Cliff Takemoto, MD
Cliff Takemoto, MD

Cliff Takemoto, MD

Member, St. Jude Faculty

  • Director, Clinical Hematology

Departments

Divisions

Education

BS (Biochemistry) - University of California at Davis, Davis
MD (Medicine) - University of California at Irvine, Irvine
Internship (Pediatrics) - The Children’s Hospital of Los Angeles, Los Angeles
Resident (Pediatrics) - The Children’s Hospital of Los Angeles, Los Angeles
Research Fellow (Hematology/Oncology) - Department of Virology at the National Children’s Medical Research Center, Tokyo, Japan
Fellow (Pediatric Hematology/Oncology) - Boston Children’s Hospital/Dana-Farber Cancer Institute, Boston

Research Interests

  • Hemostasis and thrombosis
  • Vascular malformations
  • Bone marrow failure

Selected Publications

Darbari I, Jacobs E, Gordon O, Weiss D, Winship K, Casella JF, Strouse JJ, Takemoto CM. Correlates of successful transition in young adults with sickle cell disease. Pediatr Blood Cancer  2019 Aug 20:e27939. doi: 10.1002/pbc.27939

Goel R, Chopra S, Tobian AAR, Ness PM, Frank SM, Cushing M, Vasovic L, Kaicker S, Takemoto C, Josephson CD, Nellis M, Bussel J, Krishnamurti L. Platelet transfusion practices in immune thrombocytopenia related hospitalizations. Transfusion 2018.

Thimm MA, Rhee D, Takemoto CM, Karnsakul W, Cuffari C, Guerrerio AL, Garcia A, Gearhart J, Huisman TAGM, Hwang M. Diagnosis of congenital and acquired focal lesions in the neck, abdomen, and pelvis with contrast-enhanced ultrasound: a pictorial essay. Eur J Pediatr 177:1459-1470, 2018.

Ronda J, Nord A, Arrington-Sanders R, Naik R, Takemoto CM, Baskin J, Lanzkron S, Pecker LH. Challenges in the management of the transgender patient with sickle cell disease. Am J Hematol 93:E360-E362, 2018.

Zheng G, Streiff MB, Allison D, Takemoto CM, Salimian K, Morris P, Jani J, McCord R, Kickler TS. A novel diagnostic algorithm for heparin-induced thrombocytopenia. Int J Lab Hematol 2018.

Goel R, Patel EU, Cushing MM, Frank SM, Ness PM, Takemoto CM, Vasovic LV, Sheth S, Nellis ME, Shaz B, Tobian AAR. Association of Perioperative Red Blood Cell Transfusions With Venous Thromboembolism in a North American Registry. JAMA Surg 153:826-833, 2018.

Palam LR, Mali RS, Ramdas B, Srivasa SN, Visconte V, Tiu R, Vanhaesebroek B, Roers A, Gerbaulet A, Xu M, Jnga SC, Takemoto C, Paczesny S, Kapur R. Loss of epigenetic regulator Tet2 and oncogenic KIT regulate myeloid cell transformation via PI3Kinase pathway. JCI Insight 3(4):94679, 2018. doi 10.1172/jci.insight.94679

Alder JK, Hanumanthu VS, Strong MA, Stanley SE, DeZern AE, Takemoto CM, Danilova L, Applegate CD, Bolton S, Mohr D, Brodsky RA, Casella JF, Greider C, Jackson JB, Armanios M. Diagnostic utility of telomere length testing in a hospital-based setting. Proc Natl Acad Sci U S A  115:E2358-E2365, 2018.

Bishop JC, Britton FB, Murphy AM, Sule S, Mitchell S, Takemoto C, Collaco JM, Karnsakul W, Cuffari C, Deitz E, Bodurtha J. Juvenile Idiopathic Arthritis associated with Combined JP-HHT Syndrome: A Novel Phenotype Associated with a Novel Variant in SMAD4. J Pediatric Genetics 2018 (in press).

Atchison CM, Amankwah E, Wilhelm J, Arlikar S, Branchford BR, Stock A, Streiff M, Takemoto C, Ayala I, Everett A, Stapleton G, Jacobs ML, Jacobs JP, Goldenberg NA. Risk factors for hospital-associated venous thromboembolism in critically ill children following cardiothoracic surgery or therapeutic cardiac catheterisation. Cardiol Young 1-9, 2017.

Zheng G, Streiff MB, Takemoto CM, Bynum J, Gelwan E, Jani J, Judge D, Kickler TS. The Clinical Utility of the Heparin Neutralization Assay in the Diagnosis of Heparin-Induced Thrombocytopenia. Clin Appl Thromb Hemost 24(5):749-754, 2018. doi: 10.1177/1076029617721013

Yang W, Porras J, Xu R, Takemoto CM, Garzon-Muvdi T, Caplan JM, Colby GP, Coon AL, Tamargo RJ, Huang J, Ahn ES. Effectiveness of Surgical Revascularization for Stroke Prevention in Pediatric Patients with Sickle Cell Disease (SCD) and Moyamoya Syndrome (MMS).  J Neurosurg Pediatr 20(3):232-238, 2017.

Hampton K, Chowdary P, Dunkley S, Ehrenforth S, Jacobsen L, Neff A, Santagostino E, Sathar J, Takedani H, Takemoto CM, Negrier C. First report on the safety and efficacy of an extended half-life glycoPEGylated recombinant FVIII for major surgery in severe haemophilia A. Haemophilia 23(5):689-696, 2017.

Gamper CJ, Takemoto CM, Chen AR, Symons HJ, Loeb DM, Casella JF, Dezern AE, King KE, McGonigle AM, Jones RJ, Brodsky RA. High-dose Cyclophosphamide is Effective Therapy for Pediatric Severe Aplastic Anemia. J Pediatr Hematol Oncol 38:627-635, 2016.

Yen J, Van Arendonk KJ, Streiff MB, McNamara L, Stewart FD, Conner KG, Thompson RE, Haut ER, Takemoto CM.* Risk Factors for Venous Thromboembolism in Pediatric Trauma Patients and Validation of a Novel Scoring System: The Risk of Clots in Kids With Trauma Score. Pediatr Crit Care Med 17:391-399, 2016. *corresponding author

Goel R, King KE, Takemoto CM, Ness PM, Tobian AA. Prognostic risk-stratified score for predicting mortality in hospitalized patients with thrombotic thrombocytopenic purpura: nationally representative data from 2007 to 2012. Transfusion 56:1451-1458, 2016.

Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen SR, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber TA, Golub TR, Stegmaier K, Loh ML. The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet 47:1326-1333, 2015.

Arlikar SJ, Atchison CM, Amankwah EK, Ayala IA, Barrett LA, Branchford BR, Streiff MB, Takemoto CM, Goldenberg NA. Development of a new risk score for hospital-associated venous thromboembolism in critically-ill children not undergoing cardiothoracic surgery. Thromb Res 136:717-722, 2015.

Brigham EP, McCormack MC, Takemoto CM, Matsui EC. Iron status is associated with asthma and lung function in US women. PLoS One 10:e0117545, 2015.

Goel R, Ness PM, Takemoto CM, Krishnamurti L, King KE, Tobian AA. Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality. Blood 125:1470-1476, 2015.

Trucco M, Lehmann CU, Mollenkopf N, Streiff MB, Takemoto CM.* Retrospective cohort study comparing activated partial thromboplastin time versus anti-factor Xa activity nomograms for therapeutic unfractionated heparin monitoring in pediatrics. J Thromb Haemost 13:788-794, 2015. *corresponding author

Hayashi M, Strouse JJ, Veltri MA, Curtis BR,Takemoto CM. Immune thrombocytopenia due to Trimethoprim-Sulfamethoxazole; under-recognized adverse drug reaction in children? Pediatr Blood Cancer 62:922-923, 2015.

Takemoto CM*, Sohi S, Desai K, Bharaj R, Khanna A, McFarland S, Klaus S, Irshad A, Goldenberg NA, Strouse JJ, Streiff MB. Hospital-associated venous thromboembolism in children: incidence and clinical characteristics. J Pediatr 164:332-338, 2014. *corresponding author

Oh SY, Brandal S, Kapur R, Zhu Z, Takemoto CM.* Global microRNA expression is essential for murine mast cell development in vivo. Exp Hematol 42:919-23.e1, 2014. *corresponding author

Amankwah EK, Atchison CM, Arlikar S, Ayala I, Barrett L, Branchford BR, Streiff M, Takemoto C, Goldenberg NA. Risk factors for hospital-associated venous thromboembolism in the neonatal intensive care unit. Thromb Res 134:305-309, 2014.

Atchison CM, Arlikar S, Amankwah E, Ayala I, Barrett L, Branchford BR, Streiff M, Takemoto C, Goldenberg NA. Development of a new risk score for hospital-associated venous thromboembolism in noncritically ill children: findings from a large single-institutional case-control study. J Pediatr 165:793-798, 2014.

McCrory MC, Strouse JJ, Takemoto CM, Easley RB. Computerized physician order entry improves compliance with a manual exchange transfusion protocol in the pediatric intensive care unit. J Pediatr Hematol Oncol 36:143-147, 2014.

Zhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z. SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis. PLoS One 8:e55763, 2013.

Takemoto CM, Streiff MB, Shermock KM, Kraus PS, Chen J, Jani J, Kickler T. Activated partial thromboplastin time and anti-xa measurements in heparin monitoring: biochemical basis for discordance. Am J Clin Pathol 139:450-456, 2013.

Esquilin JM, Takemoto CM, Green NS. Female factor IX deficiency due to maternally inherited X-inactivation. Clin Genet 82:583-586, 2012.

Hu P, Carlesso N, Xu M, Liu Y, Nebreda AR, Takemoto C, Kapur R. Genetic evidence for critical roles of P38alpha protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms. J Biol Chem 287:20258-20269, 2012.

Darbari DS, Desai D, Arnaldez F, Desai K, Kallen J, Strouse J, Streiff MB, Hong K, Takemoto CM.* Safety and efficacy of catheter directed thrombolysis in children with deep venous thrombosis. Br J Haematol 159:376-378, 2012. *corresponding author

Last update: September 2019