MD - Georg August University, Göttingen, Germany
Pediatric Internship - University of Münster, Germany
Pediatric Residency - Baylor College of Medicine, Houston, Texas
Pediatric Hematology-Oncology Fellowship - Baylor College of Medicine, Houston, Texas
The main purpose of 3CAR is to find out if this type of immunotherapy is safe for pediatric patients with solid tumors. We also want to learn if it is effective in fighting solid tumors.
The main purpose of this study is to find the highest dose of CD123-CAR T cells that is safe to give patients with AML. We also want to study the side effects of the treatment and learn how effective it is in fighting this type of cancer.
To find out if infants, children, and young adults develop any side effects months or years after receiving a gene transfer product as part of a research study or related treatment at St. Jude Children's Research Hospital.
The main goal of this study is to learn the largest dose of memory CAR T cells that can be safely given. Researchers also want to learn about the way memory CAR T cells act in the body and how effectively they treat this type of cancer.
Age:
Donor: At least 19 years old; Recipient: 21 years or younger
1) To determine the maximum tolerated dose (MTD) and characterize the safety profile and dose-limiting toxicities (DLTs) of treatment with SJCAR19 in these patients (Phase I);2) to evaluate the complete response rates of SJCAR19 in these patients (Phase II)
