Education
MS - Tufts New England Medical Center, Boston, Massachusetts
Clinical Fellowship - Tufts New England Medical Center, Boston, Massachusetts
Postdoctoral Fellowship - Dana Farber Cancer Institute, Boston, Massachusetts
MPH - Harvard School of Public Health, Boston, Massachusetts
MD - University of North Carolina, Chapel Hill, North Carolina
BS - Davidson College, Davidson, North Carolina
Research Interests
- Methodological approaches to the classification of cancer
- Computational techniques in the analysis of nucleic acids
- Biomarker development and commercialization
- Clinical management of thyroid malignancies
- Clinical management of aerodigestive cancers
- Clinical management of salivary cancer
Selected Publications
The Cancer Genome Atlas Research Network (Unordered Contributors) McLendon R, … Hayes DN (Member of the Writing Committee) … Thomson E. Comprehensive Genomic Characterization Defines Human Glioblastoma Genes and Core Pathways. Nature. 2008 Oct 23; 455(7216):1061-8. Erratum in: Nature. 2013 Feb 28; 494(7438):506. PMID: 18772890. PMCID: 2671642.
Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller R, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O'Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN; Cancer Genome Atlas Research Network. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR and NF1. Cancer Cell. 2010 Jan 19; 17(1):98-110. PMID: 20129251. PMCID: 2818769.
The Cancer Genome Atlas Research Network: (Unordered Contributors), Koboldt DC, … Hayes DN (Member of the Writing Committee and Disease Working Group), … Palchik JD. Comprehensive Genomic Characterization of Squamous Cell Lung Cancers. Nature. 2012 Sep 27; 489(7417):519-25. PMID: 22960745. PMCID: 3466113.
Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RGW, Meyerson M, Hoadley KA, Hayes DN, Perou CM, Ding Li, Van Den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, and Aldape K. Cancer Genome Atlas Research Network. Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma*. Cancer Cell. 2010 May 18; 17(5):510-22. PMID: 20399149. PMCID: 2872684. *Selected by Faculty of 1000 on August 22, 2010
Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L; TCGA Research Network. The Somatic Genomic Landscape of Glioblastoma. Cell. 2013 Oct 10; 155(2):462-77. PMID: 24120142. PMCID: 3910500.
International Cancer Genome Consortium (Unordered Contributors), Hudson TJ, … Hayes DN (Member of the Tissue and Clinical Annotation Working Group), … Yang H. International Network of Cancer Genome Projects. Nature. 2010 April 15: 464 (7291):993-8. Erratum in: Nature. 2010 Jun 17; 465(7300):966. PMID: 20393554. PMCID: 2902243.
Cancer Genome Atlas Research Network (Unordered Contributors), …Hayes DN, … Zou L. Integrated Genomic Characterization of Papillary Thyroid Carcinoma. Cell. 2014 Oct 23; 159(3):676-90. DOI: 10.1016/j.cell.2014.09.050. PMID: 25417114. PMCID: 4243044.
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. LKB1 Modulates Lung Cancer Differentiation and Metastasis. Nature. 2007 Aug 16; 448(7155):807-10. Epub 2007 Aug 5. PMID: 17676035.
Akbay EA, Koyama S, Carretero J, Altabef A, Tchaicha JH, Christensen CL, Mikse OR, Cherniack AD, Beauchamp EM, Pugh TJ, Wilkerson MD, Fecci PE, Butaney M, Reibel JB, Soucheray M, Cohoon TJ, Janne PA, Meyerson M, Hayes DN, Shapiro GI, Shimamura T, Sholl LM, Rodig SJ, Freeman GJ, Hammerman PS, Dranoff G, Wong KK. Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors. Cancer Discov. 2013 Dec; 3(12):1355-63. DOI: 10.1158/2159-8290.CD-13-0310. PMID: 24078774. PMCID: 3864135.
George J, … Hayes DN, … Thomas RK. Comprehensive Genomic Profiles of Small Cell Lung Cancer. Nature. 2015 Aug 6; 524(7563): 47-53. DOI: 10.1038/nature14664. PMID: 26168399. PMCID: 4861069.
Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, Gao P, Woo MS, Xu C, Yanagita M, Altabef A, Wang S, Lee C, Nakada Y, Peña CG, Sun Y, Franchetti Y, Yao C, Saur A, Cameron MD, Nishino M, Hayes DN, Wilkerson MD, Roberts PJ, Lee CB, Bardeesy N, Butaney M, Chirieac LR, Costa DB, Jackman D, Sharpless NE, Castrillon DH, Demetri GD, Jänne PA, Pandolfi PP, Cantley LC, Kung AL, Engelman JA, Wong KK. A Murine Lung Cancer Co-Clinical Trial Identifies Genetic Modifiers of Therapeutic Response. Nature. 2012 Mar 18; 483(7391):613-7. PMID: 22425996. PMCID: 3385933.
Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L; TCGA Research Network. The Somatic Genomic Landscape of Glioblastoma. Cell. 2013 Oct 10; 155(2):462-77. PMID: 24120142. PMCID: 3910500.
Hughes C, Rozenblatt-Rosen O, Copeland TD, Levine S, Lee J, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF, Hayward NK, Hess JL, Meyerson M. Menin Associates with a Trithorax Family Histone Methyltransferase Complex and with the hoxc8 locus. Mol Cell. 2004 Feb 27; 13(4):587-97. PMID: 14992727.
Hughes C, Rozenblatt-Rosen O, Copeland TD, Levine S, Lee J, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF, Hayward NK, Hess JL, Meyerson M. Menin Associates with a Trithorax Family Histone Methyltransferase Complex and with the hoxc8 locus. Mol Cell. 2004 Feb 27; 13(4):587-97. PMID: 14992727.
Last update: June 2018