Ravi Kalathur, PhD

Ravi Kalathur, PhD

  • Director, Protein Technologies Center

Departments

Ravi Kalathur received a PhD in biotechnology from India, collaborating with two labs in Germany (Profs. Rainer Rudolph and Wolfgang Schuhmann). Dr. Kalathur carried out postdoctoral work with Dr. Xinhua Ji at NCI/NIH, USA, on allosteric activation of E2-RING finger-mediated ubiquitylation. He then moved to Prof. Ian Wilson's lab at the Scripps, La Jolla, where he developed strategies to express challenging protein targets involved in the lipid-antigen presentation. Following his postdoctoral studies, Ravi joined the NYSBC, New York, as a scientist working on an NIH-funded structural genomics consortium on membrane proteins, under the leadership of Prof. Wayne Hendrickson. At the NYSBC, he developed high-throughput technologies to express eukaryotic membrane proteins. He was also key personnel in the NIH-funded P41 center grant (COMPPÅ). Ravi is an author of 21 publications with an h-index of 17.

Contact Information

Ravi Kalathur, PhD Structural Biology St. Jude Children's Research Hospital 262 Danny Thomas Place Memphis, TN 38105-3678

Selected Publications

Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature Sep;597(7876):415-419, 2021. doi: 10.1038/s41586-021-03875-8. Epub 2021 Sep 1, 2021.

Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH. Structural insights into the regulation of human serine palmitoyltransferase complexes. Nat Struct Mol Biol Mar;28(3):240-248, 2021. doi: 10.1038/s41594-020-00551-9. Epub Feb 8 2021.

Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latgé JP, Kanneganti TD. Publisher Correction: Galactosaminogalactan activates the inflammasome to provide host protection. Nature  Jan;589(7841):E3, 2021. doi: 10.1038/s41586-020-03088-5.

Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latgé JP, Kanneganti TD. Galactosaminogalactan activates the inflammasome to provide host protection. Nature Dec;588(7839):688-692, 2020. doi: 10.1038/s41586-020-2996-z. Epub Dec 2, 2020.

McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T. Direct activation of human MLKL by a select repertoire of inositol phosphate metabolites. Cell Chem Biol Jun 20;26(6):863-877.e7, 2019. doi: 10.1016/j.chembiol.2019.03.010. Epub Apr 25, 2019.

Sistla JC, Morla S, Alabbas AB, Kalathur RC, Sharon C, Patel BB, Desai UR. Polymeric fluorescent heparin as one-step FRET substrate of human heparanase. Carbohydr Polym Feb 1;205:385-391, 2019. doi: 10.1016/j.carbpol.2018.10.071. Epub 2018 Oct 28, 2018. 

Last update: October 2021

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