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Christine Yu, MD
Christine Yu, MD

Christine Yu, MD

Associate Member, St. Jude Faculty

Departments

Divisions

Education

Fellowship (Endocrinology and Pediatric Endocrinology) - University of Chicago, Chicago, IL
Chief Residency (Internal Medicine) - MacNeal Hospital, Berwyn, IL
Residency (Internal Medicine-Pediatrics) - University of Chicago, Chicago, IL
MD - University of Michigan, Ann Arbor, MI
BS (Molecular Biophysics & Biochemistry) - Yale University, New Haven, CT

Research Interests

  • Fertility after gonadotoxic therapy
  • Improving metabolic outcomes in cancer survivors 

Selected Publications

Lahoti A*, Yu C*, Brar P, Dalgo A, Gomez D, Gourgari E, Harris R, Kamboj M, Marks S, Nandagopal R, Page L, Sarafoglou K, Terrell C, and Stanley TL on behalf of the Pediatric Endocrine Society Drug & Therapeutics Committee. An endocrine perspective on menstrual suppression for adolescents: achieving good suppression while optimizing bone health. J Pediatr Endocrinol Metab Aug 13;34(11):1355-1369, 2021. PMID:34388330. https://doi.org/10.1515/jpem-2020-0539 * co-first authors

Jee YH, Gangat M, Yeliosof O, Temnycky AG, Vanapruks S, Whalen P, Gourgari E, Bleach C, Yu CH, Marshall I, Yanovski JA, Link K, Ten S, Baron J, Radovick S. Evidence That the Etiology of Congenital Hypopituitarism Has a Major Genetic Component but Is Infrequently Monogenic. Front Genet Aug 11;12:697549, 2021. PMID: 34456972; PMCID: PMC8386283. https://doi.org/10.3389/fgene.2021.697549 

Miller R, Ashraf A, Gomez D, Gourgari E, Gupta A, Kamboj M, Kohn B, Lahoti A, Mehta S, Mitchell D, Patel N, Raman V, Yu C, Krishnan S on behalf of the Pediatric Endocrine Society Drug & Therapeutics Committee. SARS-CoV-2 infection and paediatric endocrine disorders: Risks and management considerations. Endocrinol Diabetes Metab Jun 3;4(3):e00262, 2021. PMID: 34268455; PMCID:PMC 8209869. https://doi.org/10.1002/edm2.262

Counts DR, Yu C, Lasutschinkow PC, Sadeghin T, Samango-Sprouse CA. Evidence of intrauterine growth restriction (IUGR) and growth hormone deficiency (GHD) in 49,XXXXY syndrome. Am J Med Genet A Dec;185(12):3547-3553, 2021. Epub 2020 Jul 2. PMID: 32618131. https://doi.org/10.1002/ajmg.a.61738

Samango-Sprouse CA, Yu C, Porter GF, Tipton ES, Lasutschnikow PC, Gropman AL. A review of the intriguing interaction between testosterone and neurocognitive development in males with 47,XXY. Curr Opin Obstet Gynecol Apr;32(2):140-146, 2020. PMID: 32004174. https://doi.org/10.1097/gco.0000000000000612

Yu C. Endocrine consequences of childhood cancer therapy and transition considerations. Pediatr Ann Aug 1;48(8):e326-e332, 2019. PMID: 31426101. https://doi.org/10.3928/19382359-20190729-02

Rosenfield RL, Bordini B, Yu C. Comparison of detection of normal puberty in girls by a hormonal sleep test and a gonadotropin-releasing hormone agonist test. J Clin Endocrinol Metab Apr;98(4):1591-601, 2013. Epub 2013 Mar 1. PMID: 23457407; PMCID:PMC 3615202. https://doi.org/10.1210/jc.2012-4136

Rosenfield RL, Bordini B, Yu C. Comparison of detection of normal puberty in boys by a hormonal sleep test and a gonadotropin-releasing hormone agonist test. J Clin Endocrinol Metab Dec;97(12):4596-4604, 2012. Epub 2012 Oct 5. PMID: 23043188; PMCID:PMC 3513543. https://doi.org/10.1210/jc.2012-2722

Gregg B, Kociolek LK, Qin K, Rosenfield RL, Yu C. P450c17 deficiency caused by compound heterozygosity for two novel mutations presenting as hypotension in early infancy. Horm Res Paediatr 76(6):434-41, 2011. Epub 2011 Aug 4. PMID: 21822006. https://doi.org/10.1159/000329857

Yu C, Markan K, Temple KA, Deplewski D, Brady MJ, Cohen RN. The nuclear receptor corepressors NCoR and SMRT decrease PPARg transcriptional activity and repress 3T3-L1 adipogenesis. J Biol Chem Apr 8;280(14):13600-5, 2005. Epub 2005 Feb 3. PMID: 15691842. https://doi.org/10.1074/jbc.m409468200

Temple KA, Cohen RN, Wondisford SR, Yu C, Deplewski D, Wondisford FE. An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements. J Biol Chem Feb 4;280(5):3529-40, 2005. Epub 2004 Nov 29. PMID: 15572375. https://doi.org/10.1074/jbc.m411422200

Cohen RN, Cohen LE, Botero D, Yu C, Sagar A, Jurkiewicz M, Radovick S. Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endocrinol Metab Oct;88(10):4832-9, 2003. PMID: 14557462. https://doi.org/10.1210/jc.2002-021868

Last update: March 2022

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