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Deo Kumar Srivastava, PhD
Deo Kumar Srivastava, PhD

Deo Kumar Srivastava, PhD

Member, St. Jude Faculty

Departments

Education

BS – MS University of Baroda, India (1982)
MA – University of Rochester, Rochester, NY (1989)
MS – MS University of Baroda, India (1984)
PhD – University of Rochester (1993)

Research Interests

  • Univariate and multivariate robust inference
  • Robust regression
  • Goodness-of-fit
  • Longitudinal analysis
  • Clinical trials design
  • Survival analysis

Selected Publications

Iijima M, Hyun G, Brinkman TM, Khan RB, Srivastava DK, Robison LL, Hudson MM, Pui CH, Krull KR, Inaba H, Ness KK. Fine motor impairment and its impact on social outcomes in survivors of pediatric acute lymphoblastic leukemia: St Jude Lifetime Cohort Study. Phys Ther Sept 27, 2024. doi: https://doi.org/10.1093/ptj/pzae142

Papini C, Mirzaei SS, Xing M, Tonning Olsson I, Salloum R, de Blank PMK, Lange KR, King TZ, Srivastava D, Leisenring WM, Howell RM, Oeffinger KC, Robison LL, Armstrong GT, Krull KR, Brinkman TM. Neurocognitive outcomes and functional independence in adult survivors of childhood medulloblastoma diagnosed over three decades. Neuro Oncol. 2024 Jul 4:noae119. doi: 10.1093/neuonc/noae119. Epub ahead of print. PMID: 38963825.

Das S, Srivastava DK. ioSearch: An approach for identifying interacting multiomics biomarkers using a novel algorithm with applications on breast cancer data sets. Genetic Epidemiology. [Epub. ahead of print] October 2023. DOI: http://dx.doi.org/10.1002/gepi.22536

Qian C, Srivastava DK, Pan J, Hudson MM, Rai SN. Estimating transition intensity rate on interval censored data using semi-parametric with EM algorithm approach. Communications in Statistics – Theory and Methods, [Epub. ahead of print] August, 2023. DOI: https://doi.org/10.1080/03610926.2023.2239397

Liyanage JSS, Estepp JH, Srivastava DK, Rashkin SR, Sheehan VA, Hankins JS, Takemoto CM, Li Y, Mori M, Burgess S, DeBaun MR, Kang G. A versatile and efficient novel approach for Mendelian randomization analysis with application to assess the causal effect of fetal hemoglobin on anemia in sickle cell anemia. Mathematics, 10(20), 3743, 2022. DOI: https://doi.org/10.3390/math10203743

Kang G, Mirzaei SS, Zhang H, Zhu L, Rai SN, Srivastava DK, Robust Behrens-Fisher statistic based on trimmed means and its usefulness in analyzing high-throughput data. Frontiers in Systems Biology, 2:877601, June 2022, DOI: https://doi.org/10.3389/fsysb.2022.877601

Srivastava DK, George EO, Lu Z, Rai SN. Impact of unequal censoring and insufficient follow-up on comparing survival outcomes: Applications to clinical studies. Statistical Methods in Medical Research, 30(9), 2057-2074, 2021. DOI: https://doi.org/10.1177/09622802211017592 (PMID: 34232837).

Rai SN, Qian C, Pan J, Seth A, Srivastava DK, Bhatnagar A. Statistical design of phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients. BMC Medical Research Methodology, 20(1):220, August 2020. DOI: https://doi.org/10.1186/s12874-020-01101-z (PMID: 32867708).

Zhu L, Tong X, Cai D, Li Y, Sun R, Srivastava DK, Hudson MM. Maximum likelihood estimation for the proportional odds model with mixed interval-censored failure time data. Journal of Applied Statistics, 48(8), 1496-1512, 2021.

Srivastava DK, Zhu L, Hudson M, Pan J, Rai SN. Robust estimation and inference on current status data with applications to phase IV cancer trial. Journal of Modern Applied Statistical Methods, 17(1), Article 18, 2018.

Kang G, Liu W, Cheng C, Wilson CL, Neale G, Yang JJ, Ness KK, Robison LL, Hudson MM, Srivastava DK. Evaluation of a two-step iterative resampling procedure for internal validation of genome-wide association studies. Journal of Human Genetics, 60(12), 729-738, 2015. DOI: https://doi.org/10.1038/jhg.2015.110 (PMID: 26377241).

Rai SN, Ray HE, Pan J, Barnes C, Cambon AC, Wu X, Bonassi S, Srivastava DK. Phase II clinical trials: Issues and practices. Biometrics & Biostatistics International Journal, 1(2), 2014.

Huang IC, Sim JAH, Srivastava DK, Krull KR, Ness KK, Robison LL, Baker JN, Hudson MM, Schwartz CE. Response-shift effects in childhood cancer survivors: A prospective study. Psychooncology, 32(7), 1085-1095, 2023. DOI: https://doi.org/10.1002/pon.6150 (PMID: 37189277).

Song N, Sim JA, Dong Q, Zheng Y, Hou L, Li Z, Hsu CW, Pan H, Mulder H, Easton J, Walker E, Neale G, Wilson CL, Ness KK, Krull KR, Srivastava DK, Yasui Y, Zhang J, Hudson MM, Robison LL, Huang IC, Wang Z. Blood DNA methylation signatures are associated with social determinants of health among survivors of childhood cancer. Epigenetics, 17(11), 1389-1403, e2022. DOI: https://doi.org/10.1080/15592294.2022.2030883.  (PMID: 35109748), (PMCID: PMC9586655).

Shin H, Dudley WN, Bhakta N, Horan MR, Wang Z, Bartlett TR, Srivastava DK, Yasui Y, Baker JN, Robison LL, Ness KK, Krull KR, Hudson MH, Huang IC. Associations of symptom clusters and health outcomes in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study. Journal of Clinical Oncology, 41(3), 497-507, 2023. DOI: https://doi.org/10.1200/jco.22.00361 (PMID: 36166720).

Song N, Dong Q, Chen C, Li Q, Mulder H, Plyler E, Easton J., Walker E, Olson S, Neale G, Krull KR, Srivastava DK, Ness KK, Zhang J, Hudson MM, Robison LL, Huang IC, Wang Z. Social-epigenetic mediator for racial disparities in pulmonary impairments among childhood cancer survivors. Cancer Communications (London, England), 43(2), 290-293, 2023. DOI: https://doi.org/10.1002/cac2.12371 (PMID: 36256508).

Williams AM, Krull KR, Howell CR, Banerjee P, Brinkman TM, Kaste SC, Partin RE, Srivastava DK, Yasui Y, Armstrong GT, Robison LL, Hudson MM, Ness KK. Physiologic frailty and neurocognitive decline among young-adult childhood cancer survivors: A prospective study from the St. Jude Lifetime Cohort. Journal of Clinical Oncology, 39(31), 3485-3496, 2021. DOI: https://doi.org/10.1200/jco.21.00194 (PMID: 34283634).

Jefferies JL, Mazur WM, Howell CR, Plana JC, Ness KK, Li Zhenghong, Joshi VM, Green DM, Mulrooney DA, Towbin JA, Martinez HR, Goldberg JF, Howell RM, Srivastava DK, Robison LL, Hudson MM, Armstrong GT. Cardiac remodeling after anthracycline and radiotherapy exposure in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study. Cancer, 127(24), 4646-4655, 2021. DOI: https://doi.org/10.1002/cncr.33860 (PMID: 34411296).

Ogg S, Kolsky JL, Chemaitilly W, Srivastava DK, Wang Mingjuan, Carney G, Ojha R, Robison LL, Cox CL, Hudson MM. Breastfeeding practices among childhood cancer survivors. Journal of Cancer Survivorship, 14(4), 586-599, 2020. DOI: https://doi.org/10.1007/s11764-020-00882-y (PMID: 32291564).

Brinkman TM, Ness KK, Li Z, Huang IC, Krull KR, Gajjar A, Merchant TE, Klosky JL, Partin RE, Olsson IT, Boop F, Klimo P, Chemaitilly W, Khan RB, Srivastava DK, Robison LL, Hudson MM, Armstrong GT. Attainment of functional and social independence in adult survivors of pediatric CNS tumors: A report from the St. Jude Lifetime Cohort study. Journal of Clinical Oncology, 36(27), 2762-2769, 2018.  DOI: https://doi.org/10.1200/JCO.2018.77.9454 (PMID: 30091946).

Bhakta N, Liu Q, Ness KK, Baassiri M, Eissa H, Yeo F, Chemaitilly W, Ehrhardt MJ, Bass J, Bishop MW, Shelton K, Lu L, Huang S, Li Z, Caron E, Lanctot J, Howell C, Folse T, Joshi V, Green DM, Mulrooney DA, Armstrong GT, Krull KR, Brinkman TM, Khan RB, Srivastava DK, Hudson MM, Yasui Y, Robison LL. The cumulative burden of surviving childhood cancer: an initial report from the St. Jude Lifetime Cohort Study (SJLIFE). Lancet, 390(10112), 2569-2582, 2017. DOI: https://doi.org/10.1016/S0140-6736(17)31610-0 (PMID: 28890157).

Krull KR, Cheung YT, Liu W, Fellah S, Reddick WE, Brinkman TM, Kimberg C, Ogg R, Srivastava DK, Pui CH, Robison LL, Hudson MM. Chemotherapy pharmacodynamics and neuroimaging and     neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia. Journal of Clinical Oncology, 34(22), 2644-2653, 2016. DOI: https://doi.org/10.1200/JCO.2015.65.4574 (PMID: 27269941).

Hu Q, Zhu L, Sun J, Srivastava DK, Robison LL. Nonparametric screening and feature selection for ultrahigh-dimensional case II interval-censored failure time data. Biometrical Journal Jul 16;10.1002/bimj.201900154, 2020.

 doi: 10.1002/bimj.201900154.Zhu L, Tong X, Cai D, Li Y, Sun R, Srivastava DK, Hudson MM. Maximum likelihood estimation for the proportional odds model with mixed interval-censored failure time data. Journal of Applied Statistics 48(8):1496-1512, 2020.

Yen HJ, Eissa HM, Bhatt NS, Huang S, Ehrhardt MJ, Bhakta N, Ness KK, Krull KR, Srivastava DK, Robison LL, Hudson MM, Huang IC. Pateint-reported outcomes in survivors of childhood hematologic malignancies with hematopoietic stem cell transplant. Blood May 21, 135(21), 1847-1858, 2020. DOI: https://doi.org/10.1182/blood.2019003858 (PMID: 32243495).

Karlson CW, Alberts NM, Liu W, Brinkman TM, Annett RD, Mulrooney DA, Schulte F, Leisenring WM, Gibson TM, Howell RM, Srivastava DK, Oeffinger KC, Robison LL, Armstrong GT, Zelter LK, Krull KR. Longitudinal pain and pain interference in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer Jun 15; 126(12): 2915-2923, 2020. DOI: https://doi.org/10.1002/cncr.32853 PMID: 32227649

Phillips NS, Hillenbrand CM, Mitrea BG, Yan J, Li C, Scoggins MA, Merchant TE, Armstrong GT, Srivastava DK, Pui CH, Robison LL, Hudson MM, Krull KR, Sabin ND. Cerebral micorbleeds in adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation. Scientific Report 10(1):692, 2020, DOI: https://doi.org/10.1038/s41598-020-57682-8. PMID: 31959839

Olsson IT, Lubas MM, Li C, Mandrell BN, Banerjee P, Howell CR, Ness KR, Srivastava DK, Robison LL, Hudson MM, Krull KR, Brinkman TM. Insomnia and neurocognitive functioning in adult survivors of childhood cancer. JNCI Cancer Spectrum Feb 19; 4(3): pkaa008, 2020. DOI: https://doi.org/10.1093/jncics/pkaa008 PMID: 32382693

Ogg S, Kolsky JL, Chemaitilly W, Srivastava DK, Wang Mingjuan, Carney G, Ojha R, Robison LL, Cox CL, Hudson MM. Breastfeeding practices among childhood caner survivors. Journal of Cancer Survivorship Apr 14, 2020. DOI: https://doi.org/10.1007/s11764-020-00882-y (PMID: 32291564).

Ness KK, Plana JC, Joshi VM, Luepker RV, Durand JB, Green DM, Partin RE, Santucci AK, Howell RM, Srivastava DK, Hudson MM, Robison LL, Armstrong GT. Exercise intolerance, mortality, and organ system impairment in adult survivors of childhood cancer. Journal of Clinical Oncology 38(1);29-42, 2020. DOI: https://doi.org/10.1200/JCO.19.01661 (PMID: 31622133).

Chemaitilly W, Liu Q, van Iersel L, Ness KK, Li Z, Wilson CL, Brinkman TM, Klosky JL, Barnes N, Clark KL, Howell RM, Smith SA, Krasin MJ, Metzger ML, Armstrong GT, Bishop MW, van Santen HM, Pui CH, Srivastava DK, Yasui Y, Hudson MM, Robison LL, Green DM, Sklar CA. Leydig cell function in male survivors of childhood cancer: A report from the St. Jude Lifetime Cohort study. Journal of Clinical Oncology 37(32): 3018-3031, 2019. DOI: https://doi.org/10.1200/JCO.19.00738 PMID: 31557085

Banerjee P, Rossi MG, Anghelescu DL, Wei L, Breazeale AM, Reddick WE, Glass JO, Phillips NS, Jacola LM, Sabin ND, Inaba H, Srivastava DK, Robison LL, Pui CH, Hudson MM, Krull KR. Association between anesthesia exposure and neurocognitive and neuroimaging outcomes in long-term survivors of childhood Acute Lymphoblastic Leukemia. JAMA Oncology June 2019. DOI: https://doi.org/10.1001/jamaoncol.2019.1094 PMID: 31219514

van Iersel L, Li Z, Srivastava DK, Brinkman TM, Bjornard KL, Wilson CL, Green DM, Merchant TE, Pui CH, Howell RM, Smith SA, Armstrong GT, Hudson MM, Robison LL, Ness KK, Gajjar A, Krull KR, Sklar CA, van Santen HM, Chemaitilly W. Hypothalamic-pituitary disorders in childhood cancer survivors: prevalence, risk factors and long-term health outcomes. The Journal of Clinical Endocrinology and Metabolism 104(12): 6101-6115, 2019. DOI: https://doi.org/10.1210/jc.2019-00834 PMID: 31373627

Huang IC, Bhakta N, Brinkman TM, Klosky JL, Krull KR, Srivastava DK, Hudson MM, Robison LL. Determinants and consequences of financial hardship among adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort study. Journal of the National Cancer Institute 111(2):189-200, 2019. DOI: https://doi.org/10.1093/jnci/djy120 PMID: 30085213

Brinkman TM, Ness KK, Li Z, Huang IC, Krull KR, Gajjar A, Merchant TE, Klosky JL, Partin RE, Olsson IT, Boop F, Klimo P, Chemaitilly W, Khan RB, Srivastava DK, Robison LL, Hudson MM, Armstrong GT. Attainment of functional and social independence in adult survivors of pediatric CNS tumors: A report from the St. Jude Lifetime Cohort study. Journal of Clinical Oncology 36(27):2762-2769, 2018.  DOI: https://doi.org/10.1200/JCO.2018.77.9454 PMID: 30091946

Srivastava DK, Zhu L, Hudson M, Pan J, Rai SN. Robust estimation and inference on current status data with applications to phase IV cancer trial. Journal of Modern Applied Statistical Methods 17(1):18, 2018.

Rai SN, Ray HE, Pan J, Barnes C, Cambon AC, Wu X, Bonassi S, Srivastava DK. Phase II clinical trials: Issues and practices. Biometrics & Biostatistics International Journal 1(2), 2014.

Zhu L, Tong X, Sun J, Chen M, Srivastava DK, Leisenring W, Robison LL. Regression analysis of mixed recurrent-event and panel-count data. Biostatistics 15(3):555-568, 2014.    

Mudholkar GS, Srivastava DK, Marchetti CE, Mudholkar AG. Trimmed analysis of variance: A robust modification of ANOVA. Some Recent Advances in Mathematics and Statistics, Editor: Yogendra P Chaubey, World Scientific, Singapore, 150-168, 2013.

Rai SN, Pan J, Yuan X, Sun J, Hudson MM, Srivastava DK. Estimating incidence rate on current status data with application to a phase IV cancer trial. Communications in Statistics – Theory and Methods 42:3117-3133, 2013.

Zhu L, Tong X, Zhao H, Sun J, Srivastava DK, Leisenring W, Robison LL. Statistical analysis of mixed recurrent event data with application to cancer survivor study. Statistics in Medicine 32(11):1954-1963, 2013.

Zhu L, Sun J, Tong X, Srivastava DK. Regression analysis of multivariate recurrent event data with a dependent terminal event. Lifetime Data Analysis 16(4):478-490, 2010.

Srivastava DK, Jianmin P, Sarkar I, Mudholkar GS. Robust Winsorized regression using Bootstrap approach. Communications in Statistics – Simulation and Computation 39(1):45-67, 2010.

Srivastava DK, Rai SN, Pan J. Robustness of an odds-ratio test in a stratified group sequential trial with a binary outcome measure. Biometrical Journal 49(3):351-364, 2007.

Srivastava DK, Boyett JM, Jackson CW, Tong X, Rai SN.  A comparison of permutation Hotelling’s T2 test and Log-Ratio test for analyzing compositional data.  Communications in Statistics – Theory and Methods 36(2):415-431, 2007.

See full list of publications

Last update: October 2024

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