In order for our site to display correctly you will need a newer version of your web browser.
The following browsers support numerous web standards including CSS,XHTML, and the DOM (a universal means of controlling the behavior of web pages):
- Netscape v7 or higher (all platforms), Mozilla FireFox (Windows), Camino (Mac OS X), Galeon (Linux GNOME Desktop) or other browser stemming from the Mozilla.org project.
- Opera v7 or higher (Windows, Linux)
- Apple's Safari (Mac OS X)
- Konqueror (Linux KDE Desktop)
- Microsoft Internet Explorer v6 or higher (Windows) or v5 or higher (Macintosh)
Please note that this is not intended be an exhaustive list of browsers that support web standards, nor a test of browser compliance, nor a side-by-side comparison of various manufacturers’ browsers.
Finding Cures. Saving Children.
Hongbo Chi, PhD
Assistant Member, St. Jude Faculty
Departments
Immunology
Contact Information
Hongbo Chi, PhD
Immunology
MS 351, Room E7052
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: hongbo.chi@stjude.org
Phone: (901) 595-6282
FAX: (901) 595-5766
Education
PhD - University of Rochester, Rochester, NY (2000)
Research Interests
Cellular Signaling in the Innate and Adaptive Immune Systems
We utilize a combination of approaches including mouse genetics, cellular immunology and biochemistry to dissect cellular signaling pathways in immune regulation. We also investigate molecular mechanisms of autoimmune and infectious diseases (multiple sclerosis, colitis, lupus and Listeriosis). Our specific interests include the following:
- Role of the JNK and p38 MAP kinase (MAPK) pathway in T cell development, activation and differentiation (Nature Immunology 8:1236, 2007; Nature Immunology 7:851, 2006; EMBO J. 23:1576, 2004).
- Role of sphingosine 1-phosphate signaling (S1P) and Akt-mTOR in T cell trafficking and regulatory T cell biology (Nature Immunology 10:769, 2009; Journal of Immunology 174:2485, 2005).
- Regulation of the JNK and p38 MAP kinase (MAPK) pathway in Toll-like receptor (TLR) signaling and functioning of macrophages and dendritic cells (PNAS 103:2274, 2006).
Selected Publications
Liu G, Burns S, Huang G, Boyd K, Proia, RL, Flavell RA, Chi H. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol 10:769-777, 2009. (see “News and Views” by Ohkura N & Sakaguchi S. Nat Immunol 10:685-686, 2009; and “Research Highlights,” Nat Rev Immunol 9:534, 2009).
Huang G, Shi LZ, Chi H. Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination (invited review article). Cytokine 48:161-169, 2009.
Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A. Loss of Mitogen-activated Protein Kinase Kinase Kinase 4 Reveals a Requirement for MAPK Signalling in Mouse Sex Determination. Plos Biol 7:e1000196, 2009.
Chi H, Flavell RA. Acetylation of MKP-1 and the control of inflammation. Sci Signal 1:pe44, 2008.
Chi H, Flavell RA. Innate recognition of non-self nucleic acids. Genome Biol 9:211, 2008.
Menon S*, Chi H*, Zhang H, Deng X, Flavell RA, Wei N. (*equal contribution) COP9 Signalosome subunit 8 (Csn8) is essential for peripheral T cell homeostasis and antigen receptor-induced cell cycle entry from quiescence. Nat Immunol 8:1236-1245, 2007.
Chi H, Flavell RA. Immunology: sensing the enemy within. Nature 448:423-424, 2007.
Chi H, Bennett AM, Flavell RA. MAP Kinase phosphatase 1 (MKP-1), a critical regulator of innate immune responses (review article). J Organ Dysfunct 3:72-81, 2007.
Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Both epigenetic and transcriptional programs contribute to default IFN-γ production by γδ T cells. J Immunol 178:2730-2736, 2007.
Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA 103:2274-2279, 2006. (Selected by Research Highlights, Nat Rev Immunol 6:170-171, 2006).
Wan YY*, Chi H*, Xie M, Schneider MD, Flavell RA. (*equal contribution) The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol 7:851-858, 2006.
Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA Rakic P. MEKK4 signaling regulates filamin expression and neuronal migration. Neuron 52:789-801, 2006.
He Y, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, Alitalo K, Min W. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest 116:2344-2355, 2006.
Chi H, Flavell RA. Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1. J Immunol 174:2485-2488, 2005. (Selected by Research Highlights, Nat Rev Immunol 5:266, 2005).
Chi H*, Sarkisian MR*, Rakic P, Flavell RA. (*equal contribution) Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci USA 102:3846-3851, 2005.
Gao Y, Tao J, Li MO, Zhang D, Chi H, Henegariu O, Kaech S, Davis RJ, Flavell RA, Yin Z. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol 175:5783-5789, 2005.
Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA. GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNγ production in T cells. EMBO J 23:1576-1586, 2004.
Last update: November 2009
