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Chi-Lun Chang, PhD
Chi-Lun Chang, PhD

Chi-Lun Chang, PhD

Assistant Member, St. Jude Faculty



Postdoctoral Associate - HHMI - Janelia Research Campus, Ashburn, Virginia, USA
PhD - University of Texas Southwestern Medical Center, Dallas, Texas, USA
MS - National Taiwan University, Taipei, Taiwan
BS - National Taiwan University, Taipei, Taiwan

Research Interests

  • Spatial-temporal regulation of energy homeostasis at lipid droplet-organelle contact sites
  • Dynamic organization of ER-Golgi secretory compartments
  • Alteration of inter-organelle communication in neurological diseases

Selected Publications

Weigel AV *, Chang CL *, Shtengel G, Xu CS, Hoffman DP, Freeman M, Iyer N, Aaron J, Khuon S, Bogovic J, Qiu W, Hess HF, Lippincott-Schwartz J. ER to Golgi protein delivery through an interwoven, tubular network extending from ER. Cell. 184: 1-18. 2021. (*Equal contribution)

Hoffman DP, Shtengel G, Xu CS, Campbell KR, Freeman M, Wang L, Milkie DE, Pasolli HA, Iyer N, Bogovic JA, Stabley DR, Shirinifard A, Pang S, Peale D, Schaefer K, Pomp W, Chang CL, Lippincott-Schwartz J, Kirchhausen T, Solecki DJ, Betzig E, Hess H. Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells. Science 367(6475):eaaz5357, 2020. (recommended by F1000Prime)

Chang CL, Weigel AV, Ioannou MS, Pasolli HA, Xu CS, Peale DR, Shtengel G, Freeman M, Hess HF, Blackstone C, Lippincott-Schwartz L. Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III. Journal of Cell Biology 218(8):2583-99, 2019. (highlighted by JCB Spotlights & preLights; recommended by F1000Prime)

Ioannou MS, Jackson J, Sheu SH, Chang CL, Weigel AV, Liu H, Pasolli HA, Xu CS, Pang S, Mattheis D, Hess HF, Lippincott-Schwartz J, Liu Z. Neuron-astrocyte metabolic coupling during neuronal stimulation protects against fatty acid toxicity. Cell 177(6):1522-35, 2019. (recommended by F1000Prime)

Chang CL, Cheng YJ, Quintanilla CG, Hsieh TS, Liou J. EB1 binding restricts STIM1 translocation to ER–PM junctions and regulates store-operated Ca2+ entry. Journal of Cell Biology 217(6):2047-58, 2018. (highlighted by JCB Spotlights)

Chang CL, Cheng YJ, Liou J. ER-plasma membrane junctions: Why and how do we study them? BBA – Molecular Cell Research 1864(6):1496-1506, 2017. (Invited Review for the special issue of “Membrane Contact Sites”)

Hsieh TS, Chen YJ, Chang CL, Lee WR, Liou J. Cortical actin contributes to spatial organization of ER-PM junctions. Molecular Biology of the Cell 28(23):3171-80, 2017. (recommended by F1000Prime)

Chen YJ, Chang CL, Lee WR, Liou J. RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2. Journal of Cell Biology 216(7):2011-25, 2017. (highlighted by JCB Spotlights)

Chang CL, Liou J. Homeostatic Regulation of the PI(4,5)P2-Ca2+ Signaling System at ER-PM Junctions. BBA – Molecular and Cell Biology of Lipids. 1861(8B):862-73, 2016. (Invited Review for the special issue of “The Cellular Lipid Landscape”)

Chang CL, Liou J. Phosphatidylinositol 4,5-bisphosphate Homeostasis Regulated by Nir2 and Nir3 at Endoplasmic Reticulum Plasma Membrane Junctions. Journal of Biological Chemistry 290(23):14289-301, 2015.

Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN. Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance. Cell 160(4):595-606, 2015. (recommended by F1000Prime)

Chang CL, Hsieh TS, Yang TT, Rothberg KG, Azizoglu DB, Volk E, Liao JC, Liou J. Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at ER-PM Junctions. Cell Reports 5(3):813-825, 2013. (recommended by F1000Prime)

YL Huang YL, Chang CL, Tang CH, Lin YC, Ju TK, Huang WP, Lee H. Extrinsic Sphingosine 1-Phosphate Activates S1P5 and Induces Autophagy through Generating Endoplasmic Reticulum Stress in Human Prostate Cancer PC-3 Cells. Cell Signaling 26(3):611-618, 2014.

SA Arnold SA, Rivera LB, Carbon JG, Toombs JE, Chang CL, Bradshaw AD, Brekken RA. Losartan Slows Pancreatic Tumor Progression and Extends Survival of SPARC-Null Mice by Abrogating Aberrant TGFβ Activation. PLoS ONE 7(2):e31384, 2012.

Last update: April 2021