Laura Janke, DVM, PhD
Laura Janke, DVM, PhD, DACVP

Laura Janke, DVM, PhD, DACVP

Associate Member, St. Jude Faculty



BA – Concordia College, Moorhead, Minnesota (1996)
PhD – University of Minnesota, St.Paul, MN (2004)
DVM – University of Minnesota, College of Veterinary Medicine, St. Paul, MN (2006)
ACVP, Diplomate – University of Minnesota, Veterinary Diagnostic Laboratory, St. Paul, MN (2009)

Research Interests

  • Phenotyping of genetically engineered mice
  • Assessment of treatment efficacy and toxicity in mouse models of pediatric cancers
  • Use of immunohistochemistry to aid in the investigation of tissue- and cell-specific molecular changes
  • Use of histomorphometry and whole slide imaging to assist in the generation of objective data regarding histopathological lesions or antigen expression

Selected Publications

Dang J, Wei L, de Ridder J, Su X, Rust AG, Roberts KG, Payne-Turner D, Cheng J, Ma J, Qu C, Wu G, Song G, Huether RG, Schulman B, Janke L, Zhang J, Downing JR, van der Weyden L, Adams DJ, Mullighan CG. Pax5 is a haploinsufficient tumor suppressor in mouse models of acute lymphoblastic leukemia. Blood April 8, 2015. Epub ahead of print. doi:10.1182/blood-2015-02-626127.

Pabla N, Gibson AA, Buege M, Ong SS, Li L, Hu S, Du G, Sprowl JA, Vasilyeva A, Janke LJ, Schlatter E, Chen T, Ciarimboli G, Sparreboom A. Mitigation of acute kidney injury by cell cycle inhibitors that suppress both CDK4/6 and OCT2 functions. Proc Natl Acad Sci USA 112(16):5231-6, 2015.

Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong Y, Janke LJ, Kelliher MA, Kanneganti T, Green DR.  RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3.  Cell 157(5):1189-202, 2014.

Ramsey LB, Janke LJ, Edick MJ, Cheng C, Williams RT, Sherr CJ, Evans WE, Relling MV. Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model. Pharmacogenet Genomics 24(5):263-71, 2014.

Treanor LM, Zhou S, Janke L, Churchman ML, Ma Z, Lu T, Chen SC, Mullighan CG, Sorrentino BP. Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. J Exp Med 211(4):701-13, 2014.

Leung WH, Vong QP, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation. J Exp Med 210(12):2675-92, 2013.

Weinlich R, Oberst A, Dillon CP, Janke LJ, Milasta S, Lukens JR, Rodriguez DA, Gurung P, Savage C, Kanneganti TD, Green DR.  Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis, Cell Rep 5(2):340-8, 2013.

Zimmerman EI, Turner DC, Buaboonnam J, Hu S, Orwick S, Roberts MS, Janke LJ, Ramachandran A, Stewart CF, Inaba H, Baker SD. Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. Blood 122(22):3607-15, 2013.

Janke LJ, Liu C, Vogel P, Kawedia J, Boyd KL, Funk AJ, Relling MV. Primary epiphyseal arteriopathy in a mouse model of steroid-induced osteonecrosis.  American Journal of Pathology 183(1):19-25, 2013.

Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR.  Survival Function of the FADD-CASPASE-8-cFLIPL Complex. Cell Reports 1:401-7, 2012.

Last update: June 2015