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Yen-Chun Liu, MD, PhD
Yen-Chun Liu, MD, PhD

Yen-Chun Liu, MD, PhD

Associate Member, St. Jude Faculty



Molecular Genetic Pathology Fellowship –Memorial Sloan Kettering Cancer Center, New York, New York
Hematopathology Fellowship –Weill Cornell Medical College, New York, New York
Anatomic Pathology Residency– National Cancer Institute, NIH, Bethesda, Maryland
PhD – Johns Hopkins University School of Medicine, Baltimore, Maryland
MS – Harvard University School of Public Health, Boston, Massachusetts
MD – National Taiwan University School of Medicine, Taipei, Taiwan

Research Interests

  • Diagnosis and classification of the hematologic malignancies
  • Molecular characterization of the hematologic malignancies
  • Differences between the adult and pediatric hematologic malignancy

Selected Publications

Greenland NY, Van Ziffle JA, Liu YC, Qi Z, Prakash S, Wang L. Genomic analysis in myeloid sarcoma and comparison with paired acute myeloid leukemia. Hum Pathol Nov 21;108:76-83, 2020.

Carlsen E, Bailey NG, Aggarwal N, Illar GM, Wild M, Yatsenko SA, Rea B, Liu YC. Clinicopathologic characterization of hypocellular acute myeloid leukemia (AML) showed fewer genetic abnormalities involving cell proliferation and NPM1 when compared with nonhypocellular AML. Am J Clin Pathol Oct 22:aqaa150, 2020.

Barasch NJK, Liu YC, Ho J, Bailey N, Aggarwal N, Cook JR, Swerdlow SH. The molecular landscape and other distinctive features of primary cutaneous follicle center lymphoma. Hum Pathol Dec;106:93-105, 2020.

Liu YC, Illar GM, Bailey NG. Clinicopathologic characterisation of myeloid neoplasms with concurrent spliceosome mutations and myeloproliferative-neoplasm-associated mutations. J Clin Pathol Nov;73(11):728-736, 2020.

Rea B, Aggarwal N, Yatsenko SA, Bailey N, Liu YC. Acute myeloid leukemia with isolated del(5q) is associated with IDH1/IDH2 mutations and better prognosis when compared to acute myeloid leukemia with complex karyotype including del(5q). Mod Pathol Apr;33(4):566-575, 2020.

Liu YC, Margolskee E, Allan JN, Mathew S, Bhavsar E, Casano J, Orazi A, Furman RR, Geyer JT. Chronic lymphocytic leukemia with TP53 gene alterations: a detailed clinicopathologic analysis. Mod Pathol Mar;33(3):344-353, 2020.

Crane GM, Liu YC, Chadburn A. Spleen: Development, anatomy and reactive lymphoid proliferations. Semin Diagn Pathol Jun 16;S0740-2570(20)30060-5, 2020.

Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A. Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia. Mod Pathol Sep;30(9):1213-1222, 2017.

Rogers HJ, Hsi ED, Tang G, Wang SA, Bueso-Ramos CE, Lubin D, Morrissette JJ, Bagg A, Cherukuri DP, George TI, Peterson L, Liu YC, Mathew S, Orazi A, Hasserjian RP. Most Myeloid Neoplasms With Deletion of Chromosome 16q Are Distinct From Acute Myeloid Leukemia With Inv(16)(p13.1q22): A Bone Marrow Pathology Group Multicenter Study. Am J Clin Pathol Apr 1;147(4):411-419, 2017.

Tsang HC, Bussel JB, Mathew S, Liu YC, Imahiyerobo AA, Orazi A, Geyer JT. Bone marrow morphology and disease progression in congenital thrombocytopenia: a detailed clinicopathologic and genetic study of eight cases. Mod Pathol Apr;30(4):486-498, 2017.

Gianelli U, Cattaneo D, Bossi A, Cortinovis I, Boiocchi L, Liu YC, Augello C, Bonometti A, Fiori S, Orofino N, Guidotti F, Orazi A, Iurlo A. The myeloproliferative neoplasms, unclassifiable: clinical and pathological considerations. Mod Pathol Feb;30(2):169-179, 2017.

Rennert H, Eng K, Zhang T, Tan A, Xiang J, Romanel A, Kim R, Tam W, Liu YC, Bhinder B, Cyrta J, Beltran H, Robinson B, Mosquera JM, Fernandes H, Demichelis F, Sboner A, Kluk M, Rubin MA, Elemento O. Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care. npj Genomic Medicine 1, Article number: 16019, Jul 20, 2016.

Pizzi M, Covey S, Mathew S, Liu YC, Ruan J, Leonard JP, Chadburn A. Hepatosplenic T-cell Lymphoma mimicking Acute Myeloid Leukemia. Clinical Lymphoma Myeloma and Leukemia Mar;16(3):e47-50, 2016.

Lu M, Xia L, Liu YC, Hochman T, Bizzari L, Aruch D, Lew J, Weinberg R, Goldberg JD, Hoffman R. Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells. Blood Aug 20;126(8):972-82, 2015.

Subramaniyam S, Geyer JT, Liu YC, Mathew S. A translocation t(2;14)(p11.2;q32) involving rearrangements of immunoglobulin heavy chain and kappa light chain genes in B-cell lymphoma. Leuk Lymphoma May 12:1-3, 2015.

Geyer JT, Subramaniyam S, Jiang Y, Elemento O, Ferry JA, de Leval L, Nakashima MO, Liu YC, Martin P, Mathew S, Orazi A, Tam W. Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients. Hum Pathol Feb;46(2):260-71, 2015.

Rogers HJ, Vardiman JW, Anastasi J, Raca G, Savage NM, Cherry AM, Arber D, Moore E, Morrissette JJ, Bagg A, Liu YC, Mathew S, Orazi A, Lin P, Wang SA, Bueso-Ramos CE, Foucar K, Hasserjian RP, Tiu RV, Karafa M, Hsi ED. Complex or monosomal karyotype and not blast percentage is associated with poor survival in acute myeloid leukemia and myelodysplastic syndrome patients with inv(3)(q21q26.2)/t(3;3)(q21;q26.2): a Bone Marrow Pathology Group study. Haematologica May;99(5):821-9, 2014.

Aung PP*, Liu YC*, Ballester LY, Robbins PF, Rosenberg SA, Lee CC. Expression of NY-ESO-1 in primary and metastatic malignant melanoma. Human Pathology Feb;45(2):259-67, 2014. (The first 2 authors contributed equally to this work.)

Liu YC, Liu YF, Knowles DM, Orazi A, Tam W. Aberrantly Sustained PAX5 Expression in Plasma Cell Differentiation Is a Frequent Feature in Lymphoplasmacytic Lymphoma but Not Marginal Zone Lymphoma in Bone Marrow. Journal of Hematopathology Dec;6(4):169-177, 2013.

Lai JP*, Liu YC*, Quezado M, Liu QY, Aung PP, Matsuda K, Lee CC, Tsokos M, Hewitt S, Rushing EJ, Tamura D, Levens DL, DiGiovanna JJ, Fine HA, Patronas N, Khan SG, Kleiner DE, Oberholtzer JC*, Kraemer KH*.The influence of DNA repair on neurologic degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D). Acta Neuropathologica Communications May 8;1(1):4, 2013. (The first 2 authors contributed equally to this work.)

Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, Chng WJ, Eberhart CG, Bergsagel PL, Dang CV. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. PNAS Feb 23;107(8):3534-9, 2010.

Liu YC, Li F, Handler J, Huang CR, Xiang Y, Neretti N, Sedivy JM, Zeller KI, Dang CV. Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS One Jul 16;3(7):e2722, 2008.

Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol Nov;27(21):7381-93, 2007.

Last update: February 2021