Seth Karol, MD
Seth Karol, MD

Seth Karol, MD

Assistant Member, St. Jude Faculty




MD – The Ohio State University, Columbus, Ohio
BS – Duke University, Durham, North Carolina

Research Interests

  • Reducing the side effects of therapy in children with acute lymphoblastic leukemia (ALL)
  • Identifying new treatments for children with leukemia after relapse

Selected Publications

Jiang C, Whitmore-Sisco L, Gaur AH, Adderson EE, Tdap Working Group. A quality improvement initiative to increase Tdap (tetanus, diphtheria, acellular pertussis) vaccination coverage among direct health care providers at a children's hospital. Vaccine 2018. PMID: 29217370.

Ramsey LB, Pounds S, Cheng C, Cao X, Yang W, Smith C, Karol SE, Liu C, Panetta JC, Inaba H, Rubnitz JE, Metzger ML, Ribeiro RC, Sandlund JT, Jeha S, Pui CH, Evans WE, Relling MV. Genetics of pleiotropic effects of dexamethasone. Pharmacogenetics and Genomics 2017. PMID: 28628558.

Karol SE, Yang W, Smith C, Cheng C, Stewart CF, Baker SD, Sandlund JT, Rubnitz JE, Bishop MW, Pappo AS, Jeha S, Pui CH, Relling MV. Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine. Cancer 2017. PMID: 28493546.

Karol SE, Larsen E, Cheng C, Cao X, Yang W, Ramsey LB, Fernandez CA, McCorkle JR, Paugh SW, Autry RJ, Lopez-Lopez E, Diouf B, Jeha S, Pui CH, Raetz EA, Winick NJ, Carroll WL, Hunger SP, Loh ML, Devidas M, Evans WE, Yang JJ, Relling MV. Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia. Leukemia 2017. PMID: 28096535.

Liu Y, Fernandez CA, Smith C, Yang W, Cheng C, Panetta JC, Kornegay N, Liu C, Ramsey LB, Karol SE, Janke LJ, Larsen EC, Winick N, Carroll WL, Loh ML, Raetz EA, Hunger SP, Devidas M, Yang JJ, Mullighan CG, Zhang J, Evans WE, Jeha S, Pui CH, Relling MV. Genome-wide study links PNPLA3 variant with elevated hepatic transaminase after acute lymphoblastic leukemia therapy. Clinical Pharmacology and Therapeutics 2017. PMID: 28090653.

Portera MV*, Karol SE*, Smith C, Yang W, Cheng C, Neel MD, Pui CH, Relling MV, Kaste SC. Osteonecrosis is unrelated to hip anatomy in children with acute lymphoblastic leukemia. Pediatric Blood & Cancer 2016. PMID: 28035753.

Liu C, Yang W, Pei D, Cheng C, Smith C, Landier W, Hageman L, Chen Y, Yang JJ, Crews KR, Kornegay N, Karol SE, Wong FL, Jeha S, Sandlund JT, Ribeiro RR, Rubnitz JE, Metzger ML, Pui CH, Evans WE, Bhatia S, Relling MV. A Genome-wide Approach Validates that Thiopurine Methyltransferase Activity is a Monogenic Pharmacogenomic Trait. Clin Pharm & Therapeutics Epub 2016. PMID: 27564568.

Yang W, Wu G, Broeckel U, Smith C, Turner V, Haidar C, Wang S, Carter R, Karol SE, Neale G, Crews K, Yang J, Mullighan C, Downing J, Evans W, Relling RV. Comparison of Genome Sequencing and Clinical Genotyping for Pharmacogenes. Clin Pharm & Therapeutics Epub, 2016. PMID: 27311679.

Karol SE, Mattano LA, Yang W, Maloney KW, Smith C, Liu C, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, San Lucas FA, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV. Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia. Blood Feb 4;127(5):558-564, 2016. PMID: 26590194.

Karol SE*, Yang W*, Van Driest SL, Chang TY, Kaste S, Bowton E, Basford M, Bastarache L, Roden DM, Denny JC, Larsen E, Winick N, Carroll WL, Cheng C, Pei D, Fernandez CA, Liu C, Smith C, Loh ML, Raetz EA, Hunger SP, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Mattano LA Jr, Relling MV. Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia. Blood Oct 8;126(15):1770-6, 2015. PMID: 26265699.

Ramsey LB, Janke LJ, Payton MA, Cai X, Paugh SW, Karol SE, Kamdem LK, Cheng C, Williams RT, Jeha S, Pui CH, Evans WE, Relling MV. Antileukemic efficacy of continuous vs discontinuous dexamethasone in murine models of acute lymphoblastic leukemia. PLoS One Aug 7;10(8):e0135134, 2015. PMID: 26252865.

Fernandez CA, Smith C, Yang W, Mullighan CG, Qu C, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Karol SE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV. Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Blood Jul 2;126(1):69-75, 2015. PMID: 25987655.

Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti TD, Relling MV, Evans WE. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nat Genet Jun;47(6):607-14, 2015. PMID: 25938942.

Fernandez CA, Smith C, Karol SE, Ramsey LB, Liu C, Pui CH, Jeha S, Evans WE, Finkelman FD, Relling MV. Effect of premedications in a murine model of asparaginase hypersensitivity. J Pharmacol Exp Ther Mar;352(3):541-51, 2015. PMID: 25573198.

Karol SE, Coustan-Smith E, Cao X, Shurtleff S, Raimondi S, Choi J, Ribeiro R, Dahl G, Bowman P, Taub J, Degar B, Leung W, Downing J, Pui C, Rubnitz J, Campana D, Inaba H. Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. Br J Haematol Jan;168(1):94-101, 2015. PMID: 25164427.

Kirkpatrick J, Rabbani Z, Bentley R, Hardee M, Karol S, Meyer J, Oosterwiik E, Havrilesky L, Alvarez Secord A, Vujaskovic Z, Dewhirst M, Jones E. Elevated CAIX expression is associated with an increased risk of distant failure in early-stage cervical cancer. Biomark Insights Feb 1;3:45-55, 2008. PMID: 19578493.

Blaser BW, Schwind NR, Karol S, Chang D, Shin S, Roychowdhury S, Becknell B, Ferketich AK, Kusewitt DF, Blazer BR, Caligiuri MA. Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity. Blood Oct 1;108(7):2463-9, 2006. PMID: 16757683.

Nestor AL, Cicila GC, Karol SE, Langenderfer KM, Hollopeter SL, Allison DC. Linkage analysis of neointimal hyperplasia and vascular wall transformation after balloon angioplasty. Physiol Genomics Apr 13;25(2):286-93, 2006. PMID: 16434542.

Last update: July 2018