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Peter C. Doherty, PhD
Peter C. Doherty, PhD

Peter C. Doherty, PhD

Emeritus, St. Jude Faculty

  • Nobel Laureate
  • Michael F. Tamer Chair of Biomedical Research



PhD – University of Edinburgh, Scotland
MVSc – Unversity of Queensland, Australia
BVSc – University of Queensland, Australia

Honors & Awards

  • Elected to the Institute of Medicine (2009)
  • Institute of Medicine of the National Academy of Sciences (now National Academy of Medicine) (2008)
  • Nobel Prize for Physiology or Medicine (1996)
  • Honorary Doctor of Sciences Degree, Imperial College of Sciences, Technology and Medicine, London, England (2000)
  • National Academy of Sciences (1998)
  • Fellow of the Royal Society, London (1996)
  • Albert Lasker Basic Medical Research Award (1995)

Research Interests

  • Cell-mediated immunity
  • T cell recognition and repertoire
  • Immunological tolerance
  • Viral immunology
  • Immunopathology
  • Immune memory

Selected Publications

Valkenburg SA, Venturi V, Dang TH, Bird NL, Doherty PC, Turner SJ, Davenport MP, Kedzierska K. Early priming minimizes the age-related immune compromise of CD8 T cell diversity and function. PLoS Pathog Feb;8(2):e1002544, 2012.

Doherty PC, Thomas PG. Dangerous for ferrets: lethal for humans? BMC Biol Feb 20;10(1):10, 2012.

Fouchier RA, García-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz J, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Mettenleiter TC, Osterhaus AD, Palese P, Peiris JS, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG. Pause on avian flu transmission research. Science Jan 27;335(6067):400-1, 2012.

Denton AE, Wesselingh R, Gras S, Guillonneau C, Olson MR, Mintern JD, Zeng W, Jackson DC, Rossjohn J, Hodgkin PD, Doherty PC, Turner SJ. Affinity Thresholds for Naive CD8+ CTL Activation by Peptides and Engineered Influenza A Viruses. J Immunol Dec 1;187(11):5733-44, 2011.

Denton AE, Russ BE, Doherty PC, Rao S, Turner SJ. Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells. Proc Natl Acad Sci U S A Sept 13;108(37):15306-15311, 2011.

Doherty PC. The tetramer transformation. J Immunol Jul 1;187(1):5-6, 2011.

Day EB, Guillonneau C, Gras S, La Gruta NL, Vignali DA, Doherty PC, Purcell AW, Rossjohn J, Turner SJ. Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc Natl Acad Sci U S A May 2;108(23):9536-9541, 2011.

Wu C, Zanker D, Valkenburg S, Tan B, Kedzierska K, Zou QM, Doherty PC, Chen W. Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals. Proc Natl Acad Sci U S A May 31;108(22):9178-9183, 2011.

Venturi V, Davenport MP, Swan NG, Doherty PC, Kedzierska K. Consequences of suboptimal priming are apparent for low-avidity T-cell responses. Immunol Cell Biol Feb;90(2):216-23, 2012.

Day EB, Charlton KL, La Gruta NL, Doherty PC, Turner SJ. Effect of MHC Class I Diversification on Influenza Epitope-Specific CD8+ T Cell Precursor Frequency and Subsequent Effector Function. J Immunol Jun 1;186(11):6319-28, 2011.

Valkenburg SA, Rutigliano JA, Ellebedy AH, Doherty PC, Thomas PG, Kedzierska K. Immunity to seasonal and pandemic influenza A viruses. Microbes Infect 13:489-501, 2011.

Croom HA, Denton AE, Valkenburg SA, Swan NG, Olson MR, Turner SJ, Doherty PC, Kedzierska K. Memory precursor phenotype of CD8(+) T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection. Eur J Immunol Mar;41(3):682-93, 2011.

Dash P, McClaren JL, Oguin TH 3rd, Rothwell W, Todd B, Morris MY, Becksfort J, Reynolds C, Brown SA, Doherty PC, Thomas PG. Paired analysis of TCRα and TCRβ chains at the single-cell level in mice. J Clin Invest Jan 4;121(1):288-295, 2011.

Moffat JM, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL. Influenza Epitope-Specific CD8+ T Cell Avidity, but Not Cytokine Polyfunctionality, Can Be Determined by TCR{beta} Clonotype. J Immunol Dec 1;185(11):6850-6856, 2010.

Turner SJ, Doherty PC, Kelso A. Q&A: H1N1 pandemic influenza - what's new? BMC Biol Oct 11;8(1):130, 2010.

Doherty PC. The glittering prizes. Nat Immunol Oct;11(10):875-8, 2010.

Sanders CJ, Doherty PC, Thomas PG. Respiratory epithelial cells in innate immunity to influenza virus infection. Cell Tissue Res Jan;343(1):13-21, 2011.

Valkenburg SA, Gras S, Guillonneau C, La Gruta NL, Thomas PG, Purcell AW, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K. Protective Efficacy of Cross-Reactive CD8 T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold. PLoS Pathog Aug 12;6(8). pii: e1001039, 2010.

Valkenburg SA, Day EB, Swan NG, Croom HA, Carbone FR, Doherty PC, Turner SJ, Kedzierska K. Fixing an irrelevant TCRalpha chain reveals the importance of TCRbeta diversity for optimal TCRalphabeta pairing and function of virus-specific CD8(+) T cells. Eur J Immunol Sep;40(9):2470-81, 2010.

Gras S, Kedzierski L, Valkenburg SA, Laurie K, Liu YC, Denholm JT, Richards MJ, Rimmelzwaan GF, Kelso A, Doherty PC, Turner SJ, Rossjohn J, Kedzierska K. Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses. Proc Natl Acad Sci U S A July 12;107(28):12599-12604, 2010.

Cukalac T, Valkenburg SA, La Gruta NL, Turner SJ, Doherty PC, Kedzierska K. Multiplexed combinatorial tetramer staining in a mouse model of virus infection. J Immunol Methods360:157-161, 2010.

Olson MR, Russ BE, Doherty PC, Turner SJ. The role of epigenetics in the acquisition and maintenance of effector function in virus-specific CD8 T cells. IUBMB LifeJul;62(7):519-26, 2010.

La Gruta NL, Rothwell WT, Cukalac T, Swan NG, Valkenburg SA, Kedzierska K, Thomas PG, Doherty PC, Turner SJ. Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. J Clin Invest Jun 1;120(6):1885-94, 2010.

Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J. Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition. Proc Natl Acad Sci U S A March 23;107(12):5534-5539, 2010.

Thomas PG, Doherty PC. New approaches in immunotherapy. Science Jan 15 ;327(5963):249, 2010.

Thomas PG, Brown SA, Morris MY, Yue W, So J, Reynolds C, Webby RJ, Doherty PC. Physiological Numbers of CD4+ T Cells Generate Weak Recall Responses Following Influenza Virus Challenge. J Immunol Feb 15;184(4):1721-7, 2010.

Last update: March 2012