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Barry L. Shulkin, MD
Barry L. Shulkin, MD

Barry L. Shulkin, MD

Member, St. Jude Faculty



BA – University of Texas, Austin, Texas (1974)
MBA – University of Michigan School of Business, Ann Arbor, Michigan (2002)
MD – University of Texas Southwestern Medical School, Dallas, Texas (1978)

Research Interests

  • Use of radioisotopes for the noninvasive detection and management of malignant diseases in childhood
  • Use of positron emitting radiotracer probes to characterize the pathophysiology of malignant diseases in childhood
  • Application of radiopharmaceuticals as therapeutic agents for malignant diseases in childhood
  • Development of new tracers to characterize biologic features of malignant diseases in childhood
  • Characterization of the specific type 1 catecholamine uptake process in neuroendocrine tumors

Selected Publications

Tinkle CL, Duncan ED, Doubrovin M, Han Y, Li Y, Kim H, Broniscer A, Snyder SE, Merchant TE, Shulkin BL.  Evaluation of 11C-methionine PET and anatomic MRI associations in diffuse intrinsic pontine glioma.   J Nucl Med March 1, 2019 (60);3: 312-319

Davis JC, Daw NC, Navid F, Billups CA, Wu J, Bahrami A, Jenkins JJ, Snyder SE, Reddick WE, Santana VM, McCarville MB, Guo J, Shulkin BL.  18F-FDG uptake during early adjuvant chemotherapy predicts histologic response in pediatric and young adult patients with osteosarcoma.  J Nucl Med. 2018 Jan;59(1):25-30

Yanik GA, Parisi MT, Naranjo A, Nadel H, Gelfand MJ, Ladenstein RL, Poetschger U, Boubaker, A Valteau-Couanet A, Lambert B, Castellani MR, Bar-Sever Z, Oudoux A, Kaminska A, Kreissman SG, Shulkin BL, Matthay KK.  Validation of post-induction Curie scores in high-risk neuroblastoma.  A Children’s Oncology Group (COG) and SIOPEN Group report on SIOPEN/HR-NBL1 J Nucl Med. 2018 Mar;59(3):502-508

Bohl CE, Federico SM, Robinson GW, Bahrami A, Shulkin BL.  FDG PET CT in the evaluation of primary and secondary pancreatic malignancies in pediatric patients.  Pediatric Blood Cancer 2018 May 11:e27115. doi: 10.1002/pbc.27115.

Kaste SC, Snyder SE, Metzger ML, Sandlund JT, Howard SC, Krasin M, Shulkin BL.  Comparison of 11-methionine and 18F– FDG PET/CT for staging and followup of pediatric lymphoma.  J Nucl Med 2016; 10.2967/jnumed.116.17864L

Cheuk DK, Sabin ND, Hossain M, Wozniak A, Naik M, Rodriguez-Galindo C, Krasin MJ, Shulkin BL. PET/CT for staging and follow-up of pediatric nasopharyngeal carcinoma. Eur J Nucl Med Mol Imaging April 25, 2012.

Parida L, Morrisson GT, Shammas A, Hossain AK, McCarville MB, Gerstle JT, Charron M, Rao BN,Shulkin BL. Role of lymphoscintigraphy and sentinel lymph node biopsy in the management of pediatric melanoma and sarcoma. Pediatr Surg Int April 22, 2012.

Naranjo A, Parisi MT, Shulkin BL, London WB, Matthay KK, Kreissman SG, Yanik GA. Comparison of I-123-metaiodobenzylguanidine (MIBG) and I-131-MIBG semi-quantitative scores in predicting survival in patients with stage 4 neuroblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer 56(7):1041-5, 2011.

Rogers ZR, Wang WC, Luo Z, Iyer RV, Shalaby-Rana E, Dertinger SD, Shulkin BL, Miller JH, Files B, Lane PA, Thompson BW, Miller ST, Ware RE. Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial. Blood 117(9):2614-17, 2011.

Zukotynski KA, Fahey FH, Kocak M, Alavi A, Wong TZ, Treves ST, Shulkin BL, Haas-Kogan DA, Geyer JR, Vajapeyam S, Boyett JM, Kun LE, Poussaint TY. Evaluation of F-18-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. J Nucl Med 52(2):188-95, 2011.

Hossain AKM, Shulkin BL, Gelfand MJ, Bashir H, Daw NC, Sharp SE, Nadel HR, Dome JS. FDG-positron emission tomography-computerized tomography studies of Wilms' tumor. Eur J Nucl Med Mol Imaging March 2010.

Sharp SE, Shulkin BL, Gelfand MJ, Salisbury S. 123I-MIBG versus 18F-FDG: Which is better, or which can be eliminated? J Nucl Med January 2010.

Show More

Sharp SE, Shulkin BL, Gelfand MJ, Salisbury S, Furman WL. 123I-MIBG scintigraphy and 18F-FDG PET in neuroblastoma. J Nucl Med 50(8):1237-43, 2009.

Shulkin BL, Goodin GS, McCarville MB, Kaste SC, Krasin MJ, Hudson MM, Metzger M. Bone and FDG PET/CT scanning for the assessment of osseous involvement in Hodgkin lymphoma in children and young adults. Leukemia and Lymphoma 50(11):1794-802, 2009.

Shulkin BL, Mandell GA, Cooper JA, Leonard JC, Majd M, Parisi MT, Sfakianakis GN, Balon HR, Donohoe KJ. Procedure guideline for diuretic renography in children 3.0. J Nucl Med Technol 36(3):162-8, 2008.

Rufini V, Shulkin B. The evolution in the use of MIBG in more than 25 years of experimental and clinical applications. Q J Nucl Med Mol Imaging 52(4):341-50, 2008.

Nadel HR, Shulkin B. Pediatric positron emission tomography-computed tomography protocol considerations. Semin Ultrasound CT MR 29(4):271-6, 2008.

Goodin GS, Shulkin BL, Kaufman RA, McCarville MB. PET/CT Characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR 187(4):1124-8, 2006.

Messina JA, Cheng SC, Franc BL, Charron M, Shulkin B, To B, Maris JM, Yanik G, Hawkins RA, Matthay KK. Evaluation of semi-quantitative scoring system for metaiodobenzylguanidine (mIBG) scans in patients with relapsed neuroblastoma. Pediatr Blood Cancer 47(7):865-74, 2006.

Mackie GC, Shulkin BL, Ribeiro RC, Worden FP, Gauger PG, Mody RJ, Connolly LP, Kunter G, Rodriuez-Galindo C, Wallis JW, Hurwitz CA, Schteingart DE. Use of [18F] Fluorodeoxyglucose positron emission tomography in evaluating locally recurrent and metastatic adrenocortical carcinoma. J Clin Endocrin Metabol Jul;91(7):2665-71, 2006.

Tonakie A, Shulkin BL, Sisson JC, Yanik GA, Hutchinson RJ. Radiation-induced osteosarcoma and papillary carcinoma of the thyroid. Clin Nucl Med 31(1):5-8, 2006.

Avram AM, Mackie GC, Schneider BJ, Kalemkerian GP, Shulkin BL. Differentiation between carcinoid and sarcoid with F-18 FDG PET and In-111 pentetreotide. Clin Nucl Med 31(4):197-200, 2006.

Kaste SC, Shulkin BL. 18F-Fluorodeoxyglucose PET/CT in childhood lymphoma. PET Clin 1:265-73, 2006.

Mody RJ, Pohlen JA, Malde S, Strouse PJ, Shulkin BL. FDG PET for the study of primary hepatic malignancies in children. Pediatr Blood Cancer 47(1):51-55, 2006.

Mackie GC, Shulkin BL. Amiodarone-induced hyperthyroidism in a patient with functioning papillary carcinoma of the thyroid and extensive hepatic metastases. Thyroid 15(12):1337-40, 2005.

Schneider BJ, Avram AM, Shulkin BL, Kalemkerian GP. False-positive findings with positron emission tomography in the staging of non-small-cell lung cancer. Clin Advances Hematology & Oncology 3(7) 571-73, 2005.

Brouwers FM, Petricoin EF 3rd,  Ksinantova, L. Breza J, Rajapakse V, Ross S, Johann D, Mannelli M, Shulkin BL, Kvetnansky R, Eisenhofer G, Walther MM, Hitt BA, Conrads TP, Veenstra TD, Mannion DP, Wall MR, Wolfe GM, Fusaro VA, Liotta LA, Pacak K. Low molecular weight proteomic information distinguishes metastatic from benign pheochromocytoma. Endocrine-Related Cancer 12(2):263-272, 2005.

Ilias I, Shulkin B, Pacak K. New functional imaging modalities for chromaffin tumors, neuroblastomas and ganglioneuromas. Trends in Endocrinology & Metabolism 16(2):66-72, 2005.

Jadvar H, Alavi A, Mavi A, Shulkin BL. PET in pediatric diseases. Radiol Clin North Am 43(1):135-153, 2005.

Eisenhofer G, Bornstein SR, Brouwers FM, Cheung NK, Dahia PL, de Krijger RR, Giordano TJ, Greene LA, Goldstein DS, Lehnert H, Manger WM, Maris JM, Neumann HP, Pacak K, Shulkin BL, Smith DI, Tischler AS, Young WF Jr. Malignant pheochromocytoma: current status and initiatives for future progress (review). Endocrine-Related Cancer 11(3):423-436, 2004.

Shulkin BL. PET Imaging in Pediatric Oncology. Pediatr Radiol 34(3):199-204, 2004.

Roberts EG, Shulkin BL. Technical Issues in Performing PET Studies in Pediatric Patients. J Nucl Med Technol 32(1):5-9, 2004.

Miskulin J, Shulkin BL, Doherty GM, Sisson JC, Burney RE, Gauger PG. Is preoperative 123I-MIBG scintigraphy routinely necessary before initial adrenalectomy for pheochromocytoma? Surgery134(6):918-22, 2003.

Thornburg CD, Shulkin BL, Castle VP, McAllister-Lucas LM. Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. Medical & Pediatric Oncology 41(5):468-9, 2003.

Sisson JC, Shulkin BL, Lawson S. Increasing efficacy and safety of treatments of patients with well‑differentiated thyroid carcinoma by measuring body retentions of 131‑I. J Nucl Med 44:898‑903, 2003.Snyder KM. Rubin MA. Shulkin BL. Hutchinson RJ. Wechsler DS. Mediastinal seminoma in a patient with Wiskott-Aldrich syndrome. Journal of Pediatric Hematology/Oncology 24(8):672-6, 2002.

Yanik GA, Levine JE, Matthay KK, Sisson JC, Shulkin BL, Shapiro B, Hubers D, Spalding S, Braun T, Ferrara LM, Hutchinson RJ. Pilot Study of Iodine-131-Metaiodobenzyl guanidine in combination with myeloablative chemotherapy and autologous stem cell support for the treatment of neuroblastoma. J Clin Oncol 20(8): 2142-49, 2002.

Shapiro B, Gross MD, Shulkin B. Radioisotope Diagnosis and Therapy of Malignant Pheochromocytoma. Trends in Endocrinology and Metabolism 12(10):469-75, 2001.

Pacak K, Goldstein, DS, Doppman JL, Shulkin BL, Udelsman R, Eisenhofer G. A “Pheo”lurks: novel approaches for locating occult pheochromocytoma. J Clin Endocrinol Metab 86(8):3641-46, 2001.

Klemptner A, Shulkin BL, Perlman R, Kovach J. Radiotherapy induced hypothyroidism presenting as cardiac tamponade. J Clin Exp Thyroidol 12:13-16, 2000.

Jadvar H, Connolly LP, Shulkin BL, Treves ST, Fischman AJ. Positron Emission Tomography in Pediatrics. Nuclear Medicine Annual 53-83, 2000.

Last update: October 2019