St. Jude Graduate School of Biomedical Sciences

Our Faculty

 
Faculty

Our students benefit from dedicated advising and mentorship from world-class biomedical researchers. The Graduate School faculty draws leading scientific and clinical investigators from diverse research areas across St. Jude Children’s Research Hospital.

Graduate School Faculty

  1. Basic and translational research faculty teach first-year courses and serve on student committees. Most accept students for laboratory rotations and dissertation projects.

    Biostatistics

    • Arzu Onar-Thomas, PhD

      Arzu Onar-Thomas, PhD

      Onar-Thomas

      PhD – University of South Carolina

      • Early phase clinical trial designs
      • Survival analysis
      • Accelerated testing and degradation models
    • Stan Pounds, PhD

      PhD – Texas A&M University

      • Develop statistical methods for genomics studies 

    Cell & Molecular Biology

    • Hans-Martin Herz, PhD

      PhD – Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg, Germany

      • Regulation of transcription and enhancer activity by chromatin-modifying proteins
      • Non-histone substrates of histone-modifying enzymes
      • Enhancer malfunction in cancer
      • Histone lysine to methionine mutants in development and disease
    • Stacey K. Ogden, PhD

      PhD - University of Cincinnati College of Medicine

      • Mechanisms of Hedgehog signal transduction
      • Identification of factors functioning downstream of the Hedgehog receptor
      • Alteration of Hedgehog signaling in cancer 
    • Joseph T. Opferman, PhD

      PhD - University of Chicago

      • Apoptosis
      • Hematopoiesis
      • Development and regulation of the immune system
      • Regulation of homeostasis by growth factor signaling
    • P. Ryan Potts, PhD

      PhD - UT Southwestern Medical Center

      • Tumorigenic function and therapeutic targeting of cancer-testis antigens, 
      • Biochemical and molecular characterization of MAGE protein function in cellular processes
      • Physiological function of MAGE proteins in vivo using knockout animal models
    • J. Paul Taylor, MD, PhD

      MD, PhD - Jefferson Medical College, Philadelphia

      • Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in neurological diseases
      • Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration
      • Investigate the molecular genetics of amyotrophic lateral sclerosis, frontotemporal dementia, inclusion body myopathy and polyglutamine disease
      • Screen small molecules to identify clinically useful compounds

    Chemical Biology & Therapeutics

    • Taosheng Chen, PhD, PMP

      PhD -  University of Vermont

      • Regulation of PXR and CAR in drug toxicity, drug resistance and human diseases
      • Regulation of PAX3-FOXO1 and muscle differentiation in the development of rhabdomyosarcoma
      • Development of drug discovery technologies
      • High-throughput screening (HTS) and high content screening (HCS)
    • Naoaki Fujii, PhD

      PhD -  Osaka University, Japan

      • Functional small molecule inhibitor of Dishevelled
      • Small molecular agents targeting DNA replication and translesion DNA synthesis
    • Richard E. Lee, PhD

      PhD - University of Newcastle-upon-Tyne

      • Medicinal Chemistry – design, synthesis and development of novel chemotherapeutic agents to treat drug resistant infections and tumors
      • Structure based drug design of new agents using advanced computer aided and fragment based drug design technologies
      • Isolation, characterization and modification of bacterial derived natural products for therapeutic purposes
      • Anti-infective microbiology – study of problematic drug resistant bacterial pathogens including M. tuberculosis and MRSA
    • Fatima Rivas, PhD

      PhD - University of California, San Diego

      • Target oriented chemical synthesis of novel natural products from terrestrial plants
      • The development of therapeutic agents for the treatment of cancer and metabolic syndrome-related disorders
      • Isolation and structure elucidation of natural products of medicinal interest
    • Anang A. Shelat, PhD

      PhD - University of California, San Francisco

      • Multi-scale modeling of biological and chemical data

    Computational Biology

    • Jinghui Zhang, PhD

      PhD - The University of Connecticut

      • The effects of genetic alterations on cancer initiation, progression and prognosis through integrative analysis of large-scale, multi-dimensional genomic data
      • The development of highly accurate and sensitive computational methods for analyzing large-scale genomic data derived from high-throughput sequencing
      • Development of visualization tools for viewing integrative genomic data
      • Understanding the genetic and epigenetic landscape of pediatric cancer
      • Integrating whole-genome sequencing data with RNA sequencing, copy number variation, structural variation, telomere content and gene expression

    Developmental Neurobiology

    • Suzanne J. Baker, PhD

      Leader, Curriculum Committee

      PhD - The Johns Hopkins University

      • Molecular, genetic and cellular basis of oncogenesis
      • Mechanisms driving pediatric diffuse high-grade gliomas
      • Oncogenic mutations connecting tumorigenesis and chromatin regulation
    • Xinwei Cao, PhD

      PhD - Beijing (Peking) University

      • Mechanisms that regulate the growth of the vertebrate nervous system
      • Understanding how growth-control mechanisms are coupled with patterning mechanisms to achieve the size, shape, and cytoarchitecture of the nervous system
      • The connections between growth-control mechanisms and human neurological tumors and malformations
      • Identifying the genetic basis of brain size evolution
    • Fabio Demontis, PhD

      PhD - Max Planck Institute for Cell Biology and Genetics, Dresden

      • Role of proteostasis and stress responses in skeletal muscle aging
      • Systemic signaling via muscle-derived secreted factors (myokines) during aging and age-related diseases 
    • Michael A. Dyer, PhD

      Co-leader, Translational Training

      PhD - Harvard University

      • Coordination of proliferation and differentiation during neurogenesis
      • Retinal disease and stem cell based therapies
      • Retinoblastoma and targeted chemotherapy
      • Pediatric solid malignancies
      • High throughput screening and drug discovery
      • Genomics and epigenomics of pediatric solid tumors
    • Young-Goo Han, PhD

      PhD -  State University of New York, Stony Brook

      • Function of primary cilia in brain development
      • Function of primary cilia in tumorigenesis
      • Molecular mechanism of ciliary function in signaling pathways
    • Myriam Labelle, PhD

      PhD – Dresden University of Technology

      • Role of the microenvironment during cancer metastasis
      • Influence of platelets on tumor cell behavior
      • Platelet-derived factors and signals involved in cancer progression and metastasis
    • Paul A. Northcott, PhD

      PhD – University of Toronto, Ontario

      • Integrative genomics to discover genes and pathways driving pediatric brain tumorigenesis
      • Developmental biology of pediatric brain tumors including their cellular origins
      • Generation of preclinical models recapitulating the molecular features of pediatric brain tumors
    • Jamy C. Peng, PhD

      PhD - University of California at Berkeley

      • Proteins and RNAs in epigenetic programming of stem cell functions
      • Epigenetic mechanisms influencing gene expression changes
      • Epigenetic regulation of stem cell functions
    • David J. Solecki, PhD

      PhD - SUNY at Stony Brook

      • Molecular and cellular mechanisms regulating neuronal motility
      • The interplay between neuronal differentiation and neuronal polarity signaling
      • The centrosome as a focal point to coordinate cellular polarity
      • Time-lapse microscopy as a tool to unlock the cell biology of neural development
      • Cerebellar development
    • Stanislav S. Zakharenko, MD, PhD

      MD – Russian State Medical University
      PhD – Russian Academy of Sciences

      • Functional organization and plasticity of the auditory cortex
      • Molecular and cellular mechanisms of schizophrenia
      • Synaptic plasticity in the hippocampus
    • Jian Zuo, PhD

      PhD - University of California, San Francisco

      • Prestin and cochlear amplification
      • Hair cell regeneration

    Diagnostic Imaging

    • Scott E. Snyder, PhD

      PhD - Purdue University

      • Development of radiopharmaceuticals for positron emission tomographic (PET) imaging
      • Functional characterization of tumors
      • Therapy response monitoring
      • Investigation of therapy-induced neurological disorders in cancer survivors

    Genetics

    • Gerard Grosveld, PhD

      Ph.D. - University of Amsterdam, Medical Research Council, London

      • Role of chromosomal translocations in acute myeloid leukemia (AML) and alveolar rhabdomyosarcoma (ARMS)
      • The biological and biochemical roles of aberrant fusion proteins in tumorigenesis
    • Peter J. McKinnon, PhD

      PhD  - The Finders University of South Australia

      • Molecular neurobiology
      • Mouse models of human disease
      • Brain tumors
      • Neurodegeneration
      • Tumor suppressors

    Hematology

    • Wilson K. Clements, PhD

      PhD  - University of Washington, Seattle

      • The embryonic specification of hematopoietic stem cells
      • The integrated development of the vascular and hematopoietic systems
      • The molecular basis of leukemia
    • Shannon McKinney-Freeman, PhD

      PhD - Baylor College of Medicine

      • Cellular and molecular regulation of hematopoietic stem cell in vivo repopulating activity
      • Hematopoietic stem cell development and specification
    • Brian P. Sorrentino, MD

      MD – SUNY Upstate Medical Center College, Syracuse

      • Experimental Hematology
    • Mitchell Weiss, MD, PhD

      MD, PhD - University of Pennsylvania

      • Mechanisms of gene expression during blood cell development
      • Non-coding RNAs in red blood cell formation, including microRNAs and lnc RNAs
      • Use of induced pluripotent stem cells to model human blood disorders including leukemia
      • Structure and biology of hemoglobins
      • Role of ubiquitin ligases in red blood cell development

    Immunology

    • Hongbo Chi, PhD

      PhD – University of Rochester

      • Mechanisms of immune signaling and cell metabolism that control the differentiation and function of T cells 
    • Douglas Green, PhD

      PhD -  Yale University

      • Central mechanisms of apoptosis in cancer and the immune system
    • Thirumala-Devi Kanneganti, PhD

      PhD -  Osmania University, Hyderabad

      • How the innate immune system recognizes and responds to pathogens
      • How genetic mutations in innate immunity affect the development of infectious, inflammatory, and autoimmune diseases in humans
      • Nod-like Receptors and their adaptor proteins
      • The activation of signaling cascades and the mechanisms involved in the regulation of inflammation in autoinflammatory diseases

       

    • Maureen A. McGargill, PhD

      PhD - University of Minnesota

      • Regulation of the immune response in autoimmune diseases including type 1 diabetes and multiple sclerosis
      • Optimizing the immune response against conserved portions of influenza
      • Immune modulation of cartilage homeostasis and osteochondromas
    • Paul G. Thomas, PhD

      PhD – Harvard University, Cambridge, Massachusetts

      • Innate and adaptive immunity to influenza
      • T cell receptor repertoires in infection and cancer
      • Influenza-associated immune-induced healing responses and pathology
      • CD8 T cell memory and recall potential
    • Benjamin A. Youngblood, PhD

      PhD - University of California Santa Barbara

      • Viral Immunity
      • CD8 T cell memory differentiation
      • CD8 T cell exhaustion
      • Epigenetic regulation of T cell functions
      • Therapeutic vaccination

    Infectious Diseases

    • Hans Haecker, MD, PhD

      MD - Albert Einstein University, Ulm
      PhD - Technical University of Munich

      • Signal transduction of members of the Toll-like- and TNF-receptor family in innate immune cells
      • Signaling pathways in B-cells and B-cell malignancies
      • Definition and function of novel Influenza virus - host protein interactions
      • Generation of hematopoetic cell differentiation systems based on Hox genes
    • Julia L. Hurwitz, PhD

      PhD - Johns Hopkins University

      • Vaccine development
      • Immune responses at the mucosal surface
    • Jason W. Rosch, PhD

      PhD - Washington University

      • The role of metal transport systems of in bacterial signaling and virulence
      • Development of novel antibiotics targeting microbial transport systems
      • Application of live attenuated vaccines for the prevention of bacterial infections
      • Modeling invasive pneumococcal disease and colonization in a sickle cell disease model of pathogenesis
    • Charles J. Russell, PhD

      PhD - University of California at Berkeley

      • Molecular mechanisms of infectious diseases caused by emerging influenza viruses and paramyxoviruses
      • Negative-strand RNA virus replication and pathogenesis, focusing on influenza viruses and paramyxoviruses
      • Viral envelope glycoproteins as targets for novel vaccines and drugs
    • Stacey L. Schultz-Cherry, PhD

      PhD - University of Alabama, Birmingham

      • Influenza virus pathogenesis
      • Astrovirus pathogenesis
      • Novel vaccines and therapeutics
      • Microbial co-Infections
    • Amber M. Smith, PhD

      PhD - University of Utah, Salt Lake City

      • Kinetics of virus infection
      • Bacterial co-infection
      • Host immune responses
      • Computational and systems biology approaches
    • Elaine I. Tuomanen, MD

      MD - McGill University

      • Molecular pathogenesis of Streptococcus pneumoniae invasion and inflammation
      • Mouse models of pneumonia and meningitis
      • Pneumococcal vaccine design, intervention in gram-positive sepsis/meningitis, new antibiotic development strategies, and interruption of the spread of genetic elements responsible for antibiotic resistance
    • Richard Webby, PhD

      PhD - University of Otago

      • Influenza virus ecology
      • Influenza vaccination
      • Influenza virus pathogenicity
      • Determinants of host susceptibility to influenza

    Oncology

    • Kevin W. Freeman, PhD

      PhD - Baylor College of Medicine

      • Role of development in neuroblastoma
      • Molecular basis of metastasis
      • Creating preclinical models of neuroblastoma 
    • Mark E. Hatley, MD, PhD

      MD, PhD - University of Texas Southwestern Medical Center at Dallas

      • Cellular and molecular origins of embryonal rhabdomyosarcoma
      • MicroRNAs in pediatric sarcomas
      • Mouse models of pediatric sarcomas
      • Development of novel therapies for pediatric sarcomas

    Pathology

    • Terrence Geiger, MD, PhD

      MD, PhD - Yale University

      • Immune regulation
      • Autoimmunity
      • Cellular immunotherapy
      • Clinical pathology
      • Transfusion medicine and apheresis
    • Mondira Kundu, MD, PhD

      MD, PhD - Jefferson Medical College

      • Insights into the pathogenesis of hematopoietic disorders, including myelodysplastic syndromes and acute leukemias
      • The development of improved diagnostic tools and therapies
      • Characterization of signals involved in targeting mitochondria for autophagic degradation
      • Role of autophagy in erythropoiesis and tumorigenesis
    • Michael M. Meagher, PhD

      MS – Iowa State University
      BS – Colorado State University

      • Fermentation and downstream processing of recombinant proteins
      • cGMP manufacturing
      • cGMP facility design
    • Charles G. Mullighan, MBBS (Hons), MSc, MD

      MD - University of Adelaide

      • Genome-wide approaches to identify genomic aberrations contributing to leukemogenesis and influencing leukemia outcome
      • In vitro and in vivo approaches to model genomic abnormalities in leukemogenesis
      • Genetics of disease susceptibility and disease phenotype
    • Leta K. Nutt, PhD

      PhD - University of Texas M.D. Anderson Health Science Center

      • Metabolic regulation of apoptosis
      • Calcium homeostasis during apoptosis
      • Metabolic regulation of ER stress
    • Janet F. Partridge, PhD

      PhD -  University of London, National Institute for Medical Research

      • To understand how centromeric heterochromatin is formed
      • To identify new components of centromeric heterochromatin in both fission yeast and mammals through a combination of biochemical and genetic approaches
      • To determine whether mutations in mammalian factors contribute to aneuploidy and cancer progression
    • Gerard P. Zambetti, PhD

      PhD – University of Florida, Gainesville

      • Function of wild-type and mutant p53 in tumor suppression and oncogenesis
      • Regulation of cell cycle, cell survival and differentiation

    Pharmaceutical Sciences

    • Mary V. Relling, PharmD

      PharmD - University of Utah College of Pharmacy

      • Antineoplastic pharmacokinetics and pharmacodynamics in children
      • Clinical implementation of pharmacogenomic testing
      • Host- and treatment-related risk factors affecting antileukemic therapy
    • Erin G. Schuetz, PhD

      PhD – Medical College of Virginia, Virginia Commonwealth University, Richmond

      • Regulation of cytochrome P4503A
      • Interplay of drug transport, cytochromes P450 and nuclear hormone receptors
      • Pharmacogenetics of drug transporters, cytochromes P450 and nuclear hormone receptors
      • Arachnoid Barrier drug transporters - contribution to the blood-CSF barrier
    • John D. Schuetz, PhD

      PhD - Medical College of Virginia, Richmond

      • Role of ABC transporters in response to chemotherapy
      • Biological function of ABC transporters
      • Regulation of ABC transporters
    • Clinton F. Stewart, PharmD

      PharmD - University of Tennessee, Memphis

      • CNS and tumor penetration of novel agents used to treat pediatric CNS tumors in relevant mouse models
      • Pharmacokinetic and pharmacodynamic modeling to derive safe and effective anti-cancer drug regimens for infants and young children with brain tumors
      • Novel methods to optimize drug exposure in children with cancer
    • Jun J. Yang, PhD

      PhD - Purdue University

      • Genetic basis of racial differences in response to antileukemic agents
      • Molecular mechanisms of drug resistance in relapsed leukemia
      • Pharmacogenomics of novel antileukemic agents
    • Liqin Zhu, PhD

      PhD -  Purdue University

      • Mouse model of childhood hepatoblastoma
      • Stem cell in normal tissue development
      • Cell-of-origin of pediatric vs. adult cancers 

    Structural Biology

    • Eric J. Enemark, PhD

      PhD - Stanford University, Stanford

      • Molecular mechanisms of DNA replication
      • Atomic details underlying molecular recognition and site-specific DNA-binding
      • Molecular details of DNA manipulation and translocation
      • The role of ATPases and their chemical architecture 
    • Richard Kriwacki, PhD

      Leader, Admissions Committee

      PhD - Yale University

      • The molecular basis of regulation of cell division and apoptosis, with special emphasis on the role of tumor suppressor proteins
      • Application of structural biology and biophysical techniques to study biomolecular mechanisms
      • Intrinsic protein flexibility in regulatory mechanisms
      • Proteins p21, p27, p53, BCL-xL and PUMA
    • Tanja Mittag, PhD

      PhD - Johann Wolfgang Goethe University, Frankfurt

      • "Fuzzy" complexes, i.e. dynamic protein complexes, in the ubiquitination pathway
      • Liquid-like protein states and their relationship to cellular bodies
      • (Non-)structure/function relationship of intrinsically disordered proteins
    • Tudor Moldoveanu, PhD

      PhD - Queen’s University, Kingston, Ontario

      • Programmed cell death in cancer biology
      • Mechanisms of BCL-2 family proteins-mediated apoptosis
      • Molecular mechanisms of necrosis
      • Drug discovery of programmed cell death
    • Junmin Peng, PhD

      PhD - University of Iowa

      • Development of high-throughput proteomics tools
      • Analysis and function of protein ubiquitination
      • Proteomics in neurodevelopment and neurodegeneration
      • Cancer proteomics
    • Stephen White, DPhil

      Dean, St. Jude Graduate School

      DPhil - University of Oxford

      • Structure and function of biological macromolecules
      • Structure-assisted drug discovery
      • Enzyme mechanisms
      • Protein-DNA interactions
      • DNA repair and recombination

    Surgery

    • Andrew M. Davidoff, MD

      MD - University of Pennsylvania

      • Board certified pediatric surgeon (Duke University Medical Center and the Children's Hospital of Philadelphia)
      • Clinical and translational investigation and treatment of pediatric solid tumors
      • The development of new strategies for the treatment of neuroblastoma
      • Angiogenesis inhibition and gene therapy for cancer treatment
    • Jun Yang, MD, PhD
      • The role of histone modifiers in cancer
      • Rational combination therapy
      • Hypoxia signaling pathway and angiogenesis
      • miRNA function in cancer
      • Drug discovery

    Tumor Cell Biology

    • Linda M. Hendershot, PhD

      PhD - University of Alabama, Birmingham

      • Control of the synthesis and assembly of secretory proteins in the ER
      • Regulation of immunoglobulin transport
      • Elucidation of ER stress-induced signal transduction pathways
      • Role of the ER stress response in regulating tumor chemosensitivity
    • Martine F. Roussel, PhD

      PhD - Université de Lille

      • The tumor suppressor pathway Arf/Mdm2/p53 in cancer
      • Positive and negative regulation in brain development and cancer
      • Genes and microRNAs in brain tumors
      • Development of mouse models of human brain cancers to conduct pre-clinical trials with novel targeted therapies
      • G1 progression and G1/S control
      • Role of the BMP-Atohnal signaling pathway in development and tumorigenesis
  2. Clinical faculty teach first-year courses, serve on student committees and provide clinical experiences and mentorship, providing a strong grounding for translational research projects.

    Bone Marrow Transplant

    • Brandon Triplett, MD

      MD -  St. Louis University School of Medicine

      • Hematopoietic cell transplant for high risk leukemia
      • Use of alternative donors in patients lacking a fully matched sibling donor
      • Immune reconstitution following hematopoietic cell transplant
      • Broadening the use of hematopoietic cell transplant for patients with non-malignant diseases

    Epidemiology & Cancer Control

    • Gregory T. Armstrong, MD, MSCE

      MD - University of Alabama School of Medicine

      • Cancer survivorship
      • Outcomes research
      • Neuro-oncology
    • Daniel Green, MD

      MD - St. Louis University School of Medicine

      • Late effects of treatment for childhood cancer, particularly fertility and pregnancy outcome
      • Late effects of treatment for Wilms tumor

    Diagnostic Imaging

    • Julie H. Harreld, MD

      MD - University of Texas Southwestern Medical School

      • Using quantitative MR techniques to image the metabolic and microstructural changes underlying disease and post-treatment changes in the brain
      • Imaging protocol optimization
    • Mary E. (Beth) McCarville, MD

      MD - University of Iowa College of Medicine

      • Ultrasound

    Hematology

    • Jeremie H. Estepp, MD

      MD - Joan C. Edwards School of Medicine, Marshall University, West Virginia

      • Thrombosis
      • Bleeding disorders
      • Sickle Cell Disease 
    • Jane S. Hankins, MD, MS

      MD - Federal University of Rio de Janeiro

      • Decision-making in sickle cell disease
      • New therapeutic approaches in sickle cell disease
      • Long-term effects of hydroxyurea in sickle cell patients
      • Iron overload
    • Ulrike M. Reiss, MD

      MD - University of Heidelberg

      • Bleeding disorders
      • Thrombosis
      • Bone marrow failure syndromes

    Infectious Diseases

    • Miguela Caniza, MD

      MD - Universidad Nacional de Asunción

      • Educational programs in infectious diseases for international health care professionals who take care of children
      • Infection control in pediatric hematology/oncology services in countries of limited resources
    • Aditya Gaur, MD

      MD - South Gujarat University

      • Diagnosis and treatment of infections in immunocompromised children
      • Pediatric HIV infection
      • Epidemiology of infectious diseases
    • Joshua Wolf, MBBS

      MBBS - University of Melbourne

      • Prediction, prevention and treatment of infections in immunocompromised children
      • Management of device-associated infections

    Oncology

    • Justin N. Baker, MD

      MD - University of Texas–Health Science Center at San Antonio

      • Pediatric palliative and end of life care
      • Decision making in pediatric oncology
      • Symptom control at end of life in pediatrics
      • Quality of life for pediatric Phase I study participants
      • Communication interventions in pediatric Phase I studies
    • Rachel C. Brennan, MD

      MD - Johns Hopkins University School of Medicine

      • Retinoblastoma: therapy and late effects
      • Translating preclinical research into clinical trials (Lab Liaison)
      • Phase I clinical trials
      • Renal tumors
      • Minimizing early and late complications of chemotherapy
    • Sara M. Federico, MD

      MD - Virginia Commonwealth University Medical College of Virginia

      • Clinical investigation of pediatric soft tissue sarcomas
      • Translational research in pediatric solid tumor malignancies
      • Novel drug development for pediatric solid tumor malignancies
    • Hiroto Inaba, MD, PhD

      MD, PhD - Mie University School of Medicine, Japan

      • New therapeutic strategies for leukemia/lymphoma
      • Cellular therapy for hematological malignancies
    • Monika Metzger, MD

      MS - University of Tennessee Health Science Center
      MD - Rheinisch-Westfaelisch Technische Hochschule (RWTH), Aachen

      • Pediatric Hodgkin lymphoma Consortium (Principal investigator)
      • Therapy for relapsed/recurrent pediatric Hodgkin lymphoma
      • Staging evaluation and response criteria harmonization for childhood, adolescent and young adults with Hodgkin lymphoma
      • International collaborations in pediatric Hodgkin lymphoma
    • Daniel A. Mulrooney, MD, MS

      MD - Loyola University, Stritch School of Medicine
      MS - University of Minnesota, School of Public Health, Minneapolis, Minnesota

      • Late effects of childhood cancer therapy
      • Cardiovascular outcomes of cancer therapy
      • Transition of care from pediatric to adult medicine
      • Adolescent and young adult oncology
    • Kim E. Nichols, MD

      MD - Duke University School of Medicine

      • Identifying novel genetic causes of childhood cancer
      • Optimizing methods of tumor surveillance for children with increased cancer risk
      • Evaluating the factors that influence parent and adolescent decision making and communication around genetic testing for heritable cancer risk
      • Understanding the behavioral and psychological impacts of cancer genetic testing on children and their families
      • Increasing understanding and developing new therapies for malignant and non-malignant hematologic disorders, including B-cell leukemias and lymphomas, hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated lymphoproliferations
    • Alberto Pappo, MD

      Co-leader, Translational Training

      MD - Medical School, Universidad Anahuac, Mexico City

      • Development of novel therapies for pediatric solid tumors with special interest in
      • Pediatric melanoma
      • Soft tissue sarcomas
      • Pediatric gastrointestinal stromal tumors
    • Raul C. Ribeiro, MD

      MD - University of Paraná School of Medicine, Curitiba

      • Pediatric leukemia
      • Adrenocortical carcinoma
      • Pediatric hematology/oncology in developing countries
    • Giles W. Robinson, MD

      MD - Brown Medical School

      • Morbidity of children with central nervous system tumors.
      • Genomics of medulloblastoma
    • John T. Sandlund, MD

      MD - Ohio State University College of Medicine

      • The non-Hodgkin lymphomas
      • c-Myc regulation in Burkitt lymphoma
      • Acute leukemias
    • Elizabeth A. Stewart, MD

      MD - Southern Illinois University, School of Medicine

      • High risk pediatric solid tumors
      • Development of patient-derived orthotopic solid tumor xenografts
      • Translational preclinical testing of novel therapeutics for pediatric solid tumors

    Pathology

    • Armita Bahrami, MD

      MD - Tehran University of Medical Sciences

      • The morphologic spectrum and molecular biology of pediatric bone and soft tissue tumors
      • Diagnostic molecular and immunohistochemical markers in pediatric solid tumors
    • John K. Choi, MD, PhD

      MD, PhD - University of Pennsylvania

      • Mechanisms by which the transcription factor E2A regulate normal precursor B cell proliferation.
      • Mechanisms by which mutated E2A promote precursor B lymphoblastic leukemia
      • Clinical laboratory tools for identifying and classifying various hematopathologic disease entities
    • Jeffery M. Klco, MD, PhD

      MD, PhD - Washington University School of Medicine

      • Genomic and functional characterization of acute myeloid leukemia
      • Using experimental in vivo and in vitro approaches to study signaling pathways (e.g., the Notch signaling cascade) in myeloid development
      • Using genomic information to improve the outcome of acute leukemia patients

    Pediatric Medicine

    • Doralina Anghelescu, MD

      MD - Bucharest University School of Medicine

      • Neuropathic pain during treatment of acute lymphoblastic leukemia
      • Vaso-occlusive crisis pain in patients with sickle cell disease
      • Neuropathic pain after limb sparing surgery in patients with osteosarcoma
      • Safety of outpatient patient controlled analgesia
      • Patient controlled analgesia at the end of life
      • Pain management at the end of life and palliative sedation
      • Impact of psychological interventions for pain management during monoclonal antibodies infusions for pediatric cancer
      • Opioid abuse and misuse risk assessment and mitigation strategies
    • Wassim Chemaitilly, MD

      MD - Universite de Paris V-Rene Descartes-UFR-Necker Enfants Malades

      • Endocrine sequelae observed in childhood cancer survivors
      • Disorders of growth and puberty
      • Thyroid disease
      • Gonadal dysfunction
      • Changes in body composition
      • Diabetes and metabolic syndrome
      • Bone health issues
    • Belinda N. Mandrell, PhD, RN, PNP

      PhD - University of Tennessee Health Science Center

      • Genotype-phenotype association
      • Family history
      • Fatigue
      • Sleep
      • Quality of life patients and family
      • Late effects
    • R. Ray Morrison, MD

      MD - University of Nebraska College of Medicine

      • Consequences of myocardial ischemia-reperfusion, adenosine and adenosine receptors, coronary regulation, myocardial protection

    Psychology

    • Heather Conklin, PhD

      PhD - University of Minnesota

      • Cognitive Functioning in Brain Tumor Survivors
      • Improving Specification of Cognitive Deficits following Brain Tumor Treatment
      • Identifying Neurodevelopmental Changes Following Brain Tumor Treatment
      • Delineating Risk and Resiliency Factors with Respect to Cognitive Outcome
      • Identifying Interventions that Mitigate Cognitive Deficits
    • Valerie Crabtree, PhD

      PhD - University of Southern Mississippi

      • Sleep disruptions in children with cancer
    • Sean Phipps, PhD

      PhD - Case Western Reserve University

      • Psychological effects of bone marrow transplantation
      • Coping and adaptive styles in children facing serious illness
      • Personality factors in health and illness

    Radiation Oncology

    • Thomas E. Merchant, DO, PhD

      PhD - University of Utrecht

      • Application of advanced radiotherapy methods in the treatment of children with cancer
      • Conformal radiation therapy for pediatric CNS tumors
      • Proton beam therapy
  3. In addition to teaching and mentoring students, the faculty leadership team develops the core curriculum and helps guide long-term educational goals for the Graduate School.