Aditi Singh’s research interests are focused on deciphering the molecular and cellular mechanisms underlying neurodegeneration and neuroinflammation. Through interdisciplinary training in neuroscience, biology, and translational health sciences, the Dayton, Ohio, native has developed expertise in Drosophila and cell culture models, molecular signaling pathways, and experimental approaches to studying neuronal diseases.
During her graduate training at the University of Dayton, Singh investigated the neurological consequences of SARS-CoV-2 infection and demonstrated that the viral Nsp3 protein induces cell death and progressively exacerbates amyloid-β42-mediated neurodegeneration. Her broader research experience includes Alzheimer's disease, aging biology, Hippo and JNK signaling, traumatic brain injury, ALS, wound healing, and cancer-related signaling pathways, resulting in 19 peer-reviewed publications.
Building on this foundation, Singh’s long-term research interests are focused on understanding the molecular and developmental mechanisms that drive neuroinflammation in neuro-oncological diseases and identifying novel therapeutic targets that can improve outcomes for patients with neurological disorders and brain tumors.
St. Jude's commitment to integrating innovative basic science with translational research that directly impacts patient care strongly aligns with Singh’s scientific interests. For Singh, the Biomedical Sciences PhD program offers an exceptional environment to combine didactic coursework with research with multidisciplinary mentorship. The holistic career development opportunities, cutting-edge techniques, and integration of clinical sciences with benchwork to work towards translational solutions for pediatric care motivated her to join the St. Jude Graduate School.
Hometown: Dayton, OH
Education:
2023 MS, Interdisciplinary Graduate Studies: Clinical and Cellular Neuroscience, University of Dayton
2018 BS, Neuroscience, University of Pittsburgh
Awards/Honors/Scholarships:
2023 Summa Cum Laude, University of Dayton
2018 Magna Cum Laude, University of Pittsburgh
Publications:
Singh, A., Chimata, A. V., Deshpande, P., Bajpai, S., Sangeeth, A., Rajput, M., & Singh, A. (2023). SARS-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid β42-mediated neurodegeneration. Neural Regeneration Research, 19(6), 1385.
Deshpande P, Chimata AV, Snider E, Singh A, et al. (2023). N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye. Cell Death & Disease, 14, 478.
Irwin, M., Tare, M., Singh, A., Puli, O. R., Gogia, N., Riccetti, M., ... & Singh, A. (2020). A positive feedback loop of Hippo-and c-Jun-amino-terminal kinase signaling pathways regulates amyloid-beta-mediated neurodegeneration. Frontiers in Cell and Developmental Biology, 8, 117.
Anderson, E. N., Gochenaur, L., Singh, A., Grant, R., Patel, K., Watkins, S., ... & Pandey, U. B. (2018). Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models. Human Molecular Genetics, 27(8), 1366-1381.