Chelsea Goodenough, PhD

Dr. Chelsea Goodenough’s research is rooted in her appreciation of exercise and nutrition to improve the quality of life, particularly for children. Her appreciation extends to the ability of the body to adapt to physical demands and curiosity about factors that influence how successfully the body responds. 

She earned a doctorate at Texas A&M University in College Station (2019). Dr. Goodenough then joined the Department of Epidemiology and Cancer Control at St. Jude Children’s Research Hospital as a postdoctoral fellow. Her current research focuses on how childhood cancer treatment affects the musculoskeletal health and physical function of long-term survivors of childhood cancer. Dr. Goodenough’s work will help identify physiological targets for intervention to improve physical function and muscle health in children with cancer and childhood cancer survivors. 

 “Modern clinical research requires a multidisciplinary approach that transcends the traditional research paradigm. This is particularly true of pediatric cancer research.  I chose to pursue a Master of Science in Clinical Investigations to understand the clinical investigation process and to strengthen my scientific communication and collaboration capacity to become a more effective, efficient, and relevant researcher. Given the St. Jude collaborative culture and the interdisciplinary relationships required for clinical research, I strongly believe there is no better place to acquire formal training and experience in clinical investigation than from the St. Jude Children's Research Hospital Graduate School of Biomedical Sciences.”

PhD - Texas A&M University, College Station, Texas (2019)

Goodenough CG
, Diouf B, Yang W, Sapkota Y, Finch ER, Lu L, Partin RE, Wogksch MD, Hudson MM, Robison LL, Wang Z, Jeha S, Evans WE, Ness KK. Association between CEP72 genotype and persistent neuropathy in survivors of childhood acute lymphoblastic leukemia. Leukemia. 2022 Apr;36(4):1160-1163. PMID: 34980876. Role: First author

Goodenough CG, Wogksch MD, Kundu M, Lear M, Thomas PG, Srivastava DK, Wang Z, Armstrong GT, Hudson MM, Robison LL, Ness KK. Associations between exercise capacity and biomarkers of cellular senescence and inflammation among adult survivors of childhood cancer. Front Oncol.2022 Oct (in press) Role: First author

Goodenough CG, Partin RE, Ness KK. Skeletal muscle and childhood cancer: Where are we now and where we go from here. Review. Aging Cancer. 2021 Jun;2(1-2):13-35. PMID: 34541550. Role: First author

Davis AC*, Goodenough CG*, Westerlind KC, Strange R, Deaver JW, Ryan PA, Riechman SE, Fluckey JD. Myokines Derived from Contracting Skeletal Muscle Suppress Anabolism in MCF7 Breast Cancer Cells by Inhibiting mTOR. Front Physiol (Cell Physiology). 2022 Oct;13: doi: 10.3389/fphys.2022.1033585    Role: *Co-first author

Wogksch MD, Goodenough CG, Finch ER, Partin RE, Ness KK. Physical activity and fitness in childhood cancer survivors: a scoping review. Review. Aging Cancer. 2021 Dec;2(4):112-128. PMID: 35098147

 Wogksch MD, Finch ER, Nolan VG, Smeltzer MP, Mzayek F, Goodenough CG, Pui CH, Inaba H, Mulrooney DA, Kaste SC, Brinkman TM, Lanctot JQ, Srivastava DK, Jefferies JL, Armstrong GT, Robison LL, Hudson MM, Ness KK. Energy cost of walking in obese survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort. Front Pediatr. 2022 Oct; 10. doi: 10.3389/fped.2022.976012