Jason W. Rosch, PhD
Jason W. Rosch, PhD

Jason W. Rosch, PhD

Associate Member, St. Jude Faculty



BA – The College of Wooster, Wooster, Ohio
PhD – Washington University, St. Louis, Missouri

Research Interests

  • The role of metal transport systems of pathogenic streptococci in bacterial signaling and virulence
  • Development of novel antibiotics targeting microbial transport systems
  • Application of live attenuated vaccines for the prevention of bacterial infections
  • Modeling invasive pneumococcal disease and colonization in a sickle cell disease model of pathogenesis 

Selected Publications

Mann B, van Opijen T, Wang J, Obert C, Wang Y, Carter R, McGoldrick DJ, Ridout G, Camilli A, Tuomanen EI, Rosch JW. Control of Virulence by small RNA in Streptococcus pneumoniaPLOS Pathogens 8(7):e1002788, 2012.

Lebensburger JD, Howard T, Hu Y, Pestina TI, Gao G, Johnson M, Zakharenko SS, Ware RE, Tuomanen EI, Persons DA, Rosch JW. Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin. Blood 23;119(8):1915-21, 2012.

Rosch JW, Boyd AR, Hinojosa E, Pestina T, Hu Y, Persons DA, Orihuela CJ, Tuomanen EI. Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest 120:627-635, 2010.

Rosch JW, Gao G, Ridout G, Tuomanen E. Role of the manganese efflux system mntE for signaling and pathogenesis in Streptococcus pneumoniae. Mol Microbiol 72:12-25, 2009.

Kline KA, Kau AL, Chen SL, Lim A, Pinkner JS, Rosch J, Nallapareddy SR, Murray BE, Henriques-Normark B, Beatty W, Caparon MG, Hultgren SJ. Mechanism for sortase localization and role in efficient pilus assembly in Enterococcus faecalis. J Bacteriol 191:3237-3247, 2009.

Rosch JW, Sublett J, Gao G, Wang Y, Tuomanen E. Calcium efflux is essential for bacterial survival in the eukaryotic host. Mol Microbiol 70:435-444, 2008.

Rosch JW, Mann B, Sublett J, Tuomanen E. Convergence of regulatory pathways on the pilus locus of Streptococcus pneumoniae. Infect Immun 76:3187-3196, 2008.

Rosch JW, Vega L, Beyer J, Lin A, Caparon MG. The signal recognition particle pathway is required for virulence in Streptococcus pyogenes. Infect Immun 76:2612-2619, 2008.

Rosch JW, Tuomanen E. Adapting a diet from sugar to meat: double dealing genes of Streptococcus pyogenes. Mol Microbiol 64:257-259, 2007.

Rosch JW, Hsu FF, Caparon MG. Anionic lipids enriched at the ExPortal of Streptococcus pyogenes.J Bacteriol 189:801-806, 2007.

Rosch JW, Caparon MG. The ExPortal: An organelle for protein secretion and biogenesis in Streptococcus pyogenes. Mol Microbiol 58:959-968, 2005.

Rosch J, Caparon M. A microdomain for protein secretion in gram-positive bacteria. Science 304:1513-1515, 2004.

Last update: February 2013