Ruth Tatevossian, MD, PhD

Ruth Tatevossian, MD, PhD

  • Director, Diagnostic Biomarkers Shared Resource

Departments

Education

MB, BS – King’s College School of Medicine, University of London
PhD - University College London

Professional Experience

Dr. Tatevossian trained as a pediatric oncologist in the United Kingdom, and completed her PhD studying the molecular genetics of pediatric low-grade glioma. She joined the Pathology department at St. Jude in 2010 to work in the field of translational medicine, utilizing research discoveries from brain and solid tumors to develop molecular biomarkers for the clinical service. Dr. Tatevossian supervises correlative studies supporting clinical trials as Director of the Diagnostic Biomarkers Shared Resource. She is also the Technical Director for Neuropathology and Solid Tumor Pathology.

Selected Publications

Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li Y, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksford J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL, Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. Nature 506(7489):451-5, 2014. PMID 24553141

Gupta K, Orisme W, Harreld JH, Qaddoumi I, Dalton JD, Punchihewa C, Collins-Underwood R, Robertson T, Tatevossian RG, Ellison DW. Posterior fossa and spinal gangliogliomas form two distinct clinicopathologic and molecular subgroups. Acta Neuropathol Commun. 2(1):18, 2014. PMCID: PMC3931494

Broniscer A, Tatevossian RG, Sabin ND, Klimo P Jr, Dalton J, Lee R, Gajjar A, Ellison DW. Clinical, radiological, histological, and molecular characteristics of paediatric epithelioid glioblastoma.Neuropathol Appl Neurobiol 2013 Oct 15, 2013. PMID: 24127995

Henriquez HV, Forshew T, Tatevossian R, Ellis M, Richard-Loendt A, Rogers HA, Jacques TS, Reitboeck PG, Pearce K, Sheer D, Grundy RG, Brandner S. Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumour propagation in vitro. Cancer Research 73(18):5834-44, 2013. PMID: 23887970

Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B, Orisme W, Punchihewa C, Parker M, Qaddoumi I, Boop FA, Lu C, Kandoth C, Ding L, Lee R, Huether R, Chen X, Hedlund E, Nagahawatte P, Rusch M, Boggs K, Cheng J, Becksfort J, Ma J, Song G, Li Y, Wei L, Wang J, Shurtleff S, Easton J, Zhao D, Fulton RS, Fulton LL, Dooling DJ, Vadodaria B, Mulder HL, Tang C, Ochoa K, Mullighan CG, Gajjar A, Kriwacki R, Sheer D, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Baker SJ, Ellison DW. Whole –genome sequencing identifies genetic alterations in pediatric low-grade gliomas.Nat Genet 45(6):602-612, 2013. PMCID: PMC3727232

Paugh BS, Broniscer A, Qu C, Miller CP, Zhang J, Tatevossian RG, Olson JM, Geyer JR, Chi S, da Silva NS, Onar-Thomas A, Baker J, Gajjar A, Ellison DW, Baker SJ. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell cycle regulatory genes in diffuse intrinsic pontine gliomas. J Clin Oncol 29(30):3999-4006, 2011. PMCID: PMC3209696

Lawson AR, Hindley GF, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J, Jones TA, Ellison DW, Sheer D. RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology. Genome Research 21(4):505-514, 2011. PMCID: PMC3065698

Tatevossian RG, Tang B, Dalton J, Forshew T, Lawson AR, Ma J, Neale G, Shurtleff S, Bailey S, Gajjar A, Baker SJ, Sheer D, Ellison DW. MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathol 120(6):731-743, 2010. PMCID: PMC3066475

Lawson AR, Tatevossian RG, Phipps KP, Picker SR, Michalski A, Sheer D, Jacques TS, Forshew T. RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort. Acta Neuropathol 120(2):271-273, 2010. PMID: 20454969

Tatevossian RG, Lawson AR, Forshew T, Hindley GF, Ellison DW, Sheer D. MAPK pathway activation and the origins of pediatric low-grade astrocytomas. J Cell Physiol 222(3):509-514, 2010. PMID: 19937730

Nanduri V, Tatevossian R, Sirimanna T. High incidence of hearing loss in long-term survivors of multisystem Langerhans cell histiocytosis. Pediatr Blood Cancer 54(3):449-453, 2010. PMID: 19813249

Forshew T#Tatevossian RG#, Lawson ARJ, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J, Dalton J, Bailey S, Chaplin T, Carter RL, Gajjar A, Broniscer A, Young BD, Ellison DW, Sheer D. Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol 218(2):172-81, 2009. (#joint first authors). PMID: 19373855

Alston RD, Tatevossian RG, McNally RJ, Birch JM, Eden OB. ‘Incidence and survival of childhood Langerhans cell histiocytosis in Northwest England from 1954 to 1998’. Pediatr Blood Cancer 48:555-560, 2007. PMID: 16652350

Last update: February 2014