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Guolian Kang, PhD
Guolian Kang, PhD

Guolian Kang, PhD

Member, St. Jude Faculty



PhD – Institute of Systems Science, Chinese Academy of Sciences, China
MS – Qufu Normal University, China
BS – Qufu Normal University, China

Research Interests

  • Mathematical/Statistical Modeling for Complex Data
  • Pre-clinical and Clinical Trials Design and Analysis
  • Statistical Genetics/Genomics
  • Systems Biology/Genetical Genomics

Selected Publications

(*Co-first author, #Corresponding author, and Trainee)

Kang G*#, Bi W*, Zhang H, Pounds SB, Cheng C, Shete S, Zou F, Zhao Y, Zhang JF, Yue W#. A robust and powerful set-valued approach to rare variant associaiton analyses of secondary traits in case-control sequencing studies. Genetics 205(3):1049-1062, 2017. PMID: 28040743 PMCID: PMC5340322
Reported in Instagram

Ganuza M, Hall T, Finkelstein D, Chabot A, Freeman B, Kang G, Hadland R, Bernstein I, McKinney-Freeman S. Life-long hematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nature Cell Biology 19(10):1153-1163, 2017. PMID: 28920953

Estepp JH, Smeltzer MP, Kang G, Li C, Wang WC, Hankins J, Weiss M, Abrams C, Aygun B, Ware RE, Nottage K. A Clinically Meaningful Fetal Hemoglobin Threshold for Children with Sickle Cell Anemia During Hydroxyurea Therapy. American Journal of Hematology 92(12):1333-1339, 2017. PMID: 28913922

Morton LM, Sampson J, Armstrong G, Chen TH, Hudson M, Karlins E, Dagnall C, Li S, Wilson C, Srivastava K, Liu W, Kang G, Oeffinger K, Henderson T, Moskowitz C, Gibson T, Merino D, Wong J, Hammond S, Neglia JP, Turcotte LM, Miller J, Bowen L, Wheeler WA, Leisenring WM, Whitton JA, Burdette L, Chung C, Hicks BD, Jones K, Machiela MJ, Vogt A, Wang Z, Yeager M, Neale G, Lear M, Strong LC, Yasui Y, Stovall M, Weathers RE, Smith SA, Howell R, Davies SM, Radloff GA, de González AB, Inskip PD, Rajaraman P, Fraumeni JF, Bhatia S, Chanock SJ, Tucker MA, Robison L. Genome-wide association study identifies two susceptibility loci that modify radiation-related risk for breast cancer after childhood cancer: A report from the Childhood Cancer Survivor Study and St. Jude Lifetime Cohort. Journal of the National Cancer Institute 109(11), 2017. PMID: 29059430

Mastellaro Z, Seidinger AL, Kang G, Abrahao R, Miranda E, Pounds S, Fihueiredo B, Rodriguez-Galindo C, Yunes JA, Barros-Filho ADA, Ribeiro R. The contribution of the TP53 R337H mutation to the cancer burden in Southern Brazil: Insights from the study of 55 families of children with adrenocortical tumor. Cancer 123(16):3150-3158, 2017. PMID: 28387921

Nottage K, Hankins JS, Faughnan LG, James DM, Richardson J, Christensen R, Kang G, Smeltzer M, Cancio MI, Wang WC, Anghelescu DL. Addressing challenges of clinical trials in acute pain: the pain management of vaso-occlusive crisis in sickle cell disease study (PMVOC). Clinical Trials: Journal of the Society for Clinical Trials 13(4):409-416, 2016. *This is the design paper for the phase 2 randomized PMVOC clinical trial. PMID: 27000103

Kang G, Liu W, Cheng C, Wilson C, Neale G, Yang J, Ness KK, Robison LL, Hudson MM, Srivastava K. Evaluation of a two-step iterative resampling procedure for internal validation of genome-wide association studies. Journal of Human Genetics 60:729-738, 2015. PMID: 26377241 PMCID: PMC4859941

Bi W*, Kang G*#, Zhao Y, Cui Y, Yan S, Li Y, Cheng C, Pounds SB, Borowitz MJ, Relling MV, Yang JJ, Liu Z, Pui CH, Hunger SP, Hartford C, Leung W, Zhang JF#. SVSI: fast and powerful set-valued system identification approach to identifying rare variants in sequencing studies for ordered categorical traits. Annals of Human Genetics 79:294-309, 2015. PMID: 25959545 PMCID: PMC4474746

Hankins JS, McCarville B, Rankine-Mullins A, Reid M, Lobo LLC, Moura PG, Ali S, Soares D, Aldred K, Jay DW, Aygun B, Bennett J, Kang G, Goldsmith JC, Smeltzer MP, Boyett JM, Ware RE. Prevention of conversion of abnormal TCD with hydroxyurea in sickle cell anemia: a phase III international randomized clinical trial. American Journal of Hematology 90(12):1099-1105, 2015. *We were Data Coordinating Center (DCC) for this international phase III randomized clinical trial. PMID: 26414435 PMCID: PMC4715740

Addersson AK, Ma J, Wang J, Chen X, Larson-Gedman A, Dang J, Nakitandwe J, Holmfeldt L, Parker M, Eston J, Huether R, Kriwacki R,  Rusch M, Wu G, Li Y, Mulder H, Raimondi S, Pounds S, Kang G, Shi L, Becksfort J, Gupta P, Payne-Turner D, Vadodaria B, Boggs K, Yergeau D, Manne J, Song G, Edmonson M, Nagawatte P, Wei L, Cheng C, Pei D, Sutton R, Venn NC, Chetcuti A, Rush A, Catchpoole D, Heldrup J, Fioretos T, Lu C, Ding L, Pui CH, Shurtleff S, Gruber TA, Mullighan CG, Mardis ER, Wilson RK, Zhang J, Downing JR. The landscape of somatic mutations in infant MLL rearranged acute lymphoblastic leukemias. Nature Genetics 47(4):330-337, 2015. PMID: 25730765 PMCID: PMC4553269

Kang G*, Bi W*, Zhao Y, Zhang J, Yang JJ, Xu H, Reilling MV, Loh ML, Hunger SP, Pounds S, Cheng C. A new system identification approach to identify genetic variants in sequencing studies for a binary phenotype. Hum Hered 78:104-116, 2014. PMID: 25096228 PMCID: PMC4270367 *Featured in the Scientific Highlights section of the St. Jude Scientific Report 2015.

Bari R, Rujkijyanont P, Sullivan E, Kang G, Turner V, Gan K, Leung W. Effect of donor KIR2DL1 allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem cell transplantation. Journal of Clinical Oncology 31(30):3782-3790, 2013. PMID: 24043749 PMCID: PMC3795888 *Reported by ScienceDaily in September, 2013.

Chen J*, Kang G*, VanderWeele T, Zhang C, Mukherjee B. Efficient designs of gene-environment interaction studies: implications of Hardy-Weinberg equilibrium and gene-environment independence. Statistics in Medicine 31(22):2516-2530, 2012. PMID: 22362617 PMCID: PMC3448495

Jiang B, Zhang X, Zuo Y, Kang G. A powerful truncated tail strength method for testing multiple hypotheses in a dataset. J Theor Biol 277:67-73, 2011. PMID: 21295595 *The Science Unbound Foundation Best Paper Award in General Statistics Research.

Kang G, Gao G, Shete S, Redden DT, Chang B-L, Rebbeck TR, Barnholtz-Sloan JS, Patterson N, Pajewski NM, Allison DB. Capitalizing on admixture in genome-wide association studies: A two-stage testing procedure and application to height in African-Americans. Front Genet 2:11, 2011. doi: 10.3389/fgene.2011.00011 PMID: 21754915 PMCID: PMC3132882

Kang G, Ye K, Allison DB, Liu N, Gao G. Weighted multiple hypothesis testing procedures. Stat Appl Genet Mol Biol 8(1):Article 23, 2009. PMID: 19409067 PMCID: PMC2703613

Kang G, Yue W, Zhang J, Cui Y, Zuo Y, Zhang D. An entropy-based approach for testing genetic epistasis underlying complex diseases. J Theor Biol 250:362-374, 2008. PMID: 17996908

Cui Y, Kang G, Sun K, Qian M, Romero R, Fu W. Gene-centric genome-wide association study via entropy. Genetics 179:637-650, 2008. PMCID: PMC2390640 *Research highlighted in Nature Review Genetics in 2008.

Kang G, Yue W, Zhang J, Huebner M, Zhang H, Ruan Y, Lu T, Ling Y, Zuo Y, Zhang D. Two-stage designs to identify the effects of SNP combinations on complex diseases. Journal of Human Genetics 53:739-746, 2008. PMID: 18584117 *The Science Unbound Foundation Best Paper Award in Statistical Genetics Research.

Kang G, Li S, Zhang J. Entropy-based models for interpreting life systems in traditional Chinese medicine. Evidence-based Complementary and Alternative Medicine 5(3):273-279, 2008. PMID: 18830452 PMCID: PMC2529388 *Reported by the international media of “International Adaptogens” (Venezuela); 
#Included in the monograph of “Transgénicos”(Cuba)

See full list of publications

Last update: March 2018