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Elizabeth H. Kellogg, PhD

Elizabeth H. Kellogg, PhD

Associate Member, St. Jude Faculty



  • PhD (Biochemistry) – University of Washington
  • BS (Bioengineering) – University of California, Berkeley

Honors & Awards

  • 2006  UC Berkeley Bioengineering Department Award Winner (Top honor bestowed on one Bioengineering graduate per year)
  • 2021  American Crystallographic Society, Cryo-EM Interest Group Chair
  • 2021  Pew Biomedical Scholars Award
  • 2021  Rita Allen Scholar Award (declined)
  • 2022-2023  Frank N. Noyce Assistant Professor of Life Sciences and Technology
  • 2021  Margaret Dayhoff Oakley Award, Biophysical Society
  • 2023  Pew Biomedical Scholars Award
  • 2023  HHMI Hrabowski Award Finalist

Research Interests

  • The lab of genome engineering, organization, and architecture.

Selected Publications

VanderWal AR, Park J-U, Polevoda B, Kellogg EH, O'Connell MR. CRISPR-Csx28 is a membrane pore that enhances CRISPR-Cas13b-dependent antiphage defense. Science 380(6643):410-5, April 2023.

Park J-U*, Tsai AWT*, Rizo AN*, Truong VH, Wellner TX, Schargel RD, Kellogg EH. Structures of the holo CRISPR RNA-guided transposon integration complex. Nature Jan;613:775-82, 2023.

Park J-U, Tsai AW, Chen TH, Peters JE, Kellogg EH. Mechanistic Details of CRISPR-associated transposon recruitment and integration revealed by cryo-EM. PNAS Aug;119(32):e2202590119, 2022.

Jack A, Yoonji K, Strom A, Lee DSW, Williams B, Schaub J, Kellogg EH, Finkelstein IJ, Ferro LS, Yildiz A, Brangwynne CP. Compartmentalization of Telomeres through DNA-scaffolded Phase Separation. Developmental Cell Jan;57(2):277-290, 2022.

Park J, Tsai AWL*, Mehrotra E*, Petassi M, Hsieh SC, Ke A, Peters JE#, Kellogg EH.# Structural basis for target-site selection in RNA-guided DNA transposition systems. Science Aug;373(6556):768-74, 2021.

Cianfrocco ME*#, Kellogg EH.*# What could go wrong? A practical guide to single-particle cryo-EM: from biochemistry to atomic models. Journal of Chemical Information and Modeling May 26;60(5):2458-2469, 2020. doi: 10.1021/acs.jcim.9b01178

Ghanim G*, Kellogg EH*#, Nogales E, Rio DC. # Cryo-EM structure of the P element transposase strand transfer complex. Nature Structural Molecular Biology Nov;26(11):1013-22, 2019.

Kellogg EH*, Hejab N*, Poepsel S, Downing KH, Dimaio F, Nogales E. Near-atomic cryo-EM reconstruction of microtubule-tau interactions, Science June;360(6394):1242-46, 2018.

Nogales E, Kellogg EH. Challenges and opportunities in the high-resolution cryo-EM visualization of microtubules and their binding partners. Curr Op Struct Biol Oct;46:65-70, 2017.

Howes SC, Geyer E, LaFrance BJ, Zhang R, Kellogg EH, Westermann S, Rice L, Nogales E. Structural and functional differences between yeast and mammalian microtubules revealed by cryo-EM. Journal of Cell Biology Sep 4;216(9):2669-2677, 2017. doi: 10.1083/jcb.201612195

Kellogg EH, Hejab N, Howes S, Northcote P, Miller JH, Diaz FJ, Downing KH, Nogales E. Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures. Journal of Molecular Biology March;429(5):633-646, 2017.

Last update: January 2024