Jiyang Yu, PhD
Jiyang Yu, PhD

Jiyang Yu, PhD

Assistant Member, St. Jude Faculty



PhD - Columbia University, New York, NY
- Zhejiang University, Hangzhou, China

Research Interests

  • Systems Biology
  • Functional Genomics
  • Immuno-Oncology
  • Translational Oncology

Selected Publications

*Co-authorship; #Co-corresponding authorship

Tosello V, Saccomanni V, Yu J, Bordin F, Amadori A, Ferrando A, Piovan E. Calcineurin complex isolated from T-ALL cells identifies new signaling pathways whose inhibition synergize with Calcineurin inhibition to promote T-ALL cell death. Oncotarget 7 (29), 45715-45729.

Cheng H, Zhang Z, Rodriguez-Barrueco R, Borczuk A, Liu H, Yu J, Silva J, Cheng S, Perez-Soler R, Halmos B. Functional genomics screen identi_es YAP as a key determinant to enhance treatment sensitivity in lung cancer cells. Oncotarget 17;7(20):28976-88, 2016.

Rodriguez-Barrueco R*, Yu J*, Paula-Saucedo L, Olivan M, Llobet-Navas D, Putcha P, Castro V, Murga-Penas E, Castillo-Martin M, Cordon-Cardo C, Kalinsky K, Maurer M, Califano A#, Silva J#. Inhibition of the autocrine loop IL6-JAK2-STAT3-Calprotectin as targeted therapy for HR-/HER2+ breast cancers. Genes & Development 29(15):1631-48, 2015. (Clinical trial NCT02066532 was initiated based on this work; featured at Science Signaling, 25 Aug 2015).

Putcha P*, Yu J*, Rodriguez-Barrueco R, Paula-Saucedo L, Villagrasa P, Murga-Penas E, Quayle S, Yang M, Castro V, Llobet-Navas D, Birnbaum D, Finetti P, Woodward W, Bertucci F, Alpaugh M#, Califano A#, Silva J#. HDAC6 activity is a non-oncogene addiction hub for inammatory breast cancers. Breast Cancer Research 17(1):149, 2015. (Clinical trial NCT02632071 was initiated and a biomarker patent is being evaluated in the trial).

Yu J#, Silva J#, Califano A#. ScreenBEAM: a Novel Meta-Analysis Algorithm for Functional Genomics Screens via Bayesian Hierarchical Modeling. Bioinformatics btv556, 2015.

Yu J#, Putcha P, Silva J#. Recovery Drug-Induced Apoptosis Subnetwork from Connectivity Map Data. BioMed Research International 2015:708563, 2015.

Tosello V, Bordin F, Yu J, Agnusdei V, Indraccolo S, Basso G, Amadori A, Piovan E. Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through XIAP degradation. Leukemia 30:812-822, 2015.

O'Brien S, Chen L, Zhong W, Armellino D, Yu J, Loreth C, Follettie M, Damelin M. TGFB exerts opposing e_ects on breast cancer cells that survive chemotherapy versus hypoxia. Cancer Research 75(21):4605-16, 2015.

Sato M, Rodriguez-Barrueco R, Yu J, Do C, Silva J, GautierJ. MYC is a critical target of FBXW7. Oncotarget 20;6(5):3292-305, 2015.

Piovan E*, Yu J*, Tosello V, Castillo M, Indraccolo S, Paietta E, Racevskis J, Rowe J, Tallman M, Meijerink J, Cordon-Cardo C, Califano A#, Ferrando A#. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. Cancer Cell 24(6):766-76, 2013.

Yu J, Putcha P, Califano A, Silva J. Pooled ShRNA Screenings: Computational Analysis. Methods in Molecular Biology, 980:371-84, 2013.

Lv B*, Yu J*, Xu J, Chen J, Lai M. A novel approach to detect differentially expressed genes from tag-based digital databases with introducing normalization of housekeeping genes. Genomics 94(3):211-216, 2009.

Lv B, Xu J, Chen J, Yu J, Xu E, Lai M. TaqMan low density array is roughly right for gene expression quantitation in colorectal cancer. Clin Chimica Acta 389(1-2):146-151, 2008.

Last update: December 2016