Linda M. Hendershot, PhD
Linda M. Hendershot, PhD

Linda M. Hendershot, PhD

Member, St. Jude Faculty



PhD – University of Alabama, Birmingham

Research Interests

  • Control of the synthesis and assembly of secretory proteins in the ER    
  • Regulation of immunoglobulin transport
  • Elucidation of ER stress-induced signal transduction pathways
  • Role of the ER stress response in regulating tumor chemosensitivity

ER chaperones

Endoplasmic reticulum

Identification and disposal of misfolded secretory pathway proteins

Protein folding in the secretory pathway and the response of cells to alterations in the ER environment during normal and pathological conditions

The cellular response to imbalances in protein folding in the ER and its role in normal cellular differentiation and disease

Hendershot Lab

Selected Publications

Pereira ER*, Preston AM*, Hendershot LM. UPR activation in cancer cells: a double-edged sword. In: ER stress in health and disease. Edited by P. Agostinis and A. Samali, Springer. 2012 (in press).

Howes J, Shimizu Y, Feige MJ, Hendershot LM. C-terminal mutations destabilize Sil1/BAP and can cause Marinesco-Sjögren Syndrome. J Biol Chem 287:8552-8560, 2012.

Lai W*, Otero JH*, Hendershot LM, Snapp E. ERdj4 is a soluble endoplasmic reticulum DnaJ family protein that interacts with ERAD machinery. J Biol Chem 287:7969-7978, 2012.

Hendershot LM. Chaperone systems of the endoplasmic reticulum, in Houry, W.A. (ed.), Protein Homeostasis, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at, 2012.

Feige MJ, Hendershot LM. Disulfide bonds in ER protein folding and homeostasis. Curr Opin in Cell Biol 23:167-175, 2011.

Shimizu Y, Okuda-Shimizu Y, Hendershot LM. Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids. Mol Cell 40:917-926, 2010 (Faculty of 1000, 3 evaluations).

Feige MJ, Hendershot LM, Buchner J. How antibodies fold. TIBS 35:189-198, 2010.

Otero J, Lizak, B, Hendershot LM. Life and death of a BiP substrate. Sem Cell & Dev Biol 21:472-478, 2010.

Vembar SS, Jonikas MC, Hendershot LM, Weissman JS, Brodsky JL. J domain co-chaperone specificity defines the role of BiP during protein translocation. J Biol Chem 285:22484-22494, 2010.

Pereira ER, Liao N, Neale GA, Hendershot LM. Transcriptional and Post-transcriptional Regulation of Proangiogenic Factors by the Unfolded Protein Response. PLoS One e12521, 2010.

Ma Y, Shimizu Y, Mann MJ, Jin Y, Hendershot LM. Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the UPR. Cell Stress & Chap 15:281-293, 2010.

Masciarelli S, Bertolotti M. Fagioli C, Fra A, Ron D, Hendershot LM, Sitia R. The CHOP transcription factor contributes to IgM polymerization and secretion in plasma cells. Mol Immunol 47:1356-1365, 2010.

Feige MJ, Hendershot LM, Buchner J. How antibodies fold. TIBS 35:189-198, 2010.

Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J. An unfolded CH1 domain controls the assembly and secretion of lgG antibodies. Mol Cell 34:569-579, 2009 (highlighted) (Faculty of 1000, 3 evaluations).

Shimizu Y, Meunier L, Hendershot LM. pERp1 is dramatically upregulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin. PNAS 106:17013-17018, 2009.

Vembar S, Jin Y, Brodsky JL, Hendershot LM. The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions. J Biol Chem 284:32462-32471, 2009.

Jin Y, Zhang M, Hendershot LM. ERdj3, a lumenal ER DnaJ homolog binds directly to unfolded proteins in the mammalian ER: identification of critical residues. Biochemistry 48:41-49, 2009.

Okuda-Shimizu Y, Shen Y, Hendershot LM. Quality control in the endoplasmic reticulum. In: The Handbook of Cell Signaling. Edited by R. Bradshaw and E. Dennis, Elsevier, Inc., pp. 2471-2476, 2009.

Shimizu Y, Hendershot LM. Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species. Forum Review, Antioxidants & Redox Signaling11;2317-2331, 2009.

Awad W, Estrada I, Shen Y, Hendershot LM. Characterization of BiP mutants that are unable to interact with resident ER DnaJ family members provides insights into inter-domain interactions in BiP. Proc Natl Acad Sci USA 105:1164-1169, 2008.

Petrova K, Oyadomari S, Hendershot LM, Ron D. Regulated association of misfolded endoplasmic reticulum proteins with p58IPK/DNAJc3. EMBO J 27:2862-2872, 2008.

Jin Y, Awad W, Petrova K, Hendershot LM. Regulated release of ERdj3 from unfolded proteins by BiP. EMBO J 27:2873-2882, 2008.

Okuda-Shimizu Y, Hendershot LM. Characterization of an ERAD pathway for non-glycosylated BiP substrates, which requires Herp. Mol Cell 28:544-554, 2007.

Last update: July 2012