Katherine Verbist, PhD

Katherine Verbist, PhD

  • Senior Research Technologist

Departments

Divisions

Education

BA - Furman University, Greenville, SC
BS - Furman University, Greenville, SC
PhD - University of Georgia, Athens, GA

Honors & Awards

  • 2013 University of Georgia Excellence in Research Award, University of Georgia Research Foundation
  • 2011-2012 Achievement Reward for College Scientists (ARCS) Scholar Award, National ARCS Foundation, Georgia Chapter
  • 2009 BD Research Award for Best Poster Presentation, Influenza Pathogenesis and Immunobiology Conferences

Research Interests

I am investigating the role of cytotoxic lymphocytes in a variety of pathological states including infectious diseases, cancers, and cytokine-mediate disorders in order to better understand their therapeutic potential.

Selected Publications

Verbist KC and Nichols KE. Cytokine Storm Syndrome. Editors Cron and Behrens. Cytokine Storm Syndromes associated with Epstein-Barr Virus. 2019. Springer International Publishing. ed 1 (253-76). DOI: 10.1007/978-3-030-22094-5 2019

Verweyen E, Holzinger D, Weinhage T, Hinze C, Wittkowski H, Pickkers P, Albeituni S, Verbist K, Nichols KE, Schulert G, Grom A, Foell D, Kessel C. Synergistic TLR/IFNα/β-Signaling Facilitates Escape of IL-18 Expression from Endotoxin Tolerance. Am J Respir Crit Care Med. 2019 Nov 11. doi: 10.1164/rccm.201903-0659OC. [Epub ahead of print] 2019 PMID: 31710506

Albeituni S, Verbist KC, Tedrick PE, Tillman H, Picarsic J, Bassett R, Nichols KE. Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis. Blood. 2019 Jul 11;134(2):147-159. doi: 10.1182/blood.2019000761. Epub  Apr 23 2019. PMID: 31015190

Churchman ML, Qian M, Te Kronnie G, Zhang R, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Peters JL, Devidas M, Larsen E, Moore IM, Gu Z, Qu C, Yoshihara H, Porter SN, Pruett-Miller SM, Wu G, Raetz E, Martin PL, Bowman WP, Winick N, Mardis E, Fulton R, Stanulla M, Evans WE, Relling MV, Pui CH, Hunger SP, Loh ML, Handgretinger R, Nichols KE, Yang JJ, Mullighan CG. Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. Cancer Cell. 2018 May 14;33(5):937-948.e8. doi: 10.1016/j.ccell.2018.03.021. Epub Apr 19 2018. PMID: 29681510

Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S. RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16. PMID: 27321907

Verbist KC, Guy C, Milasta S, Liedmann S, Kaminski MM, Wang R, Green DR. Metabolic maintenance of cell asymmetry following division in activated lymphocytes. Nature 532(7599): 389-93, 2016.

Das R, Guan P, Sprague L, Verbist K, Tedrick P, Qi A, Cheng C, Kurachi M, Levine RL, Wherry J, Canna S, Behrens EM, Nichols K. Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis. Blood 127(13):1666-75, 2016.

Milasta S, Dillon CP, Sturm OE, Verbist KC, Brewer TL, Quarato G, Brown SA, Frase S, Janke LJ, Perry SS, Thomas PG, Green DR. Apoptosis-Inducing-Factor-dependent mitochondrial function is required for T cells but not B cell funciton. Immunity 44(1):88-102, 2016.    

Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A. Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1. Sci Transl Med Jan 13;8(321):321ra7, 2016. doi: 10.1126/scitranslmed.aad1565

Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell 157(5):1189-202, 2014.

Martinez, JA, Verbist KC, Wang, R, Green DR. The relationship between metabolism and the autophagy machinery during the innate immune response. Cell Metabolism 17(6):895-900, 2013.

Verbist KC, Wang, R, and Green DR. T cell metabolism and the immune response. Semin Immunol 24(6): 399-404, 2013.

Verbist KC, Klonowski KD. Functions of IL-15 in anti-viral immunity: multiplicity and variety. Cytokine 59(3):467-78, 2012.

Verbist KC, Rose DL, Cole CJ, Field MB, Klonowski KD. IL-15 participates in the Respiratory Innate Immune Response to Influenza Virus Infection. PLoS One 7(5):e37539, 2012.

Verbist KC, Field MB, Klonowski KD. IL-15-independent maintenance of mucosally generated memory CD8 T cells.Cutting Edge: J Immunol 186:6667-6671, 2011.

Verbist KC, Cole CJ, Field MB, Klonowski KD. A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. J Immunol 186:174-182, 2011.

Ramos IB, Miranda K, Pace DA, Verbist KC, Lin FY, Zhang Y, Oldfield E, Machado EA, De Souza W, Docampo R. Calcium and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes but are not the targets for NAADP. Bichem J 429:485-495, 2010.

Last update: November 2009