R. Ray Morrison, MD
R. Ray Morrison, MD

R. Ray Morrison, MD

Associate Member, St. Jude Faculty

  • Chief, Critical Care Division




BA – University of Nebraska (1988)
MD – University of Nebraska College of Medicine (1992)

Research Interests

  • Consequences of myocardial ischemia-reperfusion, adenosine and adenosine receptors, coronary regulation, myocardial protection

Selected Publications

Ashton KJ, Reichelt ME, Mustafa SJ, Teng B, Ledent C, Delbridge L, Hofmann PA, Morrison RR, Headrick JP. Transcriptomic Effects of Adenosine A2A Receptor Deletion in Healthy and Endotoxemic Murine Myocardium. Purinergic Signal 13(1):27-49, 2017.

Elbahlawan L, Montoya L, Avent Y, Wilder K, Pei D, Cheng C, Morrison RR, Jeha S. Safety and Benefits of Bronchoalveolar Lavage and Lung Biopsy in the Management of Pulmonary Infiltrates in Children with Leukemia. J Pediatr Hematol Oncol 38(8):597-601, 2016.

Elbahlawan L, Srinivasan A, Morrison RR. A Critical Care and Transplantation-Based Approach to Acute Respiratory Failure After Hematopoietic Stem Cell Transplantation in Children. Biol Blood Marrow Transplant 22(4):617-626, 2016.

Teng B, Smith JD, Rosenfeld ME, Robinet P, Davis ME, Morrison RR, Mustafa SJ. A1 Adenosine Receptor Deficiency or Inhibition Reduces Atherosclerotic Lesions in Apolipoprotein E Deficient Mice. Cardiovasc Res 102(1):157-165, 2014.

Reichelt ME, Ashton KJ, Tan XL, Mustafa SJ, Ledent C, Delbridge LMD, Hofmann PA, Headrick JP, Morrison RR. The adenosine A(2A) receptor - myocardial protectant and coronary target in endotoxemia. Int J Cardiol 166(3):672-80, 2013.

Duncan CN, Lehmann LE, Cheifetz IM, Greathouse K, Haight AE, Hall MW, Herschberger A, Hill KS, Moffet JR, Morrison RR, Norris AL, Petrovic A, Spear DA, Steiner ME, Talano JA, Tamburro RF, Wagner J, McArthur J, Pediatric Acute Lung Injury and Sepsis (PALISI) Network. Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant.Pediatr Crit Care Med 14(3):261-7, 2013.

Elbahlawan L, Morrison RR. Continuous renal replacement therapy in children post-hematopoietic stem cell transplantation: the present and the future. Curr Stem Cell Res Ther 7(5):381-7, 2012.

Elbahlawan L, Morrison RR, Jeha S, Cheng C, Liu W, Fiser RT. Impact of neutrophil recovery on oxygenation in pediatric oncology patients with acute hypoxemic respiratory failure. J Pediatr Hematol Oncol 33(7):296-9, 2011.

Elbahlawan L, Gaur AH, Furman W, Jeha S, Woods T, Norris A, Morrison RR. Severe H1N1-associated acute respiratory failure in immunocompromised children. Pediatr Blood Cancer 57(4): 625-8, 2011.

Cai C, Lothstein L, Morrison RR, Hofmann PA. Protection from doxorubicin-induced cardiomyopathy using the modified anthracycline N-benzyladriamycin-14-valerate(AD 198). Pharmacol Exp Ther 335(1):223-230, 2010.

Elbahlawan L, West NK, Avent Y, Cheng C, Liu W, Barfield RC, Jones DP, Rajasekaran S, Morrison RR. Impact of continuous renal replacement therapy on oxygenation in children with acute lung injury after allogeneic hematopoietic stem cell transplantation. Pediatr Blood Cancer 55(3):540-545, 2010.

Mustafa SJ, Morrison RR, Teng B, Pelleg A. Adenosine Receptors in the Heart: Role in Regulation of Coronary Blood Flow and Cardiac Electrophysiology. Handbook of Experimental Pharmacology193: 161-188, 2009.

Rajasekaran S, Jones DP, Avent Y, Shaffer ML, Elbahlawan L, Henderson N, Barfield RC, Morrison RR, Tamburro RF. Outcomes of hematopoietic stem cell transplant patients who received continuous renal replacement therapy in a pediatric oncology intensive care unit. Pediatr Crit Care Med 11(6):699-706, 2010.

Leary PJ, Rajasekaran S, Morrison RR, Chin T, Tuomanen EI, Hofmann PA. A Cardioprotective Role for Platelet Activating Factor Through NOS Dependent S-Nitrosylation. Am J Physiol Heart Circ Physiol 294(6):H2775-H2284, 2008.

Inaba H, Jenkins JJ, McCarville ME, Morrison RR, Howard SC, Pui CH, Ribeiro RC. Pulmonary Alveolar Proteinosis in Pediatric Leukemia.Pediatr Blood Cancer 51(1):66-77, 2008.

Tamburro RF, Barfield RC, Shaffer ML, Rajasekaran S, Woodard P, Morrison RR, Howard SC, Fiser RT, Schmidt JC, Sillos EM. Changes in Outcomes (1996-2004) for Pediatric Oncology and Hematopoietic Stem Cell Transplant Patients Requiring Invasive Mechanical Ventilation. Pediatr Crit Care Med 9(1):270-277, 2008.

Morrison RR, Tan XL, Ledent C, Mustafa SJ, Hofmann PA. Targeted Deletion of A2A Adenosine Receptors Attenuates the Protective Effects of Myocardial Postconditioning. Am J Physiol Heart Circ Physiol 293:H2523-H2529, 2007.

Ashton KJ, Peart JN, Morrison RR, Matherne GP, Blackburn MR, Headrick JP. Genetic Modulation of Adenosine Receptor Function and Adenosine Handling in Murine Hearts: Insights and Issues. J Mol Cell Cardiol 42:693-705, 2007.

Fiordalisi I, Novotny WE, Holbert D, Finberg L, Harris GD and The Critical Care Management Group (Morrison RR). An 18-Year Prospective Study of Pediatric Diabetic Ketoacidosis: An Approach to Minimizing the Risk of Brain Herniation During Treatment. Pediatr Diabetes 8:142-149, 2007.

Morrison RR, Teng B, Oldenburg PJ, Katwa LC, Schnermann JB, Mustafa SJ. Effects of Targeted Deletion of A1 Adenosine Receptors on Post-Ischemic Cardiac Function and Expression of Adenosine Receptor Subtypes. Am J Physiol Heart Circ Physiol 291:H1875-H1882, 2006.

Tawfik HE, Teng B, Morrison RR, Schnermann JB, Mustafa SJ. Role of A1 Adenosine Receptor in the Regulation of Coronary Flow. Am J Physiol Heart Circ Physiol 291:H467-H472, 2006.

Talukder MAH, Morrison RR, Ledent C, Mustafa SJ. Endogenous Adenosine Increases Coronary Flow by Activation of Both A2A and A2B Receptors in Mice. J Cardiovasc Pharmacol 41(4):562-570, 2003.

Lin JJ, McKenney DW, Price K, Morrison RR, Novotny WE. Continuous Venovenous Hemodiafiltration in Hypernatremic Hyperglycemic Nonketotic Coma. Pediatr Nephrol 17(11):969-973, 2002.

Talukder MAH, Morrison RR, Jacobson MA, Jacobson KA, Ledent C, Mustafa SJ. Targeted Deletion of Adenosine A3 Receptors Augments Adenosine-Induced Coronary Flow in Isolated Mouse Hearts.Am J Physiol 282(6):H2183-2189, 2002.

Cerniway RJ, Morrison RR, Byford AM, Lankford AR, Headrick JP, Van Wylen DGL, Matherne GP. A1 Adenosine Receptor Overexpression Decreases Stunning from Anoxia-Reoxygenation: Role of the KATP Channel. Basic Res Cardiol 97(3):232-238, 2002.

Zucchi R, Cerniway RJ, Ronca-Testoni S, Morrison RR, Ronca G, Matherne GP. Effect of Cardiac A1 Adenosine Receptor Overexpression on Sarcoplasmic Reticulum Function. Cardiovasc Res 53:326-333, 2002.

Morrison RR, Talukder MAH, Ledent C, Mustafa SJ. Cardiac Effects of Adenosine in A2A Receptor Knockout Hearts: Uncovering A2B Receptors. Am J Physiol 282(2):H437-H444, 2002.

Talukder MAH, Morrison RR, Mustafa SJ. Comparison of the Vascular Effects of Adenosine in Isolated Mouse Heart and Aorta. Am J Physiol 282(1):H49-H57, 2002.

Show More

Morrison RR, Kiker MS, Baum VC. What Happens When Chest Tubes are Removed in Children?Pediatr Crit Care Med 2(1):17-19, 2001.

Headrick JP, Gauthier NS, Morrison RR, Matherne GP. Cardioprotection by KATP Channels in Wild-type Hearts and Hearts Overexpressing A1 Adenosine Receptors. Am J Physiol 279(4):H1690-H1697, 2000.

Morrison RR, Jones R, Byford AM, Stell AR, Headrick JP, Peart J, Matherne GP. Transgenic Overexpression of Cardiac A1 Adenosine Receptors Mimics Ischemic Preconditioning. Am J Physiol 279(3):H1071-H1078, 2000.

Headrick JP, Gauthier NS, Morrison RR, Matherne GP. Chronotropic and Vasodilatory Responses to Adenosine and Isoproterenol in Mouse Heart: Effects of Adenosine A1 Receptor Overexpression.Clin Exp Pharmacol Physiol 27(3):185-190, 2000.

Morrison RR, Saulsbury FT. Acute Hemorrhagic Edema of Infancy Associated With Pneumococcal Bacteremia. Ped Infect Dis J 18(9):832-833, 1999.

Gauthier NS, Morrison RR, Byford AM, Jones R, Headrick JP, Matherne GP. Functional Genomics of Transgenic Overexpression of A1 Adenosine Receptors in the Heart. Drug Devel Res 45:402-409, 1998.

Headrick JP, Gauthier NS, Berr SS, Morrison RR, Matherne GP. Transgenic A1 Adenosine Receptor Overexpression Markedly Improves Myocardial Energy State During Ischemia-Reperfusion. J Mol Cell Cardiol 30(5):1059-1064, 1998.

Gauthier NS, Matherne GP, Morrison RR, Headrick, JP. Determination of Function in the Isolated Working Mouse Heart: Issues in Experimental Design. J Mol Cell Cardiol 30(3):453-461, 1998.

Morrison RR. “The Match: Make Sure To...”; for WebRounds, a World Wide Web site for medical students maintained by the publishers Williams and Wilkins. March, 1996.

Last update: April 2017