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Mary E. (Beth) McCarville, MD
Mary E. (Beth) McCarville, MD

Mary E. (Beth) McCarville, MD

Member, St. Jude Faculty

  • Interim Chair, Department of Diagnostic Imaging
  • Chief, Clinical Radiation
  • Chief, Body Imaging Section



RT – Iowa Methodist Medical Center, School of Radiologic Technology, Des Moines, IA (1977)
 – University of Iowa, Iowa City, IA (1986)
MD – University of Iowa College of Medicine, Iowa City, IA (1990)

Honors & Awards

  • 2009-2017  Recognized in Best Doctors in America®
  • 2015  John Caffey Award for Best Clinical Science Paper presented at the 2015 annual meeting of the Society for Pediatric Radiology: Contrast Enhanced Ultrasound in the Assessment of Pediatric Solid Tumor Response to Anti-Angiogenic Therapy.  McCarville MB, Coleman J, Guo J, Li Y, Li X, Navid F. 
  • 2011  Certificate of Merit from the Society for Pediatric Radiology presented at the International Paediatric Radiology Congress, May 27th-31st, 2011, London, UK, for the scientific exhibit: Ultrasound and Magnetic Resonance Imaging Features of Unusual Ocular Disease in Children with Clinical and Pathological Correlation. McCarville MB, Kaste SC, Wilson W.
  • 2005  John Caffey Award for Basic Science Research from the Society for Pediatric Radiology, presented at the 2005 annual meeting, for the oral presentation: Quantitative Measurement of Microbubble Ultrasound Contrast Agent Flow To Assess the Efficacy of Angiogenesis Inhibitors In Vivo. McCarville B, Streck C, Li C-S, Davidoff A.
  • 2004  Certificate of Merit from the Society for Pediatric Radiology presented at the 2004 annual meeting, for the scientific exhibit: Not all 18FDG-Avid Sites Represent Active Disease in Pediatric Hodgkin’s. Kaste SC, Howard S, McCarville MB, Krasin MJ, Hudson MM.

Research Interests

  • Ultrasound

Selected Publications

Navid F, Santana VM, Neel M, McCarville MB, Shulkin BL, Mao S, Wu J, Billups CA, Daryani VM, Stewart CF, Kunkel M, Smith W, Ward D, Jenkins JJ, Pappo AS, Loeb DM, Willert JR, Ahn H, Rao BN, Daw NC. A Phase II Trial Evaluating the Feasibility of Adding Bevacizumab to the Therapy of Osteosarcoma.  Int J Cancer 2017 (in press).

O’Neill AF, Towbin AJ, Krailo MD, Xia C, Gao Y, McCarville MB, Meyers RL, McGahren ED, Tiao GM, Dunn SP, Langham Jr MR, Weldon CB, Finegold MJ, Ranganathan S, Furman WL, Malogolowkin M, Rodriguez-Galindo C, Katzenstein HM. Characterization of Pulmonary Metastases in Children with Hepatoblastoma. J Clin Onc 2017 (in press).

Ferrari A, Chi YY, De Salvo GL, Orbach D, Brennan B, Randall RL, McCarville MB, Black JO, Alaggio R, Hawkins DS, Bisogno G, Spunt SL.Surgery alone is sufficient therapy for children and adolescents with low-risk synovial sarcoma: A joint analysis from the European paediatric soft tissue sarcoma Study Group and the Children's Oncology Group. Eur J Cancer Apr 6;78:1-6, 2017. doi: 10.1016/j.ejca.2017.03.003. [Epub ahead of print] PMID 28391003

Sharp SE, Shulkin BA, Gelfand MJ, McCarville MB. FDG PET/CT appearance of local osteosarcoma recurrences in pediatric patients. Pediatr Radiol 2017 (in press).

Hains DS,  McCarville MB, Ellison EE, Huffman A, Glass S,  Qureshia,AH, Pierce KR, Cahill AL, Dixon A, Delos Santos N,  Cohen HL. Elucidation of renal scars in children with vesicoureteral reflux using contrast enhanced ultrasound: A pilot study. Kidney Int Rep 2017 (in press). doi 10.1016/j.ekir.2017.01.008

Katzenstein HM,Furman WL, Malogolowkin MH, Krailo MD, McCarville MB, Towbin AJ, Tiao GM, Finegold M, Ranganathan S, Dunn SP, Langham MR, McGahren ED, Rodriguez-Galindo C, Meyers RL. Vincristine/irinotecan upfront window treatment of high-risk hepatoblastoma: A report from the Children’s Oncology Group (COG) AHEP0731 Study Committee. Cancer Jun 15;123(12):2360-2367, 2017. doi: 10.1002/cncr.30591. [Epub ahead of print]. PMID 28211941.

Krafft A, Loeffler R, Song R, Tipirneni-Sajji A, McCarville MB, Robson M, Hankins J, Hillenbrand C. Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla. Magn Reson Med Jan 16, 2017. doi: 10.1002/mrm.26592. [Epub ahead of print] PMID 28090666

VanHouwelingen L, Seims A, Ortega-Laureano L, Coleman J, McCarville MB, Davidoff AM, Fernandez-Pineda I. Postoperative small bowel intussusception in pediatric surgical oncology patients:  A single center retrospective review. Pediatric Radiol 2017 (in press).

Tipirneni-Sajja A, Krafft AJ, McCarville MB, Loeffler RB, Song R, Hankins JS. Radial UTE imaging removes the need for breath-holding in hepatic iron overload quantification by R2*-MRI. Am J Roentgen 2017 (in press).

Interiano RB, McCarville MB, Delos Santos N, Mao S, Wu J, Dome JS, Kieran K, Williams MA, Brennan RC, Krasin MJ, Green DM, Davidoff AM. Comprehensive renal function evaluation in patients with synchronous bilateral Wilms tumor. J Pediatr Surg Jan;52(1):98-103, 2017. doi: 10.1016/j.jpedsurg.2016.10.027  

Loeffler RB, McCarville MB, Smeltzer MP, Krafft AJ, Song R, Hankins JS, Hillenbrand CM. Can multi-slice or navigator-gated R2*-MRI replace single-slice breath-hold acquisition for hepatic iron quantification? Pediatr Radiol Jan;47(1):46-54, 2017. doi: 10.1007/s00247-016-3700-1. Epub 2016 Oct 17.PMID 27752732; PMCID 5203961

Davis JC, Daw NC, Navid F, Billups CA, Wu J, Bahrami A, Jenkins JJ, Snyder SE, Reddick WE, Santana VM,      McCarville MB, Guo J, Shulkin BL. FDG uptake during early adjuvant chemotherapy predicts histologic response in osteosarcoma. Jo Nuc Med 2017 Jun 13. 2017. pii: jnumed.117.190595. doi: 10.2967/jnumed.117.190595. [Epub ahead of print]

Alexander TB, McGee RB, Kaye E, McCarville MB, Choi JK, Cavender CP, Nichols KE, Sandlund JT. Metachronous T-lymphoblastic lymphoma and Burkitt lymphoma in a child with constitutional mismatch repair deficiency syndrome. Pediatr Blood Cancer Aug;63(8):1454-6, 2016. doi: 10.1002/pbc.25989. Epub 2016 Apr PMID 27037742; PMCID 4915984

Hurley C, McCarville MB, Shulkin BL, Mao S, Wu J, Navid F, Daw N, PappoA, Bishop M. Comparison of  18F-FDG-PET-CT and bone scintigraphy for evaluation of osseous metastases in newly diagnosed and recurrent osteosarcoma. Pediatr Blood Cancer Aug;63(8):1381-6, 2016. doi: 10.1002/pbc.26014. Epub 2016 Apr. PMID 27082077; PMCID 5082741

Green DM, Zhu L, Krasin MJ, McCarville ME, Stokes DC, Ness KK, Armstrong GT, Srivastave DK, Mulrooney DA, Metzger M, Spunt SL, Navid F, Ojha R, Davidoff A, Rao BN, Robison LL, Hudson MM. Pulmonary function after treatment for childhood cancer: a report from the St. Jude lifetime cohort study (SJLIFE). Ann Am Thor Soc Sep;13(9):1575-85, 2016. PMID 27391297; PMCID 5059496

Talleur A, Navid F, Spunt SL, McCarville MB, Wu J, Mao S, Davidoff AM, Neel M, Krasin MJ. Limited margin radiotherapy for children and young adults with Ewing sarcoma achieves high rates of local tumor control. Int J Radiat Oncol Biol Phys Apr 12, 2016. pii: S0360-3016(16)30104-3. doi: 10.1016/j.ijrobp.2016.04.001. [Epub ahead of print] PMID: 27319287

McCarville MB, Guo J, Coleman JL, Li Y, Li X, Davidoff AM, Navid F. Quantitative dynamic contrast enhanced ultrasound to assess response to anti-angiogenic therapy in children and adolescents with solid malignancies: a pilot study. Am Jo Roentgenol 206(5):933-939, 2016. doi:10.2214/AJR 15.15789. PMID 26999488; PMCID 5153883  Selected for the Focus on Pediatric Imaging Special Issue

Tipirneni-Sajja A, Loeffler RB, Oesingmann N, Winchell AM, Song R, McCarville B, Jones DP, Hudson M, Spunt SL, Hillenbrand CM. Measurement of glomerular filtration rate by dynamic contrast enhanced magnetic resonance I maging using a subject-specific two-compartment model. Physiol Rep Apr;4(7), 2016. pii: e12755. doi: 10.14814/phy2.12755. Epub 2016 Apr 13.PMID 27081161

Hankins JS, McCarville MB,  Rankine-Mullins A, Reid M, Lobo CL,Moura PG, Ali S, Soares D,  Alred K,  Jay D, Aygun B, Bennett J, Kang G,  Goldsmith JC, Smeltzer MP, Boyett JM, Ware RE. Prevention of conversion to abnormal TCD with hydroxyurea in children with sickle cell anemia: A phase III international randomized clinical trial. Am Jo Hematol Dec;90(12):1099-105, 2015. doi: 10.1002/ajh.24198. PMID 26414435; PMCID 4715740

Guo J, Glass JO, McCarville MB, Shulkin BL, Vinay MD, Stewart, CF, Wu J, Mao S, Dwek JR, Fayad LM, Madewell JE, Navid F, Daw NC, Reddick WE. Assessing vascular effects of adding bevacizumab to neoadjuvant chemotherapy in osteosarcoma using dynamic contrast enhanced MRI. Br Jo Cancer Nov 3;113(9):1282-8, 2015. doi: 10.1038/bjc.2015.351. PMID 26461056; PMCID 4815789

Fernandez-Pineda I, McCarville MB, Brennan RC, Spunt SL, Neel MD, Rao BN. Bilateral internal hemipelvectomy for osteosarcoma in a pediatric patient previously treated for rhabdomyosarcoma. Orthop Traumatol Surg Res May;101(3):395-7, 2015. doi: 10.1016/j.otsr.2015.01.012. Epub 2015 Mar 25. PMID 25817906

Davidoff AM, Interiano RB, Wynn L, Delos Santos N, Dome JS, Green DM, Brennan RC, McCarville MB,  Krasin MJ, Kieran K, Williams MA. Overall survival and renal function of patients with synchronous bilateral Wilms tumor undergoing surgery at a single institution. Ann Surg Oct;262(4):570-576, 2015. PMID 26366536; PMCID 5187953

Bhojwani D,  McCarville MB, Choi JK, Sawyer J, Metzger ML, Inaba H, Davidoff AM, Gold R, Shulkin BL,Sandlund JT. The role of FDG-PET/CT in the evaluation of residual disease in pediatric non-Hodgkin lymphoma. Br J Haematol Mar;168(6):845-53, 2015. doi: 10.1111/bjh.13219. Epub 2014 Nov 10. PMID 25382494; PMCID 4351138

McCarville MB, Chen JY, Coleman JL, Li Y, Li X, Adderson EE, Neel MD, Gold RE, Kaufman RA. Distinguishing osteomyelitis from Ewing sarcoma. Am J Roentgenol Sep;205(3):640-51, 2015. doi: 10.2214/AJR.15.14341 PMID 26295653. Selected for the Am J Roentgenol, Journal Club

Interiano RB, McCarville MB, Wu J, Davidoff AM, Sandoval J, Navid F. Pneumothorax as a complication of combination antiangiogenic therapy in children and young adults with refractory solid tumors. J Pediatr Surg Sep;50(9):1484-9, 2015. doi: 10.1016/j.jpedsurg.2015.01.005. Epub 2015 Jan 16. PMID 25783402;  PMCID 5218869

Sargar K, Kao SC, Spunt SL, Hawkins D, Parham DM, Coffin C, McCarville MB. MR and CT imaging of low grade fibromyxoid sarcoma in children: A report from the Children’s Oncology Group Study ARST0332. Am J Roentgenol Aug;205(2):414-20, 2015. doi: 10.2214/AJR.14.13972. PMID 26204295; PMCID 4570741

Krafft AJ, Loeffler RB, Song R, Bian X, McCarville MB, Hankins JS, Hillenbrand CM. Does fat suppression via chemically selective saturation (CHESS) affect R2*-MRI based transfusional iron overload assessment? A clinical evaluation at 1.5 and 3 Tesla. Magn Reson Med Aug 26, 2015. doi: 10.1002/mrm.25868. [Epub ahead of print] PMID 26308155; PMCID 4769126

Show More

Lai L, McCarville MB, Sato Y, Kirby P, Kao S, Clark E, Ishigami K, Bahrami A, Moritani T. Shedding light on inflammatory pseudotumor in children: spotlight on inflammatory myofibroblastic tumor. Pediatr Radiol 1-15, 2015, doi: 10.1007/s00247-015-3360-6. PMID 25964134; Cited in PMC Related citations

Ostermeier A, McCarville MB, Navid F, Shulkin BL. 18F-Fluorodeoxyglucose positron-emission tomography/computed tomography scanning for the assessment of desmoplastic small round cell tumors. Pediatr Radiol Aug;45(9):1308-15, 2015. doi: 10.1007/s00247-015-3315-y. Epub 2015 Feb 27. PMID 25721584;  PMCID 4529370

McCarville MB, Muzzafar S, Kao SC, Coffin C, Parham DM, Anderson J,  Spunt SL. Imaging features of alveolar soft part sarcoma: a report from Children’s Oncology Group Study ARST0332. Am J Roentgenol Dec;203(6):1345-52, 2014. doi: 10.2214/AJR.14.12462. PMID 25415714; PMCID 4438280

Coleman JL, Navid F, Furman W, McCarville MB. Safety of ultrasound contrast agents in the pediatric oncologic population: a single institutional experience. Am J Roentgenol May;202(5):966-70, 2014. PMID 24758648; PMCID 4278346 Selected for a Special Focus on Pediatric Imaging Issue of the Am J Roentgenol

Wahid FN, Malkan AD, McCarville MB, Davidoff AM.  Double small bowel intussusception complicating bilateral partial nephrectomies. J Pediatr Surg Case Rep Jan;2(1):30-32, 2014. PMID 24795858

Loh AHP, Wang C, Bahrami A, Navid F, McCarville MB, Wu J, Daw NC, Neel MN, Rao BN. Influence of bony resection margins and surgicopathological factors on outcomes in limb-sparing surgery for pediatric extremity osteosarcoma. Pediatr Blood Cancer Nov 8, 2014. doi: 10.1002/pbc.25307. PMID 25381958; PMCID 4425640 [Epub ahead of print]

Littooij AS, McHugh K, McCarville MB, Sebire N, Bahrami A, Roebuck DJ. Yolk sac tumour: a rare cause of raised AFP in a young child with a large liver mass. Pediatr Radiol Jan;44(1):18-22, 2014. doi: 10.1007/s00247-013-2780-4. Epub 2013 Aug 28. PMID 23982265; PMCID 23982265

Last update: June 2017