Hiroto Inaba, MD, PhD
Hiroto Inaba, MD, PhD

Hiroto Inaba, MD, PhD

Member, St. Jude Faculty

Departments

Divisions

Education

MD – Mie University School of Medicine, Japan
PhD – Mie University School of Medicine, Japan

Honors & Awards

  • 2013  Joseph V. Simone, MD Golden Apple Award, St. Jude Children’s Research Hospital
  • 2011  Outstanding Physician Award, St. Jude Children’s Research Hospital

Research Interests

  • Total therapy for acute lymphoblastic leukemia/lymphoma
  • New therapeutic strategies for leukemia/lymphoma

Selected Publications

Browne EK, Zhou Y, Chemaitilly W, Panetta JC, Ness KK, Kaste SC, Cheng C, Relling MV, Pui CH, Inaba H. Changes in body mass index, height, and weight in children during and after therapy for acute lymphoblastic leukemia. Cancer 2018. [Epub ahead of print]

Alexander TB, Gu Z, Iacobucci I, Dickerson K, Choi JK, Xu B, Payne-Turner D, Yoshihara H, Loh ML, Horan J, Buldini B. Basso G, Elitzur S, de Haas V, Zwaan CM, Yeoh A, Reinhardt D, Tomizawa D, Kiyokawa N, Lammens T, De Moerloose B, Catchpoole D, Hori H, Moorman A, Moore AS, Hrusak O, Meshinchi S, Orgel E, Devidas M, Borowitz M, Wood B, Heerema NA, Carrol A, Yang YL, Smith MA, Davidsen TM, Hermida LC, Gesuwan P, Marra MA, Ma Y, Mungall AJ, Moore RA, Jones SJM, Valentine M, Janke LJ, Rubnitz JE, Pui CH, Ding L, Liu Y, Zhang J, Nichols KE, Downing JR, Cao X, Shi L, Pounds S, Newman S, Pei D, Guidry Auvil JM, Gerhard DS, Hunger SP, Inaba H*, Mullighan CG. The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature 2018. [Epub ahead of print]

Inaba H, Cao X, Han AQ, Panetta JC, Ness KK, Metzger ML, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Cheng C, Pui CH, Relling MV, Kaste SC. Bone mineral density in children with acute lymphoblastic leukemia. Cancer 124:1025-1035, 2018.

Inaba H, Azzato EM, Mullighan CG. Integration of Next-Generation Sequencing to Treat Acute Lymphoblastic Leukemia with Targetable Lesions: The St. Jude Children's Research Hospital Approach. Front Pediatr 5:258. eCollection, 2017.

Inaba H, Pei D, Wolf  J, Howard SC, Hayden RT, Go M, Varechtchouk O, Hahn T, Buaboonnam J. Metzger ML, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Cheng C, Evans WE, Relling MV, Pui C-H. Infection-related complications during treatment for childhood acute lymphoblastic leukemia. Ann Oncol 28:386-392, 2017.

Eissa HM, Zhou Y, Panetta JC, Browne EK, Jeha S, Cheng C, Relling MV, Campana D, Pui CH, Inaba H. The effect of body mass index at diagnosis on clinical outcome in children with newly diagnosed acute lymphoblastic leukemia. Blood Cancer J 7(2):e531, 2017.

Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC. Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study. Blood 126:1575-84, 2015.

Karol SE, Coustan-Smith E, Cao X, Shurtleff SA, Raimondi SC, Choi JK, Ribeiro RC, Dahl GV, Bowman WP, Taub JW, Degar B, Leung W, Downing JR, Pui CH, Rubnitz JE, Campana D, Inaba H. Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. Br J Haematol 168:94-101, 2015.

Inaba H, Gaur AH, Cao X, Flynn PM, Pounds SB, Avutu V, Marszal LN, Howard SC, Pui CH, Ribeiro RC, Hayden RT, Rubnitz JE. Feasibility, efficacy, and adverse effects of outpatient antibacterial prophylaxis in children with acute myeloid leukemia. Cancer 120:1985-92, 2014.

Zimmerman EI, Turner DC, Buaboonnam J, Hu S, Orwick S, Roberts MS, Janke LJ, Ramachandran A, Stewart CF, Inaba H, Baker SD. Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. Blood 122:3607-15, 2013.

Buaboonnam J, Cao X, Pauley JL, Pui CH, Ribeiro RC, Rubnitz JE, Inaba H. Sequential administration of methotrexate and asparaginase in relapsed or refractory pediatric acute myeloid leukemia. Pediatr Blood Cancer 60:1161-4, 2013.

Baker SD, Zimmerman EI, Wang YD, Orwick S, Zatechka DS, Buaboonnam J, Neale G, Olsen SR, Enemark EJ, Shurtleff S, Rubnitz J, Mullighan CG, Inaba H. Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia. Clin Cancer Res 19:5758-68, 2013.

Inaba H, Greaves M, Mullighan CG. Acute lymphoblastic leukemia. Lancet 381(9881):1943-55, 2013.

Inaba H, Yang J, Kaste SC, Hartford CM, Motosue M, Chemaitilly W, Triplett BM, Shook DR, Pui C-H, Leung W. Longitudinal changes in body mass and composition in survivors of childhood hematological malignancies after allogeneic hematopoietic stem cell transplantation. J Clin Oncol 30(32):3991-7, 2012.

Rubnitz JE, Inaba H. Childhood acute myeloid leukaemia. Br J Haematol 159(3):259-76, 2012.

Inaba H, Coustan-Smith E, Cao X, Pounds SB, Shurtleff SA, Wang KY, Raimondi SC, Onciu M, Jacobsen J, Ribeiro RC, Dahl G, Bowman WP, Taub JW, Degar B, Leung W, Downing JR, Pui C-H, Rubnitz JE, Campana D. Comparative Analysis Of Different Approaches To Measure Treatment Response In Acute Myeloid Leukemia. J Clin Oncol 30(29):3625-32, 2012.

Rubnitz JE, Pounds S, Cao X, Jenkins L, Dahl G, Bowman WP, Taub JW, Pui CH, Ribeiro RC, Campana D, Inaba H. Treatment outcome in older patients with childhood acute myeloid leukemia. Cancer 118:6253-9, 2012.

Inaba H, Surprise HC, Pounds S, Cao X, Howard SC, Ringwald-Smith K, Buaboonnam J, Dahl G, Bowman WP, Taub JW, Campana D, Pui CH, Ribeiro RC, Rubnitz JE. Effect of body mass index on the outcome of children with acute myeloid leukemia. Cancer 118:5989-96, 2012.

Inaba H, Hartford CM, Pei D, Posner MJ, Yang J, Hayden RT, Srinivasan A, Triplett BM, McCullers JA, Pui CH, Leung W. Longitudinal analysis of antibody response to immunization in paediatric survivors after allogeneic haematopoietic stem cell transplantation. Br J Haematol 156:109-17, 2011.

Inaba H, Bhojwani D, Pauley JL, Pei D, Cheng C, Metzger ML, Howard SC, Rubnitz JE, Sandlund JT, Ribeiro RC, Leung W, Campana D, Pui CH, Jeha S. Combination chemotherapy with clofarabine, cyclophosphamide, and etoposide in children with refractory or relapsed haematological malignancies. Br J Haematol 156:109-17, 2011.

Motosue MS, Zhu L, Srivastava K, Stokes DC, Hudson MM, McPherson V, Srinivasan S, Krasin MJ, Green DM, Spunt SL, Inaba H. Pulmonary function after whole lung irradiation in pediatric patients with solid malignancies. Cancer 118:1450-6, 2011.

Inaba H, Rubnitz JE, Coustan-Smith E, Li L, Furmanski BD, Mascara GP, Heym KM, Christensen R, Onciu M, Shurtleff SA, Pounds SB, Pui CH, Ribeiro RC, Campana D, Baker SD. Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia. J Clin Oncol 29:3293-300, 2011.

Hu S, Niu H, Inaba H, Orwick S, Rose C, Panetta JC, Yang S, Pounds S, Fan Y, Calabrese C, Rehg JE, Campana D, Rubnitz JE, Baker SD. Activity of the Multikinase Inhibitor Sorafenib in Combination With Cytarabine in Acute Myeloid Leukemia. J Natl Cancer Inst 103:893-905, 2011.

Inaba H, Londero M, Maurer SH, Onciu M, Ge Y, Taub JW, Rubnitz JE, Raimondi SC. Acute megakaryoblastic leukemia without the GATA1 mutation following transient myeloproliferative disorder in an infant without Down syndrome. J Clin Oncol 29:e230-3, 2011.

Inaba H, Cao X, Pounds S, Pui CH, Rubnitz JE, Ribeiro RC, Razzouk BI. Randomized trial of two dosages of prophylactic granulocyte colony-stimulating factor after induction chemotherapy in pediatric acute myeloid leukemia. Cancer 117:1313-20, 2011.

Inaba H, Pui CH. Glucocorticoid use in acute lymphoblastic leukemia: comparison of prednisone and dexamethasone. Lancet Oncol 11:1096-106, 2010.

Rubnitz JE, Inaba H, Dahl G, Ribeiro RC, Bowman WP, Taub J, Pounds S, Razzouk BI, Lacayo NJ, Cao X, Meshinchi S, Degar B, Airewele G, Raimondi SC, Onciu M, Coustan-Smith E, Downing JR, Leung W, Pui CH, Campana D. Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial. Lancet Oncol11:543-52, 2010.

Inaba H, Yang J, Pan J, Stokes DC, Krasin MJ, Srinivasan A, Hartford CM, Pui CH, Leung W. Pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation. Cancer 116:2020-30, 2010. PMCID: PMC2919832.

Rubnitz JE, Inaba H, Ribeiro RC, Pounds S, Rooney B, Bell T, Pui CH, Leung W. NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol Feb 20;28(6):955-9, 2010. PMCID: PMC2834435

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Inaba H, Stewart CF, Crews KR, Yang S, Pounds S, Pui CH, Rubnitz JE, Razzouk BI, Ribeiro RC. Combination of cladribine plus topotecan for relapsed or refractory pediatric acute myeloid leukemia. Cancer 116:98-105, 2009. PMCID: PMC151111

Brugnoletti F, Morris EB, Laningham FH, Patay Z, Pauley JL, Pui CH, Jeha S, Inaba H. Recurrent intrathecal methotrexate induced neurotoxicity in an adolescent with acute lymphoblastic leukemia: Serial clinical and radiologic findings. Pediatr Blood Cancer52:293-5, 2009. PMCID: PMC2605174

Inaba H, Steeves M, Nguyen P, Geiger TL. In vivo suppression of naive CD4 T cell responses by IL-2- and antigen-stimulated T lymphocytes in the absence of APC competition. J Immunol 181:3323-35, 2008. PMCID: PMC2559971

Inaba H, Khan RB, et al. Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer. Ann Oncol 19:178-84, 2008.

Inaba H, Jenkins JJ, et al. Pulmonary alveolar proteinosis in pediatric leukemia. Pediatr Blood Cancer 51:66-70, 2008.

Hu S, Niu H, Minkin P, Orwick S, Shimada A, Inaba H, et al. Comparison of antitumor effects of multitargeted tyrosine kinase inhibitors in acute myelogenous leukemia. Mol Cancer Ther 7:1110-20, 2008.

Inaba H, Fan Y, et al. Clinical and Biological Features and Treatment Outcome of Children With Newly Diagnosed Acute Myeloid Leukemia and Hyperleukocytosis. Cancer 113:522-9, 2008.

Inaba H, Jones DP, et al. BK virus-induced tubulointerstitial nephritis in a child with acute lymphoblastic leukemia. J Pediatr 151:215-7, 2007.

Inaba H, Handgretinger R, et al. Allogeneic graft-versus-hepatoblastoma effect. Pediatr Blood Cancer 46:501-5, 2006.

Inaba H, Hale G, et al. Diagnostic challenge in recurrent skin rash after autologous bone marrow transplantation. J Pediatr Hematol Oncol 28:525-8, 2006.

Inaba H, Geiger TL. Defective cell cycle induction by IL-2 in naive T-cells antigen stimulated in the presence of refractory T-lymphocytes. Int Immunol 18:1043-54, 2006.

Inaba H, Geiger TL, et al. A case of hemoglobin SC disease with cold agglutinin-induced hemolysis. Am J Hematol 78:37-40, 2005.

Inaba H, Shimada K, et al. Acquisition of Fas resistance by Fas receptor mutation in a childhood B-precursor acute lymphoblastic leukemia cell line, MML-1. Int J Oncol 27:573-9, 2005.

Inaba H, Glibetic M, et al. Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. Pediatr Blood Cancer 43:729-36, 2004.

Inaba H, Rabah R, et al. Herpes simplex virus pneumonia in a patient with ependymoma. J Pediatr Hematol Oncol 26:108-11, 2004.

Last update: October 2018