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St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
- Fundraising
Norman Davey, PhD
Member, St. Jude Faculty
On this page:
Contact Information
Norman Davey, PhD
Cell & Molecular Biology
MS 340, Room M4421
St. Jude Childen's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678 United States
Affiliations
Education
BSc – Dublin City University, Dublin, Ireland MSc – Dublin City University, Dublin, Ireland PhD – University College Dublin, Dublin, Ireland Postdoctoral Fellow – European Molecular Biology Laboratories (EMBL), Heidelberg, Germany Postdoctoral Fellow – University Of California, San Francisco (UCSF), San Francisco, CA Group Leader – University College Dublin, Dublin, Ireland Group Leader – Institute Of Cancer Research (ICR), London, United Kingdom
Research Interests
- Function of Intrinsically Disordered Regions (IDRs): Investigation of the functional importance of unstructured protein regions, exploring how IDRs mediate protein interactions and contribute to cell physiology despite lacking stable folded structures.
- Short Linear Motifs (SLiMs): Discovery, characterization, and functional analysis of SLiMs within intrinsically disordered regions, with a focus on how these compact protein interaction modules direct cellular regulation.
- SLiM-Mediated Regulation of Key Biological Processes: Characterization of the central role of SLiMs in orchestrating critical cellular processes, including cell cycle progression and host-pathogen interactions, illustrating how these motifs serve as fundamental regulatory switches that are frequently hijacked in disease and infection.
- Therapeutic Relevance of IDRs: Exploration of the therapeutic significance of intrinsically disordered regions, with a focus on pinpointing vulnerabilities within IDR-mediated interaction networks that can be exploited as novel targets for therapeutic intervention in disease.
- High-Throughput Approaches to Protein Interaction and Function: Development and application of high-throughput experimental and computational approaches to systematically characterize protein interactions and function at scale, enabling a deeper and more comprehensive understanding of the molecular mechanisms underlying cellular regulation.