John D. Schuetz, PhD
John D. Schuetz, PhD

John D. Schuetz, PhD

Member, St. Jude Faculty

  • Vice-Chair, Pharmaceutical Sciences Department



PhD – Medical College of Virginia, Richmond (1984)

Honors & Awards

  • 2017  Elected President, ASPET
  • 2016  The Ohio State University Distinguished Lecturer
  • 2015  ASPET Toxicology Career Development Award
  • 2013  Elected Councilor, ASPET
  • 2010  Elected Chair, ASPET Division of Toxicology
  • 2006  Elected AAAS Electorate Nominating Committee of Pharmaceutical Sciences
  • 2002  John Doull Award Lecture
  • 2002  ASBMB nomination          

Research Interests

  • Role of ABC transporters in response to chemotherapy
  • Biological function of ABC transporters
  • Regulation of ABC transporters

Selected Publications

Fukuda Y, Wang Y, Lian S, Lynch J, Nagai S, Fanshawe B, Kandilci A, Janke LJ, Neale G, Fan Y, Sorrentino BP, Roussel MF, Grosveld G, Schuetz JD. Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis. JCI insight 2(15), 2017. Epub 2017/08/05. doi: 10.1172/jci.insight.92409. PMID: 28768907; PMCID: PMC5543914

Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Wang Y, Yu B, Ney P, Vogel P, Ford RC, Trent RJ and Schuetz JD. The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6. Nat Commun Aug 10;7:12353, 2016. doi: 10.1038/ncomms12353. PMCID: PMC4987512

Morgan JA, Lynch J, Panetta JC, Wang Y, Frase S, Bao J, Zhang J, Opferman JT, Janke L, Green DM, Chemaitilly W, Schuetz JD. Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. Sci Rep Nov 18;5:16488, 2015. doi: 10.1038/srep16488. (PMCID:  PMC4649703)

*Cheepala SB, *Pitre A, Fukuda Y, Takenaka K, Zhang Y, Wang Y, Frase S, Pestina T, Gartner TK, Jackson C, Schuetz JD. The ABCC4 membrane transporter modulates platelet aggregation. Blood Nov 12;126(20):2307-19, 2015. (PMCID: PMC4643005) *co-first authorship

Zhang Y, Li F, Wang Y, Fang Z, Frank M, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD. Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun 2015 Sep 29;6:8186, 2015. doi: 10.1038/ncomms9186. 2015 Selected to Faculty 1000 Must Read

Morfouace M, Cheepala S, Jackson S, Albert YP, Kawauchi D, Shelat A, Fukuda Y, Sorrentino B, Schuetz JD*, Roussel MF*. (*co-corresponding authors) ABCG2 transporter expression impacts Group3 Medulloblastoma response to chemotherapy.   Cancer Res Sep 15;75(18):3879-89, 2015. PMCID: PMC4573843

Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Woodrooffe K, Lin S, Schuetz JD, Ziady AG, Naren AP. PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration. Cell Signal Jul;27(7):1345-55, 2015. PMCID: PMC4437852

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Lener D, Stanzl U, Theurl I, Seifert M, Haschka D, Asshoff M, Sichtl S, Nairz M, Huber E, Stadlinger M, Li X, Pallweber P, Scharnagl H, Stojakovic T, Marz W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge U, Trauner M, Norata G, Claudel T, Hicks AA, Weiss G, Tancevski I. The Arachidonic Acid Metabolome as Conserved Regulator of Cholesterol Metabolism. Cell Metab Oct 16; 20(5):787-798, 2014. PMCID: PMC4232508 Featured in “Research Highlight in Nature Reviews Endocrinology

Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP. Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport. Nat Cell Biol Sep; 16(9):841-51, 2014. PMCID: PMC4154319 Featured in News and Views in Nature Cell Biology

Murphy AJ, Sarrezy V, Wang N, Bijl N, Abramowicz S, Welch CB, Schuetz JD, Yuan-Charvet L. Deficiency of ATP binding cassette transporter B6 in Megakaryocyte progenitors accelerates atheroschlerosis in mice. Arterioscler Thromb Vasc Biol 34(4):751-8, 2014. PMID: 24504733

Sinha C, Ren A, Arora K, Moon C-S, Sunitha Y, Zhang W, Schuetz JD, Naren AP. Multidrug Resistance Protein 4 (MRP4) mediated regulation of fibroblast cell migration reflects dichotomous role of cyclic nucleotides. J Biol Chem Feb 8;288(6):3786-94, 2013.

Cheepala S, Hulot J-S, Morgan J, Zhang W, Naren AP, Schuetz JD. Cyclic Nucleotide Compartmentalization: contributions of Phosphodiesterases and ABC transporters. Annu Rev Pharmacol Toxicol 53:231-53, 2013.

Zhang Y, Li F, Patterson AD, Wang Y, Krausz KW, Neale G, Thomas S, Nachagari D, Vogel P, Vore M, Gonzalez FJ, Schuetz JD. Abcb11 Deficiency Induces Cholestasis Coupled to Impaired β-Fatty Acid Oxidation in Mice. J Biol Chem 287(29):24784-94, 2012.

Morgan JA, Cheepala SB, Wang Y, Neale G, Adachi M, Nachagari D, Leggas M, Zhao W, Boyd K, Venkataramanan R, Schuetz JD. Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. J Biol Chem 287(18):14456-66, 2012.

Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagari D, Du G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz JD. ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity. J Biol Chem 287(16):12679-90, 2012.

Fukuda Y, Schuetz JD. ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol 83(8):1073-83, 2012.

Li C, Krishnamurthy PC, Penmatsa H, Marrs KL, Wang XQ, Zaccolo M, Jalink K, Li M, Nelson DJ, Schuetz JD, Naren AP. Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell 131(5):940-51, 2007.

Krishnamurthy P, Du G, Fukuda Y, Sun D, Mercer K, Wang J, Sosa-Pineda B, Murti G, Schuetz JD. Identification of a mitochondrial porphyrin transporter. Nature 443:586-9, 2006. *2006 Featured in Nature 443 “Making the Paper”; 2008 Selected to Faculty 1000 “must read.”

Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology 43(5):1013-21, 2006.

Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 279:24218, 2004.

Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. Interactions between hepatic Mrp4 and Sult2A as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem 279:22250, 2004.

Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, Scheper RJ, Stewart CF, Schuetz JD. Mrp4 confers resistance to topotecan and acts as a double agent in protecting the brain from chemotherapy. Mol Cell Biol 24(17):7612-21, 2004.

Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD and Sorrentino BP1. Bcrp1 Gene Expression is Required for the Presence of Side Population Stem Cells in Murine Bone Marrow. Proc Natl Acad Sci USA 99:12339-44, 2002.

Adachi M, Sampath J, Lan L-B, Tammur J, Sun D, Hargrove P, Flatley R, Tatum A, Allikmets R, Matherly L, Drake R, Schuetz J. MRP4 confers resistance to the cytotoxic effects of the antiviral ganciclovir and plays a role in the bystander effect. J Biol Chem 277(41):38998-9004, 2002.

Zhou S, Schuetz JD, Bunting KD, Colapietro A-M, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. The ABC transporter Bcrp1/ABCB2 is expressed in a wide variety of side population stem cells and inhibits hematpoietic development with enforced expression. Nature Med 7:1028-34, 2001.

Schuetz EG, Yasuda K, Lecureur V, Assem M, Brimer C, Ramchardan V, Strom S, Kim R, Sinal C, Gonzalez F and Schuetz JD. Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction Among Nuclear Hormone Receptors, Transporters and Cytochorme P450. J Biol Chem 276:39411-8, 2001.

Sampath J, Sun D, Kidd VJ, Grenet J, Gandhi A, Shapiro LH, Wang Q, Zambetti GP and Schuetz JD. Mutant p53 cooperates with ETS and selectively upregulates MDR1not MRP1. J Biol Chem 276:39359-67, 2001.

Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A, Fridland A. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 5(9):1048-1051, 1999. *Commentary in: The Lancet: vol 354:pg 923, 1999; AIDS Alert vol 15(2) pg 24, 2000; BioWorld Today Vol 10 (168) pt 1, 1999; ReutersHealth comments: Gene may contribute to HIV resistance Health eLine 1999-08-30.

Lutterbach B, Sun D, Schuetz J, Heibert SW. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21)fusion protein. Mol Cell Biol 18(6):3604-3611, 1998.

Thottassery JV, Zambetti GP, Arimori K, Schuetz EG, Schuetz JD. p53-dependent Regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. Proc Natl Acad Sci 94:11037-11042, 1997.

Last update: September 2017

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