylation with Severe Immunodeficiency and Skeletal Dysplasia. Am J Hum Genet Jul 3;95(1):96-107, 2014. PMID: 24931394

Clemente MJ, Przychodzen B, Jerez A, Dienes BE, Afable MG, Husseinzadeh H, Rajala HL, Wlodarski MW, Mustjoki S, Maciejewski JP. Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes. Blood Dec 12;122(25):4077-85, 2013. PMID: 24149287

Jerez A, Clemente MJ, et al, Zhang D, Wlodarski MW, Porkka K, (et al) Loughran TP, Maciejewski JP. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood Oct 11;120(15):3048-57, 2012. PMID: 22859607

Hirabayashi S, Flotho C, Moetter J, Heuser M, Hasle H, (et al) Niemeyer CM and Wlodarski MW. Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML. Blood Mar 15;119(11):e96-9, 2012. PMID: 22238327

Meyer S, Bristow C, (et al) Hanenberg H, Neitzel H, Wlodarski MW, Ebell W, Tönnies H. Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA. Blood Jun 2;117(22):6047-50, 2011. PMID: 21636719.

Clemente MJ, Wlodarski MW, Makishima H, Viny AD, (et al), Loughran TP Jr, Maciejewski JP. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood Oct 20;118(16):4384-93, 2011. PMID: 21865345.

Wlodarski MW, Mötter J, Gorr TA, Olk-Batz C, Hasle H, Dworzak M, Niemeyer CM,  Flotho C. Abnormal promoter DNA methylation in juvenile myelomonocytic leukemia is not caused by mutation in DNMT3A. Blood Oct 20;118(16):4490-1, 2011. PMID: 22021454.  

Afable MG 2nd*, Wlodarski M*,(*equal contribution) Makishima H, Shaik M, Sekeres MA, Tiu RV, Kalaycio M, O'Keefe CL, Maciejewski JP. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes. Blood Jun 23;117(25):6876-84, 2011. PMID: 21527527.

Loh ML, Sakai DS, Flotho C, (et al) Locatelli F, Stary J, Trebo M, Wlodarski M, Zecca M, Shannon KM, Niemeyer CM. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood Aug 27;114(9):1859-63, 2009. PMID: 19571318.

Wlodarski MW, Nearman Z, Jiang Y, Lichtin A, Maciejewski JP. Clonal predominance of CD8(+) T cells in patients with unexplained neutropenia. Exp Hematol Mar;36(3):293-300, 2008. PMID: 18279717.

Wlodarski MW, Nearman Z, Jankowska A, Babel N, Powers J, Leahy P, Volk HD, Maciejewski JP. Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia. J Leukoc Biol Mar;83(3):589-601, 2008. PMID: 18086899.

Wlodarski MW, Gondek LP, Nearman ZP, Plasilova M, Kalaycio M, Hsi ED, Maciejewski JP. Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome. Blood Oct 15;108(8):2632-41, 2006. PMID: 16614248.

Wlodarski MW, O'Keefe C, Howe EC, Risitano AM, Rodriguez A, Warshawsky I, Loughran TP Jr, Maciejewski JP. Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia. Blood Oct 15;106(8):2769-80, 2005. PMID: 15914562.

Demuth I, Wlodarski M, Tipping AJ, Morgan NV, (et al) Joenje H, Sperling K, Digweed M. Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9. Eur J Hum Genet Nov;8(11):861-8, 2000. PMID: 11093276.

Last update: May 2018