Katherine M. Knapp, MD
Katherine M. Knapp, MD

Katherine M. Knapp, MD

Associate Member, St. Jude Faculty

  • Medical Director, Perinatal HIV Program



BA – Vanderbilt University, Nashville, Tennessee (1990)
MD – University of Arkansas for Medical Sciences, Little Rock, Arkansas (1994)

Research Interests

  • Pediatric/adolescent HIV infection
  • Prevention of mother-to-child HIV transmission
  • Long-term outcomes of perinatal HIV/antiretroviral exposure
  • Infectious complications in immunocompromised hosts, particularly fungal infections

Selected Publications

Jao J, Yu W, Patel K, Miller TL, Karalius B, Geffner ME, DiMeglio LA, Mirza A, Chen JS, Silio M, McFarland EJ, Van Dyke RB, Jacobson D; Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol (AMP) Study. Improvement in lipids after switch to boosted atazanavir or darunavir in children/adolescents with perinatally acquired HIV on older protease inhibitors: results from the Pediatric HIV/AIDS Cohort Study. HIV Med Nov 21, 2017. Epub ahead of print. PMID: 29159965 DOI: 10.1111/hiv.12566 (collaborator)

Jao J, Kacanek D, Williams PL, Geffner ME, Livingston EG, Sperling RS, Patel K, Bardequez AD, Burchett SK, Chakhtoura N, Scott GB, Van Dyke RB, Abrams EJ; Pediatric HIV/AIDS Cohort Study and the International Maternal Pediatric Adolescent AIDS Clinic Trials P1025 Protocol. Birth weight and preterm delivery outcomes of perinatally vs nonperinatally human immunodeficiency virus-infected pregnant women in the United States: Results from the PHACS SMARTT study and IMPAACT P1025 protocol. Clin Infect Dis Sep 15;65(6):982-989, 2017. PMID: 28575201 DOI: 10.1093/cid/cix488 (collaborator)

Uprety P, Patel K, Karalius B, Ziemniak C, Chen YH, Brummel SS, Siminski S, Van Dyke RB, Seage GR, Persaud D; Pediatric HIV/AIDS Cohort Study (PHACS). Human immunodeficiency virus type 1 DNA decay dynamics with early, long-term virologic control of perinatal infection. Clin Infect Dis Jun 1; 64(11):1471-1478, 2017. PMID: 28329153 PMC: PMC5434384 DOI: 10.1093/cid/cix192 (collaborator)

Tassiopoulos K, Huo Y, Braun J, Williams PL, Smith R, Aschengrau A, Nichols S, Hazra R, Meyer WA 3rd, Knapp K, Deygoo NS, and Seage GR 3rd, for the Pediatric HIV/AIDS Cohort Study. Blood lead levels and neurodevelopmental function in perinatally HIV-exposed, uninfected children in a US-based longitudinal cohort study. AIDS Res Hum Retroviruses Sep 1;33(9):919-928, 2017. Epub 2017 Mar 21. PMID:28322573 PMC: PMC5576211 DOI: 10.1089/aid.2016.0265

Van Dyke RB, Patel K, Kagan RM, Karalius B, Traite S, Meyer WA 3rd, Tassiopoulos KK, Seage GR 3rd, Seybolt LM, Burchett S, Hazra R; Pediatric HIV/AIDS Cohort Study (PHACS). Antiretroviral drug resistance among children and youth in the United States with perinatal HIV. Clin Infect Dis Jul 1;63(1):133-137, 2016. Epub 2016 Apr 7. PMID: 27056398 PMC: PMC4901868 DOI: 10.1093/cid/ciw213 (collaborator)

Purswani MU, Karalius B, Yao TJ, Schmid DS, Burchett SK, Siberry GK, Patel K, Van Dyke RB, Yogev R; Pediatric HIV/AIDS Cohort Study (PHACS). Prevalence and persistence of varicella antibodies in previously immunized children and youth with perinatal HIV-1 infection. Clin Infect Dis Jan 1;62(1):106-114, 2016. Epub 2015 Sep 18. PMID: 26385992 PMC: PMC4678104 DOI: 10.1093/cid/civ734 (collaborator)

Mirani G, Williams PL, Chernoff M, Abzug MJ, Levin MJ, Seage GR 3rd, Oleske JM, Purswani MU, Hazra R, Traite S, Zimmer B, Van Dyke RB; IMPAACT P1074 Study Team. Changing trends in complications and mortality rates among US youth and young adults with HIV infection in the era of combination antiretroviral therapy. Clin Infect Dis Dec 15;61(12):1850-1861, 2015. Epub 2015 Aug 12. PMID: 26270680 PMC:PMC4657532 DOI: 10.1093/cid/civ687 (collaborator)

Wattier RL, Dvorak CC, Hoffman JA, Brozovich AA, Bin-Hussain I, Groll AH, Castagnola E, Knapp KM, Zaoutis TE, Gustafsson B, Sung L, Berman D, Halasa NB, Abzug MJ, Velegraki A, Sharma TS, Fisher BT, Steinbach WJ. A prospective, international cohort study of invasive mold infections in children. J Pediatr Infect Dis Soc Dec;4(4):313-322, 2015. Epub 2014 Jul 16. PMID: 26582870 PMC: PMC4681382 DOI:10.1093/jpids/piu074 (co-author)

Colbers A, Best B, Schalkwijk S, Wang J, Stek A, Hidalgo Tenorio C, Hawkins D, Taylor G, Kreitchmann R, Burchett S, Haberl A, Kabeya K, van Kasteren M, Smith E, Capparelli E, Burger D, Mirochnick M; PANNA Network and the IMPAACT 1026 Study Team. Maraviroc pharmacokinetics in HIV-1-infected pregnant women. Clin Infect Dis Nov 15;61(10):1582-1589, 2015. Epub 2015 Jul 22. PMID: 26202768 PMC:PMC4614410 DOI: 10.1093.cid/civ587 (collaborator)

Siberry GK, Patel K, Bellini WJ, Karalius B, Purswani MU, Burchett SK, Meyer WA 3rd, Sowers SB, Ellis A, Van Dyke RB; Pediatric HIV/AIDS Cohort Study (PHACS). Immunity to measles, mumps, and rubella in US children with perinatal HIV infection or perinatal HIV exposure without infection. Clin Infect Dis Sep 15;61(6):988-995, 2015. Epub 2015 Jun 9. PMID: 26060291 PMC: PMC4551008 DOI: 10.1093/cid/civ440 (collaborator)

Siberry GK, Jacobson DL, Kalkwarf HJ, Wu JW, DiMeglio LA, Yogev R, Knapp KM, Wheeler JJ, Butler L, Hazra R, Miller TL, Seage GR 3rd, Van Dyke RB, Barr E, Davtyan M, Rich KC, Pediatric HIV/AIDS Cohort Study. Lower newborn bone mineral content associated with maternal use of tenofovir disoproxil fumarate during pregnancy. Clin Infect Dis Sep 15;61(6):996-1003, 2015. Epub 2015 Jun 9. PMID: 26060285 PMC: PMC4551007 DOI:10.1093/cid/civ437

Best BM, Burchett S, Li H, Stek A, Hu C, Wang J, Hawkins E, Byroads M, Watts DH, Smith E, Fletcher CV, Capparelli EV, Mirochnick M; International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) P1026s Team. Pharmacokinetics of tenofovir during pregnancy and postpartum. HIV Med Sep;16(8):502-511, 2015. Epub 2015 May 11. PMID: 25959631 PMC: PMC4862736 DOI:10.1111/hiv.12252 (collaborator)

Nichols SL, Brummel SS, Smith RA, Garvie PA, Hunter SJ, Malee KM, Kammerer BL, Wilkins ML, Rutstein R, Tassiopoulos K, Chernoff MC, Mellins CA; Pediatric HIV/AIDS Cohort Study. Executive functioning in children and adolescents with perinatal HIV infection. Pediatr Infect Dis J Sep;34(9):969-975, 2015. PMID: 26376309 PMC :PMC4761421 DOI: 10.1097/inf.0000000000000809 (collaborator)

Himes SK, Tassiopoulos K, Yogev R, Huestis MA; Pediatric HIV/AIDS Cohort Study (PHACS). Antiretroviral drugs in meconium: detection for different gestational periods of exposure. J Pediatr Aug;167(2):305-311.e3, 2015. Epub 2015 May 19. PMID: 26001315 PMC: PMC4516688 DOI:10.1016/j.jpeds.2015.04.062 (collaborator)

Himes SK, Wu JW, Jacobson DL, Tassiopoulos K, Hazra R, Kacanek D, Van Dyke RB, Rich KC, Siberry GK, Huestis MA; Pediatric HIV/AIDS Cohort Study (PHACS). Meconium tenofovir concentrations and growth and bone outcomes in prenatally tenofovir exposed HIV-uninfected children. Pediatr Infect Dis J Aug;34(8)851-857, 2015. PMID: 25961889 PMC: PMC4573821 DOI: 10.1097/inf.0000000000000747 (collaborator)

Himes SK, Huo Y, Siberry GK, Williams PL, Rice ML, Sirois PA, Frederick T, Hazra R, Huestis MA; Pediatric HIV/AIDS Cohort Study. Meconium atazanavir concentrations and early language outcomes in HIV-exposed uninfected infants with prenatal atazanavir exposure. J Acquir Immune Defic Syndr Jun 1;69(2):178-186, 2015. PMID: 26009830 PMC: PMC4887272 DOI: 10.1097/qai.0000000000000558 (collaborator)

Torre P 3rd, Yao TJ, Zeldow B, Williams P, Hoffman HJ, Siberry GK; Pediatric HIV/AIDS Cohort Study (PHACS). Distortion product otoacoustic emission data in perinatally HIV-infected and HIV-exposed but uninfected children and adolescents in the Pediatric HIV/AIDS Cohort Study. Pediatr Infect Dis J Mar;34(3):276-278, 2015. PMID: 25742077 PMC: PMC4365792 DOI: 10.1097/inf.0000000000000598 (collaborator)

Crowell CS, Huo Y, Tassiopoulos K, Malee KM, Yogev R, Hazra R, Rutstein RM, Nichols SL, Smith RA, Williams PL, Oleske J, Muller WJ; PACTG 219C Study Team and the Pediatric HIV/AIDS Cohort Study (PHACS). Early viral suppression improves neurocognitive outcomes in HIV-infected children. AIDS Jan 28;29(3):295-304, 2015. PMID: 25686678 PMC: PMC4332557 DOI: 10.1097/qad.0000000000000528 (collaborator)

Rough K, Tassiopoulos K, Kacanek D, Griner R, Yogev R, Rich KC, Seage GR 3rd; Pediatric HIV/AIDS Cohort Study. Dramatic decline in substance use by HIV-infected pregnant women in the United States from 1990 to 2012. AIDS Jan 2;29(1):117-123. PMID: 25562496 PMC: PMC4285630 DOI:10.1097/qad.0000000000000503 (collaborator)

Lipshultz SE, Williams PL, Zeldow B, Wilkinson JD, Rich KC, Van Dyke RB, Seage GR 3rd, Dooley LB, Kaltman JR, Siberry GK, Mofenson LM, Shearer WT, Colan SD; Pediatric HIV/AIDS Cohort Study (PHACS). Cardiac effects of in-utero exposure to antiretroviral therapy in HIV-uninfected children born to HIV-infected mothers. AIDS Jan 2;29(1):91-100, 2015. PMID: 25562493 PMC: PMC4287991 DOI:10.1097/qad.0000000000000499 (collaborator)

Marsit CJ, Brummel SS, Kacanek D, Seage GR 3rd, Spector SA, Armstrong DA, Lester BM, Rich K; Pediatric HIV/AIDS Cohort Study. Infant peripheral blood repetitive element hypomethylation associated with antiretroviral therapy in utero. Epigenetics 10(8):708-716, 2015. PMID: 26067216 PMC:PMC4622750 DOI: 10.1080/15592294.2015.1060389 (collaborator)

Williams PL, Crain MJ, Yildirim C, Hazra R, Van Dyke RB, Rich K, Read JS, Stuard E, Rathore M, Mendez HA, Watts DH; Pediatric HIV/AIDS Cohort Study. Congenital anomalies and in utero antiretroviral exposure in human immunodeficiency virus-exposed uninfected infants. JAMA Pediatr Jan;169(1):48-55, 2015. PMID: 25383770 PMC: PMC4286442 DOI: 10.1001/jamapediatrics.2014.1889 (collaborator)

Mitchell CD, Chernoff MC, Seage GR 3rd, Purswani MU, Spiegel HM, Zilleruelo G, Abitbol C, Heckman B, Ponce CB, Oleske JM; IMPAACT 219/219C Study Team. Predictors of resolution and persistence of renal laboratory abnormalities in pediatric HIV infection. Pediatr Nephrol Jan;30(1):153-165, 2015. Epub 2014 Aug 24. PMID: 25149860 PMC: PMC4301405 DOI: 10.1007/s00467-014-2909-1 (collaborator)

Nozyce ML, Huo Y, Williams PL, Kapetanovic S, Hazra R, Nichols S, Hunter S, Smith R, Seage GR 3rd, Sirois PA; Pediatric HIV/AIDS Cohort Study. Safety of in utero and neonatal antiretroviral exposure: cognitive and academic outcomes in HIV-exposed, uninfected children 5-13 years of age. Pediatr Infect Dis J Nov;33(11):1128-1133, 2014. PMID: 25361407 PMC: PMC4217087 DOI:10.1097/inf.0000000000000410 (collaborator)

Garvie PA, Zeldow B, Malee K, Nichols SL, Smith RA, Wilkins ML, Williams PL; Pediatric HIV/AIDS Cohort Study (PHACS). Discordance of cognitive and academic achievement outcomes in youth with perinatal HIV exposure. Pediatr Infect Dis J Sep;33(9):e232-238, 2014. PMID: 25361033 PMC: PMC4217131 DOI:10.1097/inf.0000000000000314 (collaborator)

Kauffman CA, Freifeld AG, Andes DR, Baddley JW, Herwaldt L, Walker RC, Alexander BD, Anaissie EJ, Benedict K, Ito JI, Knapp KM, Lyon GM, Marr KA, Morrison VA, Park BJ, Patterson TF, Schuster MG, Chiller TM, Pappas PG. Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET). Transpl Infect Dis Apr;16(2):213-224, 2014. Epub 2014 Mar 4. PMID: 24589027 PMC :PMC5664161 DOI:10.1111/tid.12186

Last update: May 2019