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Content creator and gamer DrLupo sets sights on record $13 million lifetime goal for St. Jude Children’s Research Hospital with Build Against Cancer 24-hour livestream

Event to be streamed live for the first time from St. Jude campus in Memphis, Tenn. with surprise celebrity drop-ins

Memphis, Tennessee, Dec. 7, 2022

Record-breaking content creator DrLupo and his 12.4 million followers are preparing for the fifth annual Build Against Cancer 24-hour livestream event benefiting St. Jude Children’s Research Hospital®. Beginning at noon CT on December 17, fans and St. Jude supporters can tune into the livestream on YouTube as well as visit digital fundraising platform Tiltify to help DrLupo surpass a $13 million cumulative fundraising milestone and seal his status as the top fundraiser for St. Jude among gamers. 

This year’s Build Against Cancer marks DrLupo’s first in-person livestream event on the St. Jude campus. Throughout the broadcast, he will conduct interviews and play games with St. Jude patients and drop surprise incentives. A secret lineup of celebrities and notable online personalities will join DrLupo on his quest to help St. Jude families.

The gaming community’s support is crucial to helping St. Jude advance research and treatment for childhood cancer and other life-threatening diseases. Cancer is a multi-trillion-dollar, multi-year problem and funds raised from the Build Against Cancer livestream will be channeled toward the six-year, $12.9 billion St. Jude strategic plan that increases its global investment to impact more of the 400,000 kids around the world with cancer each year. 

“We are thrilled to have DrLupo on our campus this year to host his Build Against Cancer event for the kids of St. Jude Children’s Research Hospital,” said Richard C. Shadyac Jr., president and CEO of ALSAC, the fundraising and awareness organization for St. Jude Children’s Research Hospital. “His new $13 million lifetime fundraising goal is bold — and it reflects the same visionary spirit that led to the founding of St. Jude 60 years ago as a place where children with catastrophic diseases receive cutting-edge care at no charge to their families. We are immensely grateful for the generosity, creativity and dedication of DrLupo and the gamer community, who play a vital role in advancing the lifesaving work of St. Jude.”

Just last year, St. Jude opened a 625,000-square-foot facility called the Inspiration4 Advanced Research Center which focuses on transformative science and is designed for collaboration across scientific fields. Among other things, it is home to specialized technology for conducting computational biology, using artificial intelligence, gene editing and analyzing cell samples via some of the world’s most advanced microscopes. There will be a biorepository onsite that contains tumor samples for sharing with researchers anywhere. These sophisticated resources keep St. Jude on the forefront of research on pediatric cancer and other catastrophic diseases.

"I look forward to this event every year, as it is a special time for the gaming community to join together and make a real difference in the lives of children and families battling cancer,” said DrLupo. “This year feels even more special, as I'll be streaming live for the very first time from St. Jude in Memphis. We have some exciting surprises up our sleeve and are hoping to make this year the best Build Against Cancer yet!"

During the 2021 Build Against Cancer event, DrLupo raised more than $890,000, surpassing $10 million cumulatively to break the record for the most money raised by a single creator benefiting St. Jude. That livestream featured appearances by celebrities and content creators including Ninja, Robbie Amell, Mark Hoppus, CourageJD, Paul Scheer, Taran Killam, Felicia Day, Rahul Kohli, Mike Shinoda, Matt Mercer, Gary Whitta, Penny Arcade, NickMercs, BigCheeseKit, AnneMunition, lilsimsie, luxiegames, frisk and brickinnick. 

Build Against Cancer streams live on YouTube and will be supported by creator-first fundraising platform, Tiltify for its fifth consecutive year. Responsible for powering today’s most popular social media platforms and live streaming services like TikTok, YouTube and more, Tiltify works with new and existing partners to create more interactive, live and personalized experiences for creators to do good.

“Tiltify is proud to partner with DrLupo on this life-saving fundraising event,” said Michael Wasserman, CEO of Tiltify. “The innovative work St. Jude is doing to treat and defeat childhood cancer is truly remarkable and brings so much hope to families impacted by this devastating illness. We’re implementing the most engaging, interactive donation technology to ensure this is the best year for Build Against Cancer yet and DrLupo continues to raise funds for the mission of St. Jude.” 

Become a part of gaming history and help St. Jude push the frontiers of research through this year’s Build Against Cancer.

To stay up to date on the latest gaming and content creator activities that support St. Jude, follow @StJudePLAYLIVE and @StJude on Twitter and Instagram.

About St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital is leading the way the world understands, treats and defeats childhood cancer and other life-threatening diseases. Its purpose is clear: Finding cures. Saving children.® It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. When St. Jude opened in 1962, childhood cancer was considered largely incurable. Since then, St. Jude has helped push the overall survival rate from 20% to more than 80%, and it won't stop until no child dies from cancer. St. Jude shares the breakthroughs it makes to help doctors and researchers at local hospitals and cancer centers around the world improve the quality of treatment and care for even more children. Because of generous donors, families never receive a bill from St. Jude for treatment, travel, housing or food, so they can focus on helping their child live. Visit St. Jude Inspire to discover powerful St. Jude stories of hope, strength, love and kindness. Support the St. Jude mission by donating at, liking St. Jude on Facebook, following St. Jude on XInstagramLinkedIn and TikTok, and subscribing to its YouTube channel.

A fan-favorite with a heart of gold, DrLupo has made a name for himself as one of the most generous streamers in the business, raising millions for St. Jude over the years through his 24 hour charity stream, Build Against Cancer. A family man who’s always ready with a dad joke, DrLupo brings a level of maturity that’s often absent among elite streamers. 

Tiltify is the fundraising platform for the digital generation, providing live, interactive and telethon-style technology that engages donors to invest in the cause. Tiltify harnesses the power of both traditional fundraising and modern digital livestream engagement with platforms like Twitch, TikTok and YouTube, enabling any organization and fundraiser to dramatically expand audience reach. Organizations like United Way Worldwide, St. Jude Children's Research Hospital, Save the Children, No Kid Hungry, Make-A-Wish and hundreds more use Tiltify to engage the socially active Millennials and Gen Z communities for single signature events and large DIY campaigns that launch in minutes. To learn more visit

Media Contact:
Maggie Meisinger,