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Infant immune systems respond differently to severe COVID-19
05/16/2025
Infants show unique immune responses to COVID-19, differing from adults and children. New study may guide better treatments for severe infant infections.
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Study reveals targetable mechanism behind high-risk predisposition gene in pediatric medulloblastoma
05/15/2025
Uncover how ELP1 gene defects drive pediatric brain cancer—and learn how that revealed MDM2 inhibition as a targeted therapy to restore tumor suppressor p53.
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St. Jude neurologist Richard Finkel named to TIME100 Health
05/08/2025
Dr. Richard Finkel, St. Jude Center for Experimental Neurotherapeutics director, recognized by TIME Magazine for influencing global health.
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Unique model of rare epileptic disease helps pinpoint potential treatment route
05/07/2025
See how a cortical organoid model for UBA5-associated encephalopathy reveal development faults including stunted GABAergic interneuron growth linked to seizures
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Hongbo Chi, PhD named Chair of Department of Immunology at St. Jude
05/07/2025
Department will continue to grow and develop new treatments and discoveries to help treat catastrophic diseases.
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The 23rd Annual FedEx/St. Jude Angels and Stars Gala Raises $900,000 for St. Jude Children’s Research Hospital
05/05/2025
The 23rd annual FedEx/St. Jude Angels and Stars Gala brought together St. Jude patient families, numerous celebrities, and philanthropic community members, raising over $900,000 for St. Jude.
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Researchers crack the code of cell movement
04/23/2025
New research found chemokines & G protein-coupled receptors encode cell migration information in small, disordered regions, and how to alter these proteins.
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Roberts, Zhang receive prestigious appointments at AACR annual meeting
04/22/2025
St. Jude researchers and clinicians to be recognized for achievements in cancer research
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Discovery of FOXR2 activation in various brain tumors refines diagnosis to improve care
04/15/2025
Read research showing activation of oncogene FOXR2 occurs in multiple pediatric central nervous system tumor types, with implications for clinical diagnosis.
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Study provides scaffold to selectively target drug breakdown process
04/10/2025
See how a panel of CYP3A4 inhibitors lay groundwork for selective cytochrome P450 inhibition by avoiding CYP3A5.
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Chromatin remodeling captured in comprehensive structural study
04/02/2025
See how St. Jude scientists used cryo-EM to uncover the structural mechanisms of chromatin remodeling enzyme SNF2H, advancing gene regulation research.
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Preventable pediatric cancer mortality surges in areas of armed conflict, exceeding rates in non-conflict regions
03/31/2025
Discover how St. Jude collaborated on a global study showing the severe impact of living in areas of conflict on childhood cancer outcomes and mortality.
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Removing a protein ‘signal jammer’ improves immunotherapy
03/19/2025
Find how a mitochondrial protein protects cancer cells from immunotherapy, giving scientists a new target type to improve solid tumor treatment & save lives.
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Current antivirals likely less effective against severe infection caused by bird flu in cows’ milk
03/17/2025
Read new research showing that current antivirals do not work well against bird flu found in cow’s milk, and the route of infection affects disease severity.
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Spotiphy integrative analysis tool turns spatial RNA sequencing into imager
03/12/2025
Explore Spotiphy, a program that enhances spatial transcriptomics, providing single-cell resolution & comprehensive gene coverage with a generative algorithm.
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St. Jude Children’s Research Hospital Recognized as a Top U.S. Brand by YouGov
03/06/2025
The YouGov Best Global Brands 2025 report named St. Jude to its list of top 10 brands in the U.S. – the only non-profit organization to be recognized and the brand with the highest reputation score of all brands in the top 10.
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Repurposed ALS drug becomes imaging probe to help diagnose neurodegeneration
03/05/2025
See how scientists at St. Jude Children’s Research Hospital use positron emission tomography scanning and an ALS drug edaravone to detect neurodegeneration
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St. Jude scientists solve mystery of how the drug retinoic acid works to treat neuroblastoma
02/28/2025
Find new research showing how retinoic acid hijacks a developmental pathway in metastasized neuroblastoma in the bone marrow, solving a 50 year-long mystery.
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Altering tumor microenvironment may reduce relapses after leukemia immunotherapy
02/25/2025
Discover research identifying GRP65 as a potential biomarker predicting relapse after immunotherapy in childhood leukemia & potential combination therapies.
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Promising results from first prenatal therapy for spinal muscular atrophy
02/19/2025
See how spinal muscular atrophy (SMA) can be treated prenatally in utero with the survival of motor neuron 2-directed RNA splicing modifier risdiplam (Evrysdi)
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2025 Damon Runyon-St. Jude Fellows announced
02/13/2025
Cancer researchers in Seattle, San Francisco, Boston, New York and Memphis were selected as Pediatric Fellows
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WHO, St. Jude launch groundbreaking international delivery of childhood cancer medicines
02/11/2025
St. Jude Global announces delivery of critically-needed cancer medicines to countries
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St. Jude researchers create tool incorporating transcriptome size to improve RNA-seq analysis
02/03/2025
Discover how ReDeconv accounts for transcriptome size to get more from bulk & single-cell RNA sequencing analysis with better deconvolution and normalization.
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Schwarz wins presidential science award
01/30/2025
The Presidential Early Career Award for Scientists and Engineers (PECASE) recognizes innovative and far-reaching developments in science
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ESPN Anchor Hannah Storm to Be Honored With 2025 Pat Summerall Award During Super Bowl LIX Week, 20th Legends for Charity Dinner Benefiting St. Jude Children’s Research Hospital
01/27/2025
ESPN anchor, award-winning journalist, producer and director Hannah Storm will receive the 2025 Pat Summerall Award at the 20th Legends for Charity event, held Thursday, Feb. 6 at Hyatt Regency New Orleans, the NFL headquarters hotel.
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Elizabeth Hillman joins St. Jude as chair of Imaging Sciences
01/22/2025
Hillman joins St. Jude from Columbia University to bring technology innovators and accelerate scientific discovery and advance clinical care.
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Brenda J. Weigel, MD, named vice president of clinical research industry engagement at St. Jude Children's Research Hospital
01/21/2025
Brenda Weigel MD, pediatric tumor expert, will advance external partnerships to enhance clinical research for children with catastrophic diseases.
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ZIC1 gene drives distinct medulloblastoma types in different ways
01/08/2025
Discover research showing how the context of distinct & opposing mutations in the ZIC1 gene drive Group 4 (G4) and sonic hedgehog (SHH) medulloblastoma types.
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St. Jude scientists create scalable solution for analyzing single-cell data
01/08/2025
Explore how Consensus and Scalable Inference of Gene Expression Programs (CSI-GEP)’s unsupervised machine learning provides unbiased single-cell RNA analysis.
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Signaling circuit interplay pushes newborn neurons out of the neuronal nest
01/07/2025
See how Netrin-1, Siah2, Pard3 and JamC interconnect in a coincidence detection circuit in neuronal development and migration from germinal zone
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Discovery of ‘pliancy genes’ showcases role of latent epigenetic programs in retinal recovery
01/02/2025
Learn how the discovery of pliancy genes by scientists at St. Jude showcases the role of latent epigenetic programs in the retina’s response to stress.
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Mitochondrial DNA plays an underappreciated role in leukemia development
01/01/2025
See how mitochondrial DNA (mtDNA) mutation affects leukemogenesis by altering metabolic pathways via pyruvate dehydrogenase and affecting cell plasticity
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Brain map clarifies neuronal connectivity behind motor function
12/23/2024
See how St. Jude researchers tracked spinal cord V1 interneuron connections with neurons in the brain to see how they work in motor function signaling
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Universal barcodes unlock fast-paced small molecule synthesis
12/11/2024
Learn how St. Jude scientists discovered a universal barcode in fragmentation patterns to revolutionize chemical reaction analysis and small molecule synthesis.
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TelevisaUnivision Brings Together Latin Media and Artists for Annual Promesa y Esperanza® Fundraiser Supporting St. Jude Children’s Research Hospital
12/10/2024
TelevisaUnivision brings together Latin media and artists for annual Promesa y Esperanza fundraiser supporting St. Jude Children’s Research Hospital, raising $5.3 million.
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St. Jude names Maria Megdal as executive vice president and chief administrative officer
12/10/2024
Medgal will oversee departments vital to St. Jude operations. She previously led operations at major cancer centers in Boston and New York
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ALSAC announces transition of Richard C. Shadyac, Jr. as CEO
12/09/2024
Richard C. Shadyac Jr. will step down as President and Chief Executive Officer of ALSAC, the fundraising and awareness organization for St. Jude Children’s Research Hospital, on March 1, 2025.
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Twenty-three years running for the kids of St. Jude: St. Jude Memphis Marathon Weekend reaches fundraising record
12/07/2024
The 2024 St. Jude Memphis Marathon Weekend®, presented by Juice Plus+® marked another major success in the event’s 23-year history, raising about $16 million for St. Jude Children’s Research Hospital.
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Late St. Jude Memphis Marathon director honored with Hero Among Us Award
12/06/2024
Late St. Jude Memphis Marathon director honored with Hero Among Us Award
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Mint Mobile donates $250,000 to benefit St. Jude Children's Research Hospital
12/06/2024
This GivingTuesday and alongside Ryan Reynolds, Mint Mobile announced that it is donating earnings from new customer purchases that took place on GivingTuesday (Dec. 3) to St. Jude — for a total contribution of $250,000.
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Research links a genetic risk for schizophrenia to a malformed skull
12/05/2024
See how St. Jude scientists study 22q schizophrenia disorder finding flocculus and paraflocculus growth in cerebellum curbed by lack of skull growth gene Tbx1
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Predicting cardiac issues in cancer survivors using a serum protein panel test
12/03/2024
See how a blood serum panel of 27 proteins can accurately predict anthracycline-related cardiomyopathy risk in subclinical pediatric cancer survivors
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Nicole Kidman, Keith Urban, Heidi Klum, Meghan Trainor, Shawn Johnson, brands and influencers unite this GivingTuesday for St. Jude Children’s Research Hospital
11/26/2024
This GivingTuesday, Dec. 3, celebrities, influencers and leading brands are calling on communities nationwide to “Join Our St. Jude Family” by supporting St. Jude in its efforts to research and treat childhood cancer and other life-threatening diseases.
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St. Jude appoints leading scientist to create groundbreaking Center of Excellence for Structural Cell Biology
11/21/2024
Georgios Skiniotis, PhD, to develop and lead new center focusing on advanced imaging techniques, including cryo-ET.
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Scientists from St. Jude Children’s Research Hospital listed among most cited globally
11/19/2024
Meet the St. Jude scientists named to the 2024 list of Highly Cited Researchers produced by Clarivate, to celebrate the global influence of their discoveries.
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St. Jude researchers identify unexpected genetic link between skin disorder and inner ear
11/18/2024
Discover St. Jude research showing how the ABC transporter links inner ear development with hearing impairment in dyschromatosis universalis hereditaria.
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Glutamine metabolic switch is key to red blood cell development and disease
11/14/2024
See how a switch from glutamine catabolism to glutamine production is a vital step in blood cell development linking the process to sickle cell disease and β-thalassemia
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Tumor suppressor forms gel-like assemblies to sacrifice cancer cells
11/11/2024
See how the tumor suppressor p14ARF undergoes phase separation with nucleophosmin to form condensates which arrest ribosome formation to kill cancer cells.
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ALSAC appoints new Chief Marketing and Brand, Data and Analytics officers to drive fundraising growth for St. Jude Children's Research Hospital
11/04/2024
Samantha Maltin and Ankur Jain are joining the executive leadership team of ALSAC, the fundraising and awareness organization for St. Jude Children’s Research Hospital, as Chief Marketing and Brand, Data and Analytics officers.
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Mitchell Weiss of St. Jude Children’s Research Hospital elected to the National Academy of Medicine
10/23/2024
Leading expert in catastrophic blood disorders becomes the eighth St. Jude faculty member tapped for this honor
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Nutrients and organelle signaling shape tissue immunity
10/14/2024
Discover research by Hongbo Chi, PhD, that uncovers the interplay between organelles, nutrient-dependent signaling pathways and tissue immunity.
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Disrupting Asxl1 gene prevents T-cell exhaustion, improving immunotherapy
10/10/2024
Explore how disruptions in ASXL1 were correlated with better patient responses to immune checkpoint inhibition and long-term tumor control in model systems.
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St. Jude ranks in top 10 of U.S. News Best Children's Hospitals for Cancer
10/08/2024
US News & World Report has recognized St. Jude Children's Research Hospital as one of the top 10 pediatric cancer hospitals for the 17th straight year.
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Hannah Storm, ESPN Anchor, award-winning director, producer to receive prestigious Pat Summerall Award during Super Bowl LIX
10/07/2024
Hannah Storm, ESPN Anchor, award-winning director, producer to receive prestigious Pat Summerall Award during Super Bowl LIX
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St. Jude names M. Madan Babu, PhD, senior vice president and chief data scientist
10/01/2024
M. Madan Babu, PhD, will lead new $195 million data science enterprise for biologic discovery to advance pediatric medicine.
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Structure of a eukaryotic CRISPR-Cas homolog, Fanzor2, shows its promise for gene editing
10/01/2024
See how structures of Fanzor2, a relation of the transposon family TnpB, show how the protein can be used in genome engineering technology like CRISPR-Cas9.
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St. Jude Spirit of the Dream honors three changemakers for community impact
09/24/2024
Carolyn Chism Hardy, Peter Woods and A C Wharton, Jr. celebrated for service to families of St. Jude Children’s Research Hospital.
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Clinical trial results show low-intensity therapy can achieve positive outcomes for certain pediatric leukemia subtypes
09/24/2024
Learn about St. Jude clinical trial findings from Hiroto Inaba, MD, PhD, showing that genomics can guide risk assessment and leukemia treatment intensity.
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Hoops for Hope: St. Jude Children’s Research Hospital partners with University of Memphis, Complete Sports Management for inaugural ‘Hoops for St. Jude Tip Off Classic’
09/12/2024
Hoops for Hope
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Sigma Gamma Rho Sorority, Inc. announces new $2 million commitment for St. Jude Children's Research Hospital
09/12/2024
Sigma Gamma Rho Sorority, Inc., a member of the National Pan-Hellenic Council (NPHC) known informally as the Divine Nine, has unveiled a historic pledge to raise $2 million for St. Jude Children’s Research Hospital® by 2028.
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Urate transporter structures reveal the mechanism behind important drug target for gout
09/09/2024
Discover how cryo-EM insights into URAT1, a urate transporter and member of the SLC22 transporter family advance gout and hypouricemia drug discovery
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Communities across America unite to support St. Jude Children's Research Hospital for Childhood Cancer Awareness Month
08/29/2024
This September, communities across the nation will come together for Childhood Cancer Awareness Month by supporting St. Jude Children's Research Hospital® as it continues driving research and treatment for pediatric cancer and other life-threatening diseases.
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Acquisition in Memphis' Pinch District enables future St. Jude growth
08/28/2024
In a letter from ALSAC President and CEO Rick Shadyac, St. Jude announces the acquisition of 23 parcels of land in the Pinch District, expanding the existing St. Jude campus westward.
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Early interventions may improve long-term academic achievement in young childhood brain tumor survivors
08/21/2024
Find how children who survive a brain tumor often fall behind peers in academic readiness, but access to early developmental resources may reduce the gap.
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T helper cells may be the key to improving annual influenza vaccines
08/20/2024
Explore how T follicular helper cells indirectly control the anti-influenza immune response, which could lead to improvements in annual flu vaccine design.
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St. Jude mourns loss of beloved member of St. Jude family, Phil Donahue
08/19/2024
St. Jude laments the passing of television icon Phil Donahue. Donahue was married to Emmy Award-winning actress, author and St. Jude National Outreach Director Marlo Thomas, the eldest daughter of St. Jude founder Danny Thomas.
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Danny Thomas Celebrity-Am, stars drive home importance of supporting St. Jude Children’s Research Hospital
08/16/2024
Danny Thomas Celebrity-Am, stars drive home importance of supporting St. Jude Children’s Research Hospital
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First successful treatment of pediatric high-risk refractory neuroblastoma with PARP inhibition
08/14/2024
Explore the first successful treatment of a pediatric patient with high-risk refractory neuroblastoma using PARP inhibition guided by clinical genomics.
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FedEx and St. Jude Children’s Research Hospital celebrate a dozen years of Purple Eagle honorees
08/14/2024
A seven-year-old who was diagnosed with acute lymphoblastic leukemia after he started kindergarten in the fall of 2022, Micah was honored Wednesday ahead of the first day of competition at the FedEx St. Jude Championship at TPC Southwind.
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New research from Children’s Hospital of Philadelphia and St. Jude poised to transform approach to diagnosing and treating acute leukemia in children
08/14/2024
Explore How research St. Jude and CHOP is transforming Acute Leukemia Diagnosis and Treatment in Children.
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PGA TOUR pro Jordan Spieth and family visit St. Jude Children’s Research Hospital, presents $500,000 Jordan Spieth Family Foundation grant
08/13/2024
PGA TOUR star Jordan Spieth and his wife, Annie, kicked off FedEx St. Jude Championship week with a special visit: a personal tour of St. Jude where they presented a check for $500,000 on behalf of the Jordan Spieth Family Foundation.
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St. Jude Children’s Research Hospital, FedEx and PGA TOUR team up to help make cures possible for childhood cancer
08/12/2024
Seventy of the world’s top PGA TOUR golfers will tee off in Memphis on August 15 for the 2024 FedEx St. Jude Championship, an event that has raised $74 million to benefit the lifesaving mission of St. Jude Children’s Research Hospital® since 1970.
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Study reveals oleoyl-ACP-hydrolase underpins lethal respiratory viral disease
08/12/2024
Learn how research from St. Jude, Doherty Institute and others revealed that OLAH underpins deadly respiratory disease from viruses such as RSV and Sars-Cov-2.
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Scientists identify genes linked to relapse in the most common form of childhood leukemia
08/09/2024
Discover St. Jude research from Charles Mullighan, MD, identifying novel genetic alterations linked to relapse in standard risk acute lymphoblastic leukemia.
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St. Jude identifies SARS-CoV-2 “mimic” contributing to pediatric inflammatory syndrome
08/07/2024
Discover St. Jude research from Paul Thomas, PhD, linking SARS-CoV-2 infections and molecular mimicry with multisystem inflammatory syndrome in children.
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Genetic ‘episignatures’ guide researchers in identifying causes of unsolved epileptic neurological disorders
08/06/2024
See how DNA methylation patterns can be used to identify and diagnose rare neurogenetic disorder cases of developmental and epileptic encephalopathies
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Age impacts pharmacogenomics and treatment outcomes for most common form of leukemia
08/05/2024
Explore how scientists at St. Jude Children’s Research Hospital have identified causes for age-related differences in the treatment outcomes of B-cell acute lymphoblastic leukemia.
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Improved chemokine homing enhances CAR T-cell therapy for osteosarcoma
08/05/2024
Learn how scientists at St. Jude are leading research to improve CAR T-cell therapy for osteosarcoma by enhancing chemokine homing.
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Serotonin uptake regulates ependymoma tumor growth
07/31/2024
Discover how St. Jude Children’s Research Hospital and Baylor College of Medicine found serotonin's role in ependymoma tumor growth, opening new drug possibilities.
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St. Jude gene panel for pediatric cancers increases access to high-quality testing
07/26/2024
Discover how a gene panel for pediatric cancer concentrates the pediatric cancer genome project & high-end sequencing’s findings into a single practical test.
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St. Jude Children’s Research Hospital earns DNV accreditation
07/23/2024
Collaboration between St. Jude and DNV will strengthen the institution’s processes and improve patient care.
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Lab-grown human neuron assembloids effectively model synaptic plasticity
07/18/2024
See how St. Jude scientists model the human thalamocortical neural network using lab-grown cells, revealing synaptic communication and demonstrating plasticity.
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Biomolecular condensate ‘molecular putty’ properties found encoded in protein sequence
07/02/2024
See how biomolecular condensates like stress granules behave like putty, a viscoelastic material that shares properties of liquids and solids based on the timescale of interactions.
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Tri Delta Raises Historic $100 Million in Grassroots Fundraising for St. Jude Children’s Research Hospital
07/01/2024
Tri Delta has raised $100 million for St. Jude in their 25-year partnership, becoming the first Greek organization to reach the historic milestone. Since 1999, Tri Delta collegians and alumnae have raised the funds through small-dollar fundraising efforts.
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Master autoimmune regulator gets by with a little help from its friends
06/27/2024
See how St. Jude researchers investigated Foxp3 function as a transcription cofactor in regulatory T cells in immune system activation and suppression.
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Study identifies high-risk type of childhood acute leukemia and potential treatment strategy
06/25/2024
Learn how St. Jude assembled an international cohort to better understand γδ T-ALL, a high-risk form of childhood cancer, and propose a new targeted treatment.
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Children genetically prone to cancer benefit from early standardized surveillance
06/20/2024
Discover new research that shows cancer surveillance deployed immediately after finding a genetic predisposition leads to earlier tumor detection & treatment.
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St. Jude scientists solve decades long mystery of NLRC5 sensor function in cell death and disease
06/14/2024
Learn about immunology research from the St. Jude laboratory of Thirumala-Devi Kanneganti, PhD, that revealed the function of the NLRC5 innate immune sensor.
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Novel insights into fluorescent ‘dark states’ illuminate ways forward for improved imaging
06/14/2024
See how fluorescent dark triplet states in single molecule FRET can be avoided with self-healing fluorophores.
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Age is just a number: Immune cell ‘epigenetic clock’ ticks independently of organism lifespan
06/12/2024
See how St. Jude researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acute lymphoblastic leukemia T cells appear hundreds of years old.
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ALSAC and Other Local Organizations Collaborate to Provide Students from Memphis-Shelby County Schools with Life Skills Training
05/30/2024
ALSAC, the fundraising and awareness organization for St. Jude Children’s Research Hospital, and Memphis-Shelby County Schools celebrated the graduation of 83 local high school students from the Fervent Family Program at a ceremony held at Dixon Gallery & Gardens.
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‘Goldilocks’ binding strength determines anti-cancer T-cell efficacy and fate
05/30/2024
Learn how progenitor exhausted T cells’ receptor binding strength to cancer antigens determines the anti-cancer response with implications for immunotherapy.
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Cell-targeting technology allows researchers to isolate neuronal subpopulations and link them to behavioral states
05/27/2024
See how neurology tool Conditional Viral Expression by Ribozyme Guided Degradation (ConVERGD) allows researchers to isolate subpopulations of cells with increased accuracy and ease
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Repurposed protease controls important signaling molecule-activating protein
05/22/2024
See how cryo-EM reveals iRhom2 acts as regulator of ADAM17 activity and controls activation of tumor necrosis factor and many growth factors by binding ADAM17 prodomain.
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Novel inhibitor insights offer pathway to preventing PXR-associated drug resistance
05/14/2024
See how novel pregnane X receptor inhibitors offer structural understanding behind activator and repressor activity, guiding future drug design research to combat drug resistance
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Domino’s® announces historic goal to raise $300 million to benefit the lifesaving mission of St. Jude Children’s Research Hospital®
05/09/2024
Domino’s®, the largest pizza company in the world, announced the largest corporate or private financial commitment to a children’s hospital: a pledge to bring its fundraising total to $300 million by 2034 to benefit St. Jude.
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Honoring three dreamers: Entrepreneur, artist, civic leader to receive top accolades at St. Jude Spirit of the Dream
05/07/2024
Community leader A C Wharton, Jr., master potter Peter Woods and trailblazing businesswoman Carolyn Chism Hardy will be honored with the Legacy Award and the St. Jude Spirit of the Dream award.
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Miami's Philanthropic Community Raises $785,000 for St. Jude Children's Research Hospital at 22nd Annual FedEx/St. Jude Angels & Stars Gala
05/06/2024
Philanthropists, influencers and celebrities, including Billboard Latin Music award winner Tito Nieves, Emmy® award-winning journalist Jackie Nespral and host, podcaster and author Alberto Sardiñas, raised $785,000 at the 22nd annual FedEx/St. Jude Angels & Stars Gala.
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Pan-cancer analysis uncovers a new class of promising CAR T–cell immunotherapy targets
05/03/2024
St. Jude found 156 potential targets for chimeric antigen receptor (CAR) T–cell immunotherapy. Explore the discovery’s promise to improve cancer therapies.
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Unraveling the roles of non-coding DNA explains childhood cancer’s resistance to chemotherapy
05/01/2024
Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. Explore new technology used in the St. Jude-led discovery.
