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Jane S. Hankins, MD, MS
Jane S. Hankins, MD, MS

Jane S. Hankins, MD, MS

Member, St. Jude Faculty

  • Director, St. Jude Global Hematology Program



MS – University of Tennessee, Memphis, Tennessee (2004)
MD – Federal University of Rio de Janeiro, Brazil (1993)

Clinical Interests

  • New therapeutic approaches in sickle cell disease
  • Transition to adult care
  • Disease progression

Selected Publications

Penkert RR, Young NS, Surman SL, Sealy RE, Rosch J, Dormitzer PR, Settembre EC, Chandramouli S, Wong S, Hankins JS, and Hurwitz JL. Saccharomyces cerevisiae-derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease. Vaccine Jun 22;35(29):3615-3620, 2017. Epub May 26, 2017.

Cancio MI, Aygun, B, Chui DHK, Rothman JA, Scot JP, Estepp JH, Hankins JS. The clinical severity of hemoglobin S/black (Aγδβ)0-THALASSEMIA. Pediatric Blood and Cancer Apr 28, 2017. [Epub ahead of print].

Grady AJ, Hankins JS, Haberman B, Schoumacher R, Stocks RMS. Hydroxyurea Treatment Effect on Children with Sickle Cell Disease and Obstructive Sleep Apnea. Sleep Breath Jan 11, 2017. [Epub ahead of print]

Tipirneni-Sajja A,  Krafft AJ, McCarville MB, Loeffler RB, Song R, PhD, Hankins JS, Hillenbrand CM. Radial UTE Imaging Removes the Need for Breath-holding in Hepatic Iron Overload Quantification by R2*-MRI. AJR Am J Roentgenol May 15:1-8, 2017.

Krafft AJ, Loeffler RB, Song R, Tipirneni-Sajja A, McCarville MB, Robson MD, Hankins JS, and Hillenbrand CM. Quantitative Ultrashort Echo Time Imaging for Assessment of Massive Iron Overload at 1.5 and 3 Tesla. Magn Reson Med Jan 16, 2017. [Epub ahead of print]

Pasternak AL, Crews KR, Caudle KE, Smith C, Pei D, Cheng C, Broeckel U, Gaur AH, Hankins JS, Relling MV, Haidar CE. The impact of the UGT1A1*60 allele on bilirubin serum concentrations. Pharmacogenomics Jan;18(1):5-16, 2017.

Loeffler RB, McCarville MB, Wagstaff AW, Smeltzer MP, Krafft AJ, Song R, Hankins JS, Hillenbrand CM. Can Multi-slice or Navigator-gated R2*-MRI Replace Single-slice Breath-hold Acquisition for Hepatic Iron Quantification? Pediatr Radiol Jan;47(1):46-54, 2017.

Cronin RM, Hankins JS, Adams-Graves P, Thompson AA, Kalinyak K, Byrd J, McClain B, Kassim A, DeBaun M, Treadwell M. Barriers and Facilitators to Research Participation Among Adults and Parents of Children with Sickle Cell Disease: A Trans-regional Survey. Am J Hematol Oct;91(10):E461-2, 2016.

Nottage KA, Ware RE, Aygun B, Smeltzer MP, Kang G, Moen J, Wang WC, Hankins JS, and Helton KJ. Hydroxyurea Treatment and Brain MRI/MRA Findings in Children with Sickle Cell Anaemia. Br J Haematol Oct;175(2):331-338, 2016.

Gammal RS, Crews KR, Haidar CE, Hoffman JM, Baker DK, Barker PJ, PharmD; Estepp JH, Pei D, Broeckel U, Wang WC, Weiss MJ, Relling MV, Hankins JS. Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease. Pediatrics Jul;138(1), 2016. PMID: 27335380

Wood JC, Cohen AR, Pressel SL, Aygun B, Imran H, Luchtman-Jones L, Thompson AA, Fuh B, Schultz WH, Davis BR, Ware RE; TWiTCH Investigators* [*Hankins JS]. Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial. Br J Haematol Jan;172(1):122-30, 2016. PMC4715688

Hankins JS, Penkert RR, Lavoie P, Tang L, Sun Y, Hurwitz JL. Parvovirus B19 infection in children with sickle cell disease in the hydroxyurea era. Experimental Biology and Medicine (Maywood) Apr;241(7):749-54, 2016. PMID: 26940953 Nottage KA, Hankins JS, Faughnan LG, James DM, Richardson J, Christensen R, Kang G, Smeltzer M, Cancio MI, Wang WC, Anghelescu DL. Challenges of Clinical Trials in Acute Pain: The Pain Management of Vaso-occlusive Crisis in Sickle Cell Disease Study (PMVOC). Clin Trials Aug;13(4):409-16, 2016. PMID: 27000103

Smeltzer MP, Nolan VG, Yu X, Nottage KA, Davis BA; Yang Y, Wang WC, Gurney JG, Hankins JS. Birth prevalence of sickle cell trait and sickle cell disease in Shelby County, TN. Pediatr Blood and Cancer Jun;63(6):1054-9, 2016. PMID: 26871988

Smeltzer MP, Nolan VG, Yu X, Nottage KA, Wang WC, Hankins JS, Gurney JG. Distance from an Urban Sickle Cell Center and its Effects on Routine Healthcare Management and Rates of Hospitalization. Hemoglobin 40(1):10-5, 2016. PMID:26372097

Hankins JS, McCarville MB, Rankine-Mullings A, Reid ME, Lobo CL, Moura PG, Ali S, Soares D,  Aldred K, Jay DW, Aygun B, Bennett J, Kang G, Goldsmith JC, Smeltzer MP, PhD, Boyett JM, Ware RE. Prevention of conversion to abnormal TCD with hydroxyurea in sickle cell anemia: a phase III international randomized clinical trial. American Journal of Hematology Dec;90(12):1099-105, 2015. PMC4715740

Whipple N, Moreau D, Moulds J, Hankins JS, Wang W, Nottage K. Paroxysmal Cold Hemoglobinuria Due to an IgA Donath-Landsteiner Antibody. Pediatr Blood Cancer Nov;62(11):2044-6, 2015. PMID: 26053459

Branstetter CN, Hankins JS, Moreau D, Nottage K. Severe autoimmune hemolytic anemia in an infant caused by warm-reactive IgM and IgA autoantibodies – a case report and review of the literature. J Pediatr Hematol Oncol Aug;37(6):468-71, 2015. PMID:26181418

Krafft A, Loeffler R, Song R, Brian X, McCarville M, Hankins J, Hillenbrand C. Does Fat Suppression via Chemically Selective Saturation (CHESS) Affect R2*-MRI for Transfusional Iron Overload Assessment? A Clinical Evaluation at 1.5 and 3 Tesla. Magn Reson Med Aug;76(2):591-601, 2015. PMC4769126

Nolan VG, Nottage KA, Cole EW, Hankins JS, Gurney JG. Prevalence of vitamin D deficiency in sickle cell disease: A systematic review. PLoS One Mar 3;10(3):e0119908, 2015. PMC4347975

Glass J, Reddick G, Paydar A, Zandieh AR, Dave R, Smeltzer M, Wu S, Hankins JS, Aygun B, Ogg R, Helton K. Comparing segmented ASL perfusion of vascular territories using manual vs. semi-automated techniques in children with sickle cell anemia. J Magn Reson Imaging Feb;41(2):439-46, 2015. PMCID: PMC4528912

Hankins JS, Aygun B, Nottage K, Thornburg C, Smeltzer MP, Ware RE, Wang WC.  From infancy to adolescence: fifteen years of continuous treatment with hydroxyurea in sickle cell anemia. Medicine (Baltimore) Dec;93(28):e215, 2014. PMC4603125

Estepp JH, Winter B, Johnson M, Smeltzer MP, Carroll Y, Howard SC, Hankins JS. Improved hydroxyurea effect with the use of text messaging in children with sickle cell anemia. Pediatr Blood Cancer Nov;61(11):2031-6, 2014. PMID: 25132074

Nottage KA, Ware RE, Winter B, Smeltzer MP, Wang WC, Hankins JS, Dertinger SD, Shulkin B, and Aygun B. Predictors of Splenic Function Preservation In Hydroxyurea Treated Children With Sickle Cell Anemia. Eur J Haematol Nov;93(5):377-83, 2014. PMID: 24796940

Porter JS, Matthews CS, Carroll YM, Anderson SM, Smeltzer MP, Hankins JS. Genetic Education and Sickle Cell Disease: Feasibility and Efficacy of a Program Tailored to Adolescents. J Pediatr Hematol Oncol Oct;36(7):572-7, 2014. PMID: 25089602

Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey MOL, Hanes M, HappelKI, Nelson S, Esteban A, Bagby GJ, Le Saux CJ, Tuomanen EI, Orihuela CJ. Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS Pathog Sep;18;10(9):e1004383, 2014. PMCID: PMC4169480

Porter J, Carroll Y, Anderson S, Lavoie P, Hamilton L, Johnson M, Hankins J. Provider transition readiness assessment for sickle cell patients: A quality improvement project. Journal of Clinical Outcomes Management 21:263-269, 2014.

Hankins JS, Verevkina N, Smeltzer MP, Wu S, Aygun B, Clarke D. Assessment of sleep-related disorders in children with sickle cell disease. Hemoglobin 38(4):244-51, 2014. PMID: 24941261

Winchell AM, Taylor BA, Song R, Loeffler RB, Grundlehner P, Hankins JS, Wang WC, Ogg RJ, Hillenbrand CM, Helton KJ. Evaluation of SWI in Children with Sickle Cell Disease. AJNR Am J Neuroradiol May;35(5):1016-21, 2014. PMCID: PMC4024339

Porter J, Lopez A, Graff C, Hankins J. Transition From Pediatric To Adult Care In Sickle Cell Disease: Perspectives on The Family Role. Child: J Pediatr Nurs Mar-Apr;29(2):158-67, 2014. PMID: 24188784

Last update: June 2017